OA12910A - Pyrimidine derivatives and their use as CB2 modulators. - Google Patents

Pyrimidine derivatives and their use as CB2 modulators. Download PDF

Info

Publication number: OA12910A
Authority: OA; OAPI
Prior art keywords: amide; carboxylic acid; trifluoromethyl; pyrimidine; chloro
Prior art date: 2002-08-21

Application number

OA1200500052A

Other languages

English (en)

Inventor

Andrew John Eatherton

Gerard Martin Paul Giblin

Richard Howard Green

William Leonard Mitchell

Alan Naylor

Derek Anthony Rawlings

Brian Peter Slingsby

Andrew Richard Whittington

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-21

Filing date

2003-08-19

Publication date

2006-10-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31948030&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA12910(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-08-21 Priority claimed from GB0219501A external-priority patent/GB0219501D0/en

2003-04-24 Priority claimed from GB0309326A external-priority patent/GB0309326D0/en

2003-08-19 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2006-10-13 Publication of OA12910A publication Critical patent/OA12910A/en

Links

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UDYFLDICVHJSOY-UHFFFAOYSA-N sulfur trioxide pyridine complex Chemical compound O=S(=O)=O.C1=CC=NC=C1 UDYFLDICVHJSOY-UHFFFAOYSA-N 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
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229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
201000004415 tendinitis Diseases 0.000 description 1
SYZGVSQZONQUDV-UHFFFAOYSA-N tert-butyl n-(oxan-4-ylmethyl)carbamate Chemical compound CC(C)(C)OC(=O)NCC1CCOCC1 SYZGVSQZONQUDV-UHFFFAOYSA-N 0.000 description 1
HJGAECGPWINXCT-UHFFFAOYSA-N tert-butyl n-methyl-n-(oxan-4-ylmethyl)carbamate Chemical compound CC(C)(C)OC(=O)N(C)CC1CCOCC1 HJGAECGPWINXCT-UHFFFAOYSA-N 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
229960004559 theobromine Drugs 0.000 description 1
DQKVZWAEWJUKAX-UHFFFAOYSA-N thiane-4-carbonitrile Chemical compound N#CC1CCSCC1 DQKVZWAEWJUKAX-UHFFFAOYSA-N 0.000 description 1
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231100000886 tinnitus Toxicity 0.000 description 1
238000003354 tissue distribution assay Methods 0.000 description 1
208000004371 toothache Diseases 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
206010044652 trigeminal neuralgia Diseases 0.000 description 1
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229960002004 valdecoxib Drugs 0.000 description 1
LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
239000012178 vegetable wax Substances 0.000 description 1
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230000009385 viral infection Effects 0.000 description 1
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BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
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239000011701 zinc Substances 0.000 description 1
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Classifications

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- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

OA1200500052A 2002-08-21 2003-08-19 Pyrimidine derivatives and their use as CB2 modulators. OA12910A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0219501A GB0219501D0 (en)	2002-08-21	2002-08-21	Compounds
GB0309326A GB0309326D0 (en)	2003-04-24	2003-04-24	Compounds

Publications (1)

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OA12910A true OA12910A (en)	2006-10-13

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US (2)	US7635701B2 (es)
EP (2)	EP1539712B1 (es)
JP (1)	JP4583174B2 (es)
KR (1)	KR20050058367A (es)
CN (1)	CN100351239C (es)
AP (1)	AP2005003219A0 (es)
AR (1)	AR041016A1 (es)
AT (2)	ATE489369T1 (es)
AU (1)	AU2003264076B2 (es)
BR (1)	BR0313676A (es)
CA (1)	CA2495880C (es)
CY (1)	CY1107871T1 (es)
DE (2)	DE60335151D1 (es)
DK (1)	DK1539712T3 (es)
EA (2)	EA012703B1 (es)
EC (1)	ECSP055613A (es)
ES (1)	ES2295682T3 (es)
HK (1)	HK1079193A1 (es)
IL (2)	IL166552A0 (es)
IS (1)	IS7749A (es)
MA (1)	MA27428A1 (es)
MX (1)	MXPA05001960A (es)
MY (1)	MY137053A (es)
NO (1)	NO20051451L (es)
NZ (1)	NZ537886A (es)
OA (1)	OA12910A (es)
PE (1)	PE20040898A1 (es)
PL (1)	PL376047A1 (es)
PT (1)	PT1539712E (es)
SI (1)	SI1539712T1 (es)
TW (1)	TW200410946A (es)
UA (1)	UA83194C2 (es)
UY (1)	UY27939A1 (es)
WO (1)	WO2004018433A1 (es)
ZA (1)	ZA200500913B (es)

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2003
- 2003-08-14 UY UY27939A patent/UY27939A1/es not_active Application Discontinuation
- 2003-08-19 SI SI200331088T patent/SI1539712T1/sl unknown
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- 2003-08-19 AU AU2003264076A patent/AU2003264076B2/en not_active Ceased
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2005
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- 2005-03-07 MA MA28132A patent/MA27428A1/fr unknown
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Also Published As

Publication number	Publication date
IL185549A0 (en)	2008-01-06
JP2006501228A (ja)	2006-01-12
UY27939A1 (es)	2004-03-31
EA012703B1 (ru)	2009-12-30
UA83194C2 (ru)	2008-06-25
EA200700934A1 (ru)	2007-08-31
MA27428A1 (fr)	2005-07-01
ATE489369T1 (de)	2010-12-15
MXPA05001960A (es)	2005-04-28
BR0313676A (pt)	2005-06-21
EP1878725A3 (en)	2008-01-30
ES2295682T3 (es)	2008-04-16
KR20050058367A (ko)	2005-06-16
PL376047A1 (en)	2005-12-12
NZ537886A (en)	2007-05-31
AU2003264076A1 (en)	2004-03-11
ECSP055613A (es)	2005-04-18
NO20051451D0 (no)	2005-03-18
PT1539712E (pt)	2008-02-08
US20060293354A1 (en)	2006-12-28
AP2005003219A0 (en)	2005-03-31
US7635701B2 (en)	2009-12-22
EP1878725B1 (en)	2010-11-24
IL166552A0 (en)	2006-01-15
EP1539712A1 (en)	2005-06-15
EP1878725A2 (en)	2008-01-16
CA2495880A1 (en)	2004-03-04
CN1688552A (zh)	2005-10-26
WO2004018433A1 (en)	2004-03-04
SI1539712T1 (sl)	2008-04-30
DE60317348T2 (de)	2008-08-28
DE60317348D1 (de)	2007-12-20
NO20051451L (no)	2005-03-18
AR041016A1 (es)	2005-04-27
EP1539712B1 (en)	2007-11-07
CN100351239C (zh)	2007-11-28
DE60335151D1 (de)	2011-01-05
CY1107871T1 (el)	2013-06-19
US20100041654A1 (en)	2010-02-18
EA200500392A1 (ru)	2005-08-25
JP4583174B2 (ja)	2010-11-17
AU2003264076B2 (en)	2007-09-20
PE20040898A1 (es)	2005-01-07
EA010130B1 (ru)	2008-06-30
ATE377591T1 (de)	2007-11-15
CA2495880C (en)	2010-04-27
HK1079193A1 (en)	2006-03-31
MY137053A (en)	2008-12-31
DK1539712T3 (da)	2008-03-17
ZA200500913B (en)	2006-07-26
IS7749A (is)	2005-03-17
TW200410946A (en)	2004-07-01

Publication	Publication Date	Title
OA12910A (en)	2006-10-13	Pyrimidine derivatives and their use as CB2 modulators.
EP1565442B1 (en)	2007-11-14	Pyridine derivatives as cb2 receptor modulators
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US20080280868A1 (en)	2008-11-13	Pyridine Derivatives and Their Use as Cb2 Receptor Modulators
US20080221097A1 (en)	2008-09-11	Imidazopyridine Derivatives as Cannabinoid Receptor Ligands
US20080261977A1 (en)	2008-10-23	Pyrimidine Derivatives as Cannabinoid Receptor Modulators
WO2007088168A1 (en)	2007-08-09	Compounds
US20090264452A1 (en)	2009-10-22	2-(Phenylamino)-Pyrimidin-5-Amides As Cannabinoid 2 Receptors Modulators for the Treatment of Immune or Inflammatory Disorders
WO2005074939A1 (en)	2005-08-18	Combination of cb2 modulators and pde4 inhibitors for use in medicine
AU2007211954A1 (en)	2007-09-13	Pyrimidine derivatives and their use as CB2 modulators