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NO975632L - Dinukleotider som er nyttige for behandling av lungesykdom - Google Patents

Dinukleotider som er nyttige for behandling av lungesykdom

Info

Publication number
NO975632L
NO975632L NO975632A NO975632A NO975632L NO 975632 L NO975632 L NO 975632L NO 975632 A NO975632 A NO 975632A NO 975632 A NO975632 A NO 975632A NO 975632 L NO975632 L NO 975632L
Authority
NO
Norway
Prior art keywords
treatment
lung disease
lungs
subject
compound
Prior art date
Application number
NO975632A
Other languages
English (en)
Other versions
NO975632D0 (no
Inventor
Iii Monroe J Stutts
Jr Richard C Boucher
Eduardo R Lazarowski
Cara A Geary
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of NO975632D0 publication Critical patent/NO975632D0/no
Publication of NO975632L publication Critical patent/NO975632L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Forbindelse av formel (I): H H )Hna ~^n^ H H H V H OH OH eller et farmasøytisk akseptabelt salt derav. I en forbindelse av formel (I): n er fra l til 6, n er fortrinnsvis fra 2 til 4, og er mest foretrukket 4. X er -OH eller -SH og er fortrinnsvis -OH. A og B er hver uavhengig valgt fra gruppen bestående av: og hvor R er H eller Br. Forbindelsene er nyttige i behandlingen av luftveissykdommer slik som cystisk fibrose. Videre beskrives farmasøytiske preparater omfattende, i farmasøytisk akseptable bærere (f.eks faste eller væskeformige bærere), en forbindelse av formel (I). Videre beskrives en metode for hydratisering av slimsekreter i lungene hos et individ som har behov for slik behandling, ved administrasjon til nevnte individs lunger av en forbindelse av formel (I). Administrasjonstrinnet utføres fortrinnsvis ved inhalering.
NO975632A 1995-06-07 1997-12-04 Dinukleotider som er nyttige for behandling av lungesykdom NO975632L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/486,988 US5635160A (en) 1995-06-07 1995-06-07 Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions
PCT/US1996/009190 WO1996040059A1 (en) 1995-06-07 1996-06-06 Dinucleotides useful for the treatment of lung disease

Publications (2)

Publication Number Publication Date
NO975632D0 NO975632D0 (no) 1997-12-04
NO975632L true NO975632L (no) 1998-02-03

Family

ID=23933941

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975632A NO975632L (no) 1995-06-07 1997-12-04 Dinukleotider som er nyttige for behandling av lungesykdom

Country Status (14)

Country Link
US (4) US5635160A (no)
EP (1) EP0831777B1 (no)
JP (1) JPH11506790A (no)
KR (1) KR100414699B1 (no)
CN (2) CN1086940C (no)
AT (1) ATE231519T1 (no)
AU (1) AU696845B2 (no)
BR (1) BR9609063A (no)
CA (1) CA2223894C (no)
DE (1) DE69625906T2 (no)
ES (1) ES2189874T3 (no)
MX (1) MX9709637A (no)
NO (1) NO975632L (no)
WO (1) WO1996040059A1 (no)

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Also Published As

Publication number Publication date
US5935555A (en) 1999-08-10
AU6176496A (en) 1996-12-30
WO1996040059A1 (en) 1996-12-19
BR9609063A (pt) 1999-01-26
JPH11506790A (ja) 1999-06-15
ATE231519T1 (de) 2003-02-15
NO975632D0 (no) 1997-12-04
US5635160A (en) 1997-06-03
EP0831777A1 (en) 1998-04-01
CN1398873A (zh) 2003-02-26
EP0831777B1 (en) 2003-01-22
AU696845B2 (en) 1998-09-17
US6235266B1 (en) 2001-05-22
CN1189097A (zh) 1998-07-29
EP0831777A4 (no) 1998-05-06
DE69625906T2 (de) 2003-11-13
CN1181088C (zh) 2004-12-22
CA2223894A1 (en) 1996-12-19
KR19990022296A (ko) 1999-03-25
US20010041682A1 (en) 2001-11-15
ES2189874T3 (es) 2003-07-16
CN1086940C (zh) 2002-07-03
MX9709637A (es) 1998-07-31
KR100414699B1 (ko) 2004-05-31
DE69625906D1 (de) 2003-02-27
CA2223894C (en) 2007-12-04

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