NO933450D0 - Antiarrytmiske og kardiobeskyttende substituerte 1(2h)isokinoliner, fremgangsmaater for deres fremstilling, medikament inneholdende disse og anvendelse derav for fremstillingav et medikament for aa bekjempe hjertefeil - Google Patents

Antiarrytmiske og kardiobeskyttende substituerte 1(2h)isokinoliner, fremgangsmaater for deres fremstilling, medikament inneholdende disse og anvendelse derav for fremstillingav et medikament for aa bekjempe hjertefeil

Info

Publication number: NO933450D0
Authority: NO; Norway
Prior art keywords: preparation; hydrogen; isoqinolines; cardi; rhythmic
Prior art date: 1992-09-28

Application number

NO933450A

Other languages

English (en)

Other versions

NO180374B (no

NO933450L (no

NO180374C (no

Inventor

Bansi Lal

Ramesh Matioram Gidwani

Ramanujam Rajagopalan

Radha Panicker

Chinnakulandai Sankar

Hans-Jochen Lang

Heinrich Englert

Wolfgang Scholz

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-28

Filing date

1993-09-27

Publication date

1993-09-27

1993-09-27 Application filed by Hoechst Ag filed Critical Hoechst Ag

1993-09-27 Publication of NO933450D0 publication Critical patent/NO933450D0/no

1994-03-29 Publication of NO933450L publication Critical patent/NO933450L/no

1996-12-30 Publication of NO180374B publication Critical patent/NO180374B/no

1997-04-09 Publication of NO180374C publication Critical patent/NO180374C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

NO933450A 1992-09-28 1993-09-27 Antiarrytmiske og kardiobeskyttende substituerte 1(2H)isokinoliner og anvendelse derav for fremstilling av et medikament for å bekjempe hjertefeil NO180374C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP92116535		1992-09-28

Publications (4)

Publication Number	Publication Date
NO933450D0 true NO933450D0 (no)	1993-09-27
NO933450L NO933450L (no)	1994-03-29
NO180374B NO180374B (no)	1996-12-30
NO180374C NO180374C (no)	1997-04-09

Family

ID=8210063

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO933450A NO180374C (no)	1992-09-28	1993-09-27	Antiarrytmiske og kardiobeskyttende substituerte 1(2H)isokinoliner og anvendelse derav for fremstilling av et medikament for å bekjempe hjertefeil

Country Status (18)

Country	Link
US (1)	US5416094A (no)
EP (1)	EP0590455B1 (no)
JP (1)	JP3645579B2 (no)
AT (1)	ATE198328T1 (no)
AU (1)	AU662079B2 (no)
CA (1)	CA2107008C (no)
DE (1)	DE69329787T2 (no)
DK (1)	DK0590455T3 (no)
ES (1)	ES2152938T3 (no)
FI (1)	FI103884B (no)
GR (1)	GR3035537T3 (no)
HU (1)	HU218208B (no)
IL (1)	IL107118A (no)
NO (1)	NO180374C (no)
NZ (1)	NZ248761A (no)
PT (1)	PT590455E (no)
TW (1)	TW272189B (no)
ZA (1)	ZA937141B (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4344550A1 (de) *	1993-12-24	1995-06-29	Hoechst Ag	Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen
DE4412334A1 (de) *	1994-04-11	1995-10-19	Hoechst Ag	Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4415873A1 (de) *	1994-05-05	1995-11-09	Hoechst Ag	Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5627193A (en) *	1995-02-09	1997-05-06	Mitsui Toatsu Chemicals, Inc.	Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
US5874443A (en) *	1995-10-19	1999-02-23	Trega Biosciences, Inc.	Isoquinoline derivatives and isoquinoline combinatorial libraries
EP0863877A4 (en) *	1995-10-19	1999-07-21	Torrey Pines Inst	ISOCHINOLINE DERIVATIVES AND COMBINATONIC LIBRARIES OF ISOCHINOLINE
DE19540995A1 (de) *	1995-11-03	1997-05-07	Hoechst Ag	Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) *	1995-11-14	1997-05-15	Hoechst Ag	Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) *	1995-11-20	1997-05-26	Hoechst Ag	Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) *	1995-12-14	1997-06-19	Hoechst Ag	Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19548708A1 (de) *	1995-12-23	1997-06-26	Merck Patent Gmbh	Cyclische Sulfone
US20040122096A1 (en) *	1996-06-03	2004-06-24	Hoechst Aktiengesellschaft	Use of inhibitors of the cellular Na+/H+ exchanger (NHE) for preparing a medicament for normalizing serum lipids
US5916899A (en) *	1996-10-18	1999-06-29	Trega Biosciences, Inc.	Isoquinoline derivatives and isoquinoline combinatorial libraries
US5952328A (en) *	1997-11-12	1999-09-14	Cephalon, Inc.	Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
CA2271116A1 (en) *	1996-11-13	1998-05-22	Gregory J. Wells	Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
WO1998055475A1 (en) *	1997-06-02	1998-12-10	Fujisawa Pharmaceutical Co., Ltd.	Guanidine deriviatives as inhibitors of na+/h+ exchange in cells
EP1076649A4 (en)	1998-04-28	2010-06-02	Trega Biosciences Inc	ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE
US6284735B1 (en)	1998-04-28	2001-09-04	Lion Bioscience Ag	HP-3228 and related peptides to treat sexual dysfunction
US6534503B1 (en)	1998-04-28	2003-03-18	Lion Bioscience Ag	Melanocortin receptor-3 ligands to treat sexual dysfunction
DE19859727A1 (de) *	1998-12-23	2000-06-29	Aventis Pharma Gmbh	Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung
MY140868A (en) *	2004-12-24	2010-01-29	Astrazeneca Ab	Amide derivatives
WO2007053610A2 (en) *	2005-11-01	2007-05-10	The Regents Of The University Of California	Methods of treating atrial fibrillation wtih pirfenidone
AU2007214709A1 (en) *	2006-02-15	2007-08-23	Sanofi-Aventis	Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
JP5484914B2 (ja)	2007-01-22	2014-05-07	ジーティーエックス・インコーポレイテッド	核内受容体結合剤
US9604931B2 (en)	2007-01-22	2017-03-28	Gtx, Inc.	Nuclear receptor binding agents
US9623021B2 (en) *	2007-01-22	2017-04-18	Gtx, Inc.	Nuclear receptor binding agents
US10344002B2 (en)	2016-09-26	2019-07-09	Nusirt Sciences, Inc.	Compositions and methods for treating metabolic disorders
WO2019195348A1 (en) *	2018-04-06	2019-10-10	The Board Of Trustees Of The University Of Illinois	1,4-substituted isoquinoline inhibitors of keap1/nrf2 protein-protein interaction
KR102605163B1 (ko) *	2021-06-01	2023-11-23	연세대학교 산학협력단	뇌암의 예방 또는 치료용 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3780027A (en) *	1970-04-29	1973-12-18	Merck & Co Inc	Anthranilic acid derivatives
DE2818423A1 (de) *	1978-04-27	1979-11-08	Hoechst Ag	Neue isochinolinderivate und verfahren zu ihrer herstellung
DE3013906A1 (de) *	1980-04-11	1981-10-15	C.H. Boehringer Sohn, 6507 Ingelheim	Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3233424A1 (de) *	1982-09-09	1984-03-15	Hoechst Ag, 6230 Frankfurt	Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
JP2930399B2 (ja) *	1990-10-18	1999-08-03	雪印乳業株式会社	新規イソキノリン誘導体またはその酸付加塩

