ATE439362T1 - Ester in position 20 von camptothecinen - Google Patents

Ester in position 20 von camptothecinen

Info

Publication number: ATE439362T1
Authority: AT; Austria
Prior art keywords: camptothecines; esters
Prior art date: 2002-05-31

Application number

AT03730481T

Other languages

English (en)

Inventor

Mauro Marzi

Domenico Alloatti

Claudio Pisano

Maria Ornella Tinti

Loredana Vesci

Franco Zunino

Original Assignee

Sigma Tau Ind Farmaceuti

Ist Naz Stud Cura Dei Tumori

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-31

Filing date

2003-05-28

Publication date

2009-08-15

2003-05-28 Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti

2009-08-15 Application granted granted Critical

2009-08-15 Publication of ATE439362T1 publication Critical patent/ATE439362T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

AT03730481T 2002-05-31 2003-05-28 Ester in position 20 von camptothecinen ATE439362T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2002RM000306A ITRM20020306A1 (it)	2002-05-31	2002-05-31	Esteri in posizione 20 di camptotecine.
PCT/IT2003/000329 WO2003101996A2 (en)	2002-05-31	2003-05-28	Esters in position 20 of camptothecins

Publications (1)

Publication Number	Publication Date
ATE439362T1 true ATE439362T1 (de)	2009-08-15

Family

ID=11456339

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03730481T ATE439362T1 (de)	2002-05-31	2003-05-28	Ester in position 20 von camptothecinen

Country Status (22)

Country	Link
US (2)	US7452900B2 (de)
EP (2)	EP2112154B1 (de)
JP (1)	JP4593270B2 (de)
KR (1)	KR101000963B1 (de)
CN (1)	CN100376583C (de)
AR (1)	AR040140A1 (de)
AT (1)	ATE439362T1 (de)
AU (1)	AU2003241161C1 (de)
CA (1)	CA2487252C (de)
CY (2)	CY1109581T1 (de)
DE (1)	DE60328777D1 (de)
DK (2)	DK1509529T3 (de)
ES (2)	ES2331569T3 (de)
HK (1)	HK1079206A1 (de)
IT (1)	ITRM20020306A1 (de)
MX (1)	MXPA04011681A (de)
PE (1)	PE20040533A1 (de)
PL (1)	PL374009A1 (de)
PT (2)	PT1509529E (de)
SI (2)	SI2112154T1 (de)
TW (1)	TWI331151B (de)
WO (1)	WO2003101996A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2852606A1 (fr) *	2003-03-18	2004-09-24	Inst Nat Sante Rech Med	Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
CA2562904C (en)	2004-04-27	2013-07-02	Wellstat Biologics Corporation	Cancer treatment using viruses and camptothecins
ITRM20040242A1 (it) *	2004-05-13	2004-08-13	Ist Naz Stud Cura Dei Tumori	"7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
US7767200B2 (en)	2005-07-14	2010-08-03	Wellstat Biologics Corporation	Cancer treatment using viruses, fluoropyrimidines and camptothecins
CN103864811A (zh) *	2012-12-13	2014-06-18	天津科技大学	一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用
WO2014121033A1 (en) *	2013-02-04	2014-08-07	Fl Therapeutics Llc	Soluble complexes of drug analogs and albumin
WO2015200837A1 (en)	2014-06-27	2015-12-30	Fl Therapeutics Llc	Abiraterone derivatives and non-covalent complexes with albumin
US10201617B2 (en)	2014-10-24	2019-02-12	Zhuhai Beihai Biotech Co., Ltd.	3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
WO2017053920A1 (en)	2015-09-25	2017-03-30	Zy Therapeutics Inc.	Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
CN106279286B (zh) *	2016-08-12	2018-11-30	华中科技大学	一种喜树碱膦酸酯类化合物、其制备方法及应用
CN110577551A (zh) *	2018-06-08	2019-12-17	遵义医学院	喜树碱-甘氨酸-5,6-二溴去甲斑蝥素结合物及其应用
MX2022000474A (es)	2019-07-11	2022-03-11	Sun Pharma Advanced Res Co Ltd	Derivados de camptotecina con un resto disulfuro y un resto piperazina.
CN116514829A (zh) *	2020-08-21	2023-08-01	诺茗(北京)生物医药有限公司	一种水溶性抗肿瘤前药及其药物组合物和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4943579A (en) *	1987-10-06	1990-07-24	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Water soluble prodrugs of camptothecin
US5004758A (en) *	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JP3186166B2 (ja) *	1992-02-10	2001-07-11	ロンザリミテッド	サリチロイル−カルニチンおよびその製造方法
US5646159A (en) *	1994-07-20	1997-07-08	Research Triangle Institute	Water-soluble esters of camptothecin compounds
WO1997021865A1 (en)	1995-12-15	1997-06-19	The Dexter Corporation	Abrasive nonwoven web and method of manufacture
CA2338638C (en)	1998-07-30	2009-03-17	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Use of l-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity
US6204257B1 (en)	1998-08-07	2001-03-20	Universtiy Of Kansas	Water soluble prodrugs of hindered alcohols
SI1044977T1 (en) *	1999-03-09	2002-08-31	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Camptothecin derivatives having antitumor activity
DE19916945C1 (de)	1999-04-15	2000-10-05	Clariant Gmbh	Aromatische Aldehydharze und ihre Verwendung als Emulsionsspalter
US6228855B1 (en)	1999-08-03	2001-05-08	The Stehlin Foundation For Cancer Research	Aromatic esters of camptothecins and methods to treat cancers
US6288072B1 (en)	1999-12-29	2001-09-11	Monroe E. Wall	Camptothecin β-alanine esters with topoisomerase I inhibition
US6629995B1 (en)	2000-03-31	2003-10-07	Super Gen, Inc.	Camptothecin conjugates

