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BR9917080A - Composto, composição farmacêutica, uso do composto e método de tratamento ou prevenção de uma disfunção tromboembólica - Google Patents

Composto, composição farmacêutica, uso do composto e método de tratamento ou prevenção de uma disfunção tromboembólica

Info

Publication number
BR9917080A
BR9917080A BR9917080-9A BR9917080A BR9917080A BR 9917080 A BR9917080 A BR 9917080A BR 9917080 A BR9917080 A BR 9917080A BR 9917080 A BR9917080 A BR 9917080A
Authority
BR
Brazil
Prior art keywords
compound
thromboembolic
dysfunction
prevention
treatment
Prior art date
Application number
BR9917080-9A
Other languages
English (en)
Inventor
John M Fevig
Joseph Cacciola
Charles G Clark
Qi Han
Patrick Yuk San Lam
Donald J P Pinto
James R Pruitt
Mimi L Quan
Karen A Rossi
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26811284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9917080(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of BR9917080A publication Critical patent/BR9917080A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DO COMPOSTO E MéTODO DE TRATAMENTO OU PREVENçãO DE UMA DISFUNçãO TROMBOEMBóLICA". A presente invenção refere-se a heterobicíclicos contendo nitrogênio e seus derivados, ou suas formas de sais farmaceuticamente aceitáveis, que são úteis como inibidores de fator Xa.
BR9917080-9A 1998-12-23 1999-12-17 Composto, composição farmacêutica, uso do composto e método de tratamento ou prevenção de uma disfunção tromboembólica BR9917080A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11362898P 1998-12-23 1998-12-23
US12763399P 1999-04-02 1999-04-02
PCT/US1999/030316 WO2000039131A1 (en) 1998-12-23 1999-12-17 Nitrogen containing heterobicycles as factor xa inhibitors

Publications (1)

Publication Number Publication Date
BR9917080A true BR9917080A (pt) 2002-03-12

Family

ID=26811284

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9917080-9A BR9917080A (pt) 1998-12-23 1999-12-17 Composto, composição farmacêutica, uso do composto e método de tratamento ou prevenção de uma disfunção tromboembólica

Country Status (26)

Country Link
US (2) US6413980B1 (pt)
EP (1) EP1140941B1 (pt)
JP (1) JP2002533465A (pt)
KR (1) KR100628407B1 (pt)
CN (1) CN100340559C (pt)
AR (1) AR024242A1 (pt)
AT (1) ATE280171T1 (pt)
AU (1) AU759711B2 (pt)
BR (1) BR9917080A (pt)
CA (1) CA2349330C (pt)
DE (1) DE69921358T2 (pt)
DK (1) DK1140941T3 (pt)
EA (1) EA004515B1 (pt)
ES (1) ES2232202T3 (pt)
HK (1) HK1052508B (pt)
HR (1) HRP990396A2 (pt)
IL (2) IL142959A0 (pt)
MX (1) MXPA01006502A (pt)
MY (1) MY138239A (pt)
NO (1) NO319816B1 (pt)
NZ (1) NZ511674A (pt)
PT (1) PT1140941E (pt)
SI (1) SI1140941T1 (pt)
TW (1) TWI225862B (pt)
WO (1) WO2000039131A1 (pt)
ZA (1) ZA200103795B (pt)

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WO2002000655A1 (en) * 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
EP1379245A4 (en) * 2001-04-18 2006-07-26 Bristol Myers Squibb Co 1, 4, 5, 6-TETRAHYDROPYRAZOLO- 3, 4-C-PYRIDINE-7-ONE AS FACTOR XA HEMMER
EP1379244A4 (en) 2001-04-18 2006-03-15 Bristol Myers Squibb Co 1,4,5,6-TETRAHYDROPYRAZOLO-3,4-C] -PYRIDINE-7-ONE AS FACTOR XA HEMMER
AU2002310070A1 (en) * 2001-05-22 2002-12-03 Bristol-Myers Squibb Company Bicyclic inhibitors of factor xa
HU228195B1 (hu) 2001-09-21 2013-01-28 Bristol Myers Squibb Co Pirazolo-piridin gyûrût tartalmazó laktámok és származékaik, valamint az ezeket tartalmazó Xa faktor gátlására szolgáló gyógyszerkészítmények
TWI320039B (en) 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
AU2002350217A1 (en) * 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
TW200303201A (en) 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
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WO2003099276A1 (en) * 2002-05-10 2003-12-04 Bristol-Myers Squibb Company 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors
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US7122557B2 (en) * 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
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ATE546452T1 (de) 2003-09-23 2012-03-15 Vertex Pharma Pyrazolopyrrolderivate als proteinkinaseinhibitoren
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CN105085515B (zh) * 2014-05-22 2019-02-01 华北制药股份有限公司 作为凝血因子Xa抑制剂的酰肼类化合物
WO2016034137A1 (zh) * 2014-09-02 2016-03-10 石药集团中奇制药技术（石家庄）有限公司 吡唑并[3，4-c]吡啶类衍生物
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CN104311557B (zh) * 2014-09-19 2016-01-06 广东东阳光药业有限公司 含有二酮取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN104311556B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有环氧烷基取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN104311574B (zh) * 2014-09-19 2016-04-20 广东东阳光药业有限公司 含有噻唑的吡唑并哌啶酮类化合物及其组合物及用途
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Also Published As

Publication number Publication date
CA2349330A1 (en) 2000-07-06
AU2371700A (en) 2000-07-31
KR100628407B1 (ko) 2006-09-26
EP1140941A1 (en) 2001-10-10
HK1052508A1 (en) 2003-09-19
DE69921358D1 (de) 2004-11-25
NO319816B1 (no) 2005-09-19
NO20013072L (no) 2001-06-20
CN1391575A (zh) 2003-01-15
US6413980B1 (en) 2002-07-02
WO2000039131A1 (en) 2000-07-06
NZ511674A (en) 2003-11-28
ATE280171T1 (de) 2004-11-15
EP1140941B1 (en) 2004-10-20
KR20010092754A (ko) 2001-10-26
IL142959A (en) 2010-05-31
PT1140941E (pt) 2005-02-28
EA004515B1 (ru) 2004-04-29
DE69921358T2 (de) 2006-03-09
IL142959A0 (en) 2002-04-21
DK1140941T3 (da) 2005-02-14
CN100340559C (zh) 2007-10-03
EA200100688A1 (ru) 2001-12-24
NO20013072D0 (no) 2001-06-20
SI1140941T1 (en) 2005-04-30
CA2349330C (en) 2009-09-29
MXPA01006502A (es) 2002-04-08
AU759711B2 (en) 2003-04-17
HRP990396A2 (en) 2000-08-31
ZA200103795B (en) 2002-08-12
US20030004167A1 (en) 2003-01-02
HK1052508B (zh) 2008-08-01
ES2232202T3 (es) 2005-05-16
JP2002533465A (ja) 2002-10-08
AR024242A1 (es) 2002-09-25
TWI225862B (en) 2005-01-01
MY138239A (en) 2009-05-29
US6673810B2 (en) 2004-01-06

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