PE20040533A1 - Esteres en posicion 20 de las camptotecinas - Google Patents
Esteres en posicion 20 de las camptotecinasInfo
- Publication number
- PE20040533A1 PE20040533A1 PE2003000528A PE2003000528A PE20040533A1 PE 20040533 A1 PE20040533 A1 PE 20040533A1 PE 2003000528 A PE2003000528 A PE 2003000528A PE 2003000528 A PE2003000528 A PE 2003000528A PE 20040533 A1 PE20040533 A1 PE 20040533A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- saturated
- butoxyiminomethyl
- cycloalkyl
- tert
- Prior art date
Links
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 2
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I, DONDE A ES UNA CADENA RECTA O RAMIFICADA, SATURADA O NO SATURADA, ALQUILO C1-C8, CICLOALQUILO C3-C10, ENTRE OTROS; n Y m SON 0-1; Y ES ALQUILO C1-C8 RECTA O RAMIFICADA, SATURADA O NO SATURADA, 4-TRIMETILAMONIO-3-HIDROXIBUTANOIL, ENTRE OTROS; R1 ES H o -C(R5)=N-O-R4; R2 Y R3 SON CADA UNO H, HIDROXI, ALCOXI C1-C5, ENTRE OTROS; R4 ES H, ALQUILO C1-C5, ALQUENILO C1-C5, CICLOALQUILO C3-C10, ENTRE OTROS; R5 ES H, ALQUILO C1-C5, CICLOALQUILO C3-C10, ARILO C6-C14, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: BROMURO DE (E)-7-TERT-BUTOXIIMINOMETIL-20-O-(4-TRIMETIL-AMONIO-3-HIDROXI)BUTANOIL-CAMPTOTECINA; BROMURO DE (E)-7-TERT-BUTOXIIMINOMETIL-20-O-(4-TRIMETIL-AMONIO)BUTANOIL-CAMPTOTECINA Y (E)-7-TERT-BUTOXIIMINOMETIL-20-O-HEMISUCCINIL-CAMPTOTECINA; ENTRE OTROS. TAMBIEN SE REFIERE A LA PREPARACION DE UN MEDICAMENTO. DICHOS COMPUESTOS SON INHIBIDORES DE LA TOPOISOMERASA I UTILES EN EL TRATAMIENTO DE TUMORES E INFECCIONES PARASITARIAS O VIRALES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000306A ITRM20020306A1 (it) | 2002-05-31 | 2002-05-31 | Esteri in posizione 20 di camptotecine. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040533A1 true PE20040533A1 (es) | 2004-08-26 |
Family
ID=11456339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000528A PE20040533A1 (es) | 2002-05-31 | 2003-05-30 | Esteres en posicion 20 de las camptotecinas |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7452900B2 (es) |
| EP (2) | EP2112154B1 (es) |
| JP (1) | JP4593270B2 (es) |
| KR (1) | KR101000963B1 (es) |
| CN (1) | CN100376583C (es) |
| AR (1) | AR040140A1 (es) |
| AT (1) | ATE439362T1 (es) |
| AU (1) | AU2003241161C1 (es) |
| CA (1) | CA2487252C (es) |
| CY (2) | CY1109581T1 (es) |
| DE (1) | DE60328777D1 (es) |
| DK (2) | DK1509529T3 (es) |
| ES (2) | ES2331569T3 (es) |
| HK (1) | HK1079206A1 (es) |
| IT (1) | ITRM20020306A1 (es) |
| MX (1) | MXPA04011681A (es) |
| PE (1) | PE20040533A1 (es) |
| PL (1) | PL374009A1 (es) |
| PT (2) | PT1509529E (es) |
| SI (2) | SI2112154T1 (es) |
| TW (1) | TWI331151B (es) |
| WO (1) | WO2003101996A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
| CA2562904C (en) | 2004-04-27 | 2013-07-02 | Wellstat Biologics Corporation | Cancer treatment using viruses and camptothecins |
| ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
| US7767200B2 (en) | 2005-07-14 | 2010-08-03 | Wellstat Biologics Corporation | Cancer treatment using viruses, fluoropyrimidines and camptothecins |
| CN103864811A (zh) * | 2012-12-13 | 2014-06-18 | 天津科技大学 | 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用 |
| WO2014121033A1 (en) * | 2013-02-04 | 2014-08-07 | Fl Therapeutics Llc | Soluble complexes of drug analogs and albumin |
| WO2015200837A1 (en) | 2014-06-27 | 2015-12-30 | Fl Therapeutics Llc | Abiraterone derivatives and non-covalent complexes with albumin |
| US10201617B2 (en) | 2014-10-24 | 2019-02-12 | Zhuhai Beihai Biotech Co., Ltd. | 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin |
| WO2017053920A1 (en) | 2015-09-25 | 2017-03-30 | Zy Therapeutics Inc. | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
| CN106279286B (zh) * | 2016-08-12 | 2018-11-30 | 华中科技大学 | 一种喜树碱膦酸酯类化合物、其制备方法及应用 |
| CN110577551A (zh) * | 2018-06-08 | 2019-12-17 | 遵义医学院 | 喜树碱-甘氨酸-5,6-二溴去甲斑蝥素结合物及其应用 |
| MX2022000474A (es) | 2019-07-11 | 2022-03-11 | Sun Pharma Advanced Res Co Ltd | Derivados de camptotecina con un resto disulfuro y un resto piperazina. |
| CN116514829A (zh) * | 2020-08-21 | 2023-08-01 | 诺茗(北京)生物医药有限公司 | 一种水溶性抗肿瘤前药及其药物组合物和用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JP3186166B2 (ja) * | 1992-02-10 | 2001-07-11 | ロンザ リミテッド | サリチロイル−カルニチンおよびその製造方法 |
| US5646159A (en) * | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| WO1997021865A1 (en) | 1995-12-15 | 1997-06-19 | The Dexter Corporation | Abrasive nonwoven web and method of manufacture |
| CA2338638C (en) | 1998-07-30 | 2009-03-17 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of l-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| SI1044977T1 (en) * | 1999-03-09 | 2002-08-31 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
| DE19916945C1 (de) | 1999-04-15 | 2000-10-05 | Clariant Gmbh | Aromatische Aldehydharze und ihre Verwendung als Emulsionsspalter |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6288072B1 (en) | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| US6629995B1 (en) | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
-
2002
- 2002-05-31 IT IT2002RM000306A patent/ITRM20020306A1/it unknown
-
2003
- 2003-05-26 TW TW092114165A patent/TWI331151B/zh not_active IP Right Cessation
- 2003-05-28 KR KR1020047016881A patent/KR101000963B1/ko not_active IP Right Cessation
- 2003-05-28 ES ES03730481T patent/ES2331569T3/es not_active Expired - Lifetime
- 2003-05-28 SI SI200332302T patent/SI2112154T1/sl unknown
- 2003-05-28 DE DE60328777T patent/DE60328777D1/de not_active Expired - Lifetime
- 2003-05-28 PL PL03374009A patent/PL374009A1/xx unknown
- 2003-05-28 PT PT03730481T patent/PT1509529E/pt unknown
- 2003-05-28 CA CA2487252A patent/CA2487252C/en not_active Expired - Fee Related
- 2003-05-28 EP EP09162737.2A patent/EP2112154B1/en not_active Expired - Lifetime
- 2003-05-28 WO PCT/IT2003/000329 patent/WO2003101996A2/en active Application Filing
- 2003-05-28 AT AT03730481T patent/ATE439362T1/de active
- 2003-05-28 DK DK03730481T patent/DK1509529T3/da active
- 2003-05-28 PT PT91627372T patent/PT2112154E/pt unknown
- 2003-05-28 CN CNB038125447A patent/CN100376583C/zh not_active Expired - Fee Related
- 2003-05-28 AU AU2003241161A patent/AU2003241161C1/en not_active Ceased
- 2003-05-28 ES ES09162737T patent/ES2432379T3/es not_active Expired - Lifetime
- 2003-05-28 JP JP2004509687A patent/JP4593270B2/ja not_active Expired - Fee Related
- 2003-05-28 US US10/512,094 patent/US7452900B2/en not_active Expired - Fee Related
- 2003-05-28 MX MXPA04011681A patent/MXPA04011681A/es active IP Right Grant
- 2003-05-28 DK DK09162737.2T patent/DK2112154T3/da active
- 2003-05-28 SI SI200331685T patent/SI1509529T1/sl unknown
- 2003-05-28 EP EP03730481A patent/EP1509529B1/en not_active Expired - Lifetime
- 2003-05-30 AR ARP030101916A patent/AR040140A1/es not_active Application Discontinuation
- 2003-05-30 PE PE2003000528A patent/PE20040533A1/es not_active Application Discontinuation
-
2005
- 2005-12-12 HK HK05111354A patent/HK1079206A1/xx not_active IP Right Cessation
-
2007
- 2007-04-10 US US11/783,495 patent/US7498340B2/en not_active Expired - Fee Related
-
2009
- 2009-11-04 CY CY20091101143T patent/CY1109581T1/el unknown
-
2013
- 2013-09-24 CY CY20131100832T patent/CY1114692T1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |