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PE20020858A1 - Indanil aminas aciladas - Google Patents

Indanil aminas aciladas

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Publication number
PE20020858A1
PE20020858A1 PE2002000102A PE2002000102A PE20020858A1 PE 20020858 A1 PE20020858 A1 PE 20020858A1 PE 2002000102 A PE2002000102 A PE 2002000102A PE 2002000102 A PE2002000102 A PE 2002000102A PE 20020858 A1 PE20020858 A1 PE 20020858A1
Authority
PE
Peru
Prior art keywords
alkyl
indanil
amines
indan
benzamide
Prior art date
Application number
PE2002000102A
Other languages
English (en)
Inventor
Ramalinga Dharanipragada
Alena Safarova
Karl Schonafinger
Paulus Wohlfart
Teri Suzuki
Armin Walser
Hartmut Strobel
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PE20020858A1 publication Critical patent/PE20020858A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
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    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
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Abstract

SE REFIERE A INDANIL AMINAS ACILADAS DE FORMULA I DONDE R1 Y R4 SON H, ALQUILO C1-C10, ALQUENILO C2-C10, ALQUINILO C2-C10, ENTRE OTROS; R2 Y R3 SON H, HALOGENO, ALQUILO C1-C10 CON OH, FENILO, HETEROARILO, ENTRE OTROS; A ES CH2, CHOH, CH-(ALQUILO C1-C3); B ES CH2, CH-(ALQUILO C1-C3); R5 ES AR, GRUPO HET, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 4-FLUORO-N-(4-METIL-INDAN-2-IL)BENZAMIDA, 4-FLUORO-N-(5-METOXI-INDAN-2-IL)BENZAMIDA, 4-FLUORO-N-(5,6-DIMETOXI-INDAN-2-IL)BENZAMIDA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS ELEVAN LA EXPRESION DE eNOS EN CELULAS ENDOTELIALES Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES
PE2002000102A 2001-02-13 2002-02-11 Indanil aminas aciladas PE20020858A1 (es)

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