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PE20020543A1 - Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos - Google Patents

Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos

Info

Publication number
PE20020543A1
PE20020543A1 PE2001001079A PE2001001079A PE20020543A1 PE 20020543 A1 PE20020543 A1 PE 20020543A1 PE 2001001079 A PE2001001079 A PE 2001001079A PE 2001001079 A PE2001001079 A PE 2001001079A PE 20020543 A1 PE20020543 A1 PE 20020543A1
Authority
PE
Peru
Prior art keywords
alkylene
antihistamine
halogen
alkylenexy
alkyl
Prior art date
Application number
PE2001001079A
Other languages
English (en)
Inventor
Silvia Fonquerna Pou
Lluis Pages Santacana
Carles Puig Duran
Lidia Soca Pueyo
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of PE20020543A1 publication Critical patent/PE20020543A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A COMPUESTOS DE INDOLIL PIPERIDINA DE FORMULA I DONDE A1 ES ALQUILENO, ALQUILENOXI, ALQUILENTIO, ALCANOILENO, HIDROXIALQUILENO; A2 ES ALQUILENO, ALQUILENOXI, ALQUILENTIO, ALCANOILENO, ALQUILENOXIALQUILENO; W1 ES FENILENO, FURANILENO, PIRIDINILENO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO; W2 ES UN GRUPO DE 3-10 MIEMBROS MONOCICLICO O BICICLICO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO, ALCOXI, OXO; R2 ES CARBOXILO; R1 ES H, HALOGENO, ALQUILO, ALCOXI, METILAMINO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS TIENEN ACTIVIDAD ANTIHISTAMINICA Y ANTIALERGICA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DEL ASMA BRONQUIAL, RINITIS, CONJUNTIVITIS, DERMATITIS, URTICARIA
PE2001001079A 2000-10-31 2001-10-30 Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos PE20020543A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002615A ES2172436B1 (es) 2000-10-31 2000-10-31 Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.

Publications (1)

Publication Number Publication Date
PE20020543A1 true PE20020543A1 (es) 2002-07-17

Family

ID=8495472

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001079A PE20020543A1 (es) 2000-10-31 2001-10-30 Derivados de la indolilpiperidina como agentes antihistaminicos y antialergicos

Country Status (16)

Country Link
US (1) US7189741B2 (es)
EP (1) EP1330453B1 (es)
JP (1) JP4184785B2 (es)
AR (1) AR031168A1 (es)
AT (1) ATE321761T1 (es)
AU (1) AU2002223655A1 (es)
CA (1) CA2427589A1 (es)
DE (1) DE60118434T2 (es)
DK (1) DK1330453T3 (es)
ES (2) ES2172436B1 (es)
MY (1) MY155914A (es)
PE (1) PE20020543A1 (es)
PT (1) PT1330453E (es)
SI (1) SI1330453T1 (es)
UY (1) UY27001A1 (es)
WO (1) WO2002036589A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2201899B1 (es) 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
ES2201907B1 (es) * 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
EP1539742B1 (en) * 2002-06-24 2006-11-08 Schering Corporation Indole derivatives useful as histamine h3 antagonists
AU2003297597A1 (en) * 2002-11-26 2004-06-18 Isis Pharmaceuticals, Inc. Benzimidazoles and analogs thereof as antibacterials
US20080015214A1 (en) * 2005-10-24 2008-01-17 Bignan Gilles C 3-piperidin-4-yl-indole orl-1 receptor modulators
JP5581055B2 (ja) * 2006-10-27 2014-08-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピペリジル−プロパン−チオールｃｃｒ３モジュレーター
GEP20125487B (en) * 2007-03-15 2012-04-25 Novartis Ag Organic compounds and their use
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK471479A (da) 1978-12-13 1980-06-14 Pfizer Fremgangsmaade til fremstilling af imidazolderivater og salte deraf
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
US4843068A (en) 1985-12-27 1989-06-27 Nihon Nohyaku Co., Ltd. Pyrazole oxime derivatives and compositions
DK733788A (da) 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
NZ249286A (en) * 1992-02-13 1996-02-27 Merrell Dow Pharma Piperidine-4-ylmethyl thiophene and thiazole derivatives and pharmaceutical compositions
JP3338913B2 (ja) * 1993-06-29 2002-10-28 大鵬薬品工業株式会社 テトラゾール誘導体
IT1271417B (it) 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
DE19500689A1 (de) 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
DE19707628A1 (de) 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
AR013669A1 (es) 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
ES2165274B1 (es) 1999-06-04 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AR028685A1 (es) 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol

Also Published As

Publication number Publication date
AU2002223655A1 (en) 2002-05-15
EP1330453B1 (en) 2006-03-29
JP4184785B2 (ja) 2008-11-19
CA2427589A1 (en) 2002-05-10
AR031168A1 (es) 2003-09-10
DE60118434D1 (de) 2006-05-18
MY155914A (en) 2015-12-15
SI1330453T1 (sl) 2006-08-31
UY27001A1 (es) 2001-12-28
US20040116471A1 (en) 2004-06-17
ES2172436B1 (es) 2004-01-16
DE60118434T2 (de) 2006-12-14
JP2004513127A (ja) 2004-04-30
ATE321761T1 (de) 2006-04-15
DK1330453T3 (da) 2006-08-07
PT1330453E (pt) 2006-07-31
ES2172436A1 (es) 2002-09-16
ES2259052T3 (es) 2006-09-16
WO2002036589A1 (en) 2002-05-10
EP1330453A1 (en) 2003-07-30
US7189741B2 (en) 2007-03-13

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FD Application declared void or lapsed