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NO940305L - Kinazolin-derivater som acetylcholinesteraseinhibitorer - Google Patents

Kinazolin-derivater som acetylcholinesteraseinhibitorer

Info

Publication number
NO940305L
NO940305L NO940305A NO940305A NO940305L NO 940305 L NO940305 L NO 940305L NO 940305 A NO940305 A NO 940305A NO 940305 A NO940305 A NO 940305A NO 940305 L NO940305 L NO 940305L
Authority
NO
Norway
Prior art keywords
kinazoline
derivatives
acetylcholinesterase inhibitors
crr
iia
Prior art date
Application number
NO940305A
Other languages
English (en)
Other versions
NO940305D0 (no
Inventor
Vlad Edward Gregor
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO940305D0 publication Critical patent/NO940305D0/no
Publication of NO940305L publication Critical patent/NO940305L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Det er beskrevet en metode for behandling av kognitive lidelser ved administrering av et kinazolin-derivat med den generelle formel hvor A betyr (CH2)m(CH2)n Ila 11 b eller O. lic Ild Ile hvor n er 1-10, P er en binding eller (CH;,)m hvor m er 0-10, og R K er =0, = S, =NR, =CRR', ; R1 nye forbindelser for ovenstående er også beskrevet, samt metoder for fremstilling og farmasøytiske preparater.
NO940305A 1991-07-29 1994-01-28 Kinazolin-derivater som acetylcholinesteraseinhibitorer NO940305L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73688891A 1991-07-29 1991-07-29
US91166292A 1992-07-16 1992-07-16
PCT/US1992/005864 WO1993003034A1 (en) 1991-07-29 1992-07-22 Quinazoline derivatives as acetylcholinesterase inhibitors

Publications (2)

Publication Number Publication Date
NO940305D0 NO940305D0 (no) 1994-01-28
NO940305L true NO940305L (no) 1994-03-28

Family

ID=27113138

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940305A NO940305L (no) 1991-07-29 1994-01-28 Kinazolin-derivater som acetylcholinesteraseinhibitorer

Country Status (13)

Country Link
US (1) US5486512A (no)
EP (1) EP0597956A1 (no)
JP (1) JPH06509576A (no)
AU (1) AU665207B2 (no)
CA (1) CA2113115A1 (no)
CZ (1) CZ281628B6 (no)
FI (1) FI940393A (no)
HU (1) HUT66324A (no)
IE (1) IE922434A1 (no)
MX (1) MX9204425A (no)
NO (1) NO940305L (no)
PT (1) PT100742A (no)
WO (1) WO1993003034A1 (no)

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US20030153598A1 (en) * 2000-07-25 2003-08-14 Raymond Pratt Methods for treating Parkinson's disease with cholinesterase inhibitors
EP2138177A1 (en) * 2000-03-03 2009-12-30 Eisai R&D Management Co., Ltd. Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments
IL149357A0 (en) * 2000-09-07 2002-11-10 Bayer Ag Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents
US7022844B2 (en) 2002-09-21 2006-04-04 Honeywell International Inc. Amide-based compounds, production, recovery, purification and uses thereof
GEP20084551B (en) * 2004-05-06 2008-11-25 Warner Lambert Co 4-phenylamino-quinazolin-6-yl-amides
EP1827468B1 (en) * 2004-12-23 2012-08-22 Curaxis Pharmaceutical Corporation Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
EP1910367A2 (en) * 2005-05-20 2008-04-16 Alantos Pharmaceuticals, Inc. Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
MX2009009234A (es) 2007-03-01 2009-12-01 Probiodrug Ag Uso nuevo de inhibidores de ciclasa de glutaminilo.
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
CN101220043A (zh) * 2008-01-24 2008-07-16 沈阳药科大学 噻唑并[3,2-a]嘧啶类衍生物及其应用
US8486940B2 (en) 2009-09-11 2013-07-16 Probiodrug Ag Inhibitors
CA2789014C (en) 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
EP2542549B1 (en) 2010-03-03 2016-05-11 Probiodrug AG Inhibitors of glutaminyl cyclase
CA2789440C (en) 2010-03-10 2020-03-24 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
JP6050264B2 (ja) 2011-03-16 2016-12-21 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
EP2956138B1 (en) 2013-02-15 2022-06-22 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
EP3763710A1 (en) 2013-02-20 2021-01-13 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
CN106061261B (zh) 2013-11-01 2018-04-24 卡拉制药公司 治疗化合物的结晶形式及其用途
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EA034167B8 (ru) 2015-05-22 2021-04-27 Эйджинбайо, Инк. Фармацевтические композиции леветирацетама пролонгированного высвобождения
CR20170568A (es) 2015-06-26 2018-04-20 Takeda Pharmaceuticals Co Compuesto heterocíclico
US10548899B2 (en) 2015-10-20 2020-02-04 Takeda Pharmaceutical Company Limited Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity
MX2019002629A (es) 2016-09-08 2019-10-07 Kala Pharmaceuticals Inc Formas cristalinas de compuestos terapéuticos y usos de los mismos.
WO2018048747A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2992221A (en) * 1958-07-03 1961-07-11 Petersen Siegfried Polymethylene-oxoquinazolines and their production
US3271396A (en) * 1964-08-17 1966-09-06 Squibb & Sons Inc Pyrido-quinazoline derivatives
US3745216A (en) * 1969-12-18 1973-07-10 Smith Kline French Lab Compositions and methods for producing hypotensive activity with imidazo and pyrimido(2,1-b)quinazoline compounds
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
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NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
HU182009B (en) * 1977-08-19 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines
DE2845766A1 (de) * 1978-10-18 1980-04-30 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
AT377586B (de) * 1981-06-30 1985-04-10 Erba Farmitalia Verfahren zur herstellung von substituierten pyrrolo-(2,1-b)-chinazolinen und pyrido(2,1-b)chinazolinen
FR2512674B1 (fr) * 1981-09-16 1986-01-10 Sandoz Sa Nouveaux derives tricycliques de la quinazolinone, leur preparation et medicaments contenant ces derives
US4395554A (en) * 1981-12-01 1983-07-26 Mobil Oil Corporation Process for producing alpha-picoline
HU191316B (en) * 1984-02-15 1987-02-27 Syntex Usa Inc.,Us Process for producing (2-oxo-1,2,3,5-tetrahydro-imidazo /2,1-b/ quinazoline)-oxy-lakyl-amides and pharmacutical compositions containing them
US4783467A (en) * 1985-06-05 1988-11-08 Pfizer Inc. Tetrahydroimidazoquinazolinone inotropic agents
US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4766126A (en) * 1986-01-10 1988-08-23 Daiichi Seiyaku Co., Ltd. Process for treatment of nephritis with imidazoquinazolines
US4760065A (en) * 1986-02-13 1988-07-26 Hardtmann Goetz E Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity

Also Published As

Publication number Publication date
CA2113115A1 (en) 1993-02-18
PT100742A (pt) 1993-10-29
CZ13594A3 (en) 1994-05-18
AU2397892A (en) 1993-03-02
JPH06509576A (ja) 1994-10-27
FI940393A0 (fi) 1994-01-26
MX9204425A (es) 1993-01-01
FI940393A (fi) 1994-03-11
WO1993003034A1 (en) 1993-02-18
NO940305D0 (no) 1994-01-28
IE922434A1 (en) 1993-02-10
AU665207B2 (en) 1995-12-21
CZ281628B6 (cs) 1996-11-13
HU9400258D0 (en) 1994-06-28
HUT66324A (en) 1994-11-28
US5486512A (en) 1996-01-23
EP0597956A1 (en) 1994-05-25

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