[go: up one dir, main page]

NO970431L - Tetrahydroisokinolin-derivater - Google Patents

Tetrahydroisokinolin-derivater

Info

Publication number
NO970431L
NO970431L NO970431A NO970431A NO970431L NO 970431 L NO970431 L NO 970431L NO 970431 A NO970431 A NO 970431A NO 970431 A NO970431 A NO 970431A NO 970431 L NO970431 L NO 970431L
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
hydroxy
derivatives
tetrahydroisoquinoline derivatives
Prior art date
Application number
NO970431A
Other languages
English (en)
Other versions
NO970431D0 (no
Inventor
Alexander Alanine
Anne Bourson
Bernd Buettelmann
Guenther Fischer
Marie-Paule Heitz Neidhart
Vincent Mutel
Emmanuel Pinard
Stephan Roever
Gerhard Trube
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO970431D0 publication Critical patent/NO970431D0/no
Publication of NO970431L publication Critical patent/NO970431L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Den foreliggende oppfinnelse vedrører anvendelsen av tetrahydroisokolinderivater med den generell formel. hvori. A er aryl. er hydrogen, hydroksy, lavere alkyl, lavere alkoksy, R-CO- eller R-COO-, hvori R. er lavere alkyl;. er hydrogen, lavere alkyl eller syklol-akyl ;. er hydrogen, lavere alkyl, lavere alkoksy, hydroksy eller. ogdanner sammen -(CH)„- eller. ogdanner sammen -OCH0-, og. n er 3 eller,. samt farmasøytisk akseptable salter derav for pro-duksjon av medikamenter for kontroll eller behand-ling av sykdommer som representerer terapeutiske indikasjoner for NMDA-reseptorundertype spesifikke blokkere.
NO970431A 1996-02-03 1997-01-31 Tetrahydroisokinolin-derivater NO970431L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96101553 1996-02-03

Publications (2)

Publication Number Publication Date
NO970431D0 NO970431D0 (no) 1997-01-31
NO970431L true NO970431L (no) 1997-08-04

Family

ID=8222462

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970431A NO970431L (no) 1996-02-03 1997-01-31 Tetrahydroisokinolin-derivater

Country Status (29)

Country Link
US (2) US5952344A (no)
JP (1) JP3217290B2 (no)
KR (1) KR100229298B1 (no)
CN (1) CN1167762A (no)
AR (1) AR005613A1 (no)
AU (1) AU723586B2 (no)
BR (1) BR9700816A (no)
CA (1) CA2196392A1 (no)
CO (1) CO4761069A1 (no)
CZ (1) CZ29497A3 (no)
DE (1) DE19703985A1 (no)
ES (1) ES2124672B1 (no)
FR (1) FR2744447B1 (no)
GB (1) GB2309642A (no)
HR (1) HRP970060A2 (no)
HU (1) HUP9700273A1 (no)
ID (1) ID15866A (no)
IL (1) IL120100A (no)
IT (1) IT1289621B1 (no)
MA (1) MA24078A1 (no)
NO (1) NO970431L (no)
NZ (1) NZ314130A (no)
PE (1) PE35698A1 (no)
PL (1) PL318256A1 (no)
SG (1) SG55273A1 (no)
TR (1) TR199700071A2 (no)
TW (1) TW427978B (no)
YU (1) YU3997A (no)
ZA (1) ZA97672B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2440284A1 (en) * 2001-03-08 2002-09-19 Emory University Ph-dependent nmda receptor antagonists
KR20100045983A (ko) 2007-06-29 2010-05-04 에모리 유니버시티 신경보호를 위한 ｎｍｄａ 수용체 길항물질
JP2012158527A (ja) * 2011-01-31 2012-08-23 Mitsubishi Gas Chemical Co Inc うつ予防

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067203A (en) * 1962-12-04 Tetrahybroisqquinoline derivatives
US3217007A (en) * 1965-11-09 Halo- and nitro-substituted phenethyl-z- methyl tetrahydroisoquinolsnes
NL286505A (no) * 1961-12-15
US3243438A (en) * 1962-02-23 1966-03-29 Hoffmann La Roche Octahydro phenanthridine compounds
CH418336A (de) * 1962-02-23 1966-08-15 Hoffmann La Roche Verfahren zur Herstellung von Octahydrophenanthridinverbindungen
US3480714A (en) * 1966-02-07 1969-11-25 Ciba Geigy Corp N-substituted isoquinolines as antiprotozoal agents
US3361767A (en) * 1966-04-04 1968-01-02 American Home Prod 10, 5(epoxymethano)-10, 11-dihydro-5h-dibenzo[a, d]cyclohepten-13-one and derivatives
GB1386076A (en) * 1971-06-03 1975-03-05 Wyeth John & Brother Ltd Isoquinoline derivatives
US3803151A (en) * 1972-08-23 1974-04-09 Bristol Myers Co Synthesis for the preparation of 3-hydroxy-n-alkylisomorphinans
JPS5291868A (en) * 1976-01-26 1977-08-02 Takeda Chem Ind Ltd Indenopyridine derivatives
US4689330A (en) * 1985-04-15 1987-08-25 Janssen Pharmaceutica N.V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
EP0226511B1 (fr) * 1985-12-13 1989-08-02 LABORATOIRE L. LAFON Société anonyme dite: Dérivés de 5-phényl-1,4,5,6-tétrahydropyrimidine, procédé de préparation et utilisation en thérapeutique
DE68910999T2 (de) * 1988-02-19 1994-03-24 Smithkline Beecham Farma 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten.
US5011834A (en) * 1989-04-14 1991-04-30 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon PCP receptor ligands and the use thereof
EP0554247B1 (en) * 1990-05-10 2000-04-26 Pfizer Inc. Neuroprotective indolone and related derivatives
US5192751A (en) * 1992-07-24 1993-03-09 Eli Lilly And Company Use of competitive NMDA receptor antagonists in the treatment of urinary incontinence
JPH0741481A (ja) * 1993-05-21 1995-02-10 Hokuriku Seiyaku Co Ltd 両性型三環系化合物
US5389638A (en) * 1993-09-10 1995-02-14 Abbott Laboratories Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
US5439915A (en) * 1994-10-20 1995-08-08 American Home Products Corporation Pyrido[3,4-B]indole carboxamide derivatives as serotonergic agents
US5605906A (en) * 1995-03-24 1997-02-25 Merck Frosst Canada, Inc. Cannabinoid receptor agonists
ZA9610738B (en) * 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof

Also Published As

Publication number Publication date
ZA97672B (en) 1997-08-04
TW427978B (en) 2001-04-01
HUP9700273A1 (hu) 1999-08-30
US5952344A (en) 1999-09-14
PL318256A1 (en) 1997-08-04
GB2309642A (en) 1997-08-06
CO4761069A1 (es) 1999-04-27
ES2124672A1 (es) 1999-02-01
AU723586B2 (en) 2000-08-31
ID15866A (id) 1997-08-14
CN1167762A (zh) 1997-12-17
US6071929A (en) 2000-06-06
IL120100A (en) 2001-01-28
FR2744447B1 (fr) 2000-09-29
ITMI970153A1 (it) 1998-07-28
MA24078A1 (fr) 1997-10-01
SG55273A1 (en) 1998-12-21
GB9702049D0 (en) 1997-03-19
NZ314130A (en) 1998-04-27
CZ29497A3 (en) 1997-08-13
KR970061871A (ko) 1997-09-12
TR199700071A2 (tr) 1997-08-21
FR2744447A1 (fr) 1997-08-08
IL120100A0 (en) 1997-04-15
YU3997A (sh) 1999-09-27
ES2124672B1 (es) 1999-11-16
JP3217290B2 (ja) 2001-10-09
CA2196392A1 (en) 1997-08-04
AR005613A1 (es) 1999-06-23
HRP970060A2 (en) 1998-04-30
JPH09221474A (ja) 1997-08-26
BR9700816A (pt) 1998-07-07
IT1289621B1 (it) 1998-10-15
PE35698A1 (es) 1998-07-16
AU1233597A (en) 1997-08-07
KR100229298B1 (ko) 1999-11-01
NO970431D0 (no) 1997-01-31
HU9700273D0 (en) 1997-03-28
DE19703985A1 (de) 1997-10-30

Similar Documents

Publication Publication Date Title
MY119150A (en) Azetidine derivatives, their preparation and medicaments containing them
MY117896A (en) Quinazoline derivatives
NO20073465L (no) Benzotiazol-derivater
NZ514487A (en) Carbamic acid derivatives and their use as metabotropic glutamate receptor ligands
ATE157346T1 (de) Hexahydronapththalinesterderivate, ihre herstellung und ihre therapeutischen verwendungen
NO990433L (no) Nye forbindelser og blandinger for behandling av sykdommer i forbindelse med tryptase-aktivitet
NO20001514L (no) Vitronectin-reseptor-antagonist
DK132188D0 (da) Anvendelse af tetrahydrobenz(c,d)indol-6-carboxamider som anxiolytika
NO975094L (no) Vinylpyrrolidoncefalosporinderivater
DK0526313T3 (da) Nye ureaderivater, deres fremstilling og terapeutiske anvendelse
ATE26273T1 (de) 3-indolcarboxamid-verbindungen.
NO970431L (no) Tetrahydroisokinolin-derivater
SE9702716D0 (sv) Substituted phenylazacycloalkanes in the treatment of cognitive disorders
DE69828197D1 (de) Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut
ATE196080T1 (de) Verwendung von diphenylethanderivaten zur herstellung eines arzneimittels zur behandlung von glaukom
AU1878297A (en) Use of 4-phenyl-3,6-dihydro-2h-pyridyl derivatives as nmda receptor subtype blockers
NO976024L (no) Anvendelse av N-cykloheksylbenzamider for å behandle tarmlidelser
ES2102295A1 (es) Nuevos compuestos derivados de la n-benzoilmetil-piperidina.
NZ332687A (en) use of 1-methyl-carbapenem derivatives as anti-helicobacter pylori agents
NO934227L (no) Pyrrolderivater, fremgangsmåte for deres fremstilling og terapeutiske anvendelse
SE9801516D0 (sv) M100907/4-Piperidinemethanol derivatives for autism
ZA939153B (en) Use of idazoxan and its derivatives for the preparation of a medicinal product intended for the treatment of parkinson's disease and its development
BR9708922A (pt) Piridil-e pirimidil-piperazinas no tratamento de doenças causadas por substâncias usadas em excesso
ZA917141B (en) 3-(1h-indazol-3-yl)-4-pyridinamines,a process and intermediates for their preparation and their use as medicaments
MX9700775A (es) Derivados de tetrahidroisoquinolina.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application