PE20000435A1 - Compuestos azapoliciclicos condensados con arilo - Google Patents
Compuestos azapoliciclicos condensados con ariloInfo
- Publication number
- PE20000435A1 PE20000435A1 PE1999000340A PE00034099A PE20000435A1 PE 20000435 A1 PE20000435 A1 PE 20000435A1 PE 1999000340 A PE1999000340 A PE 1999000340A PE 00034099 A PE00034099 A PE 00034099A PE 20000435 A1 PE20000435 A1 PE 20000435A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- azapolicyclic
- fluor
- piperazine
- bound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- -1 AZETHYDINE Chemical compound 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000208125 Nicotiana Species 0.000 abstract 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract 1
- 206010057852 Nicotine dependence Diseases 0.000 abstract 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 208000025569 Tobacco Use disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000006949 cholinergic function Effects 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 230000001148 spastic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS AZAPOLICICLICOS CONDENSADOS CON ARILO DE FORMULA I, DONDE Z ES CH2, C=O, CF2; R1 ES H, ALQUILO C1-C6, ALQUENILO C3-C6, BENCILO, XC(=O)R13, -CH2CH2-O-(ALQUILO C1-C4); R2 Y R3 SON H, ALQUENILO C2-C6, ALQUINILO C2-C6, OH, -SOq-(ALQUILO C1-C6), ENTRE OTROS; q ES 0-2, CO2R4, CONR5R6, SO2NR7R8, C(=O)R13, X(C=O)R13; O R2 Y R3 FORMAN UN ANILLO CARBOCICLICO MONOCICLICO DE 4-7 MIEMBROS O BICICLICO DE 10-14 MIEMBROS DE PREFERENCIA DE FORMULA a, b, ENTRE OTROS; R10 Y R17 SON H Y ALQUILO C1-C6; R4, R5, R6, R7, R8, R13 SON H, ALQUILO C1-C6; O R5 Y R6 O R7 Y R8 JUNTO CON N FORMAN PIRROLIDINA, PIPERIDINA, MORFOLINA, AZETIDINA, PIPERAZINA, -N-(ALQUIL C1-C6)PIPERAZINA, TIOMORFOLINA; X ES ALQUILENO C1-C6; a)UNO DE R1, R2 Y R3 NO ES H; b)CUANDO R2 Y R3 SON H; R1 NO ES METILO o H; c)NINGUN FLUOR DE ALQUILO O ALCOXI SUSTITUIDO CON FLUOR DE R2 Y R3 ESTA UNIDO AL CARBONO QUE ESTA UNIDO A UN HETEROATOMO. EL COMPUESTO I SE UNE A SITIOS ESPECIFICOS DE RECEPTORES NICOTINICOS DE ACETILCOLINA PRESENTES EN LAS NEURONAS Y SON UTILES PARA MODULAR LA FUNCION COLINERGICA Y PUEDE SER UTIL PARA LA REDUCCION DE LA ADICCION A LA NICOTINA, REDUCIR EL USO DE TABACO, TRATAMIENTO DE LA ENFERMEDAD INFLAMATORIA DEL INTESTINO, SINDROME DEL INTESTINO IRRITABLE, DISTONIA ESPASTICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8355698P | 1998-04-29 | 1998-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000435A1 true PE20000435A1 (es) | 2000-05-26 |
Family
ID=22179102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000340A PE20000435A1 (es) | 1998-04-29 | 1999-04-23 | Compuestos azapoliciclicos condensados con arilo |
Country Status (41)
| Country | Link |
|---|---|
| US (3) | US6462035B1 (es) |
| EP (1) | EP1076650B1 (es) |
| JP (1) | JP2002513007A (es) |
| KR (1) | KR100420423B1 (es) |
| CN (1) | CN1144787C (es) |
| AP (1) | AP1154A (es) |
| AR (1) | AR018596A1 (es) |
| AT (1) | ATE258921T1 (es) |
| AU (1) | AU749831B2 (es) |
| BG (1) | BG64556B1 (es) |
| BR (1) | BR9910058A (es) |
| CA (1) | CA2330576A1 (es) |
| CO (1) | CO5021124A1 (es) |
| DE (1) | DE69914594T2 (es) |
| DK (1) | DK1076650T3 (es) |
| DZ (1) | DZ2778A1 (es) |
| EA (1) | EA003669B1 (es) |
| ES (1) | ES2213354T3 (es) |
| GT (1) | GT199900059A (es) |
| HR (1) | HRP20000731A2 (es) |
| HU (1) | HUP0103340A3 (es) |
| ID (1) | ID26700A (es) |
| IL (1) | IL138917A0 (es) |
| IS (1) | IS5649A (es) |
| MA (1) | MA26623A1 (es) |
| MY (1) | MY133474A (es) |
| NO (1) | NO317300B1 (es) |
| NZ (1) | NZ507035A (es) |
| OA (1) | OA11506A (es) |
| PA (1) | PA8471301A1 (es) |
| PE (1) | PE20000435A1 (es) |
| PL (1) | PL344010A1 (es) |
| PT (1) | PT1076650E (es) |
| SK (1) | SK15952000A3 (es) |
| TN (1) | TNSN99080A1 (es) |
| TR (1) | TR200003122T2 (es) |
| UA (1) | UA61991C2 (es) |
| UY (1) | UY25636A1 (es) |
| WO (1) | WO1999055680A1 (es) |
| YU (1) | YU64400A (es) |
| ZA (1) | ZA992971B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605610B1 (en) * | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
| JP3550359B2 (ja) | 1997-12-31 | 2004-08-04 | ファイザー・プロダクツ・インク | アリール縮合アザ多環状化合物 |
| US20010036943A1 (en) * | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| ES2300430T3 (es) * | 2001-04-20 | 2008-06-16 | Pfizer Products Inc. | Procedimiento para la preparacion de indenos 1,3-sustituidos y compuestos azapoliciclicos condensados con arilo. |
| PL370549A1 (en) * | 2001-10-31 | 2005-05-30 | Pfizer Products Inc. | Nicotinic acetylcholine receptor agonists in the treatment of restless legs syndrome |
| RU2004116320A (ru) | 2001-11-30 | 2005-10-10 | Пфайзер Продактс Инк. (Us) | Арилконденсированные азаполициклические соединения |
| AU2003233228A1 (en) * | 2002-05-03 | 2003-11-17 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolyl-cis/trans-isomerases |
| US20040224963A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
| US20040224962A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| MXPA06000892A (es) * | 2003-07-21 | 2006-03-30 | Pfizer Prod Inc | Compuestos azapoliciclicos arilo fusionados. |
| ATE443705T1 (de) * | 2003-07-21 | 2009-10-15 | Pfizer Prod Inc | Nikotin abhängigkeit reduzierende heteroaryl kondensierte azapolycyclische verbindungen |
| US20050043407A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| WO2006061711A1 (en) * | 2004-12-07 | 2006-06-15 | Pfizer Products Inc. | 1, 2, 3, 3a, 8, 8a-hexahydro-2, 7a-diada-cyclopenta [a] inden-7-one derivatives which bind to neuronal nicotinic acetylcholine specific receptor sites and are useful in modulating cholinergic function and in the treatment of addictive disorders |
| US20060210498A1 (en) | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives for skin |
| US20060210497A1 (en) * | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives |
| DE102005061426A1 (de) * | 2005-12-22 | 2007-07-05 | Grünenthal GmbH | Substituierte tricyclische Piperidon-Derivate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687937A (en) * | 1970-06-23 | 1972-08-29 | Us Of America The | 1,5-methano-3-benzazocine derivatives |
| JPS4914473A (es) * | 1972-06-09 | 1974-02-07 | ||
| JPS4924968A (es) * | 1972-07-01 | 1974-03-05 |
-
1999
- 1999-04-08 CN CNB998054542A patent/CN1144787C/zh not_active Expired - Fee Related
- 1999-04-08 HR HR20000731A patent/HRP20000731A2/hr not_active Application Discontinuation
- 1999-04-08 WO PCT/IB1999/000617 patent/WO1999055680A1/en not_active Application Discontinuation
- 1999-04-08 BR BR9910058-4A patent/BR9910058A/pt not_active Application Discontinuation
- 1999-04-08 EA EA200000996A patent/EA003669B1/ru not_active IP Right Cessation
- 1999-04-08 HU HU0103340A patent/HUP0103340A3/hu unknown
- 1999-04-08 DK DK99910600T patent/DK1076650T3/da active
- 1999-04-08 EP EP99910600A patent/EP1076650B1/en not_active Expired - Lifetime
- 1999-04-08 SK SK1595-2000A patent/SK15952000A3/sk unknown
- 1999-04-08 JP JP2000545840A patent/JP2002513007A/ja not_active Withdrawn
- 1999-04-08 US US09/582,513 patent/US6462035B1/en not_active Expired - Fee Related
- 1999-04-08 IL IL13891799A patent/IL138917A0/xx unknown
- 1999-04-08 PL PL99344010A patent/PL344010A1/xx unknown
- 1999-04-08 AU AU29516/99A patent/AU749831B2/en not_active Ceased
- 1999-04-08 DE DE69914594T patent/DE69914594T2/de not_active Expired - Fee Related
- 1999-04-08 CA CA002330576A patent/CA2330576A1/en not_active Abandoned
- 1999-04-08 NZ NZ507035A patent/NZ507035A/en unknown
- 1999-04-08 YU YU64400A patent/YU64400A/sh unknown
- 1999-04-08 ID IDW20002185A patent/ID26700A/id unknown
- 1999-04-08 KR KR10-2000-7012039A patent/KR100420423B1/ko not_active Expired - Fee Related
- 1999-04-08 ES ES99910600T patent/ES2213354T3/es not_active Expired - Lifetime
- 1999-04-08 AT AT99910600T patent/ATE258921T1/de not_active IP Right Cessation
- 1999-04-08 PT PT99910600T patent/PT1076650E/pt unknown
- 1999-04-08 TR TR2000/03122T patent/TR200003122T2/xx unknown
- 1999-04-20 GT GT199900059A patent/GT199900059A/es unknown
- 1999-04-23 PE PE1999000340A patent/PE20000435A1/es not_active Application Discontinuation
- 1999-04-27 MY MYPI99001648A patent/MY133474A/en unknown
- 1999-04-27 AR ARP990101941A patent/AR018596A1/es unknown
- 1999-04-28 ZA ZA9902971A patent/ZA992971B/xx unknown
- 1999-04-28 MA MA25556A patent/MA26623A1/fr unknown
- 1999-04-28 DZ DZ990078A patent/DZ2778A1/xx active
- 1999-04-28 TN TNTNSN99080A patent/TNSN99080A1/fr unknown
- 1999-04-29 CO CO99026005A patent/CO5021124A1/es unknown
- 1999-04-29 AP APAP/P/1999/001524A patent/AP1154A/en active
- 1999-04-29 PA PA19998471301A patent/PA8471301A1/es unknown
- 1999-08-03 UY UY25636A patent/UY25636A1/es not_active Application Discontinuation
- 1999-08-04 UA UA2000095418A patent/UA61991C2/uk unknown
-
2000
- 2000-09-29 IS IS5649A patent/IS5649A/is unknown
- 2000-10-25 OA OA1200000295A patent/OA11506A/en unknown
- 2000-10-26 NO NO20005397A patent/NO317300B1/no unknown
- 2000-11-24 BG BG104983A patent/BG64556B1/bg unknown
-
2002
- 2002-08-13 US US10/217,771 patent/US6706702B2/en not_active Expired - Fee Related
-
2004
- 2004-01-23 US US10/764,167 patent/US7122534B2/en not_active Expired - Fee Related
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