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PE20071242A1 - MOLECULAS DE ARNip Y COMPOSICIONES COMO INHIBIDORES DE RTP801 - Google Patents

MOLECULAS DE ARNip Y COMPOSICIONES COMO INHIBIDORES DE RTP801

Info

Publication number
PE20071242A1
PE20071242A1 PE2007000059A PE2007000059A PE20071242A1 PE 20071242 A1 PE20071242 A1 PE 20071242A1 PE 2007000059 A PE2007000059 A PE 2007000059A PE 2007000059 A PE2007000059 A PE 2007000059A PE 20071242 A1 PE20071242 A1 PE 20071242A1
Authority
PE
Peru
Prior art keywords
sequence
gene
rtp801
present
sirna molecules
Prior art date
Application number
PE2007000059A
Other languages
English (en)
Inventor
Rami Skaliter
Elena Feinstein
Original Assignee
Quark Biotech Inc
Atugen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quark Biotech Inc, Atugen Ag filed Critical Quark Biotech Inc
Publication of PE20071242A1 publication Critical patent/PE20071242A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A MOLECULAS ARNip (RNA INTERFERENTES) QUE INHIBEN EL GEN RTP801, EN DONDE LA MOLECULA ES UN POLINUCLEOTIDO QUE COMPRENDE NUCLEOTIDOS CONSECUTIVOS QUE TIENEN UNA SECUENCIA DE LONGITUD Y HOMOLOGIA CON UNA SECUENCIA PRESENTE EN LA SECUENCIA DE UN GEN QUE CODIFICA RTP801 TAL COMO SE DESCRIBE EN LA SEC. ID. Nº: 1, 2, 3-536; SUFICIENTE PARA PERMITIR LA HIBRIDACION DEL INHIBIDOR AL GEN Y EVITAR LA EXPRESION DEL GEN RTP801. UN COMPUESTO QUE TIENE LA ESTRUCTURA: 5'(N)x-Z3' (CADENA NO CODIFICANTE); 3'Z'-(N')y5'(CADENA CODIFICANTE); EN DONDE CADA N Y N' ES UN RIBONUCLEOTIDO QUE PUEDE ESTAR MODIDFADO O NO EN SU RESTO GLUCOCIDICO Y (N)x Y (N')y ES UN OLIGOMERICO UNIDOS POR UN ENLACE COVALENTE; CADA x E y ES DE 19 A 40; Z Y Z' ESTA PRESENTE O NO, Y SI ESTA ES dTdT Y UNIDO COVALENTE EN EL EXTREMO 3' DE LA CADENA EN LA QUE ESTA PRESENTE; Y EN LA SECUENCIA (N)x COMPRENDE UNA DE LAS SECUENCIAS DEL GEN. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA; SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS MICROVASCULARES, ENFERMEDADES OCULARES, AFECCIONES RESPIRATORIAS Y TRASTORNOS AUDITIVOS
PE2007000059A 2006-01-20 2007-01-19 MOLECULAS DE ARNip Y COMPOSICIONES COMO INHIBIDORES DE RTP801 PE20071242A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76058606P 2006-01-20 2006-01-20
US79690106P 2006-05-01 2006-05-01
US85100006P 2006-10-10 2006-10-10

Publications (1)

Publication Number Publication Date
PE20071242A1 true PE20071242A1 (es) 2008-01-30

Family

ID=38288268

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000059A PE20071242A1 (es) 2006-01-20 2007-01-19 MOLECULAS DE ARNip Y COMPOSICIONES COMO INHIBIDORES DE RTP801

Country Status (19)

Country Link
US (2) US8067570B2 (es)
EP (2) EP1984003A4 (es)
JP (1) JP2009523814A (es)
KR (1) KR20080085887A (es)
AR (1) AR059093A1 (es)
AU (1) AU2007207479B2 (es)
BR (1) BRPI0707160A2 (es)
CA (1) CA2635723A1 (es)
DO (1) DOP2007000015A (es)
GT (1) GT200700004A (es)
IL (2) IL192880A0 (es)
MX (1) MX2008009355A (es)
NL (1) NL2000439C2 (es)
PE (1) PE20071242A1 (es)
SG (1) SG179410A1 (es)
TW (1) TW200806325A (es)
UY (1) UY30097A1 (es)
WO (1) WO2007084684A2 (es)
ZA (1) ZA200806150B (es)

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US7825099B2 (en) * 2006-01-20 2010-11-02 Quark Pharmaceuticals, Inc. Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
DOP2007000015A (es) 2006-01-20 2007-08-31 Quark Biotech Inc Usos terapéuticos de inhibidores de rtp801
CN101528710B (zh) 2006-10-19 2012-11-07 弗·哈夫曼-拉罗切有限公司 氨基甲基-4-咪唑类
EP2104665A2 (en) 2006-10-19 2009-09-30 F. Hoffmann-Roche AG Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes
EP2231168A4 (en) * 2007-10-03 2012-01-04 Quark Pharmaceuticals Inc NEW STRUCTURES OF ARNSI
US8614311B2 (en) 2007-12-12 2013-12-24 Quark Pharmaceuticals, Inc. RTP801L siRNA compounds and methods of use thereof
CA2718765A1 (en) * 2008-03-20 2009-09-24 Quark Pharmaceuticals, Inc. Novel sirna compounds for inhibiting rtp801
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WO2007084684A3 (en) 2008-03-20
EP1984003A2 (en) 2008-10-29
AU2007207479B2 (en) 2012-05-10
US8067570B2 (en) 2011-11-29
WO2007084684A2 (en) 2007-07-26
US9056903B2 (en) 2015-06-16
IL211835A0 (en) 2011-05-31
MX2008009355A (es) 2008-12-15
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CA2635723A1 (en) 2007-07-26
ZA200806150B (en) 2010-11-24
US20120156208A1 (en) 2012-06-21
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AU2007207479A1 (en) 2007-07-26
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AR059093A1 (es) 2008-03-12
JP2009523814A (ja) 2009-06-25
EP2402443A3 (en) 2015-10-07
KR20080085887A (ko) 2008-09-24
NL2000439A1 (nl) 2007-07-23
US20100272722A1 (en) 2010-10-28
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TW200806325A (en) 2008-02-01
BRPI0707160A2 (pt) 2011-04-26

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