2002
- 2002-05-31 IT IT2002RM000306A patent/ITRM20020306A1/it unknown
2003
- 2003-05-26 TW TW092114165A patent/TWI331151B/zh not_active IP Right Cessation
- 2003-05-28 KR KR1020047016881A patent/KR101000963B1/ko not_active IP Right Cessation
- 2003-05-28 ES ES03730481T patent/ES2331569T3/es not_active Expired - Lifetime
- 2003-05-28 SI SI200332302T patent/SI2112154T1/sl unknown
- 2003-05-28 DE DE60328777T patent/DE60328777D1/de not_active Expired - Lifetime
- 2003-05-28 PL PL03374009A patent/PL374009A1/xx unknown
- 2003-05-28 PT PT03730481T patent/PT1509529E/pt unknown
- 2003-05-28 CA CA2487252A patent/CA2487252C/en not_active Expired - Fee Related
- 2003-05-28 EP EP09162737.2A patent/EP2112154B1/de not_active Expired - Lifetime
- 2003-05-28 WO PCT/IT2003/000329 patent/WO2003101996A2/en active Application Filing
- 2003-05-28 AT AT03730481T patent/ATE439362T1/de active
- 2003-05-28 DK DK03730481T patent/DK1509529T3/da active
- 2003-05-28 PT PT91627372T patent/PT2112154E/pt unknown
- 2003-05-28 CN CNB038125447A patent/CN100376583C/zh not_active Expired - Fee Related
- 2003-05-28 AU AU2003241161A patent/AU2003241161C1/en not_active Ceased
- 2003-05-28 ES ES09162737T patent/ES2432379T3/es not_active Expired - Lifetime
- 2003-05-28 JP JP2004509687A patent/JP4593270B2/ja not_active Expired - Fee Related
- 2003-05-28 US US10/512,094 patent/US7452900B2/en not_active Expired - Fee Related
- 2003-05-28 MX MXPA04011681A patent/MXPA04011681A/es active IP Right Grant
- 2003-05-28 DK DK09162737.2T patent/DK2112154T3/da active
- 2003-05-28 SI SI200331685T patent/SI1509529T1/sl unknown
- 2003-05-28 EP EP03730481A patent/EP1509529B1/de not_active Expired - Lifetime
- 2003-05-30 AR ARP030101916A patent/AR040140A1/es not_active Application Discontinuation
- 2003-05-30 PE PE2003000528A patent/PE20040533A1/es not_active Application Discontinuation
2005
- 2005-12-12 HK HK05111354A patent/HK1079206A1/xx not_active IP Right Cessation
2007
- 2007-04-10 US US11/783,495 patent/US7498340B2/en not_active Expired - Fee Related
2009
- 2009-11-04 CY CY20091101143T patent/CY1109581T1/el unknown
2013
- 2013-09-24 CY CY20131100832T patent/CY1114692T1/el unknown

