NO974148L - Aminosyrehydroksyetylaminosulfonamid retrovirale proteaseinhibitorer - Google Patents

Aminosyrehydroksyetylaminosulfonamid retrovirale proteaseinhibitorer

Info

Publication number: NO974148L
Authority: NO; Norway
Prior art keywords: retroviral; amino acid; protease inhibitors; retroviral protease; protease
Prior art date: 1995-03-10

Application number

NO974148A

Other languages

English (en)

Other versions

NO974148D0 (no

Inventor

Daniel P Getman

Gary A Decrescenzo

John N Freskos

James A Sikorski

Michael L Vazquez

Balekudru Devadas

Srivivasan Nagarajan

David L Brown

Joseph J Mcdonald

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-10

Filing date

1997-09-09

Publication date

1997-10-27

1997-09-09 Application filed by Searle & Co filed Critical Searle & Co

1997-09-09 Publication of NO974148D0 publication Critical patent/NO974148D0/no

1997-10-27 Publication of NO974148L publication Critical patent/NO974148L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Peptides Or Proteins (AREA)

NO974148A 1995-03-10 1997-09-09 Aminosyrehydroksyetylaminosulfonamid retrovirale proteaseinhibitorer NO974148L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US40228795A	1995-03-10	1995-03-10
US08/474,052 US5756533A (en)	1995-03-10	1995-06-07	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002684 WO1996028463A1 (en)	1995-03-10	1996-03-07	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (2)

Publication Number	Publication Date
NO974148D0 NO974148D0 (no)	1997-09-09
NO974148L true NO974148L (no)	1997-10-27

Family

ID=23591303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO974148A NO974148L (no)	1995-03-10	1997-09-09	Aminosyrehydroksyetylaminosulfonamid retrovirale proteaseinhibitorer

Country Status (23)

Country	Link
US (3)	US5756533A (no)
EP (2)	EP0813542B1 (no)
JP (1)	JP4091111B2 (no)
KR (1)	KR100377855B1 (no)
CN (1)	CN1204144C (no)
AT (1)	ATE226213T1 (no)
AU (1)	AU705268B2 (no)
BR (1)	BR9607638A (no)
CA (1)	CA2215061A1 (no)
CZ (1)	CZ297719B6 (no)
DE (1)	DE69624346T2 (no)
DK (1)	DK0813542T3 (no)
EA (1)	EA000470B1 (no)
EE (1)	EE04349B1 (no)
ES (1)	ES2187640T3 (no)
HU (1)	HUP9801562A3 (no)
NO (1)	NO974148L (no)
NZ (1)	NZ303861A (no)
PL (1)	PL184748B1 (no)
PT (1)	PT813542E (no)
SK (1)	SK285688B6 (no)
UA (1)	UA56130C2 (no)
WO (1)	WO1996028463A1 (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040122000A1 (en)	1981-01-07	2004-06-24	Vertex Pharmaceuticals Incorporated.	Inhibitors of aspartyl protease
US6140505A (en)	1995-03-10	2000-10-31	G. D. Searle & Co.	Synthesis of benzo fused heterocyclic sulfonyl chlorides
US5756533A (en) *	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) *	1995-03-10	1998-07-07	G.D. Searle & Co.	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
ATE500823T1 (de) *	1998-06-23	2011-03-15	Us Of America Represented By The Secretary Dept Of Health And Human Services	Arzneimittel zur behandlung von hiv-infizierten säugetieren
WO1999067254A2 (en) *	1998-06-23	1999-12-29	The United States Of America Represented By The Secretary, Department Of Health And Human Services	Multi-drug resistant retroviral protease inhibitors and use thereof
WO2000002862A1 (en) *	1998-07-08	2000-01-20	G.D. Searle & Co.	Retroviral protease inhibitors
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
AUPR034000A0 (en) *	2000-09-25	2000-10-19	Fujisawa Pharmaceutical Co., Ltd.	Aminoalcohol derivatives
PL213327B1 (pl) *	2001-02-14	2013-02-28	Tibotec Pharm Ltd	Zwiazki 2-(podstawione-amino)-benzotiazolosulfonamidowe, sposób ich wytwarzania oraz ich zastosowanie
EE05384B1 (et) *	2001-04-09	2011-02-15	Tibotec�Pharmaceuticals�Ltd.	LaiaspektrilisedÁ2-(asendatudÁamino)bensoksasoolsulfoonamiididÁkuiÁHIVÁproteaasiÁinhibiitorid,ÁnendeÁkasutamine,ÁfarmatseutilineÁkompositsioonÁjaÁmeetodÁretroviiruseÁreplikatsiooniÁinhibeerimiseks
HUP0400438A3 (en) *	2001-05-11	2007-08-28	Tibotec Pharm Ltd	Broadspectrum 2-amino-benzoxazole-6-sulfonamides, their use as hiv protease inhibitor and pharmaceutical compositions containing them
BR0215260A (pt)	2001-12-21	2004-12-07	Tibotec Pharm Ltd	Inibidores de hiv protease de sulfonamida contendo fenila substituìda heterocìclica de amplo espectro
US7011678B2 (en) *	2002-01-31	2006-03-14	Radi Medical Systems Ab	Biodegradable stent
MY142238A (en) *	2002-03-12	2010-11-15	Tibotec Pharm Ltd	Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
US7157489B2 (en)	2002-03-12	2007-01-02	The Board Of Trustees Of The University Of Illinois	HIV protease inhibitors
US7462636B2 (en)	2002-05-17	2008-12-09	Tibotec Pharmaceuticals Ltd	Broadspectrum substituted benzisoxazole sulfonamide HIV protease inhibitors
JP4879484B2 (ja) *	2002-08-02	2012-02-22	テイボテク・フアーマシユーチカルズ・リミテツド	広スペクトルの２−アミノ−ベンゾチアゾールスルホンアミドｈｉｖプロテアーゼ阻害剤
WO2004016619A1 (en)	2002-08-14	2004-02-26	Tibotec Pharmaceuticals Ltd.	Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
US20060128634A1 (en) *	2002-11-14	2006-06-15	Carini David J	Alpha, alpha-disubstituted benzylglycine derivatives as HIV protease inhibitors
US6943170B2 (en) *	2002-11-14	2005-09-13	Bristol-Myers Squibb Company	N-cycloalkylglycines as HIV protease inhibitors
EP1725566B1 (en)	2003-12-23	2009-06-17	Tibotec Pharmaceuticals Ltd.	Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
ME01059B (me)	2003-12-23	2012-10-20	Janssen Sciences Ireland Uc	Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata
MXPA06010365A (es)	2004-03-11	2007-05-04	Sequoia Pharmaceuticals Inc	Inhibidores de proteasa retrovirales repelentes a la resistencia.
CN101674822A (zh) *	2006-08-18	2010-03-17	塞阔伊亚药品公司	抑制细胞色素p450的组合物和方法
BRPI0819883A2 (pt) *	2007-11-28	2017-05-23	Sequoia Pharmaceuticals Inc	composições e métodos para inibir citocromo p450 2d6
EP2276726A1 (en) *	2008-04-18	2011-01-26	University of Connecticut	Compounds for lysosomal modulation and methods of use
WO2011010524A1 (ja) *	2009-07-24	2011-01-27	住友精化株式会社	アルコキシベンゼンスルホニルクロライドの製造方法
DK2788349T3 (en)	2011-12-09	2017-01-30	Chiesi Farm Spa	kinase inhibitors
CN104387299B (zh) *	2014-10-23	2016-08-17	凯莱英医药集团（天津）股份有限公司	4-氨基-n-[(2r, 3s)-3-氨基-2-羟基-4-苯丁基]-n-异丁基苯磺酰胺的制备方法
CN111205206B (zh) *	2020-02-13	2021-10-22	中国医学科学院医药生物技术研究所	一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en) *	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
EP0068378B1 (en) *	1981-06-26	1986-03-05	Schering Corporation	Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4634465A (en) *	1982-07-16	1987-01-06	Ciba-Geigy Corporation	Fused N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'triazinylureas
DE3377497D1 (en) *	1982-09-15	1988-09-01	Haessle Ab	Enzyme inhibitors
US4595407A (en) *	1982-11-01	1986-06-17	E. I. Du Pont De Nemours And Company	Triazinyl-amino-carbonyl-1,3-benzohetero- or -1,4-benzohetero-sulfonamides
EP0114993B1 (en) *	1982-12-27	1990-05-16	Merck & Co. Inc.	Renin inhibitory tripeptides
US4668770A (en) *	1982-12-27	1987-05-26	Merck & Co., Inc.	Renin inhibitory tripeptides
AU573735B2 (en) *	1983-02-07	1988-06-23	Aktiebolaget Hassle	Peptide analogue enzyme inhibitors
HU197774B (en) *	1983-02-16	1989-05-29	Laszlo Paszner	Organic solvent process for the hydrolytic saccharification of vegetable materials of starch type
JPS59227851A (ja) *	1983-06-09	1984-12-21	Sankyo Co Ltd	レニン阻害作用を有するペプチド類
US4514391A (en) *	1983-07-21	1985-04-30	E. R. Squibb & Sons, Inc.	Hydroxy substituted peptide compounds
US4477441A (en) *	1983-09-14	1984-10-16	Merck & Co., Inc.	Renin inhibitors containing a C-terminal disulfide cycle
US4645759A (en) *	1984-06-22	1987-02-24	Abbott Laboratories	Renin inhibiting compounds
US4616088A (en) *	1984-10-29	1986-10-07	E. R. Squibb & Sons, Inc.	Amino acid ester and amide renin inhibitor
US4599198A (en) *	1985-08-02	1986-07-08	Pfizer Inc.	Intermediates in polypeptide synthesis
US4668769A (en) *	1985-08-02	1987-05-26	Hoover Dennis J	Oxa- and azahomocyclostatine polypeptides
CA1282549C (en) *	1985-11-12	1991-04-02	Eric M. Gordon	Aminocarbonyl renin inhibitors
CA1297631C (en) *	1985-12-23	1992-03-17	Sesha I. Natarajan	Ureido renin inhibitors
US4757050A (en) *	1985-12-23	1988-07-12	E. R. Squibb Sons, Inc.	Ureido renin inhibitors
US4880938A (en) *	1986-06-16	1989-11-14	Merck & Co., Inc.	Amino acid analogs
DE3635907A1 (de) *	1986-10-22	1988-04-28	Merck Patent Gmbh	Hydroxy-aminosaeurederivate
GB2200115B (en) *	1987-01-21	1990-11-14	Sandoz Ltd	Novel peptide derivatives, their production and use
USH725H (en) *	1987-02-26	1990-01-02	E. R. Squibb & Sons, Inc.	Ureido amino and imino acids, compositions and methods for use
GB8707412D0 (en) *	1987-03-27	1987-04-29	Fujisawa Pharmaceutical Co	Peptide compounds
DE3830825A1 (de) *	1987-09-15	1989-03-23	Sandoz Ag	Hydrophile reninhemmer, ihre herstellung und verwendung
IL89900A0 (en) *	1988-04-12	1989-12-15	Merck & Co Inc	Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
US4977277A (en) *	1988-05-09	1990-12-11	Abbott Laboratories	Functionalized peptidyl aminodiols and -triols 4-amino-5-cyclohexyl-3-hydroxy-1,2-oxopentane and derivatives thereof
IL90218A0 (en) *	1988-05-13	1989-12-15	Abbott Lab	Retroviral protease inhibitors
CA1340588C (en) *	1988-06-13	1999-06-08	Balraj Krishan Handa	Amino acid derivatives
IL91307A0 (en) *	1988-08-24	1990-03-19	Merck & Co Inc	Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them
CA2012306A1 (en) *	1989-03-28	1990-09-28	Werner Neidhart	Amino acid derivatives
JP2701932B2 (ja) *	1989-04-10	1998-01-21	サントリー株式会社	タンパク質分解酵素阻害剤
DE3912829A1 (de) *	1989-04-19	1990-10-25	Bayer Ag	Verwendung von renininhibitorischen peptiden als mittel gegen retroviren
TW225540B (no) *	1990-06-28	1994-06-21	Shionogi & Co
US5289728A (en) *	1990-11-08	1994-03-01	Jr Johanson, Inc.	Flow-no-flow tester
DE69118907T2 (de) *	1990-11-19	1996-11-14	Monsanto Co	Retrovirale proteaseinhibitoren
ZA929869B (en) *	1991-12-20	1994-06-20	Syntex Inc	Hiv protease inhibitors
DE69332002T2 (de) *	1992-08-25	2002-12-19	Monsanto Co	Hydroxyethylaminosulfonamide verwendbar als Inhibitoren retroviraler Proteasen
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DE69331421T2 (de) *	1992-10-30	2002-08-01	G.D. SEARLE & CO., CHICAGO	N-substituierte Hydroxyethylaminosulfamidsäure-Derivate verwendbar als Inhibitoren retroviraler Proteasen
JPH09502465A (ja) *	1993-06-21	1997-03-11	エクソンリサーチアンドエンジニアリングカンパニー	接触分解システム
AU7669794A (en) *	1993-08-24	1995-03-21	G.D. Searle & Co.	Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
UA49803C2 (uk) *	1994-06-03	2002-10-15	Дж.Д. Сьорль Енд Ко	Спосіб лікування ретровірусних інфекцій
US5756533A (en) *	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

1995
- 1995-06-07 US US08/474,052 patent/US5756533A/en not_active Expired - Fee Related
1996
- 1996-03-07 EA EA199700221A patent/EA000470B1/ru not_active IP Right Cessation
- 1996-03-07 EP EP96907135A patent/EP0813542B1/en not_active Expired - Lifetime
- 1996-03-07 PT PT96907135T patent/PT813542E/pt unknown
- 1996-03-07 CN CNB961936207A patent/CN1204144C/zh not_active Expired - Fee Related
- 1996-03-07 US US08/894,900 patent/US5968970A/en not_active Expired - Fee Related
- 1996-03-07 EP EP02011526A patent/EP1258491A1/en not_active Withdrawn
- 1996-03-07 CA CA002215061A patent/CA2215061A1/en not_active Abandoned
- 1996-03-07 EE EE9700201A patent/EE04349B1/xx not_active IP Right Cessation
- 1996-03-07 JP JP52764896A patent/JP4091111B2/ja not_active Expired - Fee Related
- 1996-03-07 ES ES96907135T patent/ES2187640T3/es not_active Expired - Lifetime
- 1996-03-07 AT AT96907135T patent/ATE226213T1/de not_active IP Right Cessation
- 1996-03-07 KR KR1019970706313A patent/KR100377855B1/ko not_active IP Right Cessation
- 1996-03-07 DK DK96907135T patent/DK0813542T3/da active
- 1996-03-07 BR BR9607638A patent/BR9607638A/pt not_active Application Discontinuation
- 1996-03-07 AU AU50294/96A patent/AU705268B2/en not_active Ceased
- 1996-03-07 PL PL96322784A patent/PL184748B1/pl not_active IP Right Cessation
- 1996-03-07 SK SK1224-97A patent/SK285688B6/sk unknown
- 1996-03-07 HU HU9801562A patent/HUP9801562A3/hu unknown
- 1996-03-07 NZ NZ303861A patent/NZ303861A/xx unknown
- 1996-03-07 WO PCT/US1996/002684 patent/WO1996028463A1/en active IP Right Grant
- 1996-03-07 DE DE69624346T patent/DE69624346T2/de not_active Expired - Fee Related
- 1996-03-07 CZ CZ0282497A patent/CZ297719B6/cs not_active IP Right Cessation
- 1996-07-03 UA UA97104995A patent/UA56130C2/uk unknown
1997
- 1997-09-09 NO NO974148A patent/NO974148L/no unknown
1998
- 1998-03-03 US US09/033,897 patent/US5965601A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ297719B6 (cs)	2007-03-14
HUP9801562A3 (en)	2001-02-28
US5756533A (en)	1998-05-26
DK0813542T3 (da)	2003-02-17
HUP9801562A2 (hu)	1998-11-30
UA56130C2 (uk)	2003-05-15
CN1186499A (zh)	1998-07-01
CN1204144C (zh)	2005-06-01
WO1996028463A1 (en)	1996-09-19
PT813542E (pt)	2003-01-31
EP0813542A1 (en)	1997-12-29
EP1258491A1 (en)	2002-11-20
US5965601A (en)	1999-10-12
ES2187640T3 (es)	2003-06-16
EA199700221A1 (ru)	1998-04-30
AU5029496A (en)	1996-10-02
CZ282497A3 (cs)	1998-02-18
SK122497A3 (en)	1998-03-04
KR19980702905A (ko)	1998-09-05
US5968970A (en)	1999-10-19
JP2001513746A (ja)	2001-09-04
DE69624346T2 (de)	2003-06-26
BR9607638A (pt)	1998-05-26
EA000470B1 (ru)	1999-08-26
KR100377855B1 (ko)	2003-07-23
PL322784A1 (en)	1998-02-16
AU705268B2 (en)	1999-05-20
NZ303861A (en)	1999-02-25
PL184748B1 (pl)	2002-12-31
SK285688B6 (sk)	2007-06-07
EP0813542B1 (en)	2002-10-16
CA2215061A1 (en)	1996-09-19
JP4091111B2 (ja)	2008-05-28
NO974148D0 (no)	1997-09-09
EE04349B1 (et)	2004-08-16
ATE226213T1 (de)	2002-11-15
DE69624346D1 (de)	2002-11-21
EE9700201A (et)	1998-02-16

Publication	Publication Date	Title
EE04349B1 (et)	2004-08-16	Aminohappe hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid
EE9700200A (et)	1998-02-16	Bis-aminohappe hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid
BR9607450A (pt)	1998-06-30	Inibidores de protease retroviral sulfonilalcanoilamino hidroxietilamino sulfonamida
NO974147D0 (no)	1997-09-09	Heterocykelkarbonyl aminosyre hydroksyetylamino sulfonamid retroviral protease
MX9706912A (es)	1998-01-31	Inhibidores de protesa retroviral de sulfonamida de hidroxietilamino de amino acido y uso de los mismos.