PE20001035A1 - Derivados de benzoxazina y benzotiazina como inhibidores de monoxido de nitrogeno sintasa - Google Patents
Derivados de benzoxazina y benzotiazina como inhibidores de monoxido de nitrogeno sintasaInfo
- Publication number
- PE20001035A1 PE20001035A1 PE1999000934A PE00093499A PE20001035A1 PE 20001035 A1 PE20001035 A1 PE 20001035A1 PE 1999000934 A PE1999000934 A PE 1999000934A PE 00093499 A PE00093499 A PE 00093499A PE 20001035 A1 PE20001035 A1 PE 20001035A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- benzoxazine
- aminomethyl
- cycloalkyl
- nitrogen monoxide
- Prior art date
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 4
- UJVBZCCNLAAMOV-UHFFFAOYSA-N 2h-1,2-benzothiazine Chemical compound C1=CC=C2C=CNSC2=C1 UJVBZCCNLAAMOV-UHFFFAOYSA-N 0.000 title abstract 2
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical class C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 INDANYL Chemical class 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101100439665 Arabidopsis thaliana SWI2 gene Proteins 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE BENZOXAZINA Y BENZOTIAZINA DE FORMULA I, DONDE X ES ES O, SOm, Se; R1 ES (CHR9)n-NR7-A-NR8-B; R2 ES H o R1 Y R2 JUNTOS FORMAN UN MONOCICLICO O BICICLICO DE 5 A 8 MIEMBROS SUSTITUIDO CON -(CH2R9)r-NR7-A-NR8-B; R3 ES H, NO2, CN, CF3, NR9-C(=NR10)-R11, NHCSNR12R13, ENTRE OTROS; R4 ES H o ACILO; R5 Y R6 SON H, CICLOALQUILO C3-C7, FENILO, ENTRE OTROS; R7 Y R8 SON H, ALQUILO C1-C6; A ES ALQUILENO C1-C6, -(CH2)p-Q-(CH2)q-; B ES H, (CH2)p-U; Q ES CICLOALQUILO C3-C7, ARILO C6-C10, HETEROARILO C6-C10; U ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, INDANILO, BICICLOALQUILO C7-C10, ENTRE OTROS; R8 Y B JUNTO CON N FORMAN UN HETEROCICLO DE 5-7 MIEMBROS; R7 Y A JUNTO CON N FORMAN UN HETEROCICLO DE 5-7 MIEMBROS; m ES 0-2; n, r, p Y q SON 0-6; R9 Y R10 SON H, ALQUILO C1-C6; R11 ES ALQUILO C1-C6, NH2, NH-CH3, NH-CN, ARILO C6-C10, ENTRE OTROS; R12 Y R13 SON H, ALQUILO C1-C6, FENILO, ENTRE OTROS. CUANDO X ES O, R6 ES METILO, R2, R3, R4 Y R5 SON H; R1 NO ES 6-((4-AMINOBENCIL)AMINOMETILO), ENTRE OTROS. UN COMPUESTO PREFERIDO ES TRICLORHIDRATO DE 6-((3-AMINOMETIL)-BENCIL-AMINOMETIL)-3-AMINO-2-METIL-1,4-BENZOXACINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN INHIBIDOR DE LA MONOXIDO DE NITROGENO SINTASA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844291A DE19844291A1 (de) | 1998-09-18 | 1998-09-18 | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001035A1 true PE20001035A1 (es) | 2000-10-18 |
Family
ID=7882416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000934A PE20001035A1 (es) | 1998-09-18 | 1999-09-15 | Derivados de benzoxazina y benzotiazina como inhibidores de monoxido de nitrogeno sintasa |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6841550B1 (es) |
| EP (1) | EP1114037B1 (es) |
| JP (1) | JP2002526481A (es) |
| KR (1) | KR20010075199A (es) |
| CN (1) | CN1144794C (es) |
| AR (1) | AR020474A1 (es) |
| AT (1) | ATE266647T1 (es) |
| AU (1) | AU751381B2 (es) |
| BR (1) | BR9913856A (es) |
| CA (1) | CA2341170A1 (es) |
| CZ (1) | CZ2001988A3 (es) |
| DE (2) | DE19844291A1 (es) |
| DK (1) | DK1114037T3 (es) |
| ES (1) | ES2221442T3 (es) |
| HU (1) | HUP0103505A3 (es) |
| NO (1) | NO20011339L (es) |
| NZ (1) | NZ510562A (es) |
| PE (1) | PE20001035A1 (es) |
| PL (1) | PL346699A1 (es) |
| PT (1) | PT1114037E (es) |
| SK (1) | SK3712001A3 (es) |
| WO (1) | WO2000017173A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10020667A1 (de) * | 2000-04-19 | 2001-11-22 | Schering Ag | Neue Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| WO2001081324A1 (de) * | 2000-04-25 | 2001-11-01 | Schering Aktiengesellschaft | Benzoxazin- und benzothiazin-derivate mit nos-inhibitorischen und antioxidativen eigenschaften |
| UA105182C2 (ru) * | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2509155A1 (de) | 1975-03-03 | 1976-09-09 | Hoechst Ag | 1,4-benzoxazinderivate und verfahren zu ihrer herstellung |
| US4254118A (en) * | 1979-08-13 | 1981-03-03 | Ayerst, Mckenna & Harrison Inc. | 1-Oxo-5H-pyrimido[2,1-c][1,4]benzthiazine-2-carboxylic acid esters |
| US4254121A (en) * | 1979-08-13 | 1981-03-03 | Ayerst, Mckenna & Harrison Inc. | 3-Oxo-5H-pyrimido[2,1-c][1,4 ]benzoxazines |
| US4547499A (en) * | 1984-05-10 | 1985-10-15 | The Upjohn Company | 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use |
| CN1077886C (zh) * | 1993-10-21 | 2002-01-16 | G·D·瑟尔公司 | 用作一氧化一氮合酶抑制剂的脒基衍生物 |
| US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| DE4442116A1 (de) * | 1994-11-25 | 1996-05-30 | Cassella Ag | 2-Amino-1,3-thiazine als Hemmstoffe der Stickstoffmonoxid-Synthase |
| IT1277486B1 (it) * | 1994-12-14 | 1997-11-10 | Japan Tobacco Inc | Derivati di tiazina o di tiazepina |
| TW397812B (en) * | 1995-02-11 | 2000-07-11 | Astra Ab | Bicyclic isothiourea derivatives useful in therapy |
| CZ287969B6 (cs) * | 1995-08-10 | 2001-03-14 | Astra Pharmaceuticals Limited | Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití |
| TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| AU731104B2 (en) | 1996-05-29 | 2001-03-22 | Warner-Lambert Company | Benzoxazinone dopamine D4 receptor antagonists |
| WO1998050372A1 (de) | 1997-05-02 | 1998-11-12 | Schering Aktiengesellschaft | Substituierte heterocyclen und deren verwendung in arzneimitteln |
| TR200000637T2 (tr) | 1997-09-08 | 2000-07-21 | Schering Aktiengesellschaft | Benzoksazin ve benzotiazin türevleri ve bunların ilaçlarda kullanımı. |
-
1998
- 1998-09-18 DE DE19844291A patent/DE19844291A1/de not_active Withdrawn
-
1999
- 1999-09-15 PE PE1999000934A patent/PE20001035A1/es not_active Application Discontinuation
- 1999-09-16 SK SK371-2001A patent/SK3712001A3/sk unknown
- 1999-09-16 CA CA002341170A patent/CA2341170A1/en not_active Abandoned
- 1999-09-16 AT AT99948841T patent/ATE266647T1/de not_active IP Right Cessation
- 1999-09-16 US US09/787,396 patent/US6841550B1/en not_active Expired - Fee Related
- 1999-09-16 CZ CZ2001988A patent/CZ2001988A3/cs unknown
- 1999-09-16 DK DK99948841T patent/DK1114037T3/da active
- 1999-09-16 ES ES99948841T patent/ES2221442T3/es not_active Expired - Lifetime
- 1999-09-16 KR KR1020017003496A patent/KR20010075199A/ko not_active Application Discontinuation
- 1999-09-16 HU HU0103505A patent/HUP0103505A3/hu unknown
- 1999-09-16 DE DE59909486T patent/DE59909486D1/de not_active Expired - Fee Related
- 1999-09-16 JP JP2000574083A patent/JP2002526481A/ja active Pending
- 1999-09-16 NZ NZ510562A patent/NZ510562A/en unknown
- 1999-09-16 BR BR9913856-5A patent/BR9913856A/pt not_active IP Right Cessation
- 1999-09-16 AU AU61954/99A patent/AU751381B2/en not_active Ceased
- 1999-09-16 PT PT99948841T patent/PT1114037E/pt unknown
- 1999-09-16 CN CNB998111244A patent/CN1144794C/zh not_active Expired - Fee Related
- 1999-09-16 EP EP99948841A patent/EP1114037B1/de not_active Expired - Lifetime
- 1999-09-16 WO PCT/EP1999/007089 patent/WO2000017173A1/de not_active Application Discontinuation
- 1999-09-16 PL PL99346699A patent/PL346699A1/xx not_active Application Discontinuation
- 1999-09-17 AR ARP990104683A patent/AR020474A1/es unknown
-
2001
- 2001-03-16 NO NO20011339A patent/NO20011339L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2341170A1 (en) | 2000-03-30 |
| AU6195499A (en) | 2000-04-10 |
| DE19844291A1 (de) | 2000-03-23 |
| EP1114037B1 (de) | 2004-05-12 |
| ES2221442T3 (es) | 2004-12-16 |
| DK1114037T3 (da) | 2004-08-16 |
| AU751381B2 (en) | 2002-08-15 |
| CN1319097A (zh) | 2001-10-24 |
| PT1114037E (pt) | 2004-09-30 |
| HUP0103505A3 (en) | 2003-05-28 |
| EP1114037A1 (de) | 2001-07-11 |
| AR020474A1 (es) | 2002-05-15 |
| NO20011339D0 (no) | 2001-03-16 |
| BR9913856A (pt) | 2001-06-12 |
| WO2000017173A1 (de) | 2000-03-30 |
| PL346699A1 (en) | 2002-02-25 |
| ATE266647T1 (de) | 2004-05-15 |
| CZ2001988A3 (cs) | 2001-08-15 |
| SK3712001A3 (en) | 2001-09-11 |
| NO20011339L (no) | 2001-05-09 |
| NZ510562A (en) | 2003-08-29 |
| HUP0103505A2 (hu) | 2002-02-28 |
| US6841550B1 (en) | 2005-01-11 |
| CN1144794C (zh) | 2004-04-07 |
| JP2002526481A (ja) | 2002-08-20 |
| DE59909486D1 (de) | 2004-06-17 |
| KR20010075199A (ko) | 2001-08-09 |
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