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PE20091580A1 - Compuesto heterociclico fusionado - Google Patents

Compuesto heterociclico fusionado

Info

Publication number
PE20091580A1
PE20091580A1 PE2009000360A PE2009000360A PE20091580A1 PE 20091580 A1 PE20091580 A1 PE 20091580A1 PE 2009000360 A PE2009000360 A PE 2009000360A PE 2009000360 A PE2009000360 A PE 2009000360A PE 20091580 A1 PE20091580 A1 PE 20091580A1
Authority
PE
Peru
Prior art keywords
optionally substituted
iloxi
benzoisothiazol
pyrrolo
pyrimidin
Prior art date
Application number
PE2009000360A
Other languages
English (en)
Inventor
Tomoyasu Ishikawa
Youichi Kawakita
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20091580A1 publication Critical patent/PE20091580A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRIMIDINA FUSIONADA DE FORMULA (I) DONDE A ES UN ANILLO BENCENO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C4) O ALCOXI(C1-C4); B ES UN ANILLO BENZOISOTIAZOL OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6); R1 ES H, HALOGENO, ENTRE OTROS; R2 ES H O ALQUILO OPCIONALMENTE SUSTITUIDO; R3 ES H O UN GRUPO HIDROCARBURO ALIFATICO OPCIONALMENTE SUSTITUIDO. SON COMPUESTOS PREFERIDOS: 2-(4-{[4-(1,2-BENZOISOTIAZOL-4-ILOXI)-3-CLOROFENIL]AMINO}-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL)ETANOL, N-[2-(4-{[4-(1,2-BENZOISOTIAZOL-4-ILOXI)-3-CLOROFENIL]AMINO}-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL)ETIL]ACETAMIDA, N-[2-(4-{[4-(1,2-BENZOISOTIAZOL-4-ILOXI)-3-CLOROFENIL]AMINO}-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL)ETIL]PIRROLIDIN-3-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA QUINASA DEL RECEPTOR DEL FACTOR DE CRECIMIENTO SIENDO UTILES EN EL TRATAMIENTO DE CANCER DE MAMA, CANCER GASTRICO, CANCER DE PULMON
PE2009000360A 2008-03-12 2009-03-11 Compuesto heterociclico fusionado PE20091580A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2008063363 2008-03-12

Publications (1)

Publication Number Publication Date
PE20091580A1 true PE20091580A1 (es) 2009-11-05

Family

ID=41063727

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000360A PE20091580A1 (es) 2008-03-12 2009-03-11 Compuesto heterociclico fusionado

Country Status (8)

Country Link
US (1) US20090233937A1 (es)
EP (1) EP2253633A4 (es)
JP (1) JPWO2009113560A1 (es)
AR (1) AR070874A1 (es)
PE (1) PE20091580A1 (es)
TW (1) TW200944528A (es)
UY (1) UY31704A (es)
WO (1) WO2009113560A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20105024B (en) * 2004-06-02 2010-06-25 Takeda Pharmaceuticals Co Fused heterocyclic compound
WO2011040212A1 (en) 2009-10-01 2011-04-07 Takeda Pharmaceutical Company Limited Therapeutic agent for brain tumor
SI2655375T1 (sl) 2010-12-23 2015-03-31 Sanofi Derivati pirimidinona, njihova priprava in njihova farmacevtska uporaba
KR20130015400A (ko) 2011-08-03 2013-02-14 삼성디스플레이 주식회사 헤테로고리 화합물 및 이를 포함하는 유기 전계 발광 소자
KR101930848B1 (ko) 2011-08-11 2018-12-20 삼성디스플레이 주식회사 헤테로고리 화합물 및 이를 포함하는 유기 전계 발광 소자
KR101971198B1 (ko) 2011-10-19 2019-04-23 삼성디스플레이 주식회사 헤테로시클릭 화합물, 이를 포함하는 유기 발광 소자 및 평판 표시 장치
SI3049417T1 (sl) * 2013-07-31 2019-03-29 Merck Patent Gmbh Piridini, pirimidini in pirazini kot inhibitorji BTK in njihove uporabe

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
DK0831829T3 (da) 1995-06-07 2003-12-15 Pfizer Heterocykliske, ringkondenserede pyrimidinderivater
US6395733B1 (en) * 1995-06-07 2002-05-28 Pfizer Inc Heterocyclic ring-fused pyrimidine derivatives
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
AR007855A1 (es) 1996-07-13 1999-11-24 Glaxo Group Ltd Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios, uso en medicinay composiciones farmaceuticas que los contienen
WO1998003648A1 (en) 1996-07-19 1998-01-29 Takeda Chemical Industries, Ltd. Fas ligand-like protein, its production and use
IL129825A0 (en) 1996-11-27 2000-02-29 Pfizer Fused bicyclic pyrimidine derivatives
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
PE20011178A1 (es) 2000-04-07 2001-11-19 Takeda Chemical Industries Ltd Compuestos heterociclicos y su produccion
GEP20063831B (en) 2000-06-22 2006-05-25 Pfizer Prod Inc Substituted bicyclic derivatives for treatment of abnormal cell growth
AU2001273071B2 (en) 2000-06-30 2005-09-08 Glaxo Group Limited Quinazoline ditosylate salt compounds
WO2003031442A1 (fr) 2001-10-05 2003-04-17 Takeda Chemical Industries, Ltd. Composes heterocycliques, derives oxazole, procede permettant de les presenter et leur utilisation
CA2469889A1 (en) 2001-12-12 2003-06-19 Pfizer Products Inc. Salt forms of e-2-methoxy-n-(3-(4-(3-methyl-pyridin-3-yloxy)-phenylamino)-quinazolin-6-yl)-allyl)-acetamide, its preparation and its use against cancer
PL373848A1 (en) 2001-12-12 2005-09-19 Pfizer Products Inc. Quinazoline derivatives for the treatment of abnormal cell growth
US20050009845A1 (en) 2001-12-19 2005-01-13 Caferro Thomas R. Thienopyrimidine compounds as protein tyrosine kinase inhibitors
GEP20105024B (en) * 2004-06-02 2010-06-25 Takeda Pharmaceuticals Co Fused heterocyclic compound
TW200730527A (en) * 2005-12-02 2007-08-16 Takeda Pharmaceuticals Co Fused heterocyclic compound
JP4504337B2 (ja) 2006-09-04 2010-07-14 株式会社御池鐵工所 ガス化炉及びガス化炉システム
JPWO2008072634A1 (ja) * 2006-12-12 2010-04-02 武田薬品工業株式会社 縮合複素環化合物

Also Published As

Publication number Publication date
JPWO2009113560A1 (ja) 2011-07-21
US20090233937A1 (en) 2009-09-17
WO2009113560A1 (ja) 2009-09-17
UY31704A (es) 2009-11-10
EP2253633A4 (en) 2012-02-29
TW200944528A (en) 2009-11-01
AR070874A1 (es) 2010-05-12
EP2253633A1 (en) 2010-11-24

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