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NO964434L - Bicykliske tiofenderivater og anvendelse som gonadotropinfrigivende hormonantagonister - Google Patents

Bicykliske tiofenderivater og anvendelse som gonadotropinfrigivende hormonantagonister

Info

Publication number
NO964434L
NO964434L NO964434A NO964434A NO964434L NO 964434 L NO964434 L NO 964434L NO 964434 A NO964434 A NO 964434A NO 964434 A NO964434 A NO 964434A NO 964434 L NO964434 L NO 964434L
Authority
NO
Norway
Prior art keywords
agent
cancer
releasing hormone
homo
hetero
Prior art date
Application number
NO964434A
Other languages
English (en)
Other versions
NO964434D0 (no
Inventor
Shuichi Furuya
Nobuo Choh
Koichi Kato
Shuj Hinuma
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO964434L publication Critical patent/NO964434L/no
Publication of NO964434D0 publication Critical patent/NO964434D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En gonadotropinfrlgivende horroonantagonistlsk sanroensetning som omfatter en eventuelt substituert, kondensert- blcyklisk forbindelse omfattende en homo- eller hetero-, 5- til 7-ledds ring og en homo- eller hetero-, 5- til 7-ledds ring slik som forbindelser med formel (I) eller (II) i" OD (CH^n-E1 er effektive som et profylaktisk eller terapeutisk middel for forhindring eller behandling av forskjellige honnonavhengige sykdommer, f.eks. kjønnshormonavhengig cancer, (f.eks. prostatacancer, cancer i uterine cervix, brystcancer, hypofyseadenoma), benign prostatisk hypertrofl, myoma l uterus, endoraetriose, for tidlig pubertet, amenorrhea, premenstruelt syndrom, polycystisk ovarisk syndrom og akne vulgarls; er effektiv som et fertilltets- kontrollerende middel for begge kjønn (f.eks. et gravldltetskontrollerende middel eler et menstruasjonscyklus- ,kontrollerende); det kan bli benyttet som et prevensjonsmiddel for hannkjønn og hunkjønn, som et ovulasjons- induserende middel for hunkjønn; kan bli benyttet som et infertllltetsbehandlende middel ved anvendelse av tllbakeslagseffekten som skyldes adminlstrasjonsstopp; er nyttig for modulering av østroscyklus hos dyr innen feltet husdyrhold, som et middel for forbedring av kvaliteten av kjøtt, eller for fremmlng av vekst hos dyr; det er også nyttig som et middel for fremming av gyting hos fisk.
NO964434A 1994-04-19 1996-10-18 Bicykliske tiofenderivater og anvendelse som gonadotropinfrigivende hormonantagonister NO964434D0 (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP8073294 1994-04-19
JP19554194 1994-08-19
JP27101094 1994-11-04
JP2071795 1995-02-08
JP4015195 1995-02-28
PCT/JP1995/000728 WO1995028405A1 (en) 1994-04-19 1995-04-14 Bicyclic thiophene derivatives and use as gonadotropin releasing hormone antagonists

Publications (2)

Publication Number Publication Date
NO964434L true NO964434L (no) 1996-10-18
NO964434D0 NO964434D0 (no) 1996-10-18

Family

ID=27520246

Family Applications (1)

Application Number Title Priority Date Filing Date
NO964434A NO964434D0 (no) 1994-04-19 1996-10-18 Bicykliske tiofenderivater og anvendelse som gonadotropinfrigivende hormonantagonister

Country Status (17)

Country Link
US (3) US5817819A (no)
EP (1) EP0756599B1 (no)
KR (1) KR970702282A (no)
CN (1) CN1092197C (no)
AT (1) ATE255113T1 (no)
AU (2) AU697472B2 (no)
CA (1) CA2186124A1 (no)
CZ (1) CZ290713B6 (no)
DE (1) DE69532194T2 (no)
FI (2) FI964195A (no)
HU (1) HUT76320A (no)
NO (1) NO964434D0 (no)
NZ (1) NZ283813A (no)
OA (1) OA10331A (no)
PL (1) PL316796A1 (no)
TW (1) TW449600B (no)
WO (1) WO1995028405A1 (no)

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Also Published As

Publication number Publication date
DE69532194T2 (de) 2004-09-09
CA2186124A1 (en) 1995-10-26
US6514988B1 (en) 2003-02-04
WO1995028405A1 (en) 1995-10-26
EP0756599A1 (en) 1997-02-05
HU9602884D0 (en) 1996-12-30
PL316796A1 (en) 1997-02-17
EP0756599B1 (en) 2003-11-26
FI964195A0 (fi) 1996-10-18
NZ283813A (en) 1998-11-25
AU697472B2 (en) 1998-10-08
FI964195A (fi) 1996-12-17
AU713116B2 (en) 1999-11-25
TW449600B (en) 2001-08-11
CZ302896A3 (en) 1997-05-14
FI20012326A (fi) 2001-11-28
US5817819A (en) 1998-10-06
KR970702282A (ko) 1997-05-13
HUT76320A (en) 1997-08-28
CN1146206A (zh) 1997-03-26
ATE255113T1 (de) 2003-12-15
CN1092197C (zh) 2002-10-09
OA10331A (en) 1997-10-07
AU2223995A (en) 1995-11-10
CZ290713B6 (cs) 2002-09-11
US6187788B1 (en) 2001-02-13
AU8316998A (en) 1998-11-05
DE69532194D1 (de) 2004-01-08
NO964434D0 (no) 1996-10-18

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