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NO944966L - Multimeric forms of human rhinovirus receptor protein - Google Patents

Multimeric forms of human rhinovirus receptor protein

Info

Publication number
NO944966L
NO944966L NO944966A NO944966A NO944966L NO 944966 L NO944966 L NO 944966L NO 944966 A NO944966 A NO 944966A NO 944966 A NO944966 A NO 944966A NO 944966 L NO944966 L NO 944966L
Authority
NO
Norway
Prior art keywords
human
human rhinovirus
hrv
receptor protein
multimeric
Prior art date
Application number
NO944966A
Other languages
Norwegian (no)
Other versions
NO944966D0 (en
Inventor
Jeffrey M Greve
Alan Mcclelland
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Publication of NO944966L publication Critical patent/NO944966L/en
Publication of NO944966D0 publication Critical patent/NO944966D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/085—Picornaviridae, e.g. coxsackie virus, echovirus, enterovirus
    • C07K14/095—Rhinovirus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Nye former og konfigurasjoner av intracellulært addlsjonsmolekyl (ICAM) inkludert multlmere konfigura- sjoner som effektivt blir bundet til humant rhlnovirus og som effektivt kan redusere HRV infiserbarheten. Når de er i en multlmer konfigurasjon, fortrinnsvis som dlmerer, utviser disse proteinene forsterket binding av HRV og kan også redusere HRV inflserbareheten samt infIserbarheten til andre vlruser kjent for å bli bundet til "hoved"-gruppe human rhlnovlrusreseptor (HRR). Multlmerlserte proteiner kan også bil anvendt for å blokkere tlCAM interaksjonen med lymfocytt funksjons-assoslert antigen-1 (LFA-1).New forms and configurations of intracellular addition molecule (ICAM), including multiple configurations that are efficiently bound to human rhinovirus and which can effectively reduce HRV infectivity. When in a multimeric configuration, preferably as a dimer, these proteins exhibit enhanced HRV binding and may also reduce HRV inflatability as well as infeasibility of other viruses known to be bound to the "major" human human immunodeficiency receptor (HRR) group. Multimeric proteins can also be used to block tCAM interaction with lymphocyte function-associated antigen-1 (LFA-1).

NO944966A 1992-06-22 1994-12-21 Multimeric forms of human rhinovirus receptor protein NO944966D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90306992A 1992-06-22 1992-06-22
PCT/US1993/005972 WO1994000485A1 (en) 1992-06-22 1993-06-22 Multimeric forms of human rhinovirus receptor protein

Publications (2)

Publication Number Publication Date
NO944966L true NO944966L (en) 1994-12-21
NO944966D0 NO944966D0 (en) 1994-12-21

Family

ID=25416893

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944966A NO944966D0 (en) 1992-06-22 1994-12-21 Multimeric forms of human rhinovirus receptor protein

Country Status (10)

Country Link
EP (1) EP0604624A4 (en)
JP (1) JPH06510208A (en)
KR (1) KR950702576A (en)
AU (1) AU675441B2 (en)
CA (1) CA2116109A1 (en)
FI (1) FI946006A0 (en)
HU (1) HUT75827A (en)
NO (1) NO944966D0 (en)
RU (1) RU94046450A (en)
WO (1) WO1994000485A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0362531B1 (en) 1988-09-01 1999-11-10 Bayer Corporation A human rhinovirus receptor protein that inhibits virus infectivity
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
GB9414966D0 (en) * 1994-07-26 1994-09-14 Danbiosyst Uk Pharmaceutical compositions for the nasal administration of antiviral agents
GB9520641D0 (en) * 1995-10-10 1995-12-13 Medical Res Council Improvements in or relating to protection against intracellular infection
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
EA034861B1 (en) * 2012-03-31 2020-03-30 Р-Фарм Интернешнл, Ооо (Общество С Ограниченной Ответственностью) Osteoprotegerin derived composition and method of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE125708T1 (en) * 1988-09-28 1995-08-15 Dana Farber Cancer Inst Inc INTERCELLULAR ADHESION MOLECULES AND THEIR BINDING LIGANDS.
ATE79270T1 (en) * 1989-03-09 1992-08-15 Boehringer Ingelheim Pharma USE OF INTERCELLULAR ADHAESION MOLECULES AND THEIR BINDING LIGANDS IN THE TREATMENT OF ASTHMA.
EP0468257B1 (en) * 1990-07-20 1999-09-01 Bayer Corporation Multimeric form of human rhinovirus receptor protein

Also Published As

Publication number Publication date
HUT75827A (en) 1997-05-28
HU9403720D0 (en) 1995-02-28
AU675441B2 (en) 1997-02-06
KR950702576A (en) 1995-07-29
CA2116109A1 (en) 1994-01-06
AU4543293A (en) 1994-01-24
RU94046450A (en) 1996-10-10
WO1994000485A1 (en) 1994-01-06
FI946006L (en) 1994-12-21
FI946006A0 (en) 1994-12-21
JPH06510208A (en) 1994-11-17
EP0604624A4 (en) 1997-03-12
NO944966D0 (en) 1994-12-21
EP0604624A1 (en) 1994-07-06

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application