NO984164L - Biokonjugater av mangan eller jernkomplekser bestÕende av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksid - Google Patents
Biokonjugater av mangan eller jernkomplekser bestÕende av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksidInfo
- Publication number
- NO984164L NO984164L NO984164A NO984164A NO984164L NO 984164 L NO984164 L NO 984164L NO 984164 A NO984164 A NO 984164A NO 984164 A NO984164 A NO 984164A NO 984164 L NO984164 L NO 984164L
- Authority
- NO
- Norway
- Prior art keywords
- bioconjugates
- dismutation
- superoxide
- catalysts
- manganese
- Prior art date
Links
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 title 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 title 1
- 239000003054 catalyst Substances 0.000 title 1
- 238000007323 disproportionation reaction Methods 0.000 title 1
- 150000002505 iron Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 229910052748 manganese Inorganic materials 0.000 title 1
- 239000011572 manganese Substances 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 102000019197 Superoxide Dismutase Human genes 0.000 abstract 2
- 108010012715 Superoxide dismutase Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000037906 ischaemic injury Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1334896P | 1996-03-13 | 1996-03-13 | |
| PCT/US1996/012767 WO1997006824A2 (en) | 1995-08-17 | 1996-08-14 | Bioconjugates of manganese complexes and their application as catalysts |
| PCT/US1997/002566 WO1997033877A1 (en) | 1996-03-13 | 1997-03-04 | Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO984164D0 NO984164D0 (no) | 1998-09-10 |
| NO984164L true NO984164L (no) | 1998-11-06 |
Family
ID=21759507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO984164A NO984164L (no) | 1996-03-13 | 1998-09-10 | Biokonjugater av mangan eller jernkomplekser bestÕende av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksid |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0891338A1 (zh) |
| JP (1) | JP2000508625A (zh) |
| KR (1) | KR19990087784A (zh) |
| CN (1) | CN1225631A (zh) |
| AU (1) | AU1962497A (zh) |
| BR (1) | BR9708179A (zh) |
| CA (1) | CA2249011A1 (zh) |
| CZ (1) | CZ271198A3 (zh) |
| IL (1) | IL125889A0 (zh) |
| NO (1) | NO984164L (zh) |
| WO (1) | WO1997033877A1 (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| US6180620B1 (en) | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
| IL144503A0 (en) | 1999-01-25 | 2002-05-23 | Nat Jewish Med & Res Center | Substituted porphyrins |
| WO2000054784A1 (en) * | 1999-03-15 | 2000-09-21 | Abdurafik Bakhramovich Akbarov | Complex comprising the coordination compound manganese, its medical effects and the mode of its production |
| ATE383364T1 (de) * | 1999-05-27 | 2008-01-15 | Monsanto Co | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
| US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| EP1439842A4 (en) | 2001-06-01 | 2009-09-02 | Nat Jewish Med & Res Center | OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE |
| CN102088991A (zh) | 2008-05-13 | 2011-06-08 | 堪萨斯大学 | 金属提取肽标签和相关方法 |
| ES2464728T3 (es) | 2008-05-23 | 2014-06-03 | National Jewish Health | Compuestos para su uso en el tratamiento de lesiones asociadas con la exposición a una especie química alquilante |
| WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69224839T2 (de) * | 1991-07-19 | 1998-10-08 | Monsanto Co | Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren. |
| AU3415493A (en) * | 1991-12-10 | 1993-07-19 | Dow Chemical Company, The | Bicycle-polyazamacrocyclocarboxylic acid complexes, conjugates, preparation and use as contrast agents |
| US5747026A (en) * | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
| AU6031096A (en) * | 1995-06-05 | 1996-12-24 | Duke University | Nitrosylated and nitrated superoxide oxidants and reductants |
| US6525041B1 (en) * | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| EP0830351A1 (en) * | 1995-06-07 | 1998-03-25 | Monsanto Company | Process for preparing substituted polyazamacrocycles |
-
1997
- 1997-03-04 CZ CZ982711A patent/CZ271198A3/cs unknown
- 1997-03-04 EP EP97907685A patent/EP0891338A1/en not_active Withdrawn
- 1997-03-04 WO PCT/US1997/002566 patent/WO1997033877A1/en not_active Application Discontinuation
- 1997-03-04 KR KR1019980707265A patent/KR19990087784A/ko not_active Application Discontinuation
- 1997-03-04 JP JP9532611A patent/JP2000508625A/ja active Pending
- 1997-03-04 CA CA002249011A patent/CA2249011A1/en not_active Abandoned
- 1997-03-04 CN CN97194351A patent/CN1225631A/zh active Pending
- 1997-03-04 IL IL12588997A patent/IL125889A0/xx unknown
- 1997-03-04 AU AU19624/97A patent/AU1962497A/en not_active Abandoned
- 1997-03-04 BR BR9708179A patent/BR9708179A/pt not_active Application Discontinuation
-
1998
- 1998-09-10 NO NO984164A patent/NO984164L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2249011A1 (en) | 1997-09-18 |
| KR19990087784A (ko) | 1999-12-27 |
| CZ271198A3 (cs) | 1999-01-13 |
| BR9708179A (pt) | 1999-07-27 |
| AU1962497A (en) | 1997-10-01 |
| CN1225631A (zh) | 1999-08-11 |
| WO1997033877A1 (en) | 1997-09-18 |
| JP2000508625A (ja) | 2000-07-11 |
| IL125889A0 (en) | 1999-04-11 |
| NO984164D0 (no) | 1998-09-10 |
| EP0891338A1 (en) | 1999-01-20 |
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