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BRPI0410436A - antagonistas de rage como agentes para amiloidose reversa e doenças associadas com a mesma - Google Patents

antagonistas de rage como agentes para amiloidose reversa e doenças associadas com a mesma

Info

Publication number
BRPI0410436A
BRPI0410436A BRPI0410436-6A BRPI0410436A BRPI0410436A BR PI0410436 A BRPI0410436 A BR PI0410436A BR PI0410436 A BRPI0410436 A BR PI0410436A BR PI0410436 A BRPI0410436 A BR PI0410436A
Authority
BR
Brazil
Prior art keywords
rage
agents
amyloidosis
reverse
associated diseases
Prior art date
Application number
BRPI0410436-6A
Other languages
English (en)
Inventor
Adnan M M Mjalli
Robert C Andrews
Jane M Shen
Robert Rothlein
Original Assignee
Transtech Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transtech Pharma Inc filed Critical Transtech Pharma Inc
Publication of BRPI0410436A publication Critical patent/BRPI0410436A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"ANTAGONISTAS DE RAGE COMO AGENTES PARA AMILOIDOSE REVERSA E DOENçAS ASSOCIADAS COM A MESMA". São revelados compostos antagonistas de RAGE, dotados da capacidade de reverter amiloidose preexistente. O tratamento com os compostos antagonistas de RAGE aqui descritos podem ser usados a fim de reduzir o tamanho da placa e melhorar a cognição em indivíduos nos últimos estágios da doença de Alzheimrer. Adicionalmente, os antagonistas de RAGE aqui descritos podem ser usados para reduzir o início da formação de placa e, assim, prevenir a perda da cognição e outros sintomas associados com a Doença de Alzheimer e outras doenças de deposição amilóide.
BRPI0410436-6A 2003-05-20 2004-05-20 antagonistas de rage como agentes para amiloidose reversa e doenças associadas com a mesma BRPI0410436A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47196903P 2003-05-20 2003-05-20
PCT/US2004/016104 WO2005000295A1 (en) 2003-05-20 2004-05-20 Rage antagonists as agents to reverse amyloidosis and diseases associated therewith

Publications (1)

Publication Number Publication Date
BRPI0410436A true BRPI0410436A (pt) 2006-05-30

Family

ID=33551437

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410436-6A BRPI0410436A (pt) 2003-05-20 2004-05-20 antagonistas de rage como agentes para amiloidose reversa e doenças associadas com a mesma

Country Status (10)

Country Link
US (2) US20050026811A1 (pt)
EP (1) EP1635823A1 (pt)
JP (1) JP2007503469A (pt)
CN (1) CN1805743A (pt)
AU (1) AU2004251599A1 (pt)
BR (1) BRPI0410436A (pt)
CA (1) CA2522275A1 (pt)
MX (1) MXPA05012350A (pt)
WO (1) WO2005000295A1 (pt)
ZA (1) ZA200508300B (pt)

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Also Published As

Publication number Publication date
WO2005000295A1 (en) 2005-01-06
AU2004251599A1 (en) 2005-01-06
CN1805743A (zh) 2006-07-19
ZA200508300B (en) 2007-03-28
CA2522275A1 (en) 2005-01-06
JP2007503469A (ja) 2007-02-22
US20090035302A1 (en) 2009-02-05
EP1635823A1 (en) 2006-03-22
US20050026811A1 (en) 2005-02-03
MXPA05012350A (es) 2006-05-25

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