[go: up one dir, main page]

NO963651D0 - Fremstilling av fibrinogen i transgene dyr - Google Patents

Fremstilling av fibrinogen i transgene dyr

Info

Publication number
NO963651D0
NO963651D0 NO963651A NO963651A NO963651D0 NO 963651 D0 NO963651 D0 NO 963651D0 NO 963651 A NO963651 A NO 963651A NO 963651 A NO963651 A NO 963651A NO 963651 D0 NO963651 D0 NO 963651D0
Authority
NO
Norway
Prior art keywords
fibrinogen
dna segments
human
preparation
transgenic animals
Prior art date
Application number
NO963651A
Other languages
English (en)
Other versions
NO963651L (no
NO329072B1 (no
Inventor
Ian Garner
Michael A Dalrymple
Donna E Prunkard
Donald C Foster
Original Assignee
Zymogenetics Inc
Pharmaceutical Proteins Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22765288&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO963651(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zymogenetics Inc, Pharmaceutical Proteins Ltd filed Critical Zymogenetics Inc
Publication of NO963651D0 publication Critical patent/NO963651D0/no
Publication of NO963651L publication Critical patent/NO963651L/no
Publication of NO329072B1 publication Critical patent/NO329072B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4717—Plasma globulins, lactoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4732—Casein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/103—Ovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO19963651A 1994-03-03 1996-09-02 Fremgangsmate for fremstilling av fibrinogen, fremgangsmate for fremstilling av et transgent avkom fra et ikke-humant pattedyr, samt ikke-humant pattedyr. NO329072B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/206,176 US5639940A (en) 1994-03-03 1994-03-03 Production of fibrinogen in transgenic animals
PCT/US1995/002648 WO1995023868A1 (en) 1994-03-03 1995-03-01 Production of fibrinogen in transgenic animals

Publications (3)

Publication Number Publication Date
NO963651D0 true NO963651D0 (no) 1996-09-02
NO963651L NO963651L (no) 1996-11-01
NO329072B1 NO329072B1 (no) 2010-08-16

Family

ID=22765288

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19963651A NO329072B1 (no) 1994-03-03 1996-09-02 Fremgangsmate for fremstilling av fibrinogen, fremgangsmate for fremstilling av et transgent avkom fra et ikke-humant pattedyr, samt ikke-humant pattedyr.

Country Status (20)

Country Link
US (2) US5639940A (no)
EP (1) EP0748386B9 (no)
JP (1) JPH09509839A (no)
CN (1) CN1079433C (no)
AT (1) ATE298801T1 (no)
AU (1) AU685250B2 (no)
BR (1) BR9506944A (no)
CA (1) CA2184004C (no)
CZ (1) CZ296382B6 (no)
DE (1) DE69534295T4 (no)
DK (1) DK0748386T4 (no)
ES (1) ES2245453T5 (no)
FI (1) FI963419A0 (no)
HU (1) HU224550B1 (no)
NO (1) NO329072B1 (no)
NZ (1) NZ282601A (no)
PL (1) PL186074B1 (no)
PT (1) PT748386E (no)
SK (1) SK111896A3 (no)
WO (1) WO1995023868A1 (no)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09512710A (ja) * 1994-05-02 1997-12-22 イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド 組換えフィブリン鎖、フィブリンおよびフィブリン−ホモログ
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
GB9715064D0 (en) * 1997-07-17 1997-09-24 Ppl Therapeutics Scotland Ltd Protein expression
WO1999044625A1 (en) 1998-03-03 1999-09-10 John Hopkins University Smallpox inhibitor of complement enzymes (spice) protein and methods of inhibiting complement activation
US7122620B1 (en) 1998-05-27 2006-10-17 Medical Research Services And Development Ltd. Haptotactic peptides
ATE385805T1 (de) * 1998-05-27 2008-03-15 Hadasit Med Res Service Neue peptide
ES2267289T3 (es) * 1998-09-24 2007-03-01 Pharming Intellectual Property Bv Purificacion de fibrinogeno a partir de fluidos mediante precipitacion y cromatografia de interaccion hidrofoba.
GB9825374D0 (en) * 1998-11-19 1999-01-13 Ppl Therapeutics Scotland Ltd Method
DE69940700D1 (de) 1998-11-19 2009-05-20 Pharming Intellectual Pty Bv Stabilisierung der milch transgener tieren
WO2000040693A2 (en) 1999-01-06 2000-07-13 Atlantic Biopharmaceuticals, Inc. Expression of secreted human alpha-fetoprotein in transgenic animals
US7208576B2 (en) * 1999-01-06 2007-04-24 Merrimack Pharmaceuticals, Inc. Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof
US6183803B1 (en) 1999-06-11 2001-02-06 Biosante Pharmaceuticals, Inc. Method for processing milk
HUP0203537A2 (hu) * 1999-10-14 2003-02-28 Genzyme Transgenics Corporation Célmolekula transzgénikus állatban történő előállítására és tisztítására szolgáló eljárások
EP1287013A2 (en) * 1999-12-27 2003-03-05 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
AU2001254967B2 (en) * 2000-05-13 2005-06-23 Bioacta Ltd Anti-angiogenic polypeptides
CA2420765A1 (en) * 2000-09-01 2002-03-07 Bioacta Ltd Anti-angiogenic peptides
EP2325337A1 (en) 2000-09-26 2011-05-25 Duke University RNA aptamers and methods for identifying the same
MXPA03004313A (es) * 2000-11-17 2007-02-27 Hematech Llc Expresion de inmunoglobulinas xenogenas (humanas) en ungulados transgenicos, clonados.
US20020073441A1 (en) 2000-12-13 2002-06-13 Ross Brian D. Compositions and methods for detecting proteolytic activity
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
EP1497418B1 (en) 2002-04-19 2012-10-17 Verenium Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
DE10261126A1 (de) * 2002-08-13 2004-03-04 Aventis Behring Gmbh Lagerungsstabile, flüssige Fibrinogen-Formulierung
IL152609A0 (en) * 2002-11-03 2003-06-24 Hapto Biotech Inc Liposomal compositions comprising haptotactic peptides and uses thereof
JP2006505291A (ja) 2002-11-08 2006-02-16 ヘマテック，エルエルシー プリオンタンパク質活性が低減されたトランスジェニック有蹄動物及びその用途
AU2003296085A1 (en) * 2002-12-24 2004-07-22 Nitto Boseki Co., Ltd. Marker proteins for diagnosing liver disease and method of diagnosing liver disease using the same
EP3023498B1 (en) 2003-03-06 2018-11-28 BASF Enzymes LLC Amylases, nucleic acids encoding them and methods for making and using them
EP3299465A1 (en) 2003-03-07 2018-03-28 DSM IP Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
ES2598037T3 (es) 2003-04-04 2017-01-24 Basf Enzymes Llc Pectato liasas, ácidos nucleicos que las codifican y métodos para su preparación y uso
US7514593B2 (en) 2003-05-30 2009-04-07 The University Of North Carolina At Chapel Hill Animal model for chronic obstructive pulmonary disease and cystic fibrosis
CN108486086A (zh) 2003-07-02 2018-09-04 维莱尼姆公司 葡聚糖酶，编码它们的核酸以及制备和使用它们的方法
WO2005021714A2 (en) 2003-08-11 2005-03-10 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
CA2537273A1 (en) * 2003-09-05 2005-03-17 Gtc Biotherapeutics, Inc. Method for the production of fusion proteins in transgenic mammal milk
US20050186608A1 (en) * 2004-02-19 2005-08-25 Olsen Byron V. Method for the production of transgenic proteins useful in the treatment of obesity and diabetes
DE102004009400A1 (de) 2004-02-24 2005-09-08 Zlb Behring Gmbh Fibrinogen Reinigung
CN101014715A (zh) 2004-04-22 2007-08-08 麒麟麦酒株式会社 转基因动物及其用途
EP2468853B1 (en) 2004-06-16 2015-04-01 DSM IP Assets B.V. Method for enzymatic decolorization of pheophytin
US7897337B2 (en) * 2005-03-10 2011-03-01 Gen-Probe Incorporated Method for performing multi-formatted assays
CA2614769A1 (en) 2005-03-10 2006-09-21 Verenium Corporation Lyase enzymes, nucleic acids encoding them and methods for making and using them
NZ561247A (en) 2005-03-15 2010-06-25 Verenium Corp Beta-glucosidases, nucleic acids encoding them and methods for making and using them
WO2007092314A2 (en) 2006-02-02 2007-08-16 Verenium Corporation Esterases and related nucleic acids and methods
CN103602692A (zh) 2006-02-10 2014-02-26 维莱尼姆公司 纤维素分解酶、其编码核酸及制备和使用它们的方法
BRPI0707784B1 (pt) 2006-02-14 2018-05-22 Verenium Corporation Ácido nucléico isolado, sintético ou recombinante, cassete de expressão, vetor ou veículo de clonagem, célula hospedeira isolada transformada, e método para produção de um polipeptídeo recombinante
WO2007103447A2 (en) 2006-03-06 2007-09-13 Humagene, Inc. A method for the preparation of recombinant human thrombin
JP5441417B2 (ja) 2006-03-07 2014-03-12 カーギル・インコーポレイテッド アルドース、それをコードする核酸、ならびにそれを生成および使用する方法
CN105063072A (zh) 2006-03-07 2015-11-18 巴斯夫酶有限责任公司 醛缩酶、编码它们的核酸及制备和使用它们的方法
US8124831B2 (en) * 2006-07-06 2012-02-28 Duke University Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
CN103397043A (zh) 2006-08-04 2013-11-20 维莱尼姆公司 葡聚糖酶、编码它们的核酸及制备和使用它们的方法
BRPI0716872A2 (pt) 2006-09-21 2015-06-16 Verenium Corp Fosfolipases, ácidos nucléicos codificando-as e métodos para fabricação e uso delas
EP2617729B1 (en) 2006-09-21 2016-03-16 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
DK2479266T3 (en) 2006-12-21 2016-06-20 Basf Enzymes Llc Amylases and glucoamylases, nucleic acids encoding them, and methods of making and using the same
WO2008124724A1 (en) 2007-04-09 2008-10-16 University Of Florida Research Foundation, Inc. Raav vector compositions having tyrosine-modified capsid proteins and methods for use
MX2010003600A (es) 2007-10-03 2010-12-14 Verenium Corp Xilanasas, acidos nucleicos que las codifican, y metodos para hacerlas y usarlas.
WO2009058881A1 (en) * 2007-10-29 2009-05-07 The University Of California Osteoarthritis gene therapy
DK2238242T5 (en) 2008-01-03 2015-08-03 Basf Enzymes Llc -Transferases and oxidoreductases, nucleic acids encoding FOR THEM, AND PROCESSES FOR THE STILL LING AND USE THEREOF
DK2238261T3 (da) 2008-01-03 2014-02-10 Verenium Corp Isomeraser, nukleinsyrer der koder for dem og fremgangsmåder til fremstilling og anvendelse deraf
US8557773B2 (en) 2008-05-02 2013-10-15 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Treatment of bleeding with low half-life fibrinogen
BRPI0915574A2 (pt) * 2008-07-09 2016-07-26 Profibrix Bv sequência nucleotídica, construção nucleotídica, célula ou linhagem celular, método para produção de fibrinogênio em um sistema de cultura de célula eucariótica, preparação de fibrinogênio, uso da preparação de fibrinogênio, método para seleção de célula ou linhagem celular
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
CN102216459A (zh) 2008-09-15 2011-10-12 弗·哈夫曼-拉罗切有限公司 调节细胞摩尔渗透压浓度的组合物和方法
DK2432797T3 (en) 2009-05-21 2017-01-16 Basf Enzymes Llc PHYTASES, NUCLEIC ACIDS, CODING THESE, AND METHODS OF PRODUCING AND USING THEREOF
US20100304873A1 (en) * 2009-05-28 2010-12-02 Lipa Markowitz Bowling Ball and Football Game Controller
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
DK2521566T3 (en) 2010-01-08 2014-12-08 Profibrix Bv Fibrinogen preparations enriched with fibrinogen with an extended alpha chain
US9546381B2 (en) 2010-03-17 2017-01-17 Pharming Intellectual Property Bv Use of anticoagulants in the production of recombinant proteins in the milk of transgenic animals
US9816108B2 (en) 2010-04-23 2017-11-14 University Of Florida Research Foundation, Inc. rAAV-guanylate cyclase compositions and methods for treating lebers congenital amaurosis-1 (LCA1)
MX2015010427A (es) 2013-02-13 2016-03-17 Lab Francais Du Fractionnement Anticuerpos anti-tnf-alfa altamente galactosilados y sus usos.
US10034921B2 (en) 2013-02-13 2018-07-31 Laboratoire Français Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
BR112016014804A2 (pt) * 2013-12-24 2017-08-08 Lfb Usa Inc Método para produzir heparina, mamífero não humano transgênico, células epiteliais mamárias, heparina, e, composição
CN103995077B (zh) * 2014-05-21 2016-01-27 中国计量科学研究院 一种测定奶粉中β-乳球蛋白含量的方法
FR3032621A1 (fr) 2015-02-13 2016-08-19 Lab Francais Du Fractionnement Colle biologique et son utilisation comme medicament
CN107636011B (zh) * 2015-03-20 2021-07-02 巴黎笛卡尔大学 特别在皮肤炎性疾病中用作药物的来自血纤蛋白原的分离的肽及其片段
KR101841587B1 (ko) 2016-01-12 2018-05-14 주식회사 녹십자홀딩스 피브리노겐의 정제방법
CN109689088A (zh) 2016-07-06 2019-04-26 法国血液分割暨生化制品实验室 稳定的液体纤维蛋白原
AU2019258504B2 (en) * 2018-04-24 2020-03-12 Fibriant B.V. Therapeutic uses of fibrinogen gamma prime variants
US11266129B2 (en) 2019-11-05 2022-03-08 Versiti Blood Research Institute Foundation, Inc. Murine model of fetal/neonatal alloimmune thrombocytopenia
CN114630579B (zh) 2019-11-05 2024-12-17 弗尔斯蒂血液研究所基金会股份有限公司 胎儿/新生儿同种免疫性血小板减少症的鼠模型
WO2024261097A1 (en) 2023-06-20 2024-12-26 Institut National de la Santé et de la Recherche Médicale A new relevant non-human animal model of progressive metabolic dysfunction-associated steatotic liver disease (masld) and atherosclerosis development

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT359653B (de) 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
AT359652B (de) 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4442655A (en) 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
US4462567A (en) 1982-10-28 1984-07-31 Helmut Habicht Discharge valve for granular materials
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US4627879A (en) 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5366894A (en) 1986-06-30 1994-11-22 Pharmaceutical Proteins Limited Peptide production
GB8615942D0 (en) * 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
EP0279582A3 (en) * 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
CA1340740C (en) 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
AT397203B (de) 1988-05-31 1994-02-25 Immuno Ag Gewebeklebstoff
US5087353A (en) 1988-11-03 1992-02-11 Ecological Engineering Associates Solar aquatic apparatus for treating waste
GB8826446D0 (en) * 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
US5204447A (en) 1988-11-14 1993-04-20 Zymogenetics, Inc. Purification of factor xiii
DE3928628C1 (no) 1989-08-30 1990-10-11 Kurt 5060 Bergisch Gladbach De Munny
ATE140027T1 (de) * 1989-12-01 1996-07-15 Pharming Bv Herstellung rekombinanter polypeptide durch rinder und transgene methoden
GB9028062D0 (en) * 1990-12-24 1991-02-13 Agricultural & Food Res Production of transgenic animals
AU1228592A (en) * 1991-01-11 1992-08-17 American Red Cross Expression of active human protein c in mammary tissue of transgenic animals
US5272074A (en) 1992-04-23 1993-12-21 Mcmaster University Fibrin coated polymer surfaces

Also Published As

Publication number Publication date
DK0748386T4 (da) 2010-02-15
PT748386E (pt) 2005-11-30
DE69534295T3 (de) 2010-07-01
ES2245453T3 (es) 2006-01-01
NZ282601A (en) 1997-06-24
SK111896A3 (en) 1997-07-09
AU685250B2 (en) 1998-01-15
EP0748386B1 (en) 2005-06-29
HU224550B1 (hu) 2005-10-28
US5639940A (en) 1997-06-17
PL316115A1 (en) 1996-12-23
ES2245453T5 (es) 2010-04-28
CZ257596A3 (en) 1997-06-11
DE69534295D1 (de) 2005-08-04
CZ296382B6 (cs) 2006-03-15
EP0748386A1 (en) 1996-12-18
FI963419A (fi) 1996-09-02
PL186074B1 (pl) 2003-10-31
NO963651L (no) 1996-11-01
HUT75552A (en) 1997-05-28
CA2184004A1 (en) 1995-09-08
EP0748386B2 (en) 2009-12-02
WO1995023868A1 (en) 1995-09-08
ATE298801T1 (de) 2005-07-15
DE69534295T2 (de) 2006-04-27
USRE42704E1 (en) 2011-09-13
HU9602404D0 (en) 1996-10-28
CN1079433C (zh) 2002-02-20
FI963419A0 (fi) 1996-09-02
DE69534295T4 (de) 2011-03-03
JPH09509839A (ja) 1997-10-07
EP0748386B9 (en) 2010-08-04
NO329072B1 (no) 2010-08-16
AU1977095A (en) 1995-09-18
BR9506944A (pt) 1997-09-09
CA2184004C (en) 2000-08-01
DK0748386T3 (da) 2005-10-24
CN1144539A (zh) 1997-03-05

Similar Documents

Publication Publication Date Title
NO963651D0 (no) Fremstilling av fibrinogen i transgene dyr
ATE140027T1 (de) Herstellung rekombinanter polypeptide durch rinder und transgene methoden
IL83028A (en) Heterologous protein production in transgenic mammals'mammary glands
DK0701608T3 (da) Embryostamceller til at fremstille kimære og transgene ungulatae
HK1044174A1 (zh) 通過胞質內精子注射進行哺乳動物基因轉移
DE3854555D1 (de) Expression von proteinen in milch.
DK0814159T3 (da) Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
EP0662138B8 (en) Long wap promoter for mammary expression of human protein c
AU1909695A (en) Transgenic non-human mammals with progressive neurologic disease
DE59712068D1 (de) Verfahren zur herstellung von säugetieren mit definierten genetischen eigenschaften
ATE356203T1 (de) Kerntransfer mit differenzierten fötalen und adulten spenderzellen
ATE405167T1 (de) Kollagenherstellung in der milch von transgenen säugetieren
ATE312167T1 (de) Herstellung embryonischer vogel keimzellinien durch verlängerte kultivierung von pgcs, verwendung desselben zur klonierung und chimerisierung
DK0744891T3 (da) Transgene fibrinogener
WO2000011151A3 (en) Direct oviduct transgenesis
DK326788D0 (da) Fremgangsmaade til fremstilling af en cellelinje
NZ511808A (en) Transgenic bovine that produce the heterologous protein in milk

Legal Events

Date Code Title Description
ERR Erratum

Free format text: I PATENTTIDENDE NR. 44/07 BLE PATENTSOKNAD NR. 19963651 FEILAKTIG KUNNGJORT HENLAGT. SOKNADEN ER FORTSATT UNDER BEHANDLING

MM1K Lapsed by not paying the annual fees