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NO973216D0 - Substituerte oksazolidin-calpain- og/eller cathepsin B-inhibitorer - Google Patents

Substituerte oksazolidin-calpain- og/eller cathepsin B-inhibitorer

Info

Publication number
NO973216D0
NO973216D0 NO973216A NO973216A NO973216D0 NO 973216 D0 NO973216 D0 NO 973216D0 NO 973216 A NO973216 A NO 973216A NO 973216 A NO973216 A NO 973216A NO 973216 D0 NO973216 D0 NO 973216D0
Authority
NO
Norway
Prior art keywords
calpain
cathepsin
inhibitors
substituted oxazolidine
oxazolidine
Prior art date
Application number
NO973216A
Other languages
English (en)
Other versions
NO309267B1 (no
NO973216L (no
Inventor
Norton Paul Peet
Shujaath Mehdi
Matthew D Linnik
Michael Richard Angelastro
Hwa-Ok Kim
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO973216D0 publication Critical patent/NO973216D0/no
Publication of NO973216L publication Critical patent/NO973216L/no
Publication of NO309267B1 publication Critical patent/NO309267B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO973216A 1995-01-11 1997-07-10 Substituerte oxazolidin-calpain- og/eller cathepsin B- inhibitorer og farmasöytisk preparat inneholdende disse NO309267B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37119295A 1995-01-11 1995-01-11
PCT/US1995/016565 WO1996021655A2 (en) 1995-01-11 1995-12-15 Substituted oxazolidine calpain and/or cathepsin b inhibitors

Publications (3)

Publication Number Publication Date
NO973216D0 true NO973216D0 (no) 1997-07-10
NO973216L NO973216L (no) 1997-09-09
NO309267B1 NO309267B1 (no) 2001-01-08

Family

ID=23462894

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973216A NO309267B1 (no) 1995-01-11 1997-07-10 Substituerte oxazolidin-calpain- og/eller cathepsin B- inhibitorer og farmasöytisk preparat inneholdende disse

Country Status (23)

Country Link
US (1) US5691368A (no)
EP (1) EP0802909B1 (no)
JP (1) JP4157601B2 (no)
KR (1) KR100393701B1 (no)
CN (1) CN1088456C (no)
AR (1) AR001787A1 (no)
AT (1) ATE206413T1 (no)
AU (1) AU692044B2 (no)
CA (1) CA2210258C (no)
DE (1) DE69523072T2 (no)
DK (1) DK0802909T3 (no)
ES (1) ES2165441T3 (no)
FI (1) FI972935A0 (no)
HU (1) HUT77649A (no)
IL (1) IL116724A (no)
MX (1) MX9705235A (no)
NO (1) NO309267B1 (no)
NZ (1) NZ298999A (no)
PT (1) PT802909E (no)
SI (1) SI0802909T1 (no)
TW (1) TW454001B (no)
WO (1) WO1996021655A2 (no)
ZA (1) ZA96100B (no)

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AU6134498A (en) * 1997-03-07 1998-09-22 Hoechst Marion Roussel, Inc. Method of treating trauma associated with brain, spinal cord or peripheral nerveinjury using carbobenzyloxy n-protected di- and tripeptide phenylalaninals
WO2000021550A2 (en) * 1998-10-13 2000-04-20 President And Fellows Of Harvard College Methods and compositions for treating neurodegenerative diseases
JP2002529422A (ja) * 1998-11-12 2002-09-10 リサーチ コーポレイション テクノロジーズ，インコーポレイテッド 虚血により傷害を受けた組織の処置法
WO2000051998A1 (en) * 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
CA2367348A1 (en) 1999-03-15 2000-09-21 Axys Pharmaceuticals, Inc. Novel compounds and compositions as protease inhibitors
EP1516877A1 (en) * 1999-03-15 2005-03-23 Axys Pharmaceuticals, Inc. Amine derivatives as protease inhibitors
US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
CZ20021548A3 (cs) * 1999-11-05 2002-10-16 Societe De Conseils De Recherches Et D'application Nové heterocyklické sloučeniny a jejich pouľití jako léků
FR2800737B1 (fr) * 1999-11-05 2006-06-30 Sod Conseils Rech Applic Nouveaux composes heterocycliques et leur application a titre de medicaments
CA2417744A1 (en) * 2000-07-31 2002-02-07 The Regents Of The University Of California Model for alzheimer's disease and other neurodegenerative diseases
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
CA2433520A1 (en) 2000-12-22 2002-07-04 Axys Pharmaceuticals, Inc. Novel compounds and compositions as cathepsin inhibitors
PL369312A1 (en) 2001-09-14 2005-04-18 Aventis Pharmaceuticals Inc. Novel compounds and compositions as cathepsin inhibitors
CA2467391A1 (en) 2001-11-14 2003-05-22 Aventis Pharmaceuticals Inc. Oligopeptides and compositions containing them as cathepsin s inhibitors
WO2004084830A2 (en) * 2003-03-21 2004-10-07 Buck Institute Method for treating alzheimer’s dementia
US7384970B2 (en) * 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
US7109243B2 (en) * 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
WO2004089395A2 (en) * 2003-04-01 2004-10-21 Aventis Pharmaceuticals Inc. Use of an inhibitor of cathepsin-s or -b to treat or prevent chronic obstructive pulmonary disease
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7173051B2 (en) * 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) * 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
FR2863268B1 (fr) * 2003-12-09 2006-02-24 Sod Conseils Rech Applic Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (en) 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
EP2300000A1 (en) * 2008-07-03 2011-03-30 University of Massachusetts Methods and compositions for reducing inflammation and treating inflammatory disorders
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
WO2024018245A1 (en) 2022-07-22 2024-01-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of calpain inhibitors for the treatment of the diabetic kidney disease
WO2024153744A1 (en) 2023-01-20 2024-07-25 Institut National de la Santé et de la Recherche Médicale Autophagy activators for the treatment of rhabdomyolysis

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Also Published As

Publication number Publication date
IL116724A0 (en) 1996-05-14
US5691368A (en) 1997-11-25
HUT77649A (hu) 1998-07-28
DK0802909T3 (da) 2002-01-28
JPH10512257A (ja) 1998-11-24
KR100393701B1 (ko) 2003-11-28
SI0802909T1 (en) 2002-02-28
ES2165441T3 (es) 2002-03-16
PT802909E (pt) 2002-03-28
CN1173174A (zh) 1998-02-11
MX9705235A (es) 1997-10-31
ATE206413T1 (de) 2001-10-15
IL116724A (en) 2000-08-31
FI972935L (fi) 1997-07-10
AU692044B2 (en) 1998-05-28
CN1088456C (zh) 2002-07-31
JP4157601B2 (ja) 2008-10-01
CA2210258C (en) 2002-10-01
AR001787A1 (es) 1997-12-10
ZA96100B (en) 1996-07-24
EP0802909A2 (en) 1997-10-29
TW454001B (en) 2001-09-11
NO309267B1 (no) 2001-01-08
EP0802909B1 (en) 2001-10-04
AU4473196A (en) 1996-07-31
NZ298999A (en) 1999-01-28
WO1996021655A3 (en) 1996-09-06
DE69523072D1 (en) 2001-11-08
DE69523072T2 (de) 2002-06-20
CA2210258A1 (en) 1996-07-18
WO1996021655A2 (en) 1996-07-18
FI972935A0 (fi) 1997-07-10
NO973216L (no) 1997-09-09

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Legal Events

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