PE20050131A1 - Derivados de benzoimidazol como agentes antiproliferativos - Google Patents
Derivados de benzoimidazol como agentes antiproliferativosInfo
- Publication number
- PE20050131A1 PE20050131A1 PE2003000864A PE2003000864A PE20050131A1 PE 20050131 A1 PE20050131 A1 PE 20050131A1 PE 2003000864 A PE2003000864 A PE 2003000864A PE 2003000864 A PE2003000864 A PE 2003000864A PE 20050131 A1 PE20050131 A1 PE 20050131A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- antiproliferative agents
- benzoimidazole derivatives
- cr5r6
- benzoimidazol
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 230000001028 anti-proliverative effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- AKQZEFRALAUBFS-UHFFFAOYSA-N ilamine Natural products COC(C)C(O)(C(=O)OCC1=CCN2CCCC12)C(C)(C)O AKQZEFRALAUBFS-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA A COMPUESTOS DE FORMULA I, SUS SALES, HIDRATOS Y SOLVATOS DONDE R1, R2 Y R3 SON CADA UNO H, ALQUILO C1-C6, HALO, CIANO, ENTRE OTROS; R4 ES -(CR5R6)nH, -(CR5R6)m(HETEROCICLILO DE 4 A 6 MIEMBROS); n ES 1-5; m ES 0-5. TAMBIEN REFERIDA A UN PROCESO PARA LA PREPARACION DE ESTOS COMPUESTOS CUYOS PREFERIDOS SON: 1-{2-[5-(3-MORFOLIN-4-ILPROPOXI)-BENZOIMIDAZOL-1-IL]-QUINOLIN-8-IL}PIPERIDIN-4-ILAMINA Y 1-{2-[5-(3-METIL-OXETAN-3-ILMETOXI)-BENZOIMIDAZOL-1-IL]-QUINOLIN-8-IL}PIPERIDIN-4-ILAMINA , ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS COMO EL CANCER
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40652402P | 2002-08-28 | 2002-08-28 | |
| US41704702P | 2002-10-08 | 2002-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050131A1 true PE20050131A1 (es) | 2005-03-21 |
Family
ID=31981411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000864A PE20050131A1 (es) | 2002-08-28 | 2003-08-25 | Derivados de benzoimidazol como agentes antiproliferativos |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US7071337B2 (es) |
| EP (1) | EP1594858B1 (es) |
| JP (1) | JP4551771B2 (es) |
| KR (2) | KR20070086768A (es) |
| CN (1) | CN1319966C (es) |
| AP (1) | AP2005003237A0 (es) |
| AR (1) | AR041055A1 (es) |
| AT (1) | ATE445610T1 (es) |
| AU (1) | AU2003250499B2 (es) |
| BR (1) | BRPI0313942C1 (es) |
| CA (1) | CA2495577C (es) |
| CR (1) | CR7698A (es) |
| CU (1) | CU23413B7 (es) |
| CY (1) | CY1110580T1 (es) |
| DE (1) | DE60329715D1 (es) |
| DK (1) | DK1594858T3 (es) |
| DO (1) | DOP2003000694A (es) |
| EA (1) | EA008448B1 (es) |
| EC (1) | ECSP055633A (es) |
| ES (1) | ES2333219T3 (es) |
| GE (1) | GEP20064005B (es) |
| HN (1) | HN2003000257A (es) |
| HR (1) | HRP20050191B1 (es) |
| IL (1) | IL166832A (es) |
| IS (1) | IS2738B (es) |
| MA (1) | MA27389A1 (es) |
| MX (1) | MXPA05001256A (es) |
| MY (1) | MY139357A (es) |
| NO (1) | NO20051303L (es) |
| NZ (1) | NZ538427A (es) |
| OA (1) | OA12916A (es) |
| PA (1) | PA8580301A1 (es) |
| PE (1) | PE20050131A1 (es) |
| PL (1) | PL377678A1 (es) |
| PT (1) | PT1594858E (es) |
| RS (1) | RS20050180A (es) |
| SI (1) | SI1594858T1 (es) |
| TW (1) | TW200407131A (es) |
| UY (1) | UY27952A1 (es) |
| WO (1) | WO2004020431A2 (es) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2004001470A1 (es) * | 2003-06-24 | 2005-05-13 | Pfizer Prod Inc | Procedimiento de preparacion de derivados de [(benzoimidazol-1-il)-quinolin-8-il]-piperidin-4-ilamina, utiles en el tratamiento del crecimiento celular anormal, por desproteccion del grupo boc con un alcoxido de metal en presencia de un equivalente d |
| CA2561516A1 (en) * | 2004-03-30 | 2005-10-13 | Pfizer Products Inc. | Combinations of signal transduction inhibitors |
| GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
| MX2007004183A (es) * | 2004-10-07 | 2007-06-07 | Pfizer Prod Inc | Derivados de benzoimidazol utiles como agentes antiproliferacion. |
| EP2444419A1 (en) | 2005-04-26 | 2012-04-25 | Pfizer Inc. | P-Cadherin antibodies |
| CN107056943B (zh) | 2005-09-07 | 2021-06-08 | 安进弗里蒙特公司 | 活化素受体样激酶-1的人单克隆抗体 |
| RS20080525A (en) | 2006-05-09 | 2009-09-08 | Pfizer Products Inc., | Cycloalkylamino acid derivatives and pharmaceutical compositions thereof |
| WO2008124323A1 (en) | 2007-04-03 | 2008-10-16 | Array Biopharma Inc. | Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors |
| CN103936743B (zh) * | 2008-05-21 | 2018-04-24 | 因西特控股公司 | 2-氟-N-甲基-4-[7-(喹啉-6-基甲基)咪唑并[1,2-b][1,2,4]三嗪-2-基]苯甲酰胺的盐及与其相关的制备方法 |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8859775B2 (en) | 2010-09-02 | 2014-10-14 | Merck Patent Gmbh | Pyrazolopyridinone derivatives as LPA receptor antagonists |
| GB201103578D0 (en) | 2011-03-02 | 2011-04-13 | Sabrepharm Ltd | Dipyridinium derivatives |
| TWI569799B (zh) * | 2012-09-21 | 2017-02-11 | 安羅格製藥股份有限公司 | 抑制組成型活性磷酸化ｆｌｔ３激酶的方法 |
| KR20140040594A (ko) | 2012-09-26 | 2014-04-03 | 아로그 파마슈티칼스, 엘엘씨 | 돌연변이체 c-kit의 억제 방법 |
| US11642340B2 (en) | 2012-09-26 | 2023-05-09 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| US10835525B2 (en) | 2012-09-26 | 2020-11-17 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| BR112015016282A2 (pt) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals Inc | crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
| GEP20207108B (en) * | 2014-10-31 | 2020-05-11 | Farma Jenosaiens | Substituted 2,4 diamino-quinoline as new anticancer agents |
| GB2543550A (en) | 2015-10-21 | 2017-04-26 | Hox Therapeutics Ltd | Peptides |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| DK3452465T3 (da) * | 2016-05-04 | 2021-02-08 | Genoscience Pharma | Substituerede 2,4-diaminoquinolinderivater til anvendelse til behandling af proliferative sygdomme |
| WO2018085292A1 (en) | 2016-11-02 | 2018-05-11 | Arog Pharmaceuticals, Inc. | Crenolanib for treating flt3 mutated proliferative disorders associated mutations |
| CN107382984B (zh) * | 2017-08-24 | 2020-07-10 | 扬州市三药制药有限公司 | 一种治疗白血病药物的制备方法 |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| CN110840893A (zh) | 2018-12-13 | 2020-02-28 | 安罗格制药有限责任公司 | 含克莱拉尼的药物组合物及其用途 |
| US11471451B2 (en) | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN114702428B (zh) * | 2019-12-09 | 2023-11-28 | 苏州恩华生物医药科技有限公司 | 连双环结构sigma-1受体抑制剂 |
| CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| WO2022019998A1 (en) * | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| CA3186319A1 (en) * | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| JP2023536920A (ja) * | 2020-08-05 | 2023-08-30 | ザ ジェネラル ホスピタル コーポレイション | 塩誘導性キナーゼ阻害剤 |
| US11524006B2 (en) | 2020-09-17 | 2022-12-13 | Arog Pharmaceuticals, Inc. | Crenolanib for treating TRK kinase associated proliferative disorders |
| US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
| CN113683594B (zh) * | 2021-09-07 | 2022-12-27 | 曲靖师范学院 | 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用 |
| JP2023063189A (ja) | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
| EP4430047A1 (en) | 2021-11-08 | 2024-09-18 | Progentos Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
| CN114409632B (zh) * | 2022-02-22 | 2024-04-30 | 北京鲲达宇科技有限公司 | 2-取代氨基-3-苯并咪唑取代的喹啉衍生物及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| US5990146A (en) | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| AU744939B2 (en) | 1997-09-26 | 2002-03-07 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| WO2001040214A1 (en) * | 1999-11-30 | 2001-06-07 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
| JP2008002005A (ja) * | 2006-06-21 | 2008-01-10 | Shimada Shoji Kk | 衣服用パッド |
-
2003
- 2003-08-12 PA PA8580301A patent/PA8580301A1/es unknown
- 2003-08-14 EP EP20030791110 patent/EP1594858B1/en not_active Expired - Lifetime
- 2003-08-14 MX MXPA05001256A patent/MXPA05001256A/es active IP Right Grant
- 2003-08-14 PT PT03791110T patent/PT1594858E/pt unknown
- 2003-08-14 ES ES03791110T patent/ES2333219T3/es not_active Expired - Lifetime
- 2003-08-14 HR HRP20050191AA patent/HRP20050191B1/hr not_active IP Right Cessation
- 2003-08-14 PL PL37767803A patent/PL377678A1/pl not_active Application Discontinuation
- 2003-08-14 WO PCT/IB2003/003634 patent/WO2004020431A2/en active Application Filing
- 2003-08-14 CA CA 2495577 patent/CA2495577C/en not_active Expired - Lifetime
- 2003-08-14 SI SI200331687T patent/SI1594858T1/sl unknown
- 2003-08-14 JP JP2004569727A patent/JP4551771B2/ja not_active Expired - Lifetime
- 2003-08-14 GE GEAU2003008665 patent/GEP20064005B/en unknown
- 2003-08-14 AT AT03791110T patent/ATE445610T1/de active
- 2003-08-14 KR KR1020077014809A patent/KR20070086768A/ko not_active Ceased
- 2003-08-14 AP AP2005003237A patent/AP2005003237A0/xx unknown
- 2003-08-14 KR KR20057003493A patent/KR100816166B1/ko not_active Expired - Fee Related
- 2003-08-14 BR BRPI0313942A patent/BRPI0313942C1/pt not_active IP Right Cessation
- 2003-08-14 EA EA200500174A patent/EA008448B1/ru not_active IP Right Cessation
- 2003-08-14 AU AU2003250499A patent/AU2003250499B2/en not_active Ceased
- 2003-08-14 CN CNB038206218A patent/CN1319966C/zh not_active Expired - Lifetime
- 2003-08-14 DK DK03791110T patent/DK1594858T3/da active
- 2003-08-14 DE DE60329715T patent/DE60329715D1/de not_active Expired - Lifetime
- 2003-08-14 OA OA1200500059A patent/OA12916A/en unknown
- 2003-08-14 NZ NZ538427A patent/NZ538427A/en not_active IP Right Cessation
- 2003-08-19 DO DO2003000694A patent/DOP2003000694A/es unknown
- 2003-08-25 HN HN2003000257A patent/HN2003000257A/es unknown
- 2003-08-25 PE PE2003000864A patent/PE20050131A1/es active IP Right Grant
- 2003-08-26 AR ARP030103073 patent/AR041055A1/es unknown
- 2003-08-26 US US10/648,151 patent/US7071337B2/en not_active Expired - Lifetime
- 2003-08-26 UY UY27952A patent/UY27952A1/es not_active Application Discontinuation
- 2003-08-26 MY MYPI20033225 patent/MY139357A/en unknown
- 2003-08-27 TW TW92123585A patent/TW200407131A/zh unknown
-
2005
- 2005-01-20 IS IS7660A patent/IS2738B/is unknown
- 2005-02-10 IL IL166832A patent/IL166832A/en active IP Right Grant
- 2005-02-14 CU CU20050031A patent/CU23413B7/es not_active IP Right Cessation
- 2005-02-22 CR CR7698A patent/CR7698A/es unknown
- 2005-02-28 MA MA28124A patent/MA27389A1/fr unknown
- 2005-02-28 EC ECSP055633 patent/ECSP055633A/es unknown
- 2005-03-14 NO NO20051303A patent/NO20051303L/no not_active Application Discontinuation
- 2005-08-14 RS YUP-2005/0180A patent/RS20050180A/sr unknown
-
2009
- 2009-11-30 CY CY20091101249T patent/CY1110580T1/el unknown
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration |