NZ335922A - Use of leukotriene antagonists for treating squamous cell carcinoma (cancer) - Google Patents

Abstract

Disclosed is the use of the above compound, having activity as a leukotriene B4 antagonist, for the treatment or inhibition of oral squamous cell carcinoma. Treatment involves administering to a mammal in need thereof an effective amount of a compound of the formula I wherein: R1 is C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C1-C4 alkoxy, (C1-C4 alkyl)thio, halo, or R2-substituted phenyl; R2 and R3 are each independently hydrogen, halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, (C1-C4 alkyl)-S(O)q-, trifluoromethyl, or di-(C1-C3alkyl)amino; X is -O-, -S-, -C(=O), or -CH2-; Y is -O- or -CH2-, or when taken together, -X-Y- is -CH=CH- or -C=C-; Z is a straight or branched chain C1-C10 alkylidenyl; A is a bond, -0-, -S-, -CH=CH-, or -CRaRb-, where Ra and Rb are each independently hydrogen, C1-C5 alkyl, or R7-substituted phenyl, or when taken together with the carbon atom to which they are attached, form a C4-C8 cycloalkyl ring; R4 is R6, or figure Ia, Ib, Ic, Id, Ie or If' where, R6 is independently -COOH, 5-tetrazolyl, -CON(R9)2, or -CONHSO2Rl0; R7 is hydrogen, Cl-C4 alkyl, C2-Cs alkenyl, C2-C5 alkynyl, benzyl, methoxy, -W-R6, -T-G-R6, (C1-C4 alkyl)-T-(C1-C4 alkylidenyl)-O-, or hydroxy; R8 is hydrogen or halo; R9 is independently hydrogen, phenyl, or C1-C4 alkyl, or when taken together with the nitrogen atom form a morpholino, piperidino, piperazino, or pyrrolidino group; R10 is C1-C4 alkyl or phenyl; R11 is R2, -W-R6, or -T-G-R6; W is a bond or straight or branched chain divalent hydrocarbyl radical of one to eight carbon atoms; G is a straight or branched chain divalent hydrocarbyl radical of one to eight carbon atoms; T is a bond, -CH2-, -O-, -NH-, -NHCO-, -C(=O)-, or -S(O)q"-; K is -C(=O)- or -CH(OH)-; q is independently 0, 1, or 2; p is 0 or 1; t is 0 or 1; provided when X is -O- or -S-, Y is not -O-; provided when A is -O- or -S-, R4 is not R6; provided when A is -O- or -S- and Z is a bond, Y is not -0-; provided W is not a bond when p is 0;