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PE20020102A1 - Composicion topica oral que comprende un agente modulador de la respuesta del huesped frente a patogenos periodontales - Google Patents

Composicion topica oral que comprende un agente modulador de la respuesta del huesped frente a patogenos periodontales

Info

Publication number
PE20020102A1
PE20020102A1 PE2001000646A PE2001000646A PE20020102A1 PE 20020102 A1 PE20020102 A1 PE 20020102A1 PE 2001000646 A PE2001000646 A PE 2001000646A PE 2001000646 A PE2001000646 A PE 2001000646A PE 20020102 A1 PE20020102 A1 PE 20020102A1
Authority
PE
Peru
Prior art keywords
agents
host
oral
present
oral cavity
Prior art date
Application number
PE2001000646A
Other languages
English (en)
Inventor
Matthew Joseph Doyle
Stephen Joseph Hunter-Rinderle
Robert Ernest Singer
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24432968&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20020102(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20020102A1 publication Critical patent/PE20020102A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Finger-Pressure Massage (AREA)

Abstract

SE REFIERE A UNA COMPOSICION TOPICA ORAL QUE COMPRENDE: a) UNA CANTIDAD DE UN AGENTE MODULADOR DE LA RESPUESTA AL HUESPED COMO: i) UN ANTAGONISTA H2 TAL COMO CIMETIDINA, ETINTIDINA, RANITIDINA, ROXATIDINA, ENTRE OTROS, ii) UN AGENTE ANTIINFLAMATORIO TAL COMO ASPIRINA, KETOROLACO, IBUPROFENO, NAPROXENO, ENTRE OTROS, iii) UN MODIFICADOR DEL ESTADO REDOX TAL COMO VITAMINA C, VITAMINA E, ENTRE OTROS, iv) INHIBIDOR DE METALOPROTEINASA, v) UN AGENTE ANTIOXIDANTE, ENTRE OTROS; Y b) UN AGENTE PORTADOR ORAL FARMACEUTICAMENTE ACEPTABLE. LA COMPOSICION PUEDE SER ADMINISTRADA JUNTO A UN AGENTE ANTIMICROBIANO, ANTIBIOTICO, ANALGESICO, DESENSIBILIZADORES DE LA DENTINA Y ES CLAVE PARA EL MANTENIMIENTO DE UN EQUILIBRIO DE LA RESPUESTA DEL HUESPED FRENTE A PATOGENOS PERIODONTALES EN LA CAVIDAD BUCAL ASI COMO TOXINAS Y ENDOTOXINAS LIBERADAS POR ESTOS GENTES PATOGENOS Y LA CITOQUINAS Y MEDIADORES INFLAMATORIOS INDUCIDOS POR ESTOS AGENTES PATOGENOS BUCALES. LA COMPOSICION SE ENCUENTRA EN FORMA ENJUAGUE BUCAL, PASTA DENTRIFICA, AEROSOL BUCAL, PASTILLA
PE2001000646A 2000-06-30 2001-06-28 Composicion topica oral que comprende un agente modulador de la respuesta del huesped frente a patogenos periodontales PE20020102A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60760200A 2000-06-30 2000-06-30

Publications (1)

Publication Number Publication Date
PE20020102A1 true PE20020102A1 (es) 2002-03-06

Family

ID=24432968

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000646A PE20020102A1 (es) 2000-06-30 2001-06-28 Composicion topica oral que comprende un agente modulador de la respuesta del huesped frente a patogenos periodontales

Country Status (12)

Country Link
US (1) US8277782B2 (es)
EP (1) EP1294367B1 (es)
JP (1) JP4754155B2 (es)
CN (1) CN1536989A (es)
AT (1) ATE401065T1 (es)
AU (1) AU2001271544A1 (es)
CA (1) CA2415065C (es)
DE (1) DE60134854D1 (es)
ES (1) ES2309076T3 (es)
MX (1) MXPA03000043A (es)
PE (1) PE20020102A1 (es)
WO (1) WO2002002096A2 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8283135B2 (en) * 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
US20040101494A1 (en) 2002-11-26 2004-05-27 Scott Douglas Craig Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth
JP2007505064A (ja) 2003-09-09 2007-03-08 ディーエスエム アイピー アセッツ ビー．ブイ． １種以上の酸化に感受性のある物質を含む、経口活性を持つ、本質的に無水の局所薬
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
BRPI0415741B1 (pt) 2003-11-07 2013-07-23 composições de tabaco e métodos de fabricação de uma composição de tabaco
ES2384506T3 (es) 2004-05-28 2012-07-06 Unigen, Inc. 1-(3-Metil-2,4-dimetoxifenil)-3-(2',4'-dihidroxifenil)-propano como un potente inhibidor de tirosinasa
US8168161B2 (en) * 2004-12-22 2012-05-01 Hill's Pet Nutrition, Inc. Method to promote oral health in companion animals
JP2006182662A (ja) * 2004-12-27 2006-07-13 Lion Corp 歯磨剤組成物
WO2006071659A1 (en) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivery of h2 antagonists
RU2381769C2 (ru) 2005-11-04 2010-02-20 Дзе Проктер Энд Гэмбл Компани Электрическое устройство для ухода за полостью рта
US20070140990A1 (en) 2005-12-21 2007-06-21 Nataly Fetissova Oral Compositions Comprising Propolis
ES2605794T3 (es) 2006-07-20 2017-03-16 Izun Pharmaceuticals Corporation Película, parche o formulación sólida adhesiva que comprende Sambucus nigra, Centella asiatica y sal de 1-alquilpiridinio para el tratamiento de tejidos mucosos
US8858995B2 (en) 2008-03-10 2014-10-14 University Of Louisville Research Foundation, Inc. Methods and compositions for controlled delivery of phytochemical agents
CA2755014A1 (en) * 2008-03-10 2009-09-17 University Of Louisville Research Foundation, Inc. Methods and compositions for controlled delivery of phytochemical agents
KR20200049891A (ko) 2008-07-21 2020-05-08 유니젠, 인크. 일련의 피부-화이트닝(라이트닝) 화합물
US9237988B2 (en) * 2010-02-24 2016-01-19 Bisco, Inc. Benzalkonium chloride compositions for inhibiting the hydrolytic activity of endogenous matrix metalloproteinases in dental restorations
EP2688860B1 (en) 2011-03-24 2020-12-09 Unigen, Inc. Compounds and methods for preparation of diarylpropanes
US8731747B2 (en) 2011-04-28 2014-05-20 General Electric Company Communication systems and method for a rail vehicle or other powered system
US8510026B2 (en) 2011-06-13 2013-08-13 General Electric Company Data conversion system and method for converting data that is distributed in a vehicle
US8620552B2 (en) 2011-06-13 2013-12-31 General Electric Company Data communication system and method for communicating data in a vehicle
US8798807B2 (en) 2011-06-13 2014-08-05 General Electric Company Data distribution system and method for distributing data in a vehicle
WO2013049507A1 (en) * 2011-09-30 2013-04-04 Perio Sciences, Llc Antioxidant compositions for treatment of inflammation or oxidative damage
US20130274650A1 (en) * 2012-04-17 2013-10-17 Luitpold Pharmaceuticals, Inc. Stabilized ketorolac compositions
US20150210964A1 (en) 2014-01-24 2015-07-30 The Procter & Gamble Company Consumer Product Compositions
CN110024726B (zh) * 2019-04-03 2022-03-08 中国水产科学研究院长江水产研究所 天然产物在激活斑点叉尾鮰核受体ahr1和ahr2活性中的应用
US20210177710A1 (en) * 2019-04-10 2021-06-17 Black Tulip Management, Inc. Oral rinse compositions for reducing pathogens underlying and for treating periodontal disease and oral malodor in the canine
EP3952828A4 (en) * 2019-04-10 2023-06-07 Black Tulip Management, Inc. MOUTH WASH COMPOSITIONS FOR REDUCING PATHOGENS UNDERLYING CARIES, PERIODONTITIS AND BAD BREATH
CN112494483B (zh) * 2020-11-13 2022-09-02 兰州大学 一种二硫杂环戊烯硫酮类化合物在抗菌方面的用途
CN115024355B (zh) * 2022-06-09 2023-06-09 宁波大学科学技术学院 对冷鲜肉保鲜的基于大蒜素的复合载体涂层的制备方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599228A (en) 1981-01-19 1986-07-08 Vipont Laboratories, Inc. Antimicrobial agent
US5531982A (en) * 1987-01-30 1996-07-02 Colgate Palmolive Company Antimicrobial oral composition
US5204089A (en) * 1989-08-30 1993-04-20 Mitsui Norin Co., Ltd. Method of preventing the formation or aggrevation of dental plaque and method for reducing cariogenesis
US5198220A (en) 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5464609A (en) 1990-03-16 1995-11-07 The Procter & Gamble Company Use of ketorolac for treatment of oral diseases and conditions
ES2077703T3 (es) * 1990-03-30 1995-12-01 Suntory Ltd Inhibidores de la glucosiltransferasa, asi como metodos para la prevencion de la caries dental y alimentos anticaries que utilizan estos inhibidores.
JPH0489428A (ja) 1990-07-30 1992-03-23 Kao Corp 多形核白血球活性化剤
US5147632A (en) * 1990-10-31 1992-09-15 Warner-Lambert Company Anti-plaque compositions comprising a combination of morpholinoamino alcohol and chelating agent
US5356615A (en) 1991-01-30 1994-10-18 Colgate Palmolive Company Antiplaque oral compositions
GB9110721D0 (en) * 1991-05-17 1991-07-10 Unilever Plc Dentifrice compositions
AU665381B2 (en) 1992-01-23 1996-01-04 Morinaga Milk Industry Company Limited Antibacterial agent and treatment of article therewith
CN1075868A (zh) 1992-03-02 1993-09-08 池洁 一种保健牙签
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
US5431927A (en) 1992-06-16 1995-07-11 Colgate-Palmolive Company Pet food product having oral care properties
US6004587A (en) 1992-06-25 1999-12-21 Bioxy Inc. Therapeutic, production and immunostimulatory uses of biocidal compositions
US5830511A (en) 1992-06-25 1998-11-03 Bioxy Inc. Therapeutic, production and immunostimulatory uses of biocidal compositions
JP3333584B2 (ja) * 1993-04-19 2002-10-15 三井農林株式会社 歯質の耐酸性強化組成物
JP3464807B2 (ja) 1993-04-27 2003-11-10 サンスター株式会社 歯磨用組成物
US5451401A (en) * 1993-09-29 1995-09-19 The Procter & Gamble Company Diphosphonic acid esters as tartar control agents
CN1103776A (zh) 1993-12-17 1995-06-21 王殿安 降压防栓保健药物牙膏
GB2290233B (en) 1994-05-21 1998-06-17 Medical Express Tooth-whitening compositions containing both chlorite and chlorate salts
CN1109742A (zh) 1994-09-22 1995-10-11 许我先 心、脑血管保健牙膏
US5578293A (en) 1994-12-06 1996-11-26 Colgate Palmolive Company Oral compositions containing stabilized stannous compounds having antiplaque and antitartar efficacy
US5639746A (en) 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5626838A (en) 1995-03-13 1997-05-06 The Procter & Gamble Company Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx
US5672598A (en) 1995-03-21 1997-09-30 The Procter & Gamble Company Lactam-containing hydroxamic acids
TW442287B (en) 1995-06-13 2001-06-23 American Home Produits Corp Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac)
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
WO1997016159A1 (en) 1995-10-30 1997-05-09 Warner-Lambert Company Enhanced anti-inflammatory oral composition containing h2 receptor antagonist and antimicrobial oils
DE69719834T2 (de) 1996-04-24 2003-11-20 Pfizer Inc., New York Dentalwerkstoffe enthaltend Cyclodextrine und phenolische Verbindungen
JPH11513035A (ja) * 1996-06-12 1999-11-09 ザ、プロクター、エンド、ギャンブル、カンパニー 風邪の治療用の局所用組成物の製造のためのｈ２拮抗剤の使用
US5753217A (en) 1996-08-14 1998-05-19 William C. Christopfel Method of reducing oral malodor
US5766622A (en) * 1996-08-14 1998-06-16 The Procter & Gamble Company Inhibiting undesirable taste in oral compositions
CZ62799A3 (cs) 1996-08-28 1999-07-14 The Procter & Gamble Company Heterocyklické metaloproteázové inhibitory
NZ334254A (en) 1996-08-28 2000-11-24 Procter & Gamble Heterocyclic metalloprotease inhibitors
SK25099A3 (en) 1996-08-28 2000-02-14 Procter & Gamble Substituted cyclic amine metalloprotease inhibitors
PL331838A1 (en) 1996-08-28 1999-08-02 Procter & Gamble 1,3-diheterocyclic inhibitors of metaloproteases
AU732653B2 (en) 1996-08-28 2001-04-26 Procter & Gamble Company, The Phosphinic acid amides as matrix metalloprotease inhibitors
BR9712792A (pt) 1996-08-28 1999-12-14 Procter & Gamble Inibidores de metaloprotease bidentada.
ATE272062T1 (de) 1996-08-28 2004-08-15 Procter & Gamble Spirocyclisch metalloprotease inhibitoren
AU4915797A (en) 1996-10-22 1998-05-15 Procter & Gamble Company, The Oral compositions containing zinc citrate salts
CA2269473A1 (en) 1996-10-22 1998-04-30 The Procter & Gamble Company Oral compositions containing stannous gluconate
NZ335780A (en) 1996-10-23 2001-01-26 Univ New York State Res Found Compositions to control oral microbial oxidation-reduction (Eh) levels and treat gingivitis-periodontitis
US5906811A (en) * 1997-06-27 1999-05-25 Thione International, Inc. Intra-oral antioxidant preparations
WO1999006340A2 (en) 1997-07-31 1999-02-11 The Procter & Gamble Company Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors
US5875799A (en) 1997-09-23 1999-03-02 Advanced Medical Instruments, Inc. Therapeutic dental floss for treating systemic diseases
US5875798A (en) 1997-09-23 1999-03-02 Advanced Medical Instruments, Inc. Therapeutic toothpick for treating oral and systemic diseases
CN1213534A (zh) 1997-10-06 1999-04-14 陈创 口体舒治疗保健系统牙膏
JPH11139947A (ja) 1997-11-11 1999-05-25 Sunstar Inc マトリックスメタロプロテアーゼ阻害剤含有口腔用組成物
US6228347B1 (en) * 1997-12-01 2001-05-08 Thione International, Inc. Antioxidant gel for gingival conditions
US6350438B1 (en) * 1998-02-27 2002-02-26 The Procter & Gamble Company Oral care compositions comprising chlorite and methods
US6132702A (en) * 1998-02-27 2000-10-17 The Procter & Gamble Company Oral care compositions comprising chlorite and methods
JP3763075B2 (ja) * 1998-04-24 2006-04-05 サンスター株式会社 歯周病の予防又は治療用の食品組成物、口腔用組成物及び医薬組成物
WO2007079331A2 (en) * 2005-12-13 2007-07-12 Richard Paul Bonfiglio Antibacterial oral rinse formulation for preventing coronary artery disease

Also Published As

Publication number Publication date
WO2002002096A2 (en) 2002-01-10
CA2415065A1 (en) 2002-01-10
JP2004501966A (ja) 2004-01-22
ATE401065T1 (de) 2008-08-15
EP1294367B1 (en) 2008-07-16
JP4754155B2 (ja) 2011-08-24
US8277782B2 (en) 2012-10-02
WO2002002096A8 (en) 2003-11-06
AU2001271544A1 (en) 2002-01-14
CA2415065C (en) 2009-09-15
US20060193790A1 (en) 2006-08-31
DE60134854D1 (de) 2008-08-28
CN1536989A (zh) 2004-10-13
ES2309076T3 (es) 2008-12-16
EP1294367A2 (en) 2003-03-26
WO2002002096A3 (en) 2002-09-12
MXPA03000043A (es) 2003-10-15

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