NO911854D0 - Fremgangsmaate for fremstilling av peptid-derivater. - Google Patents

Fremgangsmaate for fremstilling av peptid-derivater.

Info

Publication number: NO911854D0
Authority: NO; Norway
Prior art keywords: preparation; peptid; derivatives; procedure; same
Prior art date: 1990-05-14

Application number

NO911854A

Other languages

English (en)

Other versions

NO911854L (no

Inventor

Keiji Hemmi

Masahiro Neya

Naoki Fukami

Masashi Hashimoto

Hirokazu Tanaka

Natsuko Kayakiri

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-14

Filing date

1991-05-13

Publication date

1991-05-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27265085&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO911854(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-05-14 Priority claimed from GB909010740A external-priority patent/GB9010740D0/en

1990-12-03 Priority claimed from GB909026254A external-priority patent/GB9026254D0/en

1991-02-27 Priority claimed from GB919104064A external-priority patent/GB9104064D0/en

1991-05-13 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1991-05-13 Publication of NO911854D0 publication Critical patent/NO911854D0/no

1991-11-15 Publication of NO911854L publication Critical patent/NO911854L/no

Links

238000000034 method Methods 0.000 title abstract 3
108050009340 Endothelin Proteins 0.000 abstract 2
102000002045 Endothelin Human genes 0.000 abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 2
206010020772 Hypertension Diseases 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0217—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

NO91911854A 1990-05-14 1991-05-13 Fremgangsmaate for fremstilling av peptid-derivater. NO911854L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB909010740A GB9010740D0 (en)	1990-05-14	1990-05-14	Peptide compounds and their preparation
GB909026254A GB9026254D0 (en)	1990-12-03	1990-12-03	Peptide compound and its preparation
GB919104064A GB9104064D0 (en)	1991-02-27	1991-02-27	Peptide compound and its preparation

Publications (2)

Publication Number	Publication Date
NO911854D0 true NO911854D0 (no)	1991-05-13
NO911854L NO911854L (no)	1991-11-15

Family

ID=27265085

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO91911854A NO911854L (no)	1990-05-14	1991-05-13	Fremgangsmaate for fremstilling av peptid-derivater.

Country Status (14)

Country	Link
US (1)	US5284828A (no)
EP (1)	EP0457195B1 (no)
JP (1)	JPH04244097A (no)
KR (1)	KR910020030A (no)
CN (1)	CN1057269A (no)
AT (1)	ATE165100T1 (no)
CA (1)	CA2042442A1 (no)
DE (1)	DE69129248T2 (no)
FI (1)	FI912328A (no)
HU (2)	HUT57233A (no)
IE (1)	IE911620A1 (no)
NO (1)	NO911854L (no)
PT (1)	PT97638B (no)
RU (1)	RU2092491C1 (no)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5514691A (en) *	1993-05-20	1996-05-07	Immunopharmaceutics, Inc.	N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) *	1993-05-20	1997-01-14	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en) *	1993-05-20	1996-11-05	Texas Biotechnology Corporation	Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5962490A (en)	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5591761A (en) *	1993-05-20	1997-01-07	Texas Biotechnology Corporation	Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5430022A (en) *	1990-05-14	1995-07-04	Fujisawa Pharmaceutical Co., Ltd.	Peptide compound and its preparation
CA2043741C (en) *	1990-06-07	2003-04-01	Kiyofumi Ishikawa	Endothelin antagonistic peptide derivatives
US5496928A (en) *	1990-06-07	1996-03-05	Banyu Pharmaceutical Co., Ltd.	Endothelin antagonistic substance
US5614498A (en) *	1990-06-07	1997-03-25	Banyu Pharmaceutical Co., Ltd.	Endothelin antagonistic substance
US5736509A (en) *	1990-12-14	1998-04-07	Texas Biotechnology Corporation	Cyclic peptide surface feature mimics of endothelin
GB9123967D0 (en) *	1991-11-12	1992-01-02	Fujisawa Pharmaceutical Co	New compound and its preparation
TW217417B (no) *	1991-12-04	1993-12-11	Manyu Seiyaku Kk
WO1993013218A1 (en) *	1991-12-27	1993-07-08	Kyowa Hakko Kogyo Co., Ltd.	Endothelin-antagonizing peptide
US5614497A (en) *	1991-12-27	1997-03-25	Takeda Chemical Industries, Ltd.	Peptide, production and use thereof
AU4376893A (en) *	1992-05-19	1993-12-13	Immunopharmaceutics, Inc.	Compounds that modulate endothelin activity
US5922681A (en) *	1992-09-14	1999-07-13	Warner-Lambert Company	Endothelin antagonists
US5352800A (en) *	1993-03-11	1994-10-04	Merck & Co., Inc.	Process for the production of a novel endothelin antagonist
US5374638A (en) *	1993-03-19	1994-12-20	Merck & Co., Inc.	Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5767310A (en) *	1993-03-19	1998-06-16	Merck & Co., Inc.	Phenoxyphenylacetic acid derivatives
US5334598A (en) *	1993-03-19	1994-08-02	Merck & Co., Inc.	Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5420133A (en) *	1993-03-19	1995-05-30	Merck & Co., Inc.	Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5401745A (en) *	1993-03-19	1995-03-28	Merck & Co., Inc.	Quinazolinones substituted with phenoxyphenylacetic acid derivatives
CA2121724A1 (en) *	1993-04-21	1994-10-22	Toshifumi Watanabe	Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction
US6613804B2 (en)	1993-05-20	2003-09-02	Encysive Pharmaceuticals, Inc.	Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6342610B2 (en)	1993-05-20	2002-01-29	Texas Biotechnology Corp.	N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6030991A (en) *	1993-05-20	2000-02-29	Texas Biotechnology Corp.	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6087324A (en)	1993-06-24	2000-07-11	Takeda Chemical Industries, Ltd.	Sustained-release preparation
GB9313330D0 (en) *	1993-06-28	1993-08-11	Fujisawa Pharmaceutical Co	New compound and its preparation
US5686478A (en) *	1993-07-20	1997-11-11	Merck & Co. Inc.	Endothelin antagonists
CA2173875A1 (en) *	1993-11-01	1995-05-11	Hideyuki Saika	Endothelin receptor antagonists
US5703106A (en) *	1994-03-28	1997-12-30	Japat Ltd.	Antagonists of endothelin receptors
US5830868A (en) *	1994-09-13	1998-11-03	Warner-Lambert Company	Substituted DI- and tripeptide inhibitors of protein: farnesyl transferase
US5559135A (en) *	1994-09-14	1996-09-24	Merck & Co., Inc.	Endothelin antagonists bearing pyridyl amides
US5538991A (en) *	1994-09-14	1996-07-23	Merck & Co., Inc.	Endothelin antagonists bearing 5-membered heterocyclic amides
US5863902A (en) *	1995-01-06	1999-01-26	Sibia Neurosciences, Inc.	Methods of treating neurodegenerative disorders using protease inhibitors
US5804560A (en) *	1995-01-06	1998-09-08	Sibia Neurosciences, Inc.	Peptide and peptide analog protease inhibitors
CA2218716A1 (en) *	1995-04-21	1996-10-24	Novartis Ag	N-aroylamino acid amides as endothelin inhibitors
US5925731A (en) *	1995-09-26	1999-07-20	Takeda Chemical Industries, Ltd.	Endothelin antagonist peptides
CA2192782C (en)	1995-12-15	2008-10-14	Nobuyuki Takechi	Production of microspheres
US5977117A (en)	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5688499A (en)	1996-03-13	1997-11-18	Queen's University At Kingston	Antagonism of endothelin actions
US5958905A (en)	1996-03-26	1999-09-28	Texas Biotechnology Corporation	Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) *	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
IL131318A (en)	1997-04-28	2004-08-31	Encysive Pharmaceuticals Inc	Pharmaceutically acceptable salts of sulfonamides for treatment of endothelin-mediated disorders
US5783705A (en)	1997-04-28	1998-07-21	Texas Biotechnology Corporation	Process of preparing alkali metal salys of hydrophobic sulfonamides
DE69833254T2 (de) *	1997-06-23	2006-11-02	Cellegy Pharmaceuticals, Inc., Brisbane	Microdosistherapie von gefässbedingten erscheinungen durch no-donoren
US6998445B2 (en) *	1998-03-26	2006-02-14	Acushnet Company	Low compression, resilient golf balls with rubber core
WO1999065932A1 (en) *	1998-06-18	1999-12-23	Sepracor, Inc.	Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors
US7115664B2 (en) *	2000-03-16	2006-10-03	Sepracor Inc.	Peptidomimetic ligands for cellular receptors and ion channels
EP2042597B1 (en)	2000-06-23	2014-05-07	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CA2709771A1 (en)	2000-06-23	2002-01-03	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CA2430934C (en)	2000-12-01	2011-06-21	Takeda Chemical Industries, Ltd.	A method of producing sustained-release preparations of a bioactive substance using high-pressure gas
CA2458009C (en) *	2001-08-24	2011-08-16	Yale University	Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment
GB0326632D0 (en)	2003-11-14	2003-12-17	Jagotec Ag	Dry powder formulations
CA2615393C (en)	2005-07-19	2011-09-20	The Population Council, Inc.	Methods and compositions for emergency contraception using endothelin receptor antagonists
WO2012028745A1 (en)	2010-09-03	2012-03-08	Pharmaterials Limited	Pharmaceutical composition suitable for use in a dry powder inhaler
ES2820714T3 (es)	2011-10-26	2021-04-22	Allergan Inc	Derivados de amida de aminoácidos N-urea sustituidos como moduladores del receptor análogo al receptor 1 de péptido formilado (FPRL-1)
WO2014010586A1 (ja)	2012-07-10	2014-01-16	武田薬品工業株式会社	注射用製剤
JP6653253B2 (ja)	2013-07-16	2020-02-26	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	ホルミルペプチド受容体モジュレーターとしてのｎ−尿素置換アミノ酸の誘導体
CN109563144B (zh)	2016-06-01	2023-03-28	雅斯娜	化合物
WO2022198231A1 (en)	2021-03-18	2022-09-22	Seagen Inc.	Selective drug release from internalized conjugates of biologically active compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1049404B (it) *	1975-04-09	1981-01-20	Zambeletti Spa L	Tripeptidi loro esteri ed amidi ad attivita antiulcera
US4127534A (en) *	1977-06-16	1978-11-28	Coy David Howard	Novel tripeptides, intermediates therefor and pharmaceutical compositions and methods employing said tripeptides
CA1175810A (en) *	1979-03-30	1984-10-09	Frank A. Momany	Synthetic peptides having pituitary growth hormone releasing activity
US4228156A (en) *	1979-03-30	1980-10-14	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
GB8430255D0 (en) *	1984-11-30	1985-01-09	Erba Farmitalia	Biologically active oligopeptides
US5187156A (en) *	1988-03-16	1993-02-16	Fujisawa Pharmaceutical Co., Ltd.	Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
CA2043741C (en) *	1990-06-07	2003-04-01	Kiyofumi Ishikawa	Endothelin antagonistic peptide derivatives

1991
- 1991-05-07 US US07/696,701 patent/US5284828A/en not_active Expired - Fee Related
- 1991-05-09 EP EP91107554A patent/EP0457195B1/en not_active Expired - Lifetime
- 1991-05-09 AT AT91107554T patent/ATE165100T1/de not_active IP Right Cessation
- 1991-05-09 DE DE69129248T patent/DE69129248T2/de not_active Expired - Fee Related
- 1991-05-10 IE IE162091A patent/IE911620A1/en unknown
- 1991-05-10 PT PT97638A patent/PT97638B/pt not_active IP Right Cessation
- 1991-05-13 RU SU914895608A patent/RU2092491C1/ru active
- 1991-05-13 CN CN91103919A patent/CN1057269A/zh active Pending
- 1991-05-13 KR KR1019910007647A patent/KR910020030A/ko not_active Application Discontinuation
- 1991-05-13 CA CA002042442A patent/CA2042442A1/en not_active Abandoned
- 1991-05-13 NO NO91911854A patent/NO911854L/no unknown
- 1991-05-13 FI FI912328A patent/FI912328A/fi not_active Application Discontinuation
- 1991-05-14 JP JP3206614A patent/JPH04244097A/ja active Pending
- 1991-05-14 HU HU911619A patent/HUT57233A/hu unknown
1995
- 1995-06-22 HU HU95P/P00377P patent/HU211904A9/hu unknown

Also Published As

Publication number	Publication date
ATE165100T1 (de)	1998-05-15
AU7644691A (en)	1991-11-14
NO911854L (no)	1991-11-15
EP0457195B1 (en)	1998-04-15
JPH04244097A (ja)	1992-09-01
DE69129248D1 (de)	1998-05-20
EP0457195A3 (en)	1992-11-19
US5284828A (en)	1994-02-08
EP0457195A2 (en)	1991-11-21
KR910020030A (ko)	1991-12-19
CN1057269A (zh)	1991-12-25
IE911620A1 (en)	1991-11-20
RU2092491C1 (ru)	1997-10-10
PT97638B (pt)	1998-08-31
HUT57233A (en)	1991-11-28
PT97638A (pt)	1992-02-28
CA2042442A1 (en)	1991-11-15
AU644648B2 (en)	1993-12-16
DE69129248T2 (de)	1998-08-06
FI912328A0 (fi)	1991-05-13
HU211904A9 (en)	1996-01-29
FI912328A (fi)	1991-11-15

Publication	Publication Date	Title
NO911854D0 (no)	1991-05-13	Fremgangsmaate for fremstilling av peptid-derivater.
FR2757522B1 (fr)	1999-01-29	Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
WO1997049373A3 (en)	1998-02-26	Treatment and prevention of hiv infection by administration of derivatives of human chorionic gonadotropin
MA26458A1 (fr)	2004-12-20	Nouveaux derives cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent.
AU3753695A (en)	1996-05-23	Pyridopyrimidones, quinolines and fused n-heretocycles as bradykinin antagonists
RU94013439A (ru)	1995-12-20	Гетероциклические соединения, способ их получения, фармацевтическая композиция и способ лечения
UA56989C2 (uk)	2003-06-16	ФІЗІОЛОГІЧНО АКТИВНИЙ ПЕГ-КОН'ЮГАТ <font face="Symbol">a</font>-ІНТЕРФЕРОНУ, СПОСІБ ЙОГО ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЙОГО ОСНОВІ ТА СПОСІБ ЛІКУВАННЯ АБО ПРОФІЛАКТИКИ ІМУНОМОДУЛЯТОРНИХ ЗАХВОРЮВАНЬ
WO1997020823A3 (en)	1997-07-17	2-amino quinazoline derivatives as npy receptor antagonists
CA2272705A1 (en)	1998-06-04	Fused bicyclic pyrimidine derivatives
RU93004793A (ru)	1996-06-20	Производные хиназолина, способ их получения, фармацевтическая композиция на их основе
EP0244083A3 (en)	1989-11-15	Amino acid derivatives
DK0539479T3 (da)	1997-08-25	Heterocykliske forbindelser
CA2157792A1 (en)	1995-03-30	N-(3-piperidinyl-carbonyl)-beta-alanine derivatives as paf antagonists
CA2282279A1 (en)	1998-09-03	Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions
IE894050L (en)	1990-06-22	Compound with gastric acid inhibitory effect and process for¹its preparation
IE780921L (en)	1978-11-10	1-acyl-2-hydroxy-1,3-diamino-propanes.
UA41326C2 (uk)	2001-09-17	Фармацевтична композиція для профілактики або лікування вірусних захворювань, засіб для профілактики або лікування вірусних захворювань
RU93005013A (ru)	1996-05-10	1-аминоспиро[изохинолин-4(1н)3-пирролидин-1,2,3,5'(2н)-тетроны] и их аналоги, способ их получения и фармацевтическая композиция
WO1999006438A3 (en)	1999-04-08	Compounds with anti-ks and anti-hiv activity
WO2004073627A3 (en)	2004-11-18	Novel therapeutic method and compositions for topical administration
ATE224716T1 (de)	2002-10-15	Pharmazeutische zusammensetzungen von cinchonin dihydrochlorid
JO1664B1 (en)	1991-11-27	The compound has the effect of immobilizing gastric acid and the process of preparing it
RU93049414A (ru)	1996-06-20	Производные бенз(е)индена