PE20020597A1 - Combinacion de agonistas de gaba e inhibidores de sorbitol-deshidrogenasa - Google Patents
Combinacion de agonistas de gaba e inhibidores de sorbitol-deshidrogenasaInfo
- Publication number
- PE20020597A1 PE20020597A1 PE2001001191A PE2001001191A PE20020597A1 PE 20020597 A1 PE20020597 A1 PE 20020597A1 PE 2001001191 A PE2001001191 A PE 2001001191A PE 2001001191 A PE2001001191 A PE 2001001191A PE 20020597 A1 PE20020597 A1 PE 20020597A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxy
- pyrimidin
- hydroxyethyl
- carbonyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION QUE COMPRENDE: a)UN AGONISTA GABA TAL COMO MUSCIMOL, PROGABIDA, RILUZOL, BACLOFENO, GABAPENTINA, VIGABATRINA, ACIDO VALPROICO, TIAGABINA, LAMOTRIGINA, PREGABALINA, FENITOINA, CARBAMAZEPINA, TOPIRAMATO; b)INHIBIDOR DE SORBITOL DESHIDROGENASA TAL COMO UN COMPUESTO DE PIRIMIDINA DE FORMULA I DONDE: R1 ES FORMILO, ACETILO, PROPIONILO, C(OH)R4R5; R4 Y R5 SON H, METILO, ETILO, HIDROXI-ALQUILO C1-C3; R2 ES H, ALQUILO C1-C4, ALCOXI C1-C4; R3 ES UN RADICAL R3a (SUSTITUIDO CON R6, R7, R8); R3b; R3c, ENTRE OTROS; G, G1, G2 SON H; R6 ES H, ALQUILO C1-C4, ALCOXI C1-C4-CARBONILO, FENILO, ENTRE OTROS; R7 Y R8 SON H, ALQUILO C1-C4; G Y G1 O G1 Y G2 JUNTOS FORMAN ALQUILENO C1-C3; q ES 0-1; X ES UN ENLACE, CNR10, OXICARBONILO, VINILENILCARBONILO, OXIALQUILENIL C1-C4-CARBONILO, ENTRE OTROS; R9 ES CICLOALQUILO C3-C7, Ar1-ALQUILENILO C0-C3, ALQUILO C1-C6, ENTRE OTROS; R17 ES SO2NR21R22, ALCOXI C1-C6, ENTRE OTROS; R21 Y R22 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C7 O JUNTO A N FORMAN AZETIDINILO, PIRROLIDINILO, PIPERIDINILO, ENTRE OTROS; R23 ES CONR24R25, SO2R24R25; R24 ES H, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; R25 ES H, ALQUILO C1-C4; R26 ES Ar3-ALQUILENO. SON COMPUESTOS PREFERIDOS R-(4-{1'-[2-(1R-HIDROXIETIL)PIRIMIDIN-4-IL]-[4,4']-BIPIPERIDINIL-1-IL}PIRIMIDIN-2-IL)ETANOL; (4-CLORO-FURO[3,2-c]PIRIDIN-2-IL)-{4-[2-(1R-HIDROXIETIL)PIRIMIDIN-4-IL]3R,5S-DIMETILPIPERAZIN-1-ILMETANONA. LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DE COMPLICACIONES DE LA DIABETES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25006900P | 2000-11-30 | 2000-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020597A1 true PE20020597A1 (es) | 2002-07-08 |
Family
ID=22946187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001191A PE20020597A1 (es) | 2000-11-30 | 2001-11-28 | Combinacion de agonistas de gaba e inhibidores de sorbitol-deshidrogenasa |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6544998B2 (es) |
| EP (1) | EP1337271B1 (es) |
| JP (1) | JP2004514699A (es) |
| KR (1) | KR20030059290A (es) |
| CN (1) | CN1477975A (es) |
| AP (1) | AP2001002360A0 (es) |
| AR (1) | AR031431A1 (es) |
| AT (1) | ATE281181T1 (es) |
| AU (1) | AU2002215159A1 (es) |
| BG (1) | BG107774A (es) |
| BR (1) | BR0115783A (es) |
| CA (1) | CA2430298A1 (es) |
| CR (1) | CR6964A (es) |
| CZ (1) | CZ20031399A3 (es) |
| DE (1) | DE60106968T2 (es) |
| DO (1) | DOP2001000289A (es) |
| EA (1) | EA200300432A1 (es) |
| EC (1) | ECSP034624A (es) |
| EE (1) | EE200300248A (es) |
| ES (1) | ES2230378T3 (es) |
| HR (1) | HRP20030420A2 (es) |
| HU (1) | HUP0302160A3 (es) |
| IL (1) | IL155704A0 (es) |
| IS (1) | IS6786A (es) |
| MA (1) | MA26964A1 (es) |
| MX (1) | MXPA03004870A (es) |
| NO (1) | NO20032441L (es) |
| OA (1) | OA12534A (es) |
| PA (1) | PA8534101A1 (es) |
| PE (1) | PE20020597A1 (es) |
| PL (1) | PL365927A1 (es) |
| PT (1) | PT1337271E (es) |
| SK (1) | SK6192003A3 (es) |
| SV (1) | SV2003000751A (es) |
| TN (1) | TNSN01169A1 (es) |
| UY (1) | UY27042A1 (es) |
| WO (1) | WO2002043762A2 (es) |
| ZA (1) | ZA200303381B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU714980B2 (en) | 1996-07-24 | 2000-01-13 | Warner-Lambert Company Llc | Isobutylgaba and its derivatives for the treatment of pain |
| US6992109B1 (en) * | 1999-04-08 | 2006-01-31 | Segal Catherine A | Method for the treatment of incontinence |
| US7022678B2 (en) * | 2001-03-30 | 2006-04-04 | Warner-Lambert Company | Pregabalin lactose conjugates |
| CZ299755B6 (cs) * | 2001-05-25 | 2008-11-12 | Warner-Lambert Company Llc | Kapalná farmaceutická kompozice obsahující analoggama-aminomáselné kyseliny, zpusob její prípravy a použití |
| CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| KR20050036195A (ko) * | 2003-10-15 | 2005-04-20 | 고재영 | 신규한 망막병증 치료제 조성물 |
| US20050220873A1 (en) * | 2004-04-02 | 2005-10-06 | Chien-Hsuan Han | Pharmaceutical dosage forms having immediate and controlled release properties that contain a GABAB receptor agonist |
| US20050226927A1 (en) * | 2004-04-02 | 2005-10-13 | Impax Laboratories, Inc. | Pharmaceutical dosage forms having immediate release and/or controlled release properties that contain a GABAB receptor agonist |
| US8007827B2 (en) * | 2004-04-02 | 2011-08-30 | Impax Laboratories, Inc. | Pharmaceutical dosage forms having immediate release and/or controlled release properties |
| EP1729740A2 (en) * | 2004-04-02 | 2006-12-13 | Impax Laboratories, Inc. | PHARMACEUTICAL DOSAGE FORMS HAVING IMMEDIATE RELEASE AND/OR CONTROLLED RELEASE PROPERTIES THAT CONTAIN A GABA<SB>B</SB> RECEPTOR AGONIST |
| GB0420831D0 (en) | 2004-09-17 | 2004-10-20 | Glaxo Group Ltd | Novel compounds |
| KR101063663B1 (ko) | 2005-02-17 | 2011-09-07 | 아스텔라스세이야쿠 가부시키가이샤 | 피리딜 비방향족 질소 함유 헤테로환-1-카르복실산에스테르유도체 |
| GB0513553D0 (en) * | 2005-07-01 | 2005-08-10 | Fond D Amico Per La Ricerca Su | Rab3a |
| MY148657A (en) | 2007-04-27 | 2013-05-15 | Purdue Pharma Lp | Trpv1 antagonists and uses thereof |
| AU2008310114B2 (en) * | 2007-10-09 | 2014-01-16 | Merck Patent Gmbh | Pharmaceutical compositions containing benfotiamine and one or more pharmaceutically active agents for the treatment of pain conditions of neuropathic origin |
| SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| WO2011071995A2 (en) | 2009-12-08 | 2011-06-16 | Case Western Reserve University | Compounds and methods of treating ocular disorders |
| CN103228142A (zh) * | 2010-09-28 | 2013-07-31 | 加利福尼亚大学董事会 | 治疗代谢综合征相关疾病的gaba激动剂和治疗或预防i型糖尿病的gaba组合 |
| ES2620528T3 (es) | 2011-06-22 | 2017-06-28 | Purdue Pharma Lp | Antagonistas de TRPV1 que incluyen un sustituyente dihidroxi y usos de los mismos |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US20220169668A1 (en) | 2019-04-17 | 2022-06-02 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| MX2021013511A (es) * | 2019-05-07 | 2022-02-23 | Univ Miami | Tratamiento y deteccion de neuropatias heredadas y trastornos asociados. |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2409754A (en) | 1946-10-22 | Method for obtaining hydantoins | ||
| CH449645A (de) | 1963-07-09 | 1968-01-15 | Ciba Geigy | Verfahren zur Herstellung neuer Aminosäuren |
| CH427803A (de) | 1963-12-06 | 1967-01-15 | Geigy Ag J R | Verfahren zur Herstellung eines neuen Isoxazolderivates |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US3960927A (en) | 1975-03-18 | 1976-06-01 | Richardson-Merrell Inc. | Olefinic derivatives of amino acids |
| FR2319338A1 (fr) * | 1975-08-01 | 1977-02-25 | Synthelabo | Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent |
| EP0059987B1 (en) | 1979-06-01 | 1985-08-14 | The Wellcome Foundation Limited | Alpha-cyano-alpha-((n-guanidino)-imino) toluenes |
| FR2492258A1 (fr) * | 1980-10-17 | 1982-04-23 | Pharmindustrie | Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| DK288385D0 (da) | 1985-06-26 | 1985-06-26 | Novo Industri As | Aminosyrederivater |
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| CA2145640C (en) * | 1992-09-28 | 2001-01-30 | Banavara L. Mylari | Substituted pyrimidines for control of diabetic complications |
| US6350769B1 (en) * | 1999-02-24 | 2002-02-26 | The Regents Of The University Of California | Gaba alpha receptors mediate inhibition of T cell responses |
| ES2215570T3 (es) * | 1999-04-01 | 2004-10-16 | Pfizer Products Inc. | Compuestos para tratar y prevenir complicaciones diabeticas. |
| TR200102810T2 (tr) * | 1999-04-01 | 2002-01-21 | Pfizer Products Inc. | Sorbitol dehidrojenaz inhibitörleri olarak aminopirimidinler |
-
2001
- 2001-11-19 BR BR0115783-3A patent/BR0115783A/pt not_active IP Right Cessation
- 2001-11-19 PL PL01365927A patent/PL365927A1/xx not_active Application Discontinuation
- 2001-11-19 EA EA200300432A patent/EA200300432A1/ru unknown
- 2001-11-19 AU AU2002215159A patent/AU2002215159A1/en not_active Abandoned
- 2001-11-19 KR KR10-2003-7007237A patent/KR20030059290A/ko not_active Application Discontinuation
- 2001-11-19 IL IL15570401A patent/IL155704A0/xx unknown
- 2001-11-19 CA CA002430298A patent/CA2430298A1/en not_active Abandoned
- 2001-11-19 PT PT01983739T patent/PT1337271E/pt unknown
- 2001-11-19 JP JP2002545732A patent/JP2004514699A/ja not_active Withdrawn
- 2001-11-19 MX MXPA03004870A patent/MXPA03004870A/es unknown
- 2001-11-19 EP EP01983739A patent/EP1337271B1/en not_active Expired - Lifetime
- 2001-11-19 CN CNA018195946A patent/CN1477975A/zh active Pending
- 2001-11-19 DE DE60106968T patent/DE60106968T2/de not_active Expired - Fee Related
- 2001-11-19 AP APAP/P/2001/002360A patent/AP2001002360A0/en unknown
- 2001-11-19 SK SK619-2003A patent/SK6192003A3/sk unknown
- 2001-11-19 EE EEP200300248A patent/EE200300248A/xx unknown
- 2001-11-19 OA OA1200300142A patent/OA12534A/en unknown
- 2001-11-19 WO PCT/IB2001/002213 patent/WO2002043762A2/en not_active Application Discontinuation
- 2001-11-19 ES ES01983739T patent/ES2230378T3/es not_active Expired - Lifetime
- 2001-11-19 CZ CZ20031399A patent/CZ20031399A3/cs unknown
- 2001-11-19 HU HU0302160A patent/HUP0302160A3/hu unknown
- 2001-11-19 AT AT01983739T patent/ATE281181T1/de not_active IP Right Cessation
- 2001-11-19 DO DO2001000289A patent/DOP2001000289A/es unknown
- 2001-11-27 UY UY27042A patent/UY27042A1/es not_active Application Discontinuation
- 2001-11-28 AR ARP010105541A patent/AR031431A1/es unknown
- 2001-11-28 PE PE2001001191A patent/PE20020597A1/es not_active Application Discontinuation
- 2001-11-29 SV SV2001000751A patent/SV2003000751A/es unknown
- 2001-11-29 US US09/997,038 patent/US6544998B2/en not_active Expired - Fee Related
- 2001-11-29 TN TNTNSN01169A patent/TNSN01169A1/fr unknown
- 2001-11-30 PA PA20018534101A patent/PA8534101A1/es unknown
-
2003
- 2003-04-14 IS IS6786A patent/IS6786A/is unknown
- 2003-04-24 CR CR6964A patent/CR6964A/es not_active Application Discontinuation
- 2003-04-30 ZA ZA200303381A patent/ZA200303381B/en unknown
- 2003-05-07 BG BG107774A patent/BG107774A/xx unknown
- 2003-05-20 MA MA27165A patent/MA26964A1/fr unknown
- 2003-05-22 HR HR20030420A patent/HRP20030420A2/hr not_active Application Discontinuation
- 2003-05-27 EC EC2003004624A patent/ECSP034624A/es unknown
- 2003-05-28 NO NO20032441A patent/NO20032441L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |