NO882218L - PROCEDURE FOR THE PREPARATION OF PHOSPHORUS HMG-COA REDUCTASE INHIBITORS. - Google Patents

PROCEDURE FOR THE PREPARATION OF PHOSPHORUS HMG-COA REDUCTASE INHIBITORS.

Info

Publication number: NO882218L
Authority: NO; Norway
Prior art keywords: hmg; phosphorus; procedure; preparation; coa reductase
Prior art date: 1987-05-22

Application number

NO882218A

Other languages

Norwegian (no)

Other versions

NO882218D0 (en

Inventor

Donald Steven Karanewsky

Scott Adams Biller

Eric Michael Gordon

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-22

Filing date

1988-05-20

Publication date

1988-11-23

1988-05-20 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1988-05-20 Publication of NO882218D0 publication Critical patent/NO882218D0/en

1988-11-23 Publication of NO882218L publication Critical patent/NO882218L/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/36—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4407—Amides of acyclic saturated acids which can have further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO882218A 1987-05-22 1988-05-20 PROCEDURE FOR THE PREPARATION OF PHOSPHORUS HMG-COA REDUCTASE INHIBITORS. NO882218L (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5328187A	1987-05-22	1987-05-22
US10968087A	1987-10-19	1987-10-19

Publications (2)

Publication Number	Publication Date
NO882218D0 NO882218D0 (en)	1988-05-20
NO882218L true NO882218L (en)	1988-11-23

Family

ID=26731667

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO882218A NO882218L (en)	1987-05-22	1988-05-20	PROCEDURE FOR THE PREPARATION OF PHOSPHORUS HMG-COA REDUCTASE INHIBITORS.

Country Status (24)

Country	Link
JP (1)	JP2680347B2 (en)
KR (1)	KR880013958A (en)
CN (1)	CN88103091A (en)
AU (1)	AU610591B2 (en)
BE (1)	BE1004193A3 (en)
CH (1)	CH676984A5 (en)
DE (1)	DE3817375C2 (en)
DK (1)	DK277488A (en)
ES (1)	ES2009918A6 (en)
FI (1)	FI89493C (en)
FR (1)	FR2615508B1 (en)
GB (1)	GB2205837B (en)
GR (1)	GR1000959B (en)
HU (1)	HU205125B (en)
IE (2)	IE930324L (en)
IL (1)	IL86464A (en)
IT (1)	IT1217685B (en)
NL (1)	NL8801330A (en)
NO (1)	NO882218L (en)
NZ (1)	NZ224733A (en)
PH (1)	PH25350A (en)
PL (1)	PL154877B1 (en)
PT (1)	PT87539B (en)
SE (1)	SE503210C2 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU610174B2 (en) *	1987-05-22	1991-05-16	E.R. Squibb & Sons, Inc.	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
CA2007643A1 (en) *	1989-02-01	1990-08-01	Donald S. Karanewsky	Combination of an hmg coa reductase inhibitor and a squalene synthetase inhibitor and method for lowering serum cholesterol using such combination
CA2042526A1 (en) *	1990-06-11	1991-12-12	Adeoye Y. Olukotun	Method for preventing a second heart attack employing an hmg coa reductase inhibitor
US5202327A (en) *	1991-07-10	1993-04-13	E. R. Squibb & Sons, Inc.	Phosphorus-containing hmg-coa reductase inhibitors
GB9126144D0 (en) *	1991-12-10	1992-02-12	British Bio Technology	Compounds
US20010006644A1 (en)	1997-07-31	2001-07-05	David J. Bova	Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
TR200100774T2 (en)	1998-09-17	2001-12-21	Bristol-Myers Squibb Company	Atherosclerosis treatment method using an aP2 inhibitor and combination
AU2002254567B2 (en)	2001-04-11	2007-10-11	Bristol-Myers Squibb Company	Amino acid complexes of C-aryl glucosides for treatment of diabetes and method
US7238671B2 (en)	2001-10-18	2007-07-03	Bristol-Myers Squibb Company	Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
PL377687A1 (en)	2001-10-18	2006-02-06	Bristol-Myers Squibb Company	Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
US6806381B2 (en)	2001-11-02	2004-10-19	Bristol-Myers Squibb Company	Process for the preparation of aniline-derived thyroid receptor ligands
US7057046B2 (en)	2002-05-20	2006-06-06	Bristol-Myers Squibb Company	Lactam glycogen phosphorylase inhibitors and method of use
US6995180B2 (en)	2002-10-23	2006-02-07	Bristol Myers Squibb Company	Glycinenitrile-based inhibitors of dipeptidyl peptidase IV and methods
US7098235B2 (en)	2002-11-14	2006-08-29	Bristol-Myers Squibb Co.	Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
TW200504021A (en)	2003-01-24	2005-02-01	Bristol Myers Squibb Co	Substituted anilide ligands for the thyroid receptor
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US6995183B2 (en)	2003-08-01	2006-02-07	Bristol Myers Squibb Company	Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
US8158362B2 (en)	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
DK1725234T4 (en)	2004-03-05	2016-05-09	Univ Pennsylvania	METHODS OF TREATING DISEASES OR DISEASES CONNECTED WITH HYPERLIPIDEMIA AND HYPERCOLESTEROLYMIA WITH MINIMIZATION OF SIDE EFFECTS
US7534763B2 (en)	2004-07-02	2009-05-19	Bristol-Myers Squibb Company	Sustained release GLP-1 receptor modulators
US7145040B2 (en)	2004-07-02	2006-12-05	Bristol-Myers Squibb Co.	Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
TW200611704A (en)	2004-07-02	2006-04-16	Bristol Myers Squibb Co	Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
AR051446A1 (en)	2004-09-23	2007-01-17	Bristol Myers Squibb Co	C-ARYL GLUCOSIDS AS SELECTIVE INHIBITORS OF GLUCOSE CONVEYORS (SGLT2)
US7517991B2 (en)	2004-10-12	2009-04-14	Bristol-Myers Squibb Company	N-sulfonylpiperidine cannabinoid receptor 1 antagonists
US7589088B2 (en)	2004-12-29	2009-09-15	Bristol-Myers Squibb Company	Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7635699B2 (en)	2004-12-29	2009-12-22	Bristol-Myers Squibb Company	Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7314882B2 (en)	2005-01-12	2008-01-01	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
US7220859B2 (en)	2005-01-12	2007-05-22	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
WO2006076597A1 (en)	2005-01-12	2006-07-20	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
WO2006078697A1 (en)	2005-01-18	2006-07-27	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid receptor modulators
EP1879881A2 (en)	2005-04-14	2008-01-23	Bristol-Myers Squibb Company	Inhibitors of 11-beta hydroxysteroid dehydrogenase type i
US7521557B2 (en)	2005-05-20	2009-04-21	Bristol-Myers Squibb Company	Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
US7317012B2 (en)	2005-06-17	2008-01-08	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoind-1 receptor modulators
US7452892B2 (en)	2005-06-17	2008-11-18	Bristol-Myers Squibb Company	Triazolopyrimidine cannabinoid receptor 1 antagonists
US7632837B2 (en)	2005-06-17	2009-12-15	Bristol-Myers Squibb Company	Bicyclic heterocycles as cannabinoid-1 receptor modulators
US7629342B2 (en)	2005-06-17	2009-12-08	Bristol-Myers Squibb Company	Azabicyclic heterocycles as cannabinoid receptor modulators
TW200726765A (en)	2005-06-17	2007-07-16	Bristol Myers Squibb Co	Triazolopyridine cannabinoid receptor 1 antagonists
US8618115B2 (en)	2005-10-26	2013-12-31	Bristol-Myers Squibb Company	Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them
WO2007053819A2 (en)	2005-10-31	2007-05-10	Bristol-Myers Squibb Company	Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase iv and methods
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7553836B2 (en)	2006-02-06	2009-06-30	Bristol-Myers Squibb Company	Melanin concentrating hormone receptor-1 antagonists
EP2021014A1 (en)	2006-05-26	2009-02-11	Brystol-Myers Squibb Company	Sustained release glp-1 receptor modulators
US7919598B2 (en)	2006-06-28	2011-04-05	Bristol-Myers Squibb Company	Crystal structures of SGLT2 inhibitors and processes for preparing same
WO2008057862A2 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
PE20090185A1 (en)	2007-03-22	2009-02-28	Bristol Myers Squibb Co	PHARMACEUTICAL FORMULATIONS CONTAINING AN SGLT2 INHIBITOR
PE20090696A1 (en)	2007-04-20	2009-06-20	Bristol Myers Squibb Co	CRYSTALLINE FORMS OF SAXAGLIPTIN AND PROCESSES FOR PREPARING THEM
CA2687964A1 (en)	2007-06-01	2009-02-19	The Trustees Of Princeton University	Treatment of viral infections by modulation of host cell metabolic pathways
US20090011994A1 (en)	2007-07-06	2009-01-08	Bristol-Myers Squibb Company	Non-basic melanin concentrating hormone receptor-1 antagonists and methods
JP2010534722A (en)	2007-07-27	2010-11-11	ブリストル−マイヤーズスクイブカンパニー	Novel glucokinase activator and method of use thereof
KR20100055536A (en)	2007-09-20	2010-05-26	아이알엠 엘엘씨	Compounds and compositions as modulators of gpr119 activity
PE20091928A1 (en)	2008-05-29	2009-12-31	Bristol Myers Squibb Co	HAVE HYDROXYSUSTITUTED PYRIMIDINES AS NON-BASIC MELANIN-CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
EP2411005A1 (en)	2009-03-27	2012-02-01	Bristol-Myers Squibb Company	Methods for preventing major adverse cardiovascular events with dpp-iv inhibitors
WO2011014520A2 (en)	2009-07-29	2011-02-03	Irm Llc	Compounds and compositions as modulators of gpr119 activity
CN102686579A (en)	2009-10-09	2012-09-19	Irm责任有限公司	Compounds and compositions as modulators of GPR119 activity
ES2856888T3 (en)	2009-11-13	2021-09-28	Astrazeneca Ab	Bilayer tablet formulations
JP5798123B2 (en)	2009-11-13	2015-10-21	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Low-form metformin formulation
BR112012011733A2 (en)	2009-11-13	2019-09-24	Bristol-Myers Squibb Company	immediate release tablet formulations
US8394858B2 (en)	2009-12-03	2013-03-12	Novartis Ag	Cyclohexane derivatives and uses thereof
TWI562775B (en)	2010-03-02	2016-12-21	Lexicon Pharmaceuticals Inc	Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
JP2013523894A (en)	2010-04-14	2013-06-17	ブリストル−マイヤーズスクイブカンパニー	Novel glucokinase activator and method of use thereof
CN107080846A (en)	2010-07-09	2017-08-22	詹姆斯.特林卡.格林	Combination immediate/delayed release delivery system for short half-life drugs including repagliflozin
US8697739B2 (en)	2010-07-29	2014-04-15	Novartis Ag	Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
TWI631963B (en)	2011-01-05	2018-08-11	雷西肯製藥股份有限公司	Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2
WO2014052619A1 (en)	2012-09-27	2014-04-03	Irm Llc	Piperidine derivatives and compositions as modulators of gpr119 activity
PL2925735T3 (en)	2012-11-20	2019-08-30	Lexicon Pharmaceuticals, Inc.	Inhibitors of sodium glucose cotransporter 1
WO2015027021A1 (en)	2013-08-22	2015-02-26	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN104610262B (en) *	2013-11-01	2017-06-06	上海医药工业研究院	Biphenyl compound, intermediate, preparation method, pharmaceutical composition and its application
TW201702271A (en)	2015-04-30	2017-01-16	哈佛大學校長及研究員協會	Anti-AP2 antibody and antigen binding agent for treating metabolic disorders
EA202190226A1 (en)	2018-07-19	2021-06-16	Астразенека Аб	METHODS FOR TREATMENT OF HFpEF USING DAPAGLIFLOSIN AND COMPOSITIONS CONTAINING IT
US10968192B2 (en)	2018-09-26	2021-04-06	Lexicon Pharmaceuticals, Inc.	Crystalline solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA828650B (en) *	1981-12-01	1983-09-28	Hunt Chem Corp Philip A	Herbicidal compositions and method using phosphonalkanoic acids, esters and salts thereof
FR2596393B1 (en) *	1986-04-01	1988-06-03	Sanofi Sa	HYDROXY-3 DIHYDROXYOXOPHOSPHORIO-4 BUTANOIC ACID DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
AU610174B2 (en) *	1987-05-22	1991-05-16	E.R. Squibb & Sons, Inc.	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method

1988
- 1988-05-20 AU AU16508/88A patent/AU610591B2/en not_active Ceased
- 1988-05-20 NO NO882218A patent/NO882218L/en unknown
- 1988-05-20 DE DE3817375A patent/DE3817375C2/en not_active Expired - Fee Related
- 1988-05-20 IE IE930324A patent/IE930324L/en unknown
- 1988-05-20 FI FI882384A patent/FI89493C/en not_active IP Right Cessation
- 1988-05-20 ES ES8801610A patent/ES2009918A6/en not_active Expired
- 1988-05-20 GR GR880100331A patent/GR1000959B/en unknown
- 1988-05-20 PT PT87539A patent/PT87539B/en not_active IP Right Cessation
- 1988-05-20 IE IE154388A patent/IE63760B1/en not_active IP Right Cessation
- 1988-05-20 IL IL86464A patent/IL86464A/en not_active IP Right Cessation
- 1988-05-20 IT IT20682/88A patent/IT1217685B/en active
- 1988-05-20 NZ NZ224733A patent/NZ224733A/en unknown
- 1988-05-20 HU HU882614A patent/HU205125B/en not_active IP Right Cessation
- 1988-05-20 DK DK277488A patent/DK277488A/en not_active Application Discontinuation
- 1988-05-20 GB GB8811929A patent/GB2205837B/en not_active Expired - Fee Related
- 1988-05-20 PH PH36956A patent/PH25350A/en unknown
- 1988-05-20 SE SE8801903A patent/SE503210C2/en not_active IP Right Cessation
- 1988-05-21 CN CN198888103091A patent/CN88103091A/en active Pending
- 1988-05-21 KR KR1019880006020A patent/KR880013958A/en not_active Ceased
- 1988-05-21 PL PL1988272597A patent/PL154877B1/en unknown
- 1988-05-21 JP JP63124809A patent/JP2680347B2/en not_active Expired - Lifetime
- 1988-05-24 FR FR8806885A patent/FR2615508B1/en not_active Expired - Fee Related
- 1988-05-24 CH CH1967/88A patent/CH676984A5/fr not_active IP Right Cessation
- 1988-05-24 NL NL8801330A patent/NL8801330A/en not_active Application Discontinuation
- 1988-05-24 BE BE8800566A patent/BE1004193A3/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK277488A (en)	1988-11-23
JPS6456689A (en)	1989-03-03
DE3817375A1 (en)	1988-12-08
FR2615508B1 (en)	1994-11-25
IE63760B1 (en)	1995-06-14
JP2680347B2 (en)	1997-11-19
IT1217685B (en)	1990-03-30
FI89493C (en)	1993-10-11
FI882384A0 (en)	1988-05-20
HU205125B (en)	1992-03-30
NO882218D0 (en)	1988-05-20
AU1650888A (en)	1988-11-24
CN88103091A (en)	1988-12-21
AU610591B2 (en)	1991-05-23
FR2615508A1 (en)	1988-11-25
FI89493B (en)	1993-06-30
CH676984A5 (en)	1991-03-28
NZ224733A (en)	1990-12-21
IT8820682A0 (en)	1988-05-20
GB2205837A (en)	1988-12-21
IL86464A0 (en)	1988-11-15
ES2009918A6 (en)	1989-10-16
PH25350A (en)	1991-05-13
PL154877B1 (en)	1991-09-30
FI882384A7 (en)	1988-11-23
PL272597A1 (en)	1989-03-06
SE8801903L (en)	1988-11-23
PT87539A (en)	1989-05-31
PT87539B (en)	1992-09-30
DE3817375C2 (en)	1997-04-30
GB8811929D0 (en)	1988-06-22
SE8801903D0 (en)	1988-05-20
IE881543L (en)	1988-11-22
KR880013958A (en)	1988-12-22
GR880100331A (en)	1989-02-23
SE503210C2 (en)	1996-04-22
IL86464A (en)	1993-06-10
BE1004193A3 (en)	1992-10-13
DK277488D0 (en)	1988-05-20
NL8801330A (en)	1988-12-16
GR1000959B (en)	1993-03-16
HUT49358A (en)	1989-09-28
IE930324L (en)	1988-11-22
GB2205837B (en)	1991-11-20

Publication	Publication Date	Title
NO882218L (en)	1988-11-23	PROCEDURE FOR THE PREPARATION OF PHOSPHORUS HMG-COA REDUCTASE INHIBITORS.
NO860371L (en)	1986-08-05	PROCEDURE FOR THE PREPARATION OF PEPTIDASE INHIBITORS.
NO885605D0 (en)	1988-12-16	PROCEDURE FOR THE MANUFACTURE OF LUBRICANE OIL.
NO885106D0 (en)	1988-11-16	PROCEDURE FOR THE PREPARATION OF CYTIDIN DERIVATIVES.
DE3681991D1 (en)	1991-11-21	HMG-COA REDUCTASE INHIBITORS.
NO882219L (en)	1988-11-23	PROCEDURE FOR THE PREPARATION OF PHOSPHORUS HMG-COA REDUCTASE INHIBITORS.
NO880262L (en)	1988-07-25	PROCEDURE FOR THE PREPARATION OF B AVERMECTINES.
NO880068L (en)	1988-07-11	PROCEDURE FOR THE PREPARATION OF HETEROARYL-3-OXO-PROPANNITRIL DERIVATIVES.
NO872356D0 (en)	1987-06-04	PROCEDURE FOR THE PREPARATION OF MONOCALIUM PHOSPHATE.
NO884665L (en)	1989-04-24	PROCEDURE FOR THE PREPARATION OF 9-OH-ALCOXYGUANINE.
NO880910D0 (en)	1988-03-01	PROCEDURE FOR THE PREPARATION OF CHROMON DERIVATIVES.
PT88364A (en)	1989-07-31	PROCESS FOR PREPARING NOVEL HMG-COA REDUCTASE INHIBITORS
NO883145D0 (en)	1988-07-14	PROCEDURE FOR THE PREPARATION OF TIENOIMIDAZOLD DERIVATIVES.
NO882730L (en)	1988