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PE20050160A1 - 3-aminopirrolidinas como inhibidores de la captacion de monoaminas - Google Patents

3-aminopirrolidinas como inhibidores de la captacion de monoaminas

Info

Publication number
PE20050160A1
PE20050160A1 PE2004000546A PE2004000546A PE20050160A1 PE 20050160 A1 PE20050160 A1 PE 20050160A1 PE 2004000546 A PE2004000546 A PE 2004000546A PE 2004000546 A PE2004000546 A PE 2004000546A PE 20050160 A1 PE20050160 A1 PE 20050160A1
Authority
PE
Peru
Prior art keywords
alkyl
aminopyrrolidines
inhibitors
group
monoamine uptake
Prior art date
Application number
PE2004000546A
Other languages
English (en)
Inventor
Manuel Javier Cases-Thomas
Virginia Ann Wood
Christopher David Beadle
John Joseph Masters
Graham Henry Timms
Magnus Wilhelm Walter
Maria Ann Whatton
Peter Thadeus Gallagher
Jeremy Gilmore
Barry Peter Clark
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0313463A external-priority patent/GB0313463D0/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20050160A1 publication Critical patent/PE20050160A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A 3-AMINOPIRROLIDINAS DE FORMULA I DONDE R1 ES ALQUILO C1-C6 SUSTITUIDO CON 1-3 SUSTITUYENTES HALO Y/O CON UN SUSTITUYENTE SELECCIONADO DE -S-(ALQUILO C1-C3), -O-(ALQUILO C1-C3) SUSTITUIDO CON 1-3 ATOMOS DE F, -CN, -COO-(ALQUILO C1-C2, ALQUENILO C2-C6; R2, R3 Y R4 SON H, ALQUILO C1-C2; R5, R6, R7 Y R8 SON H, ALQUILO C1-C2; -X- ES UN ENLACE -CH2-, -CH=CH, -O-, ENTRE OTROS; Y ES UN ENLACE -CH2-, -O-; Z ES H, -OH, -O-(ALQUILO C1-C3); p ES 0-2; q ES 0-2; r ES 0-1; s ES 0-3; t ES 0-4; AR1 ES UN GRUPO FENILO O GRUPO HETEROAROMATICO MONOCICLICO DE 5 O 6 MIEMBROS CON 1-5 SUSTITUYENTES, GRUPO NAFTILO, GRUPO HETEROAROMATICO BICICLICO DE 8 A 10 MIEMBROS CON 1-6 SUSTITUYENTES SELECCIONADOS DE HALO, CIANO, ALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (3S)-N-(1-METILETIL)-N-{[3,5-DICLOROFENIL]METIL}PIRROLIDIN-3-AMINA, (3S)-N-(1-METILETIL)-N-{[2-(METILTIO)FENIL]METIL}PIRROLIDIN-3-AMINA, (3S)-N-(1-METILETIL)-N-{[2-TRIFLUOROMETIL)OXI]FENIL}METIL}PIRROLIDIN-3-AMINA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA CAPTACION DE MONOAMINAS
PE2004000546A 2003-06-11 2004-05-28 3-aminopirrolidinas como inhibidores de la captacion de monoaminas PE20050160A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0313463A GB0313463D0 (en) 2003-06-11 2003-06-11 Inhibitors on monoamine uptake
US51086703P 2003-10-14 2003-10-14
US52445003P 2003-11-24 2003-11-24
US52478103P 2003-11-25 2003-11-25

Publications (1)

Publication Number Publication Date
PE20050160A1 true PE20050160A1 (es) 2005-03-26

Family

ID=33556507

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000546A PE20050160A1 (es) 2003-06-11 2004-05-28 3-aminopirrolidinas como inhibidores de la captacion de monoaminas

Country Status (10)

Country Link
US (1) US7619096B2 (es)
EP (1) EP1638934B1 (es)
AR (1) AR044570A1 (es)
AT (1) ATE383335T1 (es)
DE (1) DE602004011221T2 (es)
ES (1) ES2298782T3 (es)
PE (1) PE20050160A1 (es)
SV (1) SV2005001805A (es)
TW (1) TW200508195A (es)
WO (1) WO2005000811A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2345261T3 (es) 2004-02-27 2010-09-20 Eli Lilly And Company Derivados de 4-amino-piperidina como inhibidores de la captacion de monoamina.
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1756050A1 (en) 2004-06-01 2007-02-28 Eli Lilly And Company Aminomethyl-azacycle derivatives as inhibitors of monoamine uptake
KR101238525B1 (ko) 2004-12-31 2013-02-28 레디 유에스 테라퓨틱스 인코포레이티드 Ｃｅｔｐ 저해제로서의 신규 벤질아민 유도체
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
TWI439452B (zh) * 2005-05-13 2014-06-01 Otsuka Pharma Co Ltd 吡咯烷化合物（二）
US20090215857A1 (en) * 2005-09-13 2009-08-27 Pfizer Products Inc. Therapeutic Pyrrolidines
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬
GB0701171D0 (en) * 2007-01-22 2007-02-28 Imp Innovations Ltd Compositions and uses thereof
WO2010091268A1 (en) 2009-02-09 2010-08-12 Sepracor Inc. Pyrrolidine triple reuptake inhibitors
US8273786B2 (en) 2009-07-21 2012-09-25 Theravance, Inc. 3-phenoxymethylpyrrolidine compounds
CA2845284C (en) 2011-08-18 2018-03-06 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors
CA2850022C (en) 2011-09-27 2018-05-01 Dr. Reddy's Laboratories, Ltd. 5 - benzylaminomethyl - 6 - aminopyrazolo [3,4-b] pyridine derivatives as cholesteryl ester-transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis
WO2014018721A1 (en) 2012-07-25 2014-01-30 Bio-Rad Laboratories, Inc. Targeted delivery of reagents through patterned transfer sheets
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物
US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6353008B1 (en) * 1998-06-30 2002-03-05 Eli Lilly And Company Pyrrolidine and pyrroline derivatives having effects on serotonin related systems
EP1125922A1 (en) * 1998-11-02 2001-08-22 Welfide Corporation Pyrrolidine compounds and medicinal utilization thereof
HUP0204071A3 (en) * 2000-01-20 2003-07-28 Eisai Co Ltd Nitrogenous cyclic compounds and pharmaceutical compositions containing the same and their use
CN101230034A (zh) * 2000-03-06 2008-07-30 阿卡蒂亚药品公司 用于治疗5-羟色胺相关性疾病的氮杂环化合物
WO2003024928A2 (en) 2001-09-14 2003-03-27 Novo Nordisk A/S Novel aminoazetidine, -pyrrolidine and -piperidine derivatives
JP2005533813A (ja) * 2002-06-24 2005-11-10 アカディア ファーマシューティカルズ，インコーポレーテッド セロトニン受容体作用物質としてのｎ−置換ピペリジン誘導体
KR20050055748A (ko) 2002-10-04 2005-06-13 유씨비 소시에떼아노님 4-아미노피페리딘 유도체, 이의 제조 방법 및 약제로서의이의 용도
AU2003290735A1 (en) 2002-12-06 2004-06-30 Eli Lilly And Company Inhibitors of monoamine uptake

Also Published As

Publication number Publication date
WO2005000811A1 (en) 2005-01-06
DE602004011221D1 (de) 2008-02-21
SV2005001805A (es) 2005-11-04
EP1638934A1 (en) 2006-03-29
AR044570A1 (es) 2005-09-21
US20060270713A1 (en) 2006-11-30
EP1638934B1 (en) 2008-01-09
DE602004011221T2 (de) 2009-01-02
ATE383335T1 (de) 2008-01-15
US7619096B2 (en) 2009-11-17
TW200508195A (en) 2005-03-01
ES2298782T3 (es) 2008-05-16

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