NZ332897A - Methods and compositions for modulating production of a T helper type 2 (Th2)-associated cytokine by regulating transcription factor activity in association with a Nuclear Factor of Activated T cells (NF-AT) protein - Google Patents
Methods and compositions for modulating production of a T helper type 2 (Th2)-associated cytokine by regulating transcription factor activity in association with a Nuclear Factor of Activated T cells (NF-AT) proteinInfo
- Publication number
- NZ332897A NZ332897A NZ332897A NZ33289797A NZ332897A NZ 332897 A NZ332897 A NZ 332897A NZ 332897 A NZ332897 A NZ 332897A NZ 33289797 A NZ33289797 A NZ 33289797A NZ 332897 A NZ332897 A NZ 332897A
- Authority
- NZ
- New Zealand
- Prior art keywords
- nip45
- protein
- methods
- maf
- activity
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000695 Cytokines Proteins 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000004127 Cytokines Human genes 0.000 title abstract 2
- 230000010632 Transcription Factor Activity Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 101000573401 Homo sapiens NFATC2-interacting protein Proteins 0.000 abstract 8
- 102100026380 NFATC2-interacting protein Human genes 0.000 abstract 8
- 230000000694 effects Effects 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000007307 Maf Transcription Factors Human genes 0.000 abstract 2
- 108010033714 Maf Transcription Factors Proteins 0.000 abstract 2
- 102000039538 Maf family Human genes 0.000 abstract 2
- 108091067370 Maf family Proteins 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 102000004388 Interleukin-4 Human genes 0.000 abstract 1
- 108090000978 Interleukin-4 Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 102000002673 NFATC Transcription Factors Human genes 0.000 abstract 1
- 108010018525 NFATC Transcription Factors Proteins 0.000 abstract 1
- 102000007987 Proto-Oncogene Proteins c-maf Human genes 0.000 abstract 1
- 108010089507 Proto-Oncogene Proteins c-maf Proteins 0.000 abstract 1
- 102000040945 Transcription factor Human genes 0.000 abstract 1
- 108091023040 Transcription factor Proteins 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 229940028885 interleukin-4 Drugs 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Environmental Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
Abstract
The specification describes methods for modulating production of a T helper type 2 (Th2)-associated cytokine, in particular interleukin-4, by modulating the activity of one or more transcription factors that cooperate with NF-AT family proteins to regulate expression of a Th2-associated cytokine gene. In one embodiment, the activity of a maf family protein (e.g., c-Maf or a small maf protein, such as p18) is modulated. In another embodiment, the activity of a protein that interacts with an NF-AT family protein (e.g., NIP45) is modulated. Combination methods, for example wherein the activities of a maf family protein and an NF-AT protein are modulated or the activities of a maf protein and an NF-AT-interacting protein are modulated, are also encompassed by the invention. Methods for modulating development of T helper type 1 (Th1) or T helper type 2 (Th2) subsets in a subject using agents that modulate transcription factor activity are also disclosed. NIP45 compositions, including isolated nucleic acid molecules encoding NIP45, antisense nucleic acid molecules, recombinant expression vectors containing a NIP45 nucleic acid molecule, host cells into which such expression vectors have been introduced and non-human transgenic animals carrying a NIP45 transgene, are also provided by the invention. The specification further provides isolated NIP45 proteins and peptides, NIP45 fusion proteins and anti-NIP45 antibodies. Methods of using the NIP45 compositions of the invention are also disclosed.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/636,602 US5958671A (en) | 1996-04-23 | 1996-04-23 | Methods and compositions for regulating T cell subsets by modulating transcription factor activity |
| US08/755,584 US5858711A (en) | 1996-11-25 | 1996-11-25 | NF-AT-interacting protein NIP45 and methods of use therefor |
| US08/755,592 US6537810B1 (en) | 1996-04-23 | 1996-11-25 | Methods for regulating T cell subsets by modulating transcription factor activity |
| PCT/US1997/006708 WO1997039721A2 (en) | 1996-04-23 | 1997-04-23 | Methods and compositions for regulating t cell subsets by modulating transcription factor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ332897A true NZ332897A (en) | 2000-04-28 |
Family
ID=27417596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ332897A NZ332897A (en) | 1996-04-23 | 1997-04-23 | Methods and compositions for modulating production of a T helper type 2 (Th2)-associated cytokine by regulating transcription factor activity in association with a Nuclear Factor of Activated T cells (NF-AT) protein |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0891425A2 (en) |
| JP (1) | JP2000510333A (en) |
| KR (1) | KR20000010606A (en) |
| CN (1) | CN1225682A (en) |
| AU (1) | AU720455B2 (en) |
| CA (1) | CA2252643A1 (en) |
| NZ (1) | NZ332897A (en) |
| WO (1) | WO1997039721A2 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9722388D0 (en) * | 1997-10-24 | 1997-12-24 | Zeneca Ltd | NIP45 human homolog |
| US6274338B1 (en) | 1998-02-24 | 2001-08-14 | President And Fellows Of Harvard College | Human c-Maf compositions and methods of use thereof |
| US6548734B1 (en) | 1998-05-28 | 2003-04-15 | President And Fellows Of Harvard College | Methods relating to modulation of cartilage cell growth and/or differentiation by modulation of NFATp activity |
| EP1254169B1 (en) | 1999-12-30 | 2007-05-09 | President And Fellows of Harvard College | Methods relating to modulation of th2 cell subset activity by modulation of xbp-1 activity |
| US20010026937A1 (en) * | 2000-01-11 | 2001-10-04 | Juha Punnonen | Monocyte-derived dendritic cell subsets |
| JP2003530883A (en) * | 2000-04-25 | 2003-10-21 | バイエル アクチェンゲゼルシャフト | Regulation of NF-AT interacting protein NIP45 variants |
| AU2001290316A1 (en) * | 2000-10-02 | 2002-04-15 | Mochida Pharmaceutical Co., Ltd. | Gata-3 expression inhibitor and method of screening the same |
| EP1372664A1 (en) | 2001-03-01 | 2004-01-02 | Hollis-Eden Pharmaceuticals Inc. | Use of certain steroids for treatment of blood cell deficiencies |
| US20050079496A1 (en) * | 2001-08-17 | 2005-04-14 | Edgar Serfling | Methods for diagnosing and treating neoplasias using nf-at transcriptions factors |
| IL147138A0 (en) | 2001-12-17 | 2002-08-14 | Yeda Res & Dev | Methods of and pharmaceutical compositions for modulating cell adhesion, migration and extravasation |
| WO2007099341A1 (en) * | 2006-03-02 | 2007-09-07 | Antitope Limited | T cell assays |
| US8940479B2 (en) | 2008-01-14 | 2015-01-27 | Cornell University | Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity |
| KR101146335B1 (en) * | 2009-10-12 | 2012-05-21 | 한국원자력의학원 | A transgenic mouse expressing a reporter protein under the control of an alpha fetal protein enhancer and a promoter, a method for preparing the same, and a method for screening a substance for increasing or decreasing alpha fetal protein expression using the same |
| WO2012109238A2 (en) | 2011-02-07 | 2012-08-16 | President And Fellows Of Harvard College | Methods for increasing immune responses using agents that directly bind to and activate ire-1 |
| WO2013134774A1 (en) | 2012-03-09 | 2013-09-12 | Cornell University | Modulation of breast cancer growth by modulation of xbp1 activity |
| WO2015019125A1 (en) | 2013-08-05 | 2015-02-12 | Societe De Developpement Et De Recherche Industrielle | Molecular targets for the treatment of wounds, in particular chronic wounds |
| EP3521431A1 (en) | 2013-09-25 | 2019-08-07 | Cornell University | Compounds for inducing anti-tumor immunity and methods thereof |
-
1997
- 1997-04-23 CA CA002252643A patent/CA2252643A1/en not_active Abandoned
- 1997-04-23 JP JP09538278A patent/JP2000510333A/en not_active Ceased
- 1997-04-23 AU AU31155/97A patent/AU720455B2/en not_active Ceased
- 1997-04-23 KR KR1019980708492A patent/KR20000010606A/en not_active Application Discontinuation
- 1997-04-23 CN CN97195740A patent/CN1225682A/en active Pending
- 1997-04-23 NZ NZ332897A patent/NZ332897A/en unknown
- 1997-04-23 EP EP97926377A patent/EP0891425A2/en not_active Withdrawn
- 1997-04-23 WO PCT/US1997/006708 patent/WO1997039721A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0891425A2 (en) | 1999-01-20 |
| JP2000510333A (en) | 2000-08-15 |
| WO1997039721A3 (en) | 1998-04-09 |
| AU720455B2 (en) | 2000-06-01 |
| CA2252643A1 (en) | 1997-10-30 |
| CN1225682A (en) | 1999-08-11 |
| KR20000010606A (en) | 2000-02-15 |
| AU3115597A (en) | 1997-11-12 |
| WO1997039721A2 (en) | 1997-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ332897A (en) | Methods and compositions for modulating production of a T helper type 2 (Th2)-associated cytokine by regulating transcription factor activity in association with a Nuclear Factor of Activated T cells (NF-AT) protein | |
| DK0941318T5 (en) | Dumbbell-shaped gene expression expression systems | |
| AU7599500A (en) | Novel gl50 molecules and uses therefor | |
| WO1999043808A8 (en) | Human c-maf compositions and methods of use thereof | |
| NO20020861L (en) | New B7-4 molecules and uses thereof | |
| EP1798239A3 (en) | G-protein coupled receptors and uses therefor | |
| WO1994029442A3 (en) | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters | |
| AP1678A (en) | Novel modified nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems. | |
| AP9901542A0 (en) | DNA encoding lepidopteran-active delta-endotoxins and its use. | |
| ATE352561T1 (en) | PGC-1, A NOVEL PPAR-GAMMA COACTIVATOR FROM BROWN ATI TISSUE | |
| DE60144021D1 (en) | FOR CELL CYCLE PROTEINS CODING NUCLEIC ACID AND ITS USE | |
| WO1999047686A3 (en) | Human mekk proteins, corresponding nucleic acid molecules, and uses therefor | |
| DK1183355T3 (en) | T-BET preparations and methods for their preparation | |
| EP1412374A4 (en) | Novel pgc-1 isoforms and uses therefor | |
| NO20012471L (en) | Potassium channel interactors and uses thereof | |
| AU2001249649A1 (en) | 16836, a novel human phospholipase c family member and uses thereof | |
| MXPA03002557A (en) | Potassium channel interactors and uses therefor. | |
| WO2001068857A3 (en) | 18615 and 48003, human ion channels and uses therefor | |
| WO2001075076A3 (en) | 33167, a novel human hydrolase and uses therefor | |
| AU2001253258A1 (en) | Human trp-like calcium channel protein-2 (tlcc-2) | |
| ATA282386A (en) | METHOD FOR EXPRESSING GENES IN YEAST AND DNA FRAGMENTS AND PLASMIDES CONTAINING THESE DNA FRAGMENTS FOR USE IN THIS METHOD | |
| AU2002234132A1 (en) | 13245, a novel human myotonic dystrophy type protein kinase and uses therefor | |
| WO2002006485A3 (en) | 47885, a novel human ubiquitin-activating enzyme and uses therefor | |
| ATE316579T1 (en) | VECTORS FOR THE CONTROLLED EXPRESSION OF RECOMBINANT GENES IN PROKARYONTIC CELLS | |
| WO2002044358A3 (en) | Methods and compositions for diagnosis and treatment of cancer using arginine m ethyltransferase 3 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) |