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PE20060569A1 - Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc - Google Patents

Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc

Info

Publication number
PE20060569A1
PE20060569A1 PE2005000809A PE2005000809A PE20060569A1 PE 20060569 A1 PE20060569 A1 PE 20060569A1 PE 2005000809 A PE2005000809 A PE 2005000809A PE 2005000809 A PE2005000809 A PE 2005000809A PE 20060569 A1 PE20060569 A1 PE 20060569A1
Authority
PE
Peru
Prior art keywords
alkyl
indol
het
compounds
amino
Prior art date
Application number
PE2005000809A
Other languages
English (en)
Inventor
Pierre Louis Beaulieu
Christian Brochu
Jean Rancourt
Bounkham Thavonekham
Youla S Tsantrizos
Timothy A Stammers
Stephen Kawai
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35784831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060569(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20060569A1 publication Critical patent/PE20060569A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE INDOL FORMULA (I), EN DONDE A O B SON INDISTINTAMENTE N Y C, LAS LINEAS PUNTEADAS REPRESENTAN UN DOBLE ENLACE SI ESTA ENTRE DOS CARBONOS Y SIMPLE SI ESTA ENTRE C Y N; R1 ES H O ALQUILO(C1-C6); R2 ES ALQUILO(C1-C6), ARILO O Het OPCIONALMENTE SUSTITUIDO CON R21, DONDE Het ES UN HETEROCICLO MONOCICLICO AROMATICO DE 5 A 6 MIEMBROS DE 1 A 4 HETEROATOMOS DE O, N O S Y OPCIONALMENTE CONDENSADO A OTRO CICLO; R3 ES CICLOALQUILO(C5-C6); R5 ES ALQUILO(C1-C6), ALQUENILO(C1-C6), Het, Het-ALQUILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; R6 ES H, ALQUILO, HALO, ENTRE OTROS O R5 Y R6 PUEDEN ESTAR ENLAZADOS; R7 ES H, ALQUILO O ALCOXI(C1-C6), ENTRE OTROS; R9 Y R10 SON INDEPENDIENTEMENTE ALQUILO(C1-C6) O JUNTOS UNIDOS COVALENTEMENTE FORMAN UN CICLOAQUILO O CICLOALQUENILO(C5-C6), HETEROCICLO DE 5 A 6 MIEMBROS. SON PREFERIDOS: (E)-3-[4-({1-[(3-CICLOPENTIL-1-METIL-2-PIRIDIN-2-IL-1H-INDOL-6-CARBONIL)-AMINO]CICLOBUTANOLCARBONIL}AMINO)-2,6-DIMETOXIFENIL]ACRILICO, ACIDO (E)-3-{4-[(1-{[2-(5-CLORO-PIRIMIDIN-2-IL)-3-CICLOPENTIL-1-METIL-1H-INDOL-6-CARBONIL]-AMINO}CICLOBUTANOCARBONIL)AMINO]2-ETOXI-FENIL}-ACRILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ADEMAS PUEDE COMPRENDER OTRO AGENTE ANTIVIRAL COMO RIBAVIRINA, AMANTADINA, INMUNOMODULADORES, INHIBIDOR DE PROTEASA NE3 DE VHC, ENTRE OTROS. ESTOS COMPUESTOS SON INHIBIDORES DE ARN POLIMERASA DEPENDIENTE DE ARN DE LA ENZIMA NE5B, CODIFICADA POR VHC Y SON UTILES EN LA INFECCION POR VHC
PE2005000809A 2004-07-16 2005-07-14 Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc PE20060569A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58867004P 2004-07-16 2004-07-16

Publications (1)

Publication Number Publication Date
PE20060569A1 true PE20060569A1 (es) 2006-06-22

Family

ID=35784831

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000809A PE20060569A1 (es) 2004-07-16 2005-07-14 Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc

Country Status (19)

Country Link
US (2) US7241801B2 (es)
EP (1) EP1771442A4 (es)
JP (1) JP2008506638A (es)
KR (1) KR20070035092A (es)
CN (1) CN1984908A (es)
AR (1) AR050172A1 (es)
AU (1) AU2005263135A1 (es)
BR (1) BRPI0513431A (es)
CA (1) CA2573210A1 (es)
EA (1) EA200700038A1 (es)
EC (1) ECSP077171A (es)
IL (1) IL180665A0 (es)
MX (1) MX2007000007A (es)
NO (1) NO20070368L (es)
PE (1) PE20060569A1 (es)
TW (1) TW200617003A (es)
UY (1) UY29017A1 (es)
WO (1) WO2006007693A1 (es)
ZA (1) ZA200609578B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US20050075279A1 (en) * 2002-10-25 2005-04-07 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
AU2005215829C1 (en) * 2004-02-20 2012-08-30 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7348425B2 (en) 2004-08-09 2008-03-25 Bristol-Myers Squibb Company Inhibitors of HCV replication
CA2593450A1 (en) * 2005-01-14 2006-07-20 Genelabs Technologies, Inc. Indole derivatives for treating viral infections
EP2530082A1 (en) * 2005-02-11 2012-12-05 Boehringer Ingelheim International GmbH Process for preparing 2, 3-disubstituted indoles
WO2006127289A1 (en) * 2005-05-20 2006-11-30 Valeant Research & Development Treatment of hcv with subtherapeutic doses of ribavirin
JP5015154B2 (ja) 2005-08-12 2012-08-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
US7816348B2 (en) 2006-02-03 2010-10-19 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2007092000A1 (en) * 2006-02-06 2007-08-16 Bristol-Myers Squibb Company Inhibitors of hcv replication
GB0608928D0 (en) 2006-05-08 2006-06-14 Angeletti P Ist Richerche Bio Therapeutic agents
RU2009109355A (ru) 2006-08-17 2010-09-27 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Ингибиторы вырусной полимеразы
FR2910813B1 (fr) 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
WO2009008906A2 (en) * 2007-02-06 2009-01-15 The Trustees Of The University Of Pennsylvania Therapeutic compounds for blocking dna synthesis of pox viruses
NZ580917A (en) 2007-05-04 2012-06-29 Vertex Pharma Combinations of protease inhibitors such as VX-950 and polymerase inhibitors for the treatment of HCV infection
CA2693533A1 (en) 2007-07-17 2009-01-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Macrocyclic indole derivatives for the treatment of hepatitis c infections
JP2010535156A (ja) 2007-08-03 2010-11-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼ阻害剤
EP2185539A4 (en) * 2007-08-03 2011-07-20 Boehringer Ingelheim Int VIRAL POLYMERASE INHIBITORS
EP2224942A4 (en) 2007-12-05 2012-01-25 Enanta Pharm Inc FLUORATED TRIPEPTIDE HCV SERINE PROTEASE INHIBITORS
MX2010006313A (es) 2007-12-19 2010-06-25 Boehringer Ingelheim Int Inhibidores de la polimerasa virica.
RU2011127080A (ru) 2009-01-07 2013-02-20 Сайнексис, Инк. Производное циклоспорина для применения в лечении заражения вирусом гепатита с и вич
EP2414344A1 (en) 2009-03-31 2012-02-08 ArQule, Inc. Substituted indolo-pyridinone compounds
CN102458444A (zh) 2009-05-13 2012-05-16 英安塔制药有限公司 用作丙型肝炎病毒抑制剂的大环化合物
UY38339A (es) 2010-09-21 2020-12-31 Enanta Pharm Inc Inhibidores de las proteasas de serina del vhc derivados de prolinas macrocíclicas
US9233921B2 (en) 2013-03-08 2016-01-12 The Trustees Of The University Of Pennsylvania Potent poxvirus inhibitor
CN113444094B (zh) * 2016-07-20 2023-12-22 纳莹(上海)生物科技有限公司 一种荧光探针及其制备方法和用途
US12060148B2 (en) 2022-08-16 2024-08-13 Honeywell International Inc. Ground resonance detection and warning system and method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
HUP0400039A3 (en) 2001-03-08 2004-10-28 Boehringer Ingelheim Ca Ltd Hcv polymerase inhibitor assay
CA2448737C (en) 2001-07-20 2010-06-01 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors

Also Published As

Publication number Publication date
EA200700038A1 (ru) 2007-08-31
CN1984908A (zh) 2007-06-20
AU2005263135A1 (en) 2006-01-26
TW200617003A (en) 2006-06-01
US20070249629A1 (en) 2007-10-25
UY29017A1 (es) 2006-02-24
IL180665A0 (en) 2007-06-03
BRPI0513431A (pt) 2008-05-06
WO2006007693A1 (en) 2006-01-26
ZA200609578B (en) 2008-08-27
ECSP077171A (es) 2007-02-28
US7241801B2 (en) 2007-07-10
CA2573210A1 (en) 2006-01-26
EP1771442A1 (en) 2007-04-11
EP1771442A4 (en) 2009-12-30
KR20070035092A (ko) 2007-03-29
JP2008506638A (ja) 2008-03-06
MX2007000007A (es) 2007-03-07
AR050172A1 (es) 2006-10-04
NO20070368L (no) 2007-01-30
US20060052418A1 (en) 2006-03-09

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