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PE20091074A1 - Triazolotriazinas y triazolopirazinas y su uso - Google Patents

Triazolotriazinas y triazolopirazinas y su uso

Info

Publication number
PE20091074A1
PE20091074A1 PE2008002006A PE2008002006A PE20091074A1 PE 20091074 A1 PE20091074 A1 PE 20091074A1 PE 2008002006 A PE2008002006 A PE 2008002006A PE 2008002006 A PE2008002006 A PE 2008002006A PE 20091074 A1 PE20091074 A1 PE 20091074A1
Authority
PE
Peru
Prior art keywords
amino
carbonitrile
ethyl
cyane
triazin
Prior art date
Application number
PE2008002006A
Other languages
English (en)
Inventor
Stephan Siegel
Andreas Wilmen
Niels Svenstrup
Mark Jean Gnoth
Stefan Heitmeier
Ulrich Rester
Adrian Tersteegen
Michael Gerisch
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102007060172A external-priority patent/DE102007060172A1/de
Priority claimed from DE200810035209 external-priority patent/DE102008035209A1/de
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of PE20091074A1 publication Critical patent/PE20091074A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/06—Antianaemics
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    • A61P9/06—Antiarrhythmics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE U ES N; V ES CR12, N; w ES N, CR16; A ES CR15, N; R12 ES H, OH, AMINO, CF3, CIANO, ENTRE OTROS; R15 ES H, HALOGENO, CIANO, CF3, ENTRE OTROS; R16 ES H, METILO; R1 ES 3-(4-AMINO-5-CARBONITRILO-2-IL)AMINO-PIPERIDIN-1-IL, 3-CARBONITRILO-2-AMINO-6-[(2-ILAMINO)ETIL]AMINO-PIRAZINA, ENTRE OTROS; R2 ES ARILO C6C10, HETEROARILO C5C10 SUSTITUIDOS O NO. SON COMPUESTOS PREFERIDOS: 6-[(2-{[6-(2,4-DICLOROFENIL)[1,2,4]TRIAZOLO[1,2,4]TRIAZIN-8-IL]AMINO}ETIL)AMINO]PIRIDIN-3-CARBONITRILO; 2-AMINO-6-{[2-({6-[4-(TRIFLUOROMETIL)FENIL][1,2,4]TRIAZOLO[3,4-f][1,2,4]TRIAZIN-8-IL}AMINO)ETIL]AMINO}PIRIDIN-3-CARBONITRILO; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE GSK3BETA (GLUCOGENO SINTASA QUIBASA 3) UTILES EN EL TRATAMIENTO DE TRASTORNOS HEMATOLOGICOS COMO LEUCOPENIA Y NEUTROPENIA
PE2008002006A 2007-12-13 2008-12-02 Triazolotriazinas y triazolopirazinas y su uso PE20091074A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007060172A DE102007060172A1 (de) 2007-12-13 2007-12-13 Triazolotriazine und Triazolopyrazine und ihre Verwendung
DE200810035209 DE102008035209A1 (de) 2008-07-29 2008-07-29 Triazolotriazine und Triazolopyrazine und ihre Verwendung

Publications (1)

Publication Number Publication Date
PE20091074A1 true PE20091074A1 (es) 2009-07-26

Family

ID=40578190

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002006A PE20091074A1 (es) 2007-12-13 2008-12-02 Triazolotriazinas y triazolopirazinas y su uso

Country Status (11)

Country Link
US (1) US20090258877A1 (es)
EP (1) EP2229392A1 (es)
JP (1) JP2011506364A (es)
AR (1) AR069636A1 (es)
CA (1) CA2708783A1 (es)
CL (1) CL2008003602A1 (es)
PA (1) PA8806501A1 (es)
PE (1) PE20091074A1 (es)
TW (1) TW200938546A (es)
UY (1) UY31508A1 (es)
WO (1) WO2009074259A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4584537B2 (ja) 2001-01-16 2010-11-24 ヴァスキュラー セラピーズ リミテッド ライアビリティ カンパニー 吸収可能なマトリックス材料および抗増殖薬を含む、血液透析血管アクセス及び他の血管移植片の機能不全を防止又は治療するための移植可能な装置および方法
WO2015157955A1 (en) * 2014-04-17 2015-10-22 Abbvie Inc. Heterocyclic btk inhibit ors
BR112020017421A2 (pt) 2018-02-27 2020-12-22 Incyte Corporation Imidazopirimidinas e triazolopirimidinas como inibidores de a2a/a2b
EP3810610A1 (en) 2018-05-18 2021-04-28 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
US11161850B2 (en) 2018-07-05 2021-11-02 Incyte Corporation Fused pyrazine derivatives as A2A / A2B inhibitors
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
JP2022520671A (ja) 2019-02-08 2022-03-31 フリークエンシー・セラピューティクス・インコーポレイテッド 耳障害を治療するためのバルプロ酸化合物及びｗｎｔ作動薬

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60236322D1 (de) * 2001-12-07 2010-06-17 Vertex Pharma Verbindungen auf pyrimidin-basis als gsk-3-hemmer
ATE377600T1 (de) * 2002-09-23 2007-11-15 Schering Corp Imidazopyrazine als cdk-inhibitoren
CA2541832C (en) * 2003-10-10 2009-11-24 Pfizer Products Inc. Substituted 2h-[1,2,4]triazolo[4,3-a]pyrazines as gsk-3 inhibitors
US7713973B2 (en) * 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors

Also Published As

Publication number Publication date
US20090258877A1 (en) 2009-10-15
CA2708783A1 (en) 2009-06-18
PA8806501A1 (es) 2009-08-26
EP2229392A1 (de) 2010-09-22
TW200938546A (en) 2009-09-16
CL2008003602A1 (es) 2009-10-09
AR069636A1 (es) 2010-02-10
JP2011506364A (ja) 2011-03-03
UY31508A1 (es) 2009-08-03
WO2009074259A1 (de) 2009-06-18

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