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NO993452D0 - Nye modifikasjoner av 2-amino-4-(4-fluorbenzylamino)-1-etoksykarbonyl-aminobenzener og fremstilling derav - Google Patents

Nye modifikasjoner av 2-amino-4-(4-fluorbenzylamino)-1-etoksykarbonyl-aminobenzener og fremstilling derav

Info

Publication number
NO993452D0
NO993452D0 NO993452A NO993452A NO993452D0 NO 993452 D0 NO993452 D0 NO 993452D0 NO 993452 A NO993452 A NO 993452A NO 993452 A NO993452 A NO 993452A NO 993452 D0 NO993452 D0 NO 993452D0
Authority
NO
Norway
Prior art keywords
fluorobenzylamino
ethoxycarbonylamino
benzenes
amino
preparation
Prior art date
Application number
NO993452A
Other languages
English (en)
Other versions
NO311642B1 (no
NO993452L (no
Inventor
Peter Meisel
Karl-Friedrich Landgraf
Juergen Schofer
Wilfried Thiel
Matthias Rischer
Alfred Olbrich
Bernhard Kutscher
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of NO993452L publication Critical patent/NO993452L/no
Publication of NO993452D0 publication Critical patent/NO993452D0/no
Publication of NO311642B1 publication Critical patent/NO311642B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NO19993452A 1997-01-20 1999-07-13 Nye modifikasjoner av 2-amino-4-(4-fluorbenzylamino)-1-etoksykarbonyl-aminobenzener, deres fremstilling og anvendelse samt legemidler inneholdende modifikasjonene NO311642B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19701694A DE19701694A1 (de) 1997-01-20 1997-01-20 Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung
PCT/EP1998/000086 WO1998031663A1 (de) 1997-01-20 1998-01-09 Neue modifikationen des 2-amino-4-(4-fluorbenzylamino)-1-ethoxycarbonyl-aminobenzen sowie verfahren zu ihrer herstellung

Publications (3)

Publication Number Publication Date
NO993452L NO993452L (no) 1999-07-13
NO993452D0 true NO993452D0 (no) 1999-07-13
NO311642B1 NO311642B1 (no) 2001-12-27

Family

ID=7817756

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19993452A NO311642B1 (no) 1997-01-20 1999-07-13 Nye modifikasjoner av 2-amino-4-(4-fluorbenzylamino)-1-etoksykarbonyl-aminobenzener, deres fremstilling og anvendelse samt legemidler inneholdende modifikasjonene
NO2011017C NO2011017I2 (no) 1997-01-20 2011-09-16 Retigabin

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2011017C NO2011017I2 (no) 1997-01-20 2011-09-16 Retigabin

Country Status (31)

Country Link
US (2) US5914425A (no)
EP (1) EP0956281B1 (no)
JP (1) JP4138886B2 (no)
CN (1) CN1125812C (no)
AR (1) AR015349A1 (no)
AT (1) ATE222235T1 (no)
AU (1) AU730776B2 (no)
BG (1) BG63893B1 (no)
BR (1) BR9806784A (no)
CA (3) CA2278201C (no)
CZ (1) CZ301778B6 (no)
DE (2) DE19701694A1 (no)
DK (1) DK0956281T3 (no)
EG (1) EG21239A (no)
ES (1) ES2178152T3 (no)
HK (1) HK1024230A1 (no)
HU (1) HU227625B1 (no)
ID (1) ID22645A (no)
IL (1) IL130384A (no)
IS (1) IS2115B (no)
NO (2) NO311642B1 (no)
NZ (1) NZ336205A (no)
PL (1) PL195956B1 (no)
PT (1) PT956281E (no)
RU (1) RU2186765C2 (no)
SK (1) SK285303B6 (no)
TR (1) TR199901674T2 (no)
TW (1) TW531527B (no)
UA (1) UA63937C2 (no)
WO (1) WO1998031663A1 (no)
ZA (1) ZA98319B (no)

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TWI287984B (en) 2000-10-17 2007-10-11 Wyeth Corp Pharmaceutical composition for modulating bladder function
US6589986B2 (en) 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
WO2002080898A2 (en) * 2001-04-04 2002-10-17 Wyeth Methods for treating hyperactive gastric motility
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US20080045534A1 (en) * 2006-08-18 2008-02-21 Valeant Pharmaceuticals North America Derivatives of 1,3-diamino benzene as potassium channel modulators
KR20090079191A (ko) * 2006-08-23 2009-07-21 밸리언트 파마슈티컬즈 인터내셔널 칼륨 채널 조절제로서 ４-(ｎ-아자사이클로알킬) 아닐리드의 유도체
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
ES2375417T3 (es) * 2006-11-28 2012-02-29 Valeant Pharmaceuticals International Análogos 1,4-diamino bicíclicos de retigabina como moduladores de los canales de potasio.
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
US20100323016A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
US20100323015A1 (en) * 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
NZ590885A (en) * 2008-07-18 2013-01-25 Valeant Pharmaceuticals Int A modified release pharmaceutical formulation of retigabine for the treatment of nervous system hyperexcitability
DE102009013613A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Trockenverarbeitung von Retigabin
DE102009013611A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Festes Retigabin in nicht-kristalliner Form
DE102009013612A1 (de) 2009-03-17 2010-09-23 Ratiopharm Gmbh Retigabin-Tabletten, bevorzugt mit modifizierter Freisetzung
WO2011039369A2 (en) 2009-10-02 2011-04-07 Medichem S.A. Amorphous forms of a 2-amino-4-(4-fluorobenzylamino)phenylcarbamate derivative
JP2013517315A (ja) 2010-01-20 2013-05-16 グラクソ グループ リミテッド 新規組成物
EP2536394A2 (en) * 2010-02-19 2012-12-26 Medichem S.A. Stabilized phenylcarbamate derivative in solid state
CN202095728U (zh) * 2010-10-29 2012-01-04 假日集团控股有限公司 行李箱把手
CN102464233A (zh) * 2010-11-18 2012-05-23 江苏邦威机械制造有限公司 一种卧式差速缠丝机用应力发生装置
WO2012098075A1 (en) 2011-01-18 2012-07-26 Glaxo Group Limited Process for the preparation of retigabine
CN102241608A (zh) * 2011-05-12 2011-11-16 天津市汉康医药生物技术有限公司 瑞替加滨化合物及其组合物
WO2013008250A2 (en) * 2011-07-01 2013-01-17 Dr.Reddys Laboratories Limited. Crystalline form of retigabine and processes for mixture of retigabine crystalline modifications
WO2013011518A1 (en) 2011-07-21 2013-01-24 Arch Pharmalabs Limited Process for the preparation of retigabine of the formula i and pharmaceutically acceptable salts thereof
CN102531966B (zh) * 2011-12-23 2013-07-24 山东创新药物研发有限公司 瑞替加滨的晶型d及其制备方法
WO2013114379A1 (en) * 2012-01-30 2013-08-08 Symed Labs Limited Novel polymorphs of n-[2-amino-4-(4-fluorobenzylamino)-phenyl] carbamic acid ethyl ester and processes thereof
CN103373941B (zh) * 2012-04-11 2016-08-17 浙江九洲药物科技有限公司 瑞替加滨及其中间体的制备方法
WO2013179298A2 (en) * 2012-04-23 2013-12-05 Cadila Healthcare Limited A process for preparation of phenyl carbamate derivative and polymorphic forms thereof
WO2014023270A1 (en) 2012-08-09 2014-02-13 Zentiva, K.S. Salts or co-crystals of ethyl n-[2-amino-4-[(4-fluorophenyl)methylamino]-phenyl]carbamate
CN102964273B (zh) * 2012-12-06 2014-04-02 北京英科博雅科技有限公司 瑞替加滨的新晶型f及其制备方法
USD773819S1 (en) 2015-05-27 2016-12-13 Travelpro Products, Inc. Handle for luggage
AU2020380961A1 (en) 2019-11-08 2022-05-26 Xenon Pharmaceuticals Inc. Methods of treating depressive disorders
MX2023009314A (es) 2021-02-09 2023-08-16 Xenon Pharmaceuticals Inc Apertura del canal de potasio dependiente de voltaje para usarse en el tratamiento de la anhedonia.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung

Also Published As

Publication number Publication date
AR015349A1 (es) 2001-05-02
HUP0000944A3 (en) 2000-10-30
CA2634811C (en) 2012-11-20
CN1125812C (zh) 2003-10-29
NO311642B1 (no) 2001-12-27
AU6208198A (en) 1998-08-07
IS2115B (is) 2006-06-15
NO2011017I2 (no) 2013-04-02
CA2278201A1 (en) 1998-07-23
CA2278201C (en) 2009-06-16
CA2634811A1 (en) 1998-07-23
DK0956281T3 (da) 2002-11-04
SK285303B6 (sk) 2006-10-05
TR199901674T2 (no) 1999-10-21
DE19701694A1 (de) 1998-07-23
HU227625B1 (en) 2011-09-28
IS5098A (is) 1999-06-29
JP2001508077A (ja) 2001-06-19
EP0956281B1 (de) 2002-08-14
HK1024230A1 (en) 2000-10-05
HUP0000944A2 (hu) 2000-09-28
JP4138886B2 (ja) 2008-08-27
PL335647A1 (en) 2000-05-08
EP0956281A1 (de) 1999-11-17
US5914425A (en) 1999-06-22
ZA98319B (en) 1998-05-07
IL130384A0 (en) 2000-06-01
NO993452L (no) 1999-07-13
EG21239A (en) 2001-03-31
CZ250899A3 (cs) 1999-11-17
CA2632585A1 (en) 1998-07-23
PT956281E (pt) 2002-12-31
AU730776B2 (en) 2001-03-15
CN1243506A (zh) 2000-02-02
BG63893B1 (bg) 2003-05-30
IL130384A (en) 2003-02-12
TW531527B (en) 2003-05-11
BR9806784A (pt) 2000-05-02
ID22645A (id) 1999-12-02
UA63937C2 (uk) 2004-02-16
NZ336205A (en) 2000-01-28
CA2632585C (en) 2010-08-24
WO1998031663A1 (de) 1998-07-23
BG103657A (en) 2000-02-29
SK95699A3 (en) 2000-03-13
RU2186765C2 (ru) 2002-08-10
ES2178152T3 (es) 2002-12-16
PL195956B1 (pl) 2007-11-30
CZ301778B6 (cs) 2010-06-23
ATE222235T1 (de) 2002-08-15
US6538151B1 (en) 2003-03-25
NO2011017I1 (no) 2011-09-26
DE59805186D1 (de) 2002-09-19

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Legal Events

Date Code Title Description
SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: TROBALT; NAT. REG. NO/DATE: EU/1/11/681/001/NO013/NO 20110404; FIRST REG. NO/DATE: EU , EU/1/11/681/001-013 20110323

Spc suppl protection certif: 2011017

Filing date: 20110916

CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: VALEANT PHARMACEUTICALS NORTH AMERICA LLC

Free format text: NEW ADDRESS: 700 ROUTE, 202/206 NORTH, US-NJ08807 BRIDGEWATER, US

SPCS Change of name or address of the owner of a supplementary protection certificate

Owner name: VALEANT PHARMACEUTICALS NORTH AMERICA LLC

Free format text: PRODUCT NAME: TROBALT; NAT. REG. NO/DATE: EU/1/11/681/001/NO013/NO 20110404; FIRST REG. NO/DATE: EU , EU/1/11/681/001-013 20110323; NEW ADDRESS: 700 ROUTE, 202/206 NORTH, US-NJ08807 BRIDGEWATER, US

Spc suppl protection certif: 2011017

Filing date: 20110916

SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: TROBALT; NAT. REG. NO/DATE: EU/1/11/681/001/NO013/NO 20110404; FIRST REG. NO/DATE: EU , EU/1/11/681/001-013 20110323

Spc suppl protection certif: 2011017

Filing date: 20110916

Extension date: 20230109

MK1K Patent expired