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NO914094L - NEW MONOCLONAL ANTIBODY AGAINST NEW ANTIGEN CONNECTED HUMAN TUMORS - Google Patents

NEW MONOCLONAL ANTIBODY AGAINST NEW ANTIGEN CONNECTED HUMAN TUMORS

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Publication number
NO914094L
NO914094L NO91914094A NO914094A NO914094L NO 914094 L NO914094 L NO 914094L NO 91914094 A NO91914094 A NO 91914094A NO 914094 A NO914094 A NO 914094A NO 914094 L NO914094 L NO 914094L
Authority
NO
Norway
Prior art keywords
new
tumors
monoclonal antibody
antibody against
human tumors
Prior art date
Application number
NO91914094A
Other languages
Norwegian (no)
Other versions
NO914094D0 (en
Inventor
Karl Erik Hellstrom
Ingegerd Hellstrom
Hans Marquardt
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/339,142 external-priority patent/US5171665A/en
Application filed by Oncogen filed Critical Oncogen
Publication of NO914094L publication Critical patent/NO914094L/en
Publication of NO914094D0 publication Critical patent/NO914094D0/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Nytt, monoklonalt antistoff som bindes sterkt til et proteinantigen forbundet med humantumorer, inkludert carcinomer fra tykktarm og lunge. Anti- stoffet bindes til normale humanceller i en mye mindre grad enn til tumor- celler. Antistoffet finner anvendelse både i diagnostiske fremgangsmåter, slik som påvisning av maligne celler forbundet med tumorer, og i terapeut- iske fremgangsmåter for behandling av mennesker med tumorer. Nytt 66.000 dalton glycoproteinantigen som finnes på celleoverflaten til humantumorceller. Aminoendeaminosyresekvensen til dette antigenet er 15 10 15 20 X-E-L-T-I-L-H-T-N-D-V-H-S-R-L-E-Q-T-S-X (I) hvor X er en uidentifisert aminosyre.New, monoclonal antibody that binds strongly to a protein antigen associated with human tumors, including colon and lung carcinomas. The antibody binds to normal human cells to a much lesser extent than to tumor cells. The antibody finds use both in diagnostic methods, such as the detection of malignant cells associated with tumors, and in therapeutic methods for treating humans with tumors. A new 66,000 dalton glycoprotein antigen found on the cell surface of human tumor cells. The amino endeamino acid sequence of this antigen is X-E-L-T-I-L-H-T-N-D-V-H-S-R-L-E-Q-T-S-X (I) where X is an unidentified amino acid.

NO914094A 1989-04-17 1991-10-17 NEW MONOCLONAL ANTIBODY AGAINST NEW ANTIGEN CONNECTED HUMAN TUMORS NO914094D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/339,142 US5171665A (en) 1989-04-17 1989-04-17 Monoclonal antibody to novel antigen associated with human tumors
PCT/US1990/001621 WO1990012594A1 (en) 1989-04-17 1990-03-26 Novel monoclonal antibody to novel antigen associated with human tumors

Publications (2)

Publication Number Publication Date
NO914094L true NO914094L (en) 1991-10-17
NO914094D0 NO914094D0 (en) 1991-10-17

Family

ID=26781330

Family Applications (1)

Application Number Title Priority Date Filing Date
NO914094A NO914094D0 (en) 1989-04-17 1991-10-17 NEW MONOCLONAL ANTIBODY AGAINST NEW ANTIGEN CONNECTED HUMAN TUMORS

Country Status (1)

Country Link
NO (1) NO914094D0 (en)

Also Published As

Publication number Publication date
NO914094D0 (en) 1991-10-17

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