NO953967L - Indolderivater som 5-HT1A og/eller 5-HT2 ligander - Google Patents

Indolderivater som 5-HT1A og/eller 5-HT2 ligander

Info

Publication number: NO953967L
Authority: NO; Norway
Prior art keywords: indole derivatives; ht1a; ligands; derivatives; processes
Prior art date: 1993-04-08

Application number

NO953967A

Other languages

English (en)

Norwegian (no)

Other versions

NO953967D0 (no

Inventor

Myrna Gil Quintero

Vincenzo Martino

Franco Borsini

Carlo Maria Pellegrini

Marco Turconi

Ettore Giraldo

Original Assignee

Boehringer Ingelheim Italia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-08

Filing date

1995-10-05

Publication date

1995-12-05

1995-10-05 Application filed by Boehringer Ingelheim Italia filed Critical Boehringer Ingelheim Italia

1995-10-05 Publication of NO953967D0 publication Critical patent/NO953967D0/no

1995-12-05 Publication of NO953967L publication Critical patent/NO953967L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Catalysts (AREA)

NO953967A 1993-04-08 1995-10-05 Indolderivater som 5-HT1A og/eller 5-HT2 ligander NO953967L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI930699A IT1271352B (it)	1993-04-08	1993-04-08	Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
PCT/EP1994/001016 WO1994024125A1 (en)	1993-04-08	1994-03-31	Indole derivatives as 5-ht1a and/or 5-ht2 ligands

Publications (2)

Publication Number	Publication Date
NO953967D0 NO953967D0 (no)	1995-10-05
NO953967L true NO953967L (no)	1995-12-05

Family

ID=11365694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO953967A NO953967L (no)	1993-04-08	1995-10-05	Indolderivater som 5-HT1A og/eller 5-HT2 ligander

Country Status (20)

Country	Link
US (1)	US5834493A (pt)
EP (1)	EP0694033A1 (pt)
JP (1)	JPH08508738A (pt)
CN (1)	CN1124960A (pt)
AU (1)	AU684276B2 (pt)
BG (1)	BG100040A (pt)
BR (1)	BR9406206A (pt)
CA (1)	CA2160020A1 (pt)
CZ (1)	CZ283398B6 (pt)
FI (1)	FI954734A0 (pt)
HU (1)	HUT74090A (pt)
IL (1)	IL109234A (pt)
IT (1)	IT1271352B (pt)
NO (1)	NO953967L (pt)
NZ (1)	NZ265055A (pt)
PL (1)	PL310995A1 (pt)
SG (1)	SG50507A1 (pt)
SK (1)	SK119795A3 (pt)
WO (1)	WO1994024125A1 (pt)
ZA (1)	ZA942383B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9420521D0 (en) *	1994-10-12	1994-11-30	Smithkline Beecham Plc	Novel compounds
BR9808740A (pt) *	1997-05-09	2000-10-03	Lundbeck & Co As H	Método para fabricação de sertindol
US6673827B1 (en)	1999-06-29	2004-01-06	The Uab Research Foundation	Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
US6861448B2 (en) *	1998-01-14	2005-03-01	Virtual Drug Development, Inc.	NAD synthetase inhibitors and uses thereof
WO1999036422A1 (en)	1998-01-14	1999-07-22	The Uab Research Foundation	Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme
US6133287A (en) *	1998-03-24	2000-10-17	Allelix Biopharmaceuticals Inc.	Piperidine-indole compounds having 5-HT6 affinity
ES2182509T3 (es) *	1998-04-08	2003-03-01	Wyeth Corp	Derivados de n-ariloxietilamina para el tratamiento de la depresion.
JP2002513018A (ja) *	1998-04-29	2002-05-08	アメリカン・ホーム・プロダクツ・コーポレイション	セロトニン作動薬
FR2799463B1 (fr) *	1999-10-12	2004-04-16	Adir	Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
DE19951360A1 (de) *	1999-10-26	2001-05-03	Aventis Pharma Gmbh	Substituierte Indole
US6503894B1 (en)	2000-08-30	2003-01-07	Unimed Pharmaceuticals, Inc.	Pharmaceutical composition and method for treating hypogonadism
PL363238A1 (en)	2000-12-22	2004-11-15	Wyeth	Heterocyclylalkylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands
US7135479B2 (en)	2002-09-12	2006-11-14	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
CA2796756A1 (en) *	2010-04-22	2011-10-27	Intra-Cellular Therapies, Inc.	Substituted pyrido(3',4':4,5)pyrrolo(1,2,3-de)quinoxalines for the treatment of central nervous system disorders
EP2836213B1 (en)	2012-04-14	2018-07-04	Intra-Cellular Therapies, Inc.	Fused gamma carbolines
DK2968320T3 (da)	2013-03-15	2021-02-01	Intra Cellular Therapies Inc	Organiske forbindelser
IL305990A (en)	2013-12-03	2023-11-01	Intra Cellular Therapies Inc	Compressed gamma-carboline heterocyclic compounds are modified for use in the treatment of type I and/or type II bipolar disorders
KR20170012209A (ko)	2014-04-04	2017-02-02	인트라-셀룰라 써래피스, 인코퍼레이티드.	유기 화합물
MX365969B (es)	2014-04-04	2019-06-21	Intra Cellular Therapies Inc	Gamma-carbolinas fusionadas con heterociclos sustituidas con deuterio.
WO2017023894A1 (en) *	2015-08-03	2017-02-09	Raze Therapeutics, Inc.	Mthfd2 inhibitors and uses thereof
DK3407888T3 (da)	2016-01-26	2021-04-06	Intra Cellular Therapies Inc	Pyridopyrroloquinoxalinforbindelser, deres sammensætninger og anvendelser
PL3407889T3 (pl)	2016-03-25	2021-11-22	Intra-Cellular Therapies, Inc.	Związki organiczne i ich zastosowanie w leczeniu lub zapobieganiu zaburzeniom ośrodkowego układu nerwowego
WO2017172795A1 (en)	2016-03-28	2017-10-05	Intra-Cellular Therapies, Inc.	Novel compositions and methods
WO2018071233A1 (en)	2016-10-12	2018-04-19	Intra-Cellular Therapies, Inc.	Amorphous solid dispersions
WO2018126140A1 (en)	2016-12-29	2018-07-05	Intra-Cellular Therapies, Inc.	Organic compounds
EP3562484B1 (en)	2016-12-29	2021-08-25	Intra-Cellular Therapies, Inc.	Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders
US10716786B2 (en)	2017-03-24	2020-07-21	Intra-Cellular Therapies, Inc.	Transmucosal and subcutaneous compositions
WO2019023063A1 (en)	2017-07-26	2019-01-31	Intra-Cellular Therapies, Inc.	ORGANIC COMPOUNDS
EP3658145A4 (en)	2017-07-26	2021-04-21	Intra-Cellular Therapies, Inc.	ORGANIC COMPOUNDS
WO2019237037A1 (en)	2018-06-08	2019-12-12	Intra-Cellular Therapies, Inc.	Novel methods
WO2020047241A1 (en)	2018-08-29	2020-03-05	Intra-Cellular Therapies, Inc.	Novel compositions and methods
US10695345B2 (en)	2018-08-31	2020-06-30	Intra-Cellular Therapies, Inc.	Pharmaceutical capsule compositions comprising lumateperone mono-tosylate
CA3108553A1 (en)	2018-08-31	2020-03-05	Intra-Cellular Therapies, Inc.	Novel methods
CA3141223A1 (en)	2019-07-07	2021-01-14	Sharon Mates	Novel methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0429341A3 (en) *	1989-11-20	1991-11-13	Rhone-Poulenc Sante	Heterocyclic derivatives, their preparation and pharmaceuticals containing them
DK0592438T5 (da) *	1990-10-15	1999-12-06	Pfizer Inc.	Indolderivater
JP3140155B2 (ja) *	1992-03-09	2001-03-05	杏林製薬株式会社	Ｎ，ｎ’−ジ置換アミド誘導体
CA2092112A1 (en) *	1992-03-23	1993-09-24	Nobuyoshi Iwata	Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

1993
- 1993-04-08 IT ITMI930699A patent/IT1271352B/it active IP Right Grant
1994
- 1994-03-31 PL PL94310995A patent/PL310995A1/xx unknown
- 1994-03-31 CN CN94192345A patent/CN1124960A/zh active Pending
- 1994-03-31 JP JP6522684A patent/JPH08508738A/ja active Pending
- 1994-03-31 SG SG1996002949A patent/SG50507A1/en unknown
- 1994-03-31 BR BR9406206A patent/BR9406206A/pt not_active Application Discontinuation
- 1994-03-31 CZ CZ952602A patent/CZ283398B6/cs unknown
- 1994-03-31 SK SK1197-95A patent/SK119795A3/sk unknown
- 1994-03-31 US US08/530,354 patent/US5834493A/en not_active Expired - Fee Related
- 1994-03-31 NZ NZ265055A patent/NZ265055A/en unknown
- 1994-03-31 EP EP94913101A patent/EP0694033A1/en not_active Withdrawn
- 1994-03-31 AU AU65382/94A patent/AU684276B2/en not_active Ceased
- 1994-03-31 WO PCT/EP1994/001016 patent/WO1994024125A1/en not_active Application Discontinuation
- 1994-03-31 CA CA002160020A patent/CA2160020A1/en not_active Abandoned
- 1994-03-31 HU HU9502913A patent/HUT74090A/hu unknown
- 1994-04-06 IL IL109234A patent/IL109234A/en not_active IP Right Cessation
- 1994-04-07 ZA ZA942383A patent/ZA942383B/xx unknown
1995
- 1995-10-02 BG BG100040A patent/BG100040A/bg unknown
- 1995-10-05 NO NO953967A patent/NO953967L/no unknown
- 1995-10-05 FI FI954734A patent/FI954734A0/fi unknown

Also Published As

Publication number	Publication date
IT1271352B (it)	1997-05-27
FI954734A (fi)	1995-10-05
SG50507A1 (en)	1998-07-20
US5834493A (en)	1998-11-10
CN1124960A (zh)	1996-06-19
HUT74090A (en)	1996-11-28
JPH08508738A (ja)	1996-09-17
IL109234A0 (en)	1994-07-31
SK119795A3 (en)	1996-04-03
CZ260295A3 (en)	1996-01-17
WO1994024125A1 (en)	1994-10-27
EP0694033A1 (en)	1996-01-31
IL109234A (en)	1998-04-05
HU9502913D0 (en)	1995-11-28
BG100040A (bg)	1996-03-29
ZA942383B (en)	1995-10-09
FI954734A0 (fi)	1995-10-05
ITMI930699A0 (it)	1993-04-08
NZ265055A (en)	1996-09-25
CA2160020A1 (en)	1994-10-27
AU684276B2 (en)	1997-12-11
AU6538294A (en)	1994-11-08
CZ283398B6 (cs)	1998-04-15
ITMI930699A1 (it)	1994-10-08
PL310995A1 (en)	1996-01-22
NO953967D0 (no)	1995-10-05
BR9406206A (pt)	1996-02-06

Publication	Publication Date	Title
NO953967L (no)	1995-12-05	Indolderivater som 5-HT1A og/eller 5-HT2 ligander
NO961687D0 (no)	1996-04-26	Nye (R)-5-karbamoyl-8-fluor-3-N,N-disubstituerte-amino-3,4-dihydro-2H-1-benzopyraner
CA2148928A1 (en)	1995-04-13	Pharmacologically active pyridine derivatives and processes for the preparation thereof
YU48765B (en)	1999-11-22	Amides isoxasole - 4 - carbon acid and amides of hidroxy-alkiliden ciano vinegar acid and the procedure for obtaining pharmaceutic preparations containing those compounds
IL104006A0 (en)	1993-05-13	Azaheterocyclylmethyl-chromans,their preparation and pharmaceutical compositions containing them
CA2012876A1 (en)	1990-09-22	Use of 5-methyltetrahydrofolic acid and 5-formyltetrahydrofolic acid in the treatment of organic mental disturbances
HUT61543A (en)	1993-01-28	Process for producing serotonin antagonist indole derivatives and pharmaceutical compositions comprising same as active ingredient
NO883229L (no)	1988-09-16	Nye benzimidazolderivater, fremgangsmaate for deres fremstilling og farmasoeytisk preparat inneholdende slike derivater.
DE69523155D1 (de)	2001-11-15	Benzimidazolonderivate mit zentraler dopaminerger aktivität
MX9403088A (es)	1997-02-28	Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso.
DK0825197T3 (da)	2000-10-30	Nye 6-hydroxy- og 6-oxo-androstanderivater, der er aktive i forhold til det cardiovaskulære system, og farmaceutiske præpar
ATE242220T1 (de)	2003-06-15	Benzimidazolderivate mit dopaminerger wirkung
ATE229953T1 (de)	2003-01-15	Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
DK162440C (da)	1992-03-23	Pyrazindiazohydroxidforbindelser
UA27738C2 (uk)	2000-10-16	2,3,4,5,6,7-гексагідро-1-[4-[1-[4-(2метоксифеніл)піперазиніл]]-2-фенілбутирил]-1н-азепін або його фармацевтично прийнятна кислотно-адитивна сіль, що мають властивість пов'язувати рецептор 5нт1а, спосіб (варіанти) їх одержання, фармацевтична композиція
NO970498L (no)	1997-02-04	Benzimidazolderivater med dopaminergisk aktivitet