PE20000271A1 - Composicion farmaceutica de (1s,4r)-cis-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]-2-ciclopenteno-1-metanol - Google Patents
Composicion farmaceutica de (1s,4r)-cis-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]-2-ciclopenteno-1-metanolInfo
- Publication number
- PE20000271A1 PE20000271A1 PE1999000088A PE00008899A PE20000271A1 PE 20000271 A1 PE20000271 A1 PE 20000271A1 PE 1999000088 A PE1999000088 A PE 1999000088A PE 00008899 A PE00008899 A PE 00008899A PE 20000271 A1 PE20000271 A1 PE 20000271A1
- Authority
- PE
- Peru
- Prior art keywords
- cyclopropylamine
- purin
- cyclopentene
- cis
- methanol
- Prior art date
Links
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108010011485 Aspartame Proteins 0.000 abstract 1
- -1 CARBOXYL GROUP Chemical group 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 239000004376 Sucralose Substances 0.000 abstract 1
- MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 abstract 1
- 229960004748 abacavir Drugs 0.000 abstract 1
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 abstract 1
- 229960005164 acesulfame Drugs 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000000605 aspartame Substances 0.000 abstract 1
- 235000010357 aspartame Nutrition 0.000 abstract 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 1
- 229960003438 aspartame Drugs 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 229960002737 fructose Drugs 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 235000019204 saccharin Nutrition 0.000 abstract 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
- 229940081974 saccharin Drugs 0.000 abstract 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 229960002920 sorbitol Drugs 0.000 abstract 1
- 235000019408 sucralose Nutrition 0.000 abstract 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UNA COMPOSICION QUE COMPRENDE a)(1S,4R)-CIS-4-[2-AMINO-6-(CICLOPROPILAMINO)-9H-PURIN-9-IL]-2-CICLOPENTENO-1-METANOL O SU SAL DE HEMISULFATO (ABACAVIR); b)UN ENDULZANTE, ENMASCARADOR DE SABOR QUE NO CONTIENE UN GRUPO CARBOXILO TAL COMO SORBITOL, SACARINA, ACESULFAME, FRUCTOSA, SUCRALOSA, ASPARTAME. LA COMPOSICION TIENE UN pH DE 2-4,5 o UN pH DE 6,6-7,5; c)DE 0,01 M A 0,1 M DE UN QUELATOR DE METAL QUE MEJORA LA ESTABILIDAD DE LA SOLUCION TAL COMO UN CITRATO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LA COMPOSICION PUEDE SER UTIL COMO ANTIVIRAL, CONTRA INFECCIONES DE VIH
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9802472.2A GB9802472D0 (en) | 1998-02-06 | 1998-02-06 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000271A1 true PE20000271A1 (es) | 2000-04-17 |
Family
ID=10826520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000088A PE20000271A1 (es) | 1998-02-06 | 1999-02-03 | Composicion farmaceutica de (1s,4r)-cis-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]-2-ciclopenteno-1-metanol |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6641843B1 (es) |
| EP (1) | EP1051156B1 (es) |
| JP (1) | JP3560550B2 (es) |
| KR (1) | KR100564854B1 (es) |
| CN (2) | CN1296406A (es) |
| AP (1) | AP1212A (es) |
| AR (1) | AR017455A1 (es) |
| AT (1) | ATE237309T1 (es) |
| AU (1) | AU754255B2 (es) |
| BR (1) | BR9907649A (es) |
| CA (1) | CA2319010C (es) |
| CO (1) | CO5070673A1 (es) |
| CZ (1) | CZ299608B6 (es) |
| DE (1) | DE69906934T2 (es) |
| DK (1) | DK1051156T3 (es) |
| EA (1) | EA002916B1 (es) |
| EE (1) | EE04217B1 (es) |
| ES (1) | ES2196779T3 (es) |
| GB (1) | GB9802472D0 (es) |
| HR (1) | HRP20000530B1 (es) |
| HU (1) | HU228315B1 (es) |
| ID (1) | ID26215A (es) |
| IL (2) | IL137403A0 (es) |
| IS (1) | IS2200B (es) |
| MA (1) | MA26604A1 (es) |
| MY (1) | MY121043A (es) |
| NO (1) | NO329041B1 (es) |
| NZ (1) | NZ505811A (es) |
| PE (1) | PE20000271A1 (es) |
| PL (1) | PL194558B1 (es) |
| PT (1) | PT1051156E (es) |
| RS (1) | RS49953B (es) |
| SI (1) | SI1051156T1 (es) |
| SK (1) | SK284397B6 (es) |
| TR (1) | TR200002293T2 (es) |
| TW (1) | TWI222878B (es) |
| WO (1) | WO1999039691A2 (es) |
| ZA (1) | ZA99890B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2080511A3 (en) * | 2000-08-22 | 2009-09-30 | Shire LLC | Active agent delivery systems and methods for protecting and administering active agents |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| US7169752B2 (en) | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| EP2085397A1 (en) | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
| EP2305680A3 (en) * | 2009-09-30 | 2011-05-18 | Aurobindo Pharma Limited | Novel salts of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol |
| CN104788451A (zh) * | 2014-01-21 | 2015-07-22 | 浙江九洲药业股份有限公司 | 一种阿巴卡韦的制备方法 |
| CN105315280A (zh) * | 2014-06-06 | 2016-02-10 | 上海迪赛诺化学制药有限公司 | 一种阿巴卡韦结晶体及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631370A (en) | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
| US5567703A (en) | 1988-01-20 | 1996-10-22 | Regents Of The University Of Minnesota | Method for treating HIV infections with dideoxycarbocyclic nucleosides |
| GB8815265D0 (en) | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| GB9417249D0 (en) * | 1994-08-26 | 1994-10-19 | Wellcome Found | A novel salt |
| CZ429398A3 (cs) * | 1996-06-25 | 1999-05-12 | Glaxo Group Limited | Kombinace účinných látek a farmaceutický prostředek |
| US6124319A (en) * | 1997-01-21 | 2000-09-26 | Merck & Co., Inc. | 3,3-disubstituted piperidines as modulators of chemokine receptor activity |
| US6177464B1 (en) * | 1997-03-14 | 2001-01-23 | Sepracor, Inc. | Ring opening metathesis of alkenes |
| GB9709945D0 (en) | 1997-05-17 | 1997-07-09 | Glaxo Group Ltd | A novel salt |
-
1998
- 1998-02-06 GB GBGB9802472.2A patent/GB9802472D0/en not_active Ceased
-
1999
- 1999-02-02 TW TW088101534A patent/TWI222878B/zh not_active IP Right Cessation
- 1999-02-03 PE PE1999000088A patent/PE20000271A1/es not_active IP Right Cessation
- 1999-02-03 AR ARP990100439A patent/AR017455A1/es active IP Right Grant
- 1999-02-04 EA EA200000736A patent/EA002916B1/ru not_active IP Right Cessation
- 1999-02-04 ES ES99907477T patent/ES2196779T3/es not_active Expired - Lifetime
- 1999-02-04 CA CA002319010A patent/CA2319010C/en not_active Expired - Lifetime
- 1999-02-04 CN CN99804843A patent/CN1296406A/zh active Pending
- 1999-02-04 CO CO99006407A patent/CO5070673A1/es unknown
- 1999-02-04 DE DE69906934T patent/DE69906934T2/de not_active Expired - Lifetime
- 1999-02-04 AT AT99907477T patent/ATE237309T1/de active
- 1999-02-04 RS YUP-482/00A patent/RS49953B/sr unknown
- 1999-02-04 ZA ZA9900890A patent/ZA99890B/xx unknown
- 1999-02-04 HR HR20000530A patent/HRP20000530B1/xx not_active IP Right Cessation
- 1999-02-04 MY MYPI99000389A patent/MY121043A/en unknown
- 1999-02-04 DK DK99907477T patent/DK1051156T3/da active
- 1999-02-04 WO PCT/EP1999/000663 patent/WO1999039691A2/en active IP Right Grant
- 1999-02-04 KR KR1020007008595A patent/KR100564854B1/ko not_active Expired - Lifetime
- 1999-02-04 EP EP99907477A patent/EP1051156B1/en not_active Expired - Lifetime
- 1999-02-04 EE EEP200000459A patent/EE04217B1/xx unknown
- 1999-02-04 JP JP2000530191A patent/JP3560550B2/ja not_active Expired - Lifetime
- 1999-02-04 ID IDW20001507A patent/ID26215A/id unknown
- 1999-02-04 IL IL13740399A patent/IL137403A0/xx active IP Right Grant
- 1999-02-04 BR BR9907649-7A patent/BR9907649A/pt not_active Application Discontinuation
- 1999-02-04 NZ NZ505811A patent/NZ505811A/xx not_active IP Right Cessation
- 1999-02-04 TR TR2000/02293T patent/TR200002293T2/xx unknown
- 1999-02-04 CN CNA2008100838827A patent/CN101239063A/zh active Pending
- 1999-02-04 PL PL99342628A patent/PL194558B1/pl unknown
- 1999-02-04 SK SK1168-2000A patent/SK284397B6/sk not_active IP Right Cessation
- 1999-02-04 SI SI9930271T patent/SI1051156T1/xx unknown
- 1999-02-04 PT PT99907477T patent/PT1051156E/pt unknown
- 1999-02-04 CZ CZ20002867A patent/CZ299608B6/cs not_active IP Right Cessation
- 1999-02-04 AU AU27221/99A patent/AU754255B2/en not_active Expired
- 1999-02-04 US US09/601,671 patent/US6641843B1/en not_active Expired - Lifetime
- 1999-02-04 AP APAP/P/2000/001878A patent/AP1212A/en active
- 1999-02-04 MA MA25452A patent/MA26604A1/fr unknown
- 1999-02-04 HU HU0100802A patent/HU228315B1/hu unknown
-
2000
- 2000-07-19 IL IL137403A patent/IL137403A/en not_active IP Right Cessation
- 2000-07-20 IS IS5569A patent/IS2200B/is unknown
- 2000-08-04 NO NO20003962A patent/NO329041B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| MK | Expiration of term |