Also Published As

Publication number	Publication date
CN100376583C (zh)	2008-03-26
CY1109581T1 (el)	2014-08-13
WO2003101996A2 (en)	2003-12-11
US7452900B2 (en)	2008-11-18
KR101000963B1 (ko)	2010-12-13
JP4593270B2 (ja)	2010-12-08
PE20040533A1 (es)	2004-08-26
EP2112154A1 (de)	2009-10-28
PL374009A1 (en)	2005-09-19
PT1509529E (pt)	2009-11-13
DK1509529T3 (da)	2009-12-14
AU2003241161A1 (en)	2003-12-19
EP1509529A2 (de)	2005-03-02
DE60328777D1 (en)	2009-09-24
CA2487252A1 (en)	2003-12-11
TW200403246A (en)	2004-03-01
CY1114692T1 (el)	2016-10-05
SI2112154T1 (sl)	2013-12-31
ES2432379T3 (es)	2013-12-03
AU2003241161B2 (en)	2009-10-22
MXPA04011681A (es)	2005-03-31
EP1509529B1 (de)	2009-08-12
ITRM20020306A0 (it)	2002-05-31
CN1656101A (zh)	2005-08-17
AR040140A1 (es)	2005-03-16
US20050256148A1 (en)	2005-11-17
WO2003101996A3 (en)	2004-01-29
WO2003101996A8 (en)	2004-04-29
EP2112154B1 (de)	2013-07-24
ITRM20020306A1 (it)	2003-12-01
PT2112154E (pt)	2013-10-02
JP2005529935A (ja)	2005-10-06
HK1079206A1 (en)	2006-03-31
DK2112154T3 (da)	2013-10-21
SI1509529T1 (sl)	2009-12-31
US7498340B2 (en)	2009-03-03
TWI331151B (en)	2010-10-01
AU2003241161C1 (en)	2010-03-04
ES2331569T3 (es)	2010-01-08
KR20050036910A (ko)	2005-04-20
US20070213353A1 (en)	2007-09-13
CA2487252C (en)	2010-08-10

Publication	Publication Date	Title
EE200300030A (et)	2004-10-15	4-jodofenüülaminobenshüdroksaamhapete oksügeenitud estrid
NO20034196D0 (no)	2003-09-19	Vinylester karbamid
EP1685218A4 (de)	2010-12-15	Fettsäureester und deren verwendung
NO20055129D0 (no)	2005-11-02	Fenylsubstituerte karboksylsyrer
ATE540943T1 (de)	2012-01-15	3-ä(2-ää4-(hexyloxycarbonylamino-imino-methyl)- phenylaminoümethylü-1-methyl-1h-benzimidazol-5- carbonyl)-pyridin-2-yl-aminoü-propionsäure- ethylester methansulfonat
LU91534I2 (fr)	2009-04-27	"Acide nicotinique/laropiprant"
DE60033885D1 (de)	2007-04-26	Schwefelenthaltende ungesättigte Carbonsäureester-Verbindung und ihre Verwendung
ITRM20040395A1 (it)	2004-11-03	Composizione comprendente statine e acidi grassi omega 3.
ID22013A (id)	1999-08-26	Senyawa-senyawa ester
DK1663936T3 (da)	2008-03-31	Biaryloxymethylaren-carboxylsyrer
DE50101545D1 (de)	2004-04-01	Selbstfurchende Schraube
EP1551384A4 (de)	2008-04-09	R-nsaid-ester und ihre verwendung
ATE439362T1 (de)	2009-08-15	Ester in position 20 von camptothecinen
IS7528A (is)	2004-11-15	Nýir etónógestrel esterar
AU2003225651A8 (en)	2003-09-22	Nematicidal fatty acid and fatty acid ester related compounds
DE60218845D1 (de)	2007-04-26	Einen lipase-inhibitor und einen saccharosefettsäuremonoester enthaltende pharmazeutische zusammensetzung
EP1551495A4 (de)	2010-06-02	Basische ester von fettalkoholen und ihre verwendung als entzündungshemmende oder immunmodulatorische mittel
DE602005015486D1 (de)	2009-08-27	Esterderivate von ascorbinsäure und 2-ketosäuresacchariden
DE60140478D1 (de)	2009-12-24	Malonamid- und malonsäureamid-ester-derivate mit aerwendung
DE602004028454D1 (de)	2010-09-16	Mit metallionen ausgetauschte feststoffe zur verwevon fettsäuren und deren alkylestern
DE69707251D1 (de)	2001-11-15	Maleimidobenzosäure Ester
DE50214840D1 (de)	2011-02-10	Ethylestern
DE50012694D1 (de)	2006-06-08	Verwendung von fettsäurealkanolaminestern
EP1552847A4 (de)	2009-10-28	Hemmer zur kontinuierlichen aktivierung von calcineurin
NO20020186D0 (no)	2002-01-14	Pseudomycinamid og esteranaloger

Legal Events

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2010-02-15	UEP	Publication of translation of european patent specification	Ref document number: 1509529 Country of ref document: EP

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