1993
- 1993-09-20 PT PT93115081T patent/PT590455E/pt unknown
- 1993-09-20 ES ES93115081T patent/ES2152938T3/es not_active Expired - Lifetime
- 1993-09-20 EP EP93115081A patent/EP0590455B1/en not_active Expired - Lifetime
- 1993-09-20 DE DE69329787T patent/DE69329787T2/de not_active Expired - Lifetime
- 1993-09-20 DK DK93115081T patent/DK0590455T3/da active
- 1993-09-20 AT AT93115081T patent/ATE198328T1/de not_active IP Right Cessation
- 1993-09-24 US US08/126,200 patent/US5416094A/en not_active Expired - Lifetime
- 1993-09-24 NZ NZ248761A patent/NZ248761A/en unknown
- 1993-09-24 FI FI934185A patent/FI103884B/fi active
- 1993-09-27 NO NO933450A patent/NO180374C/no unknown
- 1993-09-27 ZA ZA937141A patent/ZA937141B/xx unknown
- 1993-09-27 AU AU48659/93A patent/AU662079B2/en not_active Ceased
- 1993-09-27 JP JP23996693A patent/JP3645579B2/ja not_active Expired - Fee Related
- 1993-09-27 IL IL107118A patent/IL107118A/en not_active IP Right Cessation
- 1993-09-27 HU HU9302725A patent/HU218208B/hu not_active IP Right Cessation
- 1993-09-27 CA CA002107008A patent/CA2107008C/en not_active Expired - Lifetime
- 1993-10-14 TW TW082108497A patent/TW272189B/zh active
2001
- 2001-03-09 GR GR20010400378T patent/GR3035537T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0590455A1 (en)	1994-04-06
FI934185A (fi)	1994-03-29
FI103884B1 (fi)	1999-10-15
US5416094A (en)	1995-05-16
JP3645579B2 (ja)	2005-05-11
NO180374B (no)	1996-12-30
CA2107008A1 (en)	1994-03-29
NO933450L (no)	1994-03-29
CA2107008C (en)	2004-11-16
HU218208B (hu)	2000-06-28
GR3035537T3 (en)	2001-06-29
IL107118A (en)	1998-06-15
DE69329787D1 (de)	2001-02-01
ZA937141B (en)	1994-05-18
NZ248761A (en)	1995-04-27
AU662079B2 (en)	1995-08-17
ES2152938T3 (es)	2001-02-16
PT590455E (pt)	2001-04-30
HU9302725D0 (en)	1993-12-28
FI934185A0 (fi)	1993-09-24
DK0590455T3 (da)	2001-01-22
TW272189B (no)	1996-03-11
HUT70149A (en)	1995-09-28
NO180374C (no)	1997-04-09
AU4865993A (en)	1994-04-14
DE69329787T2 (de)	2001-06-13
JPH06211799A (ja)	1994-08-02
ATE198328T1 (de)	2001-01-15
EP0590455B1 (en)	2000-12-27
FI103884B (fi)	1999-10-15
IL107118A0 (en)	1993-12-28

Publication	Publication Date	Title
NO933450D0 (no)	1993-09-27	Antiarrytmiske og kardiobeskyttende substituerte 1(2h)isokinoliner, fremgangsmaater for deres fremstilling, medikament inneholdende disse og anvendelse derav for fremstillingav et medikament for aa bekjempe hjertefeil
AU6358986A (en)	1987-04-09	New quinazoline derivatives and a process for their production
HUT47567A (en)	1989-03-28	Process for production of mycophenol acid-/morpholin-ethil/-esther and its derivatives and medical compounds containing them
AU626740B2 (en)	1992-08-06	Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
HU9201887D0 (en)	1992-08-28	Process for the production of //aralkyl-piperidine-4-yl/-methyl/-2a,3,4,5-tetrahydro-1-/2h/-acenaphtylene-1-on derivatives and of medical preparations containing them as active agents
HU9201290D0 (en)	1992-07-28	1-/pirido/3,4-b/-1,4-oxazinyl-4-yl/-1h-indole derivatives, process for their production and for the production of medical preparations containing them as active agents
EP0370987A3 (en)	1990-12-19	Pyrazine derivatives as medicaments for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
HU9201033D0 (en)	1992-06-29	Tiazolidinone- and oxazolidinone derivatives, process for their production, and for the production of medical preparations containing them as active agents
HUT37797A (en)	1986-02-28	Process for production of tetrahydro-tieno-piridinderivatives and medical preparatives containing of such compounds
NO167286C (no)	1991-10-23	Fremgangsmaate for fremstilling av terapeutisk aktive benzotiazepin-derivater.
DK0570850T3 (da)	1997-06-16	Benzo(b)thiophen-3-yl-piperaziner, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
AU590748B2 (en)	1989-11-16	Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments