PE20081844A1 - DERIVADOS DE INDOL-3-IL-CARBONIL-AZASPIROPIPERIDINA COMO ANTAGONISTAS DEL RECEPTOR V1a - Google Patents
DERIVADOS DE INDOL-3-IL-CARBONIL-AZASPIROPIPERIDINA COMO ANTAGONISTAS DEL RECEPTOR V1aInfo
- Publication number
- PE20081844A1 PE20081844A1 PE2008000047A PE2008000047A PE20081844A1 PE 20081844 A1 PE20081844 A1 PE 20081844A1 PE 2008000047 A PE2008000047 A PE 2008000047A PE 2008000047 A PE2008000047 A PE 2008000047A PE 20081844 A1 PE20081844 A1 PE 20081844A1
- Authority
- PE
- Peru
- Prior art keywords
- indol
- alkyl
- carbonyl
- azaspiropiperidine
- derivatives
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- FMACSIUGOAYKJC-UHFFFAOYSA-N spiro[7h-furo[3,4-b]pyridine-5,4'-piperidine] Chemical compound C12=CC=CN=C2COC21CCNCC2 FMACSIUGOAYKJC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A DERIVADOS DE INDOL-3-IL-CARBONIL-AZASPIROPIPERIDINA DE FORMULA (I), EN DONDE U ES O Y V ES CH2, o U ES O Y V ES C=O, o U ES CH2 Y V ES O, o U ES CH2 y V ES O; o U-V ES -CH=CH-, ENTRE OTROS; UNA O DOS VARIABLES W, X, Y y Z SON NITROGENO, SIENDO EL RESTO DE LAS VARIABLES CR8; R1 ES H, ALQUILO(C1-C12), HALOALQUILO(C2-C6), -(CRiRii)m-Ra; ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), -C(O)Rn, NRjRK; R3, R4, R5 Y R6 SON INDEPENDIENTEMENTE H, HALO, ALQUILO(C1-C6), HALOALQUILO(C1-C6), ENTRE OTROS; O R1 Y R6 JUNTO CON EL INDOL AL QUE ESTAN UNIDOS FORMAN UN HETEROCICLO DE 6 MIEMBROS OPCIONALMENTE SUSTITUIDOS; R7 ES H O ALQUILO(C1-C6). SON SELECCIONADOS 1'-[(6-CLORO-1H-INDOL-3-IL)CARBONIL]-7H-SPIRO[FURO-[3,4-b]PIRIDINA-5,4'-PIPERIDINA], (2S)-2-{[6-CLORO-3-(1'H,7H-SPIRO[FURO-[3,4-b]PIRIDINA-5,4'-PIPERIDIN]-1'-ILCARBONIL)-1H-INDOL-1-IL-]METIL}-PIRROLIDINA-1-CARBOXILATO DE TREC-BUTILO. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE V1a, POR LO QUE SON UTILES EN EL TRATAMIENTO DE DISMENORREA, HIPERTENSION, FALLO CARDIACO CRONICA, ANSIEDAD, TRASTORNOS DEPRESIVOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06127334 | 2006-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081844A1 true PE20081844A1 (es) | 2009-01-26 |
Family
ID=39201403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000047A PE20081844A1 (es) | 2006-12-29 | 2008-01-02 | DERIVADOS DE INDOL-3-IL-CARBONIL-AZASPIROPIPERIDINA COMO ANTAGONISTAS DEL RECEPTOR V1a |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8044202B2 (es) |
| EP (1) | EP2125827B1 (es) |
| JP (1) | JP2010514727A (es) |
| KR (1) | KR101129861B1 (es) |
| CN (1) | CN101589046B (es) |
| AR (1) | AR064547A1 (es) |
| AT (1) | ATE486877T1 (es) |
| AU (1) | AU2007341379B2 (es) |
| BR (1) | BRPI0720827A2 (es) |
| CA (1) | CA2674154A1 (es) |
| CL (1) | CL2007003832A1 (es) |
| DE (1) | DE602007010359D1 (es) |
| DK (1) | DK2125827T3 (es) |
| ES (1) | ES2351949T3 (es) |
| MX (1) | MX2009006921A (es) |
| NO (1) | NO20092342L (es) |
| PE (1) | PE20081844A1 (es) |
| PL (1) | PL2125827T3 (es) |
| PT (1) | PT2125827E (es) |
| RU (1) | RU2009124419A (es) |
| TW (1) | TW200835483A (es) |
| WO (1) | WO2008080844A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0720004A2 (pt) * | 2006-12-07 | 2013-12-17 | Hoffmann La Roche | Derivados de espiro-piperidina como antagonista de receptor v1a |
| CN101563324A (zh) * | 2006-12-22 | 2009-10-21 | 弗·哈夫曼-拉罗切有限公司 | 螺-哌啶衍生物 |
| MX2011013816A (es) | 2009-06-29 | 2012-04-11 | Incyte Corp | Pirimidinonas como inhibidores de pi3k. |
| AR078948A1 (es) * | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
| TW201130842A (en) * | 2009-12-18 | 2011-09-16 | Incyte Corp | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
| WO2011075643A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| WO2011130342A1 (en) | 2010-04-14 | 2011-10-20 | Incyte Corporation | FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| AR084366A1 (es) | 2010-12-20 | 2013-05-08 | Incyte Corp | N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| ES2464598T3 (es) | 2011-07-22 | 2014-06-03 | Université Joseph Fourier | Nuevos derivados bis-indólicos, procedimiento para su preparación, y sus utilizaciones como fármaco |
| MY179332A (en) | 2011-09-02 | 2020-11-04 | Incyte Holdings Corp | Heterocyclylamines as pl3k inhibitors |
| CN102568615B (zh) * | 2011-12-13 | 2013-05-22 | 华中科技大学 | 一种小型精密调平装置 |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| MD3262046T2 (ro) | 2015-02-27 | 2021-03-31 | Incyte Corp | Săruri de inhibitori ai PI3K și procedee pentru prepararea lor |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| CN112469418A (zh) | 2018-06-01 | 2021-03-09 | 因赛特公司 | 治疗pi3k相关病症的给药方案 |
| UY38934A (es) | 2019-10-29 | 2021-05-31 | Biogen Ma Inc | Inhibidores de o-glucoproteína-2-acetamido-2-deoxi-3-d-glucopiranosidasa espirocíclica |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2761992B1 (fr) * | 1997-04-09 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| TWI279402B (en) * | 1999-08-20 | 2007-04-21 | Banyu Pharma Co Ltd | Spiro compounds having NPY antagonistic activities and agents containing the same |
| GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
| AP2331A (en) * | 2003-12-22 | 2011-12-05 | Pfizer | Triazole derivatives as vasopressin antagonists. |
| GB0400700D0 (en) * | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| GB0504556D0 (en) * | 2005-03-04 | 2005-04-13 | Pfizer Ltd | Novel pharmaceuticals |
-
2007
- 2007-12-19 BR BRPI0720827-8A patent/BRPI0720827A2/pt not_active IP Right Cessation
- 2007-12-19 JP JP2009543443A patent/JP2010514727A/ja active Pending
- 2007-12-19 EP EP07857806A patent/EP2125827B1/en not_active Not-in-force
- 2007-12-19 CA CA002674154A patent/CA2674154A1/en not_active Abandoned
- 2007-12-19 KR KR1020097015840A patent/KR101129861B1/ko not_active IP Right Cessation
- 2007-12-19 PT PT07857806T patent/PT2125827E/pt unknown
- 2007-12-19 PL PL07857806T patent/PL2125827T3/pl unknown
- 2007-12-19 ES ES07857806T patent/ES2351949T3/es active Active
- 2007-12-19 AU AU2007341379A patent/AU2007341379B2/en not_active Expired - Fee Related
- 2007-12-19 AT AT07857806T patent/ATE486877T1/de active
- 2007-12-19 MX MX2009006921A patent/MX2009006921A/es active IP Right Grant
- 2007-12-19 CN CN2007800479989A patent/CN101589046B/zh not_active Expired - Fee Related
- 2007-12-19 DK DK07857806.9T patent/DK2125827T3/da active
- 2007-12-19 WO PCT/EP2007/064183 patent/WO2008080844A1/en active Application Filing
- 2007-12-19 DE DE602007010359T patent/DE602007010359D1/de active Active
- 2007-12-19 RU RU2009124419/04A patent/RU2009124419A/ru not_active Application Discontinuation
- 2007-12-20 US US11/960,799 patent/US8044202B2/en not_active Expired - Fee Related
- 2007-12-20 US US11/960,779 patent/US8034937B2/en not_active Expired - Fee Related
- 2007-12-20 US US11/960,823 patent/US8039624B2/en not_active Expired - Fee Related
- 2007-12-26 TW TW096150410A patent/TW200835483A/zh unknown
- 2007-12-27 CL CL200703832A patent/CL2007003832A1/es unknown
- 2007-12-27 AR ARP070105915A patent/AR064547A1/es not_active Application Discontinuation
-
2008
- 2008-01-02 PE PE2008000047A patent/PE20081844A1/es not_active Application Discontinuation
-
2009
- 2009-06-18 NO NO20092342A patent/NO20092342L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101589046B (zh) | 2011-09-21 |
| CA2674154A1 (en) | 2008-07-10 |
| US8039624B2 (en) | 2011-10-18 |
| RU2009124419A (ru) | 2011-02-10 |
| EP2125827A1 (en) | 2009-12-02 |
| US20080161333A1 (en) | 2008-07-03 |
| US20080281103A1 (en) | 2008-11-13 |
| US20080161332A1 (en) | 2008-07-03 |
| CL2007003832A1 (es) | 2008-07-25 |
| US8034937B2 (en) | 2011-10-11 |
| JP2010514727A (ja) | 2010-05-06 |
| ATE486877T1 (de) | 2010-11-15 |
| AU2007341379B2 (en) | 2012-05-24 |
| US8044202B2 (en) | 2011-10-25 |
| DK2125827T3 (da) | 2010-12-20 |
| AU2007341379A1 (en) | 2008-07-10 |
| WO2008080844A9 (en) | 2009-10-08 |
| EP2125827B1 (en) | 2010-11-03 |
| PL2125827T3 (pl) | 2011-04-29 |
| TW200835483A (en) | 2008-09-01 |
| CN101589046A (zh) | 2009-11-25 |
| MX2009006921A (es) | 2009-07-06 |
| BRPI0720827A2 (pt) | 2014-03-04 |
| NO20092342L (no) | 2009-07-02 |
| WO2008080844A1 (en) | 2008-07-10 |
| PT2125827E (pt) | 2010-11-22 |
| KR101129861B1 (ko) | 2012-04-24 |
| DE602007010359D1 (de) | 2010-12-16 |
| KR20090094172A (ko) | 2009-09-03 |
| ES2351949T3 (es) | 2011-02-14 |
| AR064547A1 (es) | 2009-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |