PA8448801A1 - Inhibidores de la proteasa del vih - Google Patents
Inhibidores de la proteasa del vihInfo
- Publication number
- PA8448801A1 PA8448801A1 PA19988448801A PA8448801A PA8448801A1 PA 8448801 A1 PA8448801 A1 PA 8448801A1 PA 19988448801 A PA19988448801 A PA 19988448801A PA 8448801 A PA8448801 A PA 8448801A PA 8448801 A1 PA8448801 A1 PA 8448801A1
- Authority
- PA
- Panama
- Prior art keywords
- hiv protease
- hiv
- protease inhibitors
- compounds
- viruses
- Prior art date
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
LOS INHIBIDORES DE LA PROTEASA DEL VIH, OBTENIBLES POR SINTESIS QUIMICA, INHIBEN O BLOQUEAN LA ACTIVIDAD BIOLOGICA DE LA ENZIMA DE LA PROTEASA DEL VIH, HACIENDO QUE TERMINE LA REPLICACION DEL VIRUS DEL VIH. ESTOS COMPUESTOS, ASI COMO LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS Y OPCIONALMENTE OTROS AGENTES ANTIVIRICOS COMO INGREDIENTES ACTIVOS, SON APTOS PARA TRATAR A PACIENTES O HUESPEDES INFECTADOS CON EL VIRUS DEL VIH QUE SE CONOCE COMO CAUSA DEL SIDA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81595197A | 1997-03-13 | 1997-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8448801A1 true PA8448801A1 (es) | 2000-05-24 |
Family
ID=25219265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA19988448801A PA8448801A1 (es) | 1997-03-13 | 1998-03-13 | Inhibidores de la proteasa del vih |
Country Status (35)
| Country | Link |
|---|---|
| EP (1) | EP0970055A2 (es) |
| JP (1) | JP2001516350A (es) |
| KR (1) | KR100511089B1 (es) |
| CN (1) | CN1179948C (es) |
| AP (1) | AP1358A (es) |
| AR (1) | AR012556A1 (es) |
| AU (1) | AU743078B2 (es) |
| BG (1) | BG63540B1 (es) |
| BR (1) | BR9808867A (es) |
| CA (1) | CA2284163A1 (es) |
| CO (1) | CO4940496A1 (es) |
| CZ (1) | CZ296647B6 (es) |
| EA (1) | EA002378B1 (es) |
| EE (1) | EE04114B1 (es) |
| GE (1) | GEP20022764B (es) |
| HR (1) | HRP980112A2 (es) |
| HU (1) | HUP0001380A3 (es) |
| IL (2) | IL131870A0 (es) |
| IS (1) | IS5176A (es) |
| MX (1) | MXPA99008395A (es) |
| MY (1) | MY117535A (es) |
| NO (1) | NO315555B1 (es) |
| NZ (1) | NZ337706A (es) |
| OA (1) | OA11196A (es) |
| PA (1) | PA8448801A1 (es) |
| PE (1) | PE58799A1 (es) |
| PL (1) | PL192786B1 (es) |
| SA (1) | SA98181116B1 (es) |
| SK (1) | SK283636B6 (es) |
| SV (1) | SV1998000038A (es) |
| TR (1) | TR199902508T2 (es) |
| TW (1) | TW200517112A (es) |
| UA (1) | UA57772C2 (es) |
| WO (1) | WO1998040357A2 (es) |
| ZA (1) | ZA982047B (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
-
1998
- 1998-03-04 HR HR08/815,951A patent/HRP980112A2/hr not_active Application Discontinuation
- 1998-03-11 ZA ZA982047A patent/ZA982047B/xx unknown
- 1998-03-12 PL PL335672A patent/PL192786B1/pl not_active IP Right Cessation
- 1998-03-12 TW TW094100045A patent/TW200517112A/zh unknown
- 1998-03-12 HU HU0001380A patent/HUP0001380A3/hu unknown
- 1998-03-12 EE EEP199900416A patent/EE04114B1/xx not_active IP Right Cessation
- 1998-03-12 EA EA199900823A patent/EA002378B1/ru unknown
- 1998-03-12 MY MYPI98001071A patent/MY117535A/en unknown
- 1998-03-12 NZ NZ337706A patent/NZ337706A/en unknown
- 1998-03-12 EP EP98910300A patent/EP0970055A2/en not_active Withdrawn
- 1998-03-12 SK SK1222-99A patent/SK283636B6/sk not_active IP Right Cessation
- 1998-03-12 PE PE1998000171A patent/PE58799A1/es not_active Application Discontinuation
- 1998-03-12 WO PCT/US1998/004735 patent/WO1998040357A2/en active IP Right Grant
- 1998-03-12 CN CNB988045389A patent/CN1179948C/zh not_active Expired - Fee Related
- 1998-03-12 JP JP53974598A patent/JP2001516350A/ja not_active Ceased
- 1998-03-12 TR TR1999/02508T patent/TR199902508T2/xx unknown
- 1998-03-12 BR BR9808867-0A patent/BR9808867A/pt not_active Application Discontinuation
- 1998-03-12 IL IL13187098A patent/IL131870A0/xx active IP Right Grant
- 1998-03-12 CZ CZ0319199A patent/CZ296647B6/cs not_active IP Right Cessation
- 1998-03-12 AP APAP/P/1999/001648A patent/AP1358A/en active
- 1998-03-12 AR ARP980101104A patent/AR012556A1/es active IP Right Grant
- 1998-03-12 CA CA002284163A patent/CA2284163A1/en not_active Abandoned
- 1998-03-12 AU AU64575/98A patent/AU743078B2/en not_active Ceased
- 1998-03-12 MX MXPA99008395A patent/MXPA99008395A/es not_active IP Right Cessation
- 1998-03-12 KR KR10-1999-7008331A patent/KR100511089B1/ko not_active Expired - Fee Related
- 1998-03-12 GE GEAP19984984A patent/GEP20022764B/en unknown
- 1998-03-13 SV SV1998000038A patent/SV1998000038A/es not_active Application Discontinuation
- 1998-03-13 CO CO98014251A patent/CO4940496A1/es unknown
- 1998-03-13 PA PA19988448801A patent/PA8448801A1/es unknown
- 1998-04-21 SA SA98181116A patent/SA98181116B1/ar unknown
- 1998-12-03 UA UA99095049A patent/UA57772C2/uk unknown
-
1999
- 1999-09-10 NO NO19994415A patent/NO315555B1/no not_active IP Right Cessation
- 1999-09-10 IL IL131870A patent/IL131870A/en not_active IP Right Cessation
- 1999-09-10 IS IS5176A patent/IS5176A/is unknown
- 1999-09-13 BG BG103727A patent/BG63540B1/bg unknown
- 1999-09-13 OA OA9900207A patent/OA11196A/en unknown
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