JP2000508625A - スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガンまたは鉄錯体の生体分子結合体 - Google Patents

スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガンまたは鉄錯体の生体分子結合体

Info

Publication number: JP2000508625A
Authority: JP; Japan
Prior art keywords: alkyl; group; aryl; acid; attached
Prior art date: 1996-03-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP9532611A

Other languages

English (en)

Japanese (ja)

Inventor

ニューマン，ウィリアム，エル．

リレイ，デニス，ピー．

ウェイス，ランディ，エイチ．

ヘンケ，スーザン，エル．

レノン，パトリック，ジェイ．

アストン，カール，ダブリュ．

Original Assignee

モンサントカンパニー

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-13

Filing date

1997-03-04

Publication date

2000-07-11

1996-08-14 Priority claimed from PCT/US1996/012767 external-priority patent/WO1997006824A2/en

1997-03-04 Application filed by モンサントカンパニー filed Critical モンサントカンパニー

2000-07-11 Publication of JP2000508625A publication Critical patent/JP2000508625A/ja

Status Pending legal-status Critical Current

Links

OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 title claims description 35
229910052748 manganese Inorganic materials 0.000 title claims description 24
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title claims description 15
239000003446 ligand Substances 0.000 title description 40
239000011572 manganese Substances 0.000 title description 35
PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 title description 19
239000003054 catalyst Substances 0.000 title description 9
150000002505 iron Chemical class 0.000 title description 5
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
206010063837 Reperfusion injury Diseases 0.000 claims abstract description 8
201000001320 Atherosclerosis Diseases 0.000 claims abstract description 6
230000006378 damage Effects 0.000 claims abstract description 6
230000000302 ischemic effect Effects 0.000 claims abstract description 6
208000006011 Stroke Diseases 0.000 claims abstract description 5
239000007800 oxidant agent Substances 0.000 claims abstract description 4
208000027418 Wounds and injury Diseases 0.000 claims abstract description 3
208000014674 injury Diseases 0.000 claims abstract description 3
230000001590 oxidative effect Effects 0.000 claims abstract description 3
-1 cycloalkenylalkyl Chemical group 0.000 claims description 185
150000001875 compounds Chemical class 0.000 claims description 76
125000000217 alkyl group Chemical group 0.000 claims description 65
239000002253 acid Substances 0.000 claims description 45
125000005647 linker group Chemical group 0.000 claims description 38
125000003118 aryl group Chemical group 0.000 claims description 37
229920006395 saturated elastomer Polymers 0.000 claims description 33
239000001257 hydrogen Substances 0.000 claims description 30
229910052739 hydrogen Inorganic materials 0.000 claims description 30
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 28
238000000034 method Methods 0.000 claims description 27
235000001014 amino acid Nutrition 0.000 claims description 25
229910052799 carbon Inorganic materials 0.000 claims description 25
125000004432 carbon atom Chemical group C* 0.000 claims description 25
150000001450 anions Chemical class 0.000 claims description 22
150000001413 amino acids Chemical class 0.000 claims description 21
125000000753 cycloalkyl group Chemical group 0.000 claims description 20
150000004820 halides Chemical class 0.000 claims description 18
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 17
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 17
125000003342 alkenyl group Chemical group 0.000 claims description 17
229910052757 nitrogen Inorganic materials 0.000 claims description 17
102000004190 Enzymes Human genes 0.000 claims description 15
108090000790 Enzymes Proteins 0.000 claims description 15
125000002877 alkyl aryl group Chemical group 0.000 claims description 15
150000001721 carbon Chemical group 0.000 claims description 15
150000002431 hydrogen Chemical class 0.000 claims description 15
125000003710 aryl alkyl group Chemical group 0.000 claims description 14
125000000304 alkynyl group Chemical group 0.000 claims description 13
108090000765 processed proteins & peptides Proteins 0.000 claims description 13
235000013877 carbamide Nutrition 0.000 claims description 12
125000001424 substituent group Chemical group 0.000 claims description 12
201000010099 disease Diseases 0.000 claims description 11
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239000000758 substrate Substances 0.000 claims description 11
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 10
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 10
229910019142 PO4 Inorganic materials 0.000 claims description 9
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 9
150000001412 amines Chemical class 0.000 claims description 9
150000001720 carbohydrates Chemical class 0.000 claims description 9
235000014633 carbohydrates Nutrition 0.000 claims description 9
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 9
235000014113 dietary fatty acids Nutrition 0.000 claims description 9
229930195729 fatty acid Natural products 0.000 claims description 9
239000000194 fatty acid Substances 0.000 claims description 9
150000004665 fatty acids Chemical class 0.000 claims description 9
125000000623 heterocyclic group Chemical group 0.000 claims description 9
235000021317 phosphate Nutrition 0.000 claims description 9
235000018102 proteins Nutrition 0.000 claims description 9
102000004169 proteins and genes Human genes 0.000 claims description 9
108090000623 proteins and genes Proteins 0.000 claims description 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
239000004202 carbamide Substances 0.000 claims description 8
150000002632 lipids Chemical class 0.000 claims description 8
150000007523 nucleic acids Chemical class 0.000 claims description 8
102000039446 nucleic acids Human genes 0.000 claims description 8
108020004707 nucleic acids Proteins 0.000 claims description 8
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XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 7
125000000392 cycloalkenyl group Chemical group 0.000 claims description 7
238000007323 disproportionation reaction Methods 0.000 claims description 7
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
229910052742 iron Inorganic materials 0.000 claims description 7
150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 7
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 6
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
125000005119 alkyl cycloalkyl group Chemical group 0.000 claims description 6
235000008206 alpha-amino acids Nutrition 0.000 claims description 6
DKSMCEUSSQTGBK-UHFFFAOYSA-M bromite Chemical compound [O-]Br=O DKSMCEUSSQTGBK-UHFFFAOYSA-M 0.000 claims description 6
239000002552 dosage form Substances 0.000 claims description 6
JGJLWPGRMCADHB-UHFFFAOYSA-N hypobromite Chemical compound Br[O-] JGJLWPGRMCADHB-UHFFFAOYSA-N 0.000 claims description 6
WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims description 6
210000000056 organ Anatomy 0.000 claims description 6
LLYCMZGLHLKPPU-UHFFFAOYSA-M perbromate Chemical compound [O-]Br(=O)(=O)=O LLYCMZGLHLKPPU-UHFFFAOYSA-M 0.000 claims description 6
150000003904 phospholipids Chemical class 0.000 claims description 6
229910000073 phosphorus hydride Inorganic materials 0.000 claims description 6
MDDUHVRJJAFRAU-YZNNVMRBSA-N tert-butyl-[(1r,3s,5z)-3-[tert-butyl(dimethyl)silyl]oxy-5-(2-diphenylphosphorylethylidene)-4-methylidenecyclohexyl]oxy-dimethylsilane Chemical compound C1[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C(=C)\C1=C/CP(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 MDDUHVRJJAFRAU-YZNNVMRBSA-N 0.000 claims description 6
239000011782 vitamin Substances 0.000 claims description 6
235000013343 vitamin Nutrition 0.000 claims description 6
229940088594 vitamin Drugs 0.000 claims description 6
229930003231 vitamin Natural products 0.000 claims description 6
NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims description 5
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 5
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 5
208000022559 Inflammatory bowel disease Diseases 0.000 claims description 5
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 5
208000035475 disorder Diseases 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 5
ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims description 5
239000003981 vehicle Substances 0.000 claims description 5
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 4
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
229910002651 NO3 Inorganic materials 0.000 claims description 4
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 4
150000001540 azides Chemical class 0.000 claims description 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
125000004122 cyclic group Chemical group 0.000 claims description 4
239000003456 ion exchange resin Substances 0.000 claims description 4
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239000012948 isocyanate Substances 0.000 claims description 4
150000002513 isocyanates Chemical class 0.000 claims description 4
231100000252 nontoxic Toxicity 0.000 claims description 4
230000003000 nontoxic effect Effects 0.000 claims description 4
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 3
XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 3
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 3
206010027476 Metastases Diseases 0.000 claims description 3
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims description 3
201000004681 Psoriasis Diseases 0.000 claims description 3
LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims description 3
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125000003282 alkyl amino group Chemical group 0.000 claims description 3
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235000010323 ascorbic acid Nutrition 0.000 claims description 3
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SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 claims description 3
125000006448 cycloalkyl cycloalkyl group Chemical group 0.000 claims description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 claims description 3
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239000003937 drug carrier Substances 0.000 claims description 3
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VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 claims description 3
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125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
APVPOHHVBBYQAV-UHFFFAOYSA-N n-(4-aminophenyl)sulfonyloctadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 APVPOHHVBBYQAV-UHFFFAOYSA-N 0.000 description 1
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MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
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125000003386 piperidinyl group Chemical group 0.000 description 1
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239000005017 polysaccharide Substances 0.000 description 1
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229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
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125000003226 pyrazolyl group Chemical group 0.000 description 1
125000002098 pyridazinyl group Chemical group 0.000 description 1
CJVCXRMYJNMDTP-UHFFFAOYSA-N pyridine-2,3-dicarboxamide Chemical compound NC(=O)C1=CC=CN=C1C(N)=O CJVCXRMYJNMDTP-UHFFFAOYSA-N 0.000 description 1
125000000719 pyrrolidinyl group Chemical group 0.000 description 1
125000005493 quinolyl group Chemical group 0.000 description 1
210000000664 rectum Anatomy 0.000 description 1
230000002040 relaxant effect Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
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208000023504 respiratory system disease Diseases 0.000 description 1
230000003307 reticuloendothelial effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
238000012216 screening Methods 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
150000003335 secondary amines Chemical group 0.000 description 1
208000015891 sexual disease Diseases 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
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239000008107 starch Substances 0.000 description 1
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238000003860 storage Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000000859 sublimation Methods 0.000 description 1
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239000005720 sucrose Substances 0.000 description 1
OKQKDCXVLPGWPO-UHFFFAOYSA-N sulfanylidenephosphane Chemical compound S=P OKQKDCXVLPGWPO-UHFFFAOYSA-N 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
125000005063 tetradecenyl group Chemical group C(=CCCCCCCCCCCCC)* 0.000 description 1
WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
150000003567 thiocyanates Chemical class 0.000 description 1
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238000011200 topical administration Methods 0.000 description 1
238000012876 topography Methods 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
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230000008733 trauma Effects 0.000 description 1
125000001425 triazolyl group Chemical group 0.000 description 1
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210000002700 urine Anatomy 0.000 description 1
230000002792 vascular Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000002023 wood Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Toxicology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP9532611A 1996-03-13 1997-03-04 スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガンまたは鉄錯体の生体分子結合体 Pending JP2000508625A (ja)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US1334896P	1996-03-13	1996-03-13
WO96/12767		1996-08-14
WO60/013,348		1996-08-14
PCT/US1996/012767 WO1997006824A2 (en)	1995-08-17	1996-08-14	Bioconjugates of manganese complexes and their application as catalysts
PCT/US1997/002566 WO1997033877A1 (en)	1996-03-13	1997-03-04	Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Publications (1)

Publication Number	Publication Date
JP2000508625A true JP2000508625A (ja)	2000-07-11

Family

ID=21759507

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP9532611A Pending JP2000508625A (ja)	1996-03-13	1997-03-04	スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガンまたは鉄錯体の生体分子結合体

Country Status (11)

Country	Link
EP (1)	EP0891338A1 (zh)
JP (1)	JP2000508625A (zh)
KR (1)	KR19990087784A (zh)
CN (1)	CN1225631A (zh)
AU (1)	AU1962497A (zh)
BR (1)	BR9708179A (zh)
CA (1)	CA2249011A1 (zh)
CZ (1)	CZ271198A3 (zh)
IL (1)	IL125889A0 (zh)
NO (1)	NO984164L (zh)
WO (1)	WO1997033877A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6127356A (en)	1993-10-15	2000-10-03	Duke University	Oxidant scavengers
US6214817B1 (en) *	1997-06-20	2001-04-10	Monsanto Company	Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US6180620B1 (en)	1997-06-20	2001-01-30	G.D. Searle & Co.	Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
ATE238307T1 (de)	1997-11-03	2003-05-15	Univ Duke	Substituierte porphyrinen
ATE552260T1 (de)	1999-01-25	2012-04-15	Nat Jewish Health	Substituierte porphyrine und deren therapeutische verwendung
WO2000054784A1 (en) *	1999-03-15	2000-09-21	Abdurafik Bakhramovich Akbarov	Complex comprising the coordination compound manganese, its medical effects and the mode of its production
DE60018925T2 (de) *	1999-05-27	2006-04-13	Pharmacia Corp.(N.D.Ges.D.Staates Delaware)	Biomaterialien, modifiziert mit superoxid-dismutase imitatoren
US20050176790A1 (en)	2001-02-28	2005-08-11	Johannes Bartholomaus	Pharmaceutical salts
EP1439842A4 (en)	2001-06-01	2009-09-02	Nat Jewish Med & Res Center	OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE
JP2006501163A (ja)	2002-06-07	2006-01-12	デューク・ユニバーシティー	置換ポルフィリン
CA2727803C (en)	2008-05-13	2013-03-12	University Of Kansas	Metal abstraction peptide (map) tag and associated methods
AU2009280042B2 (en)	2008-05-23	2015-06-04	National Jewish Health	Methods for treating injury associated with exposure to an alkylating species
US9187735B2 (en)	2012-06-01	2015-11-17	University Of Kansas	Metal abstraction peptide with superoxide dismutase activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3155552B2 (ja) *	1991-07-19	2001-04-09	モンサントカンパニー	超酸化物の不均斉変化に有効な触媒としての窒素含有−大環状リガンドのマンガン錯体
ES2145041T3 (es) *	1991-12-10	2000-07-01	Dow Chemical Co	Complejos de acidos biciclopoliazamacrociclocarboxilicos, sus conjugados, preparacion y uso como agentes de contraste.
US5747026A (en) *	1993-10-15	1998-05-05	University Of Alabama At Birmingham Research Foundation	Antioxidants
AU6031096A (en) *	1995-06-05	1996-12-24	Duke University	Nitrosylated and nitrated superoxide oxidants and reductants
US6525041B1 (en) *	1995-06-06	2003-02-25	Pharmacia Corporation	Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
JPH11507621A (ja) *	1995-06-07	1999-07-06	モンサントカンパニー	置換ポリアザ大環状化合物の製造法

1997
- 1997-03-04 CN CN97194351A patent/CN1225631A/zh active Pending
- 1997-03-04 KR KR1019980707265A patent/KR19990087784A/ko not_active Withdrawn
- 1997-03-04 CA CA002249011A patent/CA2249011A1/en not_active Abandoned
- 1997-03-04 JP JP9532611A patent/JP2000508625A/ja active Pending
- 1997-03-04 CZ CZ982711A patent/CZ271198A3/cs unknown
- 1997-03-04 WO PCT/US1997/002566 patent/WO1997033877A1/en not_active Application Discontinuation
- 1997-03-04 BR BR9708179A patent/BR9708179A/pt not_active Application Discontinuation
- 1997-03-04 IL IL12588997A patent/IL125889A0/xx unknown
- 1997-03-04 AU AU19624/97A patent/AU1962497A/en not_active Abandoned
- 1997-03-04 EP EP97907685A patent/EP0891338A1/en not_active Withdrawn
1998
- 1998-09-10 NO NO984164A patent/NO984164L/no unknown

Also Published As

Publication number	Publication date
AU1962497A (en)	1997-10-01
BR9708179A (pt)	1999-07-27
NO984164D0 (no)	1998-09-10
WO1997033877A1 (en)	1997-09-18
CN1225631A (zh)	1999-08-11
NO984164L (no)	1998-11-06
CZ271198A3 (cs)	1999-01-13
CA2249011A1 (en)	1997-09-18
EP0891338A1 (en)	1999-01-20
IL125889A0 (en)	1999-04-11
KR19990087784A (ko)	1999-12-27

Publication	Publication Date	Title
US6525041B1 (en)	2003-02-25	Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US6204259B1 (en)	2001-03-20	Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
JP3155552B2 (ja)	2001-04-09	超酸化物の不均斉変化に有効な触媒としての窒素含有−大環状リガンドのマンガン錯体
US5637578A (en)	1997-06-10	Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US20090098047A1 (en)	2009-04-16	Bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
JP2012097097A (ja)	2012-05-24	スーパーオキシドジスムターゼ活性を有する置換型ピリジノペンタアザ大環錯体
JP2000508625A (ja)	2000-07-11	スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガンまたは鉄錯体の生体分子結合体
JP2000513322A (ja)	2000-10-10	スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガン錯体の生体分子結合体
JPH10500401A (ja)	1998-01-13	金属錯体を用いる診断画像解析法
JPH11514971A (ja)	1999-12-21	窒素含有大環状リガンドの金属錯体を使用する診断造影検査方法
US5721361A (en)	1998-02-24	Process for preparing substituted polyazamacrocycles
WO1997033588A9 (en)	1997-11-06	Iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
JP2000507929A (ja)	2000-06-27	ジスムタチンスーパーオキシドの触媒として有効な窒素含有大環状化合物配位子を持つ鉄錯体
MXPA98001322A (en)	1998-10-23	Bioconjugados de complejos de manganeso de ligandos macrociclicos containing nitrogen, effective as catalysts to dismute superox
KR0154346B1 (ko)	1998-12-01	슈퍼옥사이드의 불균환 촉매로서 효과적인 질소를 포함하는 마크로사이클릭 리간드의 망간 착물
MXPA98007449A (en)	1999-04-06	Complexes with iron of macrocyclic ligands containing nitrogen, effective as catalysts to dismute superox