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BR9908702A - Composto, processos para inibir sìntese de óxido nìtrico em um paciente, para inibir seletivamente sìntese de óxido nìtrico produzido pela no sintase indutìvel no óxido nìtrico produzido pelas formas constitutivas de no sintase em um paciente e para diminuir nìveis de óxido nìtrico em um paciente, e, composição farmacêutica - Google Patents

Composto, processos para inibir sìntese de óxido nìtrico em um paciente, para inibir seletivamente sìntese de óxido nìtrico produzido pela no sintase indutìvel no óxido nìtrico produzido pelas formas constitutivas de no sintase em um paciente e para diminuir nìveis de óxido nìtrico em um paciente, e, composição farmacêutica

Info

Publication number
BR9908702A
BR9908702A BR9908702-2A BR9908702A BR9908702A BR 9908702 A BR9908702 A BR 9908702A BR 9908702 A BR9908702 A BR 9908702A BR 9908702 A BR9908702 A BR 9908702A
Authority
BR
Brazil
Prior art keywords
nitric oxide
patient
synthesis
produced
synthase
Prior art date
Application number
BR9908702-2A
Other languages
English (en)
Inventor
Ann E Halinan
Barnett S Pitnel
Dale P Spangler
Arija A Bergmanis
Timothy J Hagen
Sofya Tsymbalov
Mihaly V Toth
Keith R Webber
Donald W Hansen Jr
Alik K Awasthi
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of BR9908702A publication Critical patent/BR9908702A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

"COMPOSTO, PROCESSOS PARA INIBIR SìNTESE DE óXIDO NìTRICO EM UM PACIENTE, PARA INIBIR SELETIVAMENTE SìNTESE DE óXIDO NìTRICO PRODUZIDO PELA NO SINTASE INDUTìVEL NO óXIDO NìTRICO PRODUZIDO PELAS FORMAS CONSTITUTIVAS DE NO SINTASE EM UM PACIENTE E PARA DIMINUIR NìVEIS DE óXIDO NìTRICO EM UM PACIENTE, E, COMPOSIçãO FARMACêUTICA" Derivados de aminoácido amidino halogenados úteis como inibidores da sintase do óxido nítrico de Fórmula (I), ou um seu sal farmaceuticamente aceitável, em que todos os substituintes são descritos no relatório descritivo.
BR9908702-2A 1998-03-11 1999-03-04 Composto, processos para inibir sìntese de óxido nìtrico em um paciente, para inibir seletivamente sìntese de óxido nìtrico produzido pela no sintase indutìvel no óxido nìtrico produzido pelas formas constitutivas de no sintase em um paciente e para diminuir nìveis de óxido nìtrico em um paciente, e, composição farmacêutica BR9908702A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3828498A 1998-03-11 1998-03-11
PCT/US1999/003728 WO1999046240A2 (en) 1998-03-11 1999-03-04 Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
BR9908702A true BR9908702A (pt) 2000-11-21

Family

ID=21899068

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9908702-2A BR9908702A (pt) 1998-03-11 1999-03-04 Composto, processos para inibir sìntese de óxido nìtrico em um paciente, para inibir seletivamente sìntese de óxido nìtrico produzido pela no sintase indutìvel no óxido nìtrico produzido pelas formas constitutivas de no sintase em um paciente e para diminuir nìveis de óxido nìtrico em um paciente, e, composição farmacêutica

Country Status (35)

Country Link
US (1) US6344483B1 (pt)
EP (2) EP1415982A1 (pt)
JP (1) JP2002506056A (pt)
KR (1) KR20010034598A (pt)
CN (1) CN1171861C (pt)
AP (1) AP2000001900A0 (pt)
AR (1) AR018159A1 (pt)
AT (1) ATE277894T1 (pt)
AU (1) AU746235B2 (pt)
BG (1) BG104766A (pt)
BR (1) BR9908702A (pt)
CA (1) CA2322873A1 (pt)
CU (1) CU23047A3 (pt)
DE (1) DE69920670T2 (pt)
EA (1) EA200000826A1 (pt)
EE (1) EE200000519A (pt)
ES (1) ES2239839T3 (pt)
GE (1) GEP20043179B (pt)
HR (1) HRP20000595A2 (pt)
HU (1) HUP0101467A3 (pt)
ID (1) ID26208A (pt)
IL (1) IL137654A0 (pt)
IS (1) IS5583A (pt)
NO (1) NO20004531L (pt)
NZ (1) NZ506721A (pt)
OA (1) OA11901A (pt)
PL (1) PL343380A1 (pt)
PT (1) PT1062201E (pt)
SI (1) SI1062201T1 (pt)
SK (1) SK13012000A3 (pt)
TR (1) TR200002605T2 (pt)
UA (1) UA67767C2 (pt)
WO (1) WO1999046240A2 (pt)
YU (1) YU52200A (pt)
ZA (1) ZA991894B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ520812A (en) 2000-03-24 2004-04-30 Pharmacia Corp Amidino compound and salts thereof useful as nitric oxide synthase inhibitors
AR032318A1 (es) * 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR034120A1 (es) * 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
US6956131B2 (en) 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
AR031608A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR031129A1 (es) 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR031609A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa
AR035585A1 (es) * 2000-09-15 2004-06-16 Pharmacia Corp Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos
GB0031179D0 (en) 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
US6613280B2 (en) * 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
US6582387B2 (en) * 2001-03-20 2003-06-24 Therox, Inc. System for enriching a bodily fluid with a gas
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US20040087653A1 (en) * 2002-05-16 2004-05-06 Manning Pamela T. Methods for the treatment of respiratory diseases and conditions with a selective iNOS inhibitor and a PDE inhibitor and compositions therefor
CN104803865A (zh) * 2004-12-22 2015-07-29 Ambrx公司 含有非天然氨基酸和多肽的组合物、涉及非天然氨基酸和多肽的方法以及其用途
KR101280929B1 (ko) * 2005-03-14 2013-07-01 얀센 파마슈티카 엔.브이. 오피오이드 모듈레이터의 제조방법
CN101400646A (zh) 2005-11-08 2009-04-01 Ambrx公司 用于修饰非天然氨基酸和非天然氨基酸多肽的促进剂
EP1968635B1 (en) * 2005-12-14 2014-09-17 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
KR101103720B1 (ko) * 2011-06-02 2012-01-11 한국건설기술연구원 자연환기에 의한 중공층의 온도제어가 가능한 일체형 다중유리 복합창짝
WO2015035332A1 (en) 2013-09-09 2015-03-12 Canimguide Therapeutics Ab Immune system modulators
AU2016229309B2 (en) 2015-03-06 2021-12-02 Canimguide Therapeutics Ab Immune system modulators and compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
CA2192668A1 (en) 1994-06-15 1995-12-21 Harold Francis Hodson Amidino sulfone derivatives for use as inos inhibitors claims
GB9425701D0 (en) * 1994-12-20 1995-02-22 Wellcome Found Enzyme inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors

Also Published As

Publication number Publication date
PT1062201E (pt) 2005-02-28
ZA991894B (en) 1999-09-27
CN1292779A (zh) 2001-04-25
HUP0101467A2 (hu) 2001-08-28
NZ506721A (en) 2003-07-25
WO1999046240A3 (en) 1999-11-11
GEP20043179B (en) 2004-02-25
AR018159A1 (es) 2001-10-31
CU23047A3 (es) 2005-04-26
HUP0101467A3 (en) 2003-03-28
KR20010034598A (ko) 2001-04-25
UA67767C2 (uk) 2004-07-15
OA11901A (en) 2006-04-10
AU2778699A (en) 1999-09-27
SI1062201T1 (en) 2005-10-31
JP2002506056A (ja) 2002-02-26
HRP20000595A2 (en) 2001-04-30
BG104766A (bg) 2001-03-30
AP2000001900A0 (en) 2000-09-30
EA200000826A1 (ru) 2001-04-23
EP1062201A2 (en) 2000-12-27
EP1415982A1 (en) 2004-05-06
DE69920670D1 (de) 2004-11-04
IL137654A0 (en) 2001-10-31
AU746235B2 (en) 2002-04-18
SK13012000A3 (sk) 2001-06-11
ATE277894T1 (de) 2004-10-15
TR200002605T2 (tr) 2000-12-21
WO1999046240A2 (en) 1999-09-16
ES2239839T3 (es) 2005-10-01
ID26208A (id) 2000-11-07
CN1171861C (zh) 2004-10-20
EP1062201B1 (en) 2004-09-29
NO20004531D0 (no) 2000-09-11
PL343380A1 (en) 2001-08-13
US6344483B1 (en) 2002-02-05
YU52200A (sh) 2002-09-19
IS5583A (is) 2000-08-04
DE69920670T2 (de) 2006-02-16
NO20004531L (no) 2000-10-30
CA2322873A1 (en) 1999-09-16
EE200000519A (et) 2002-02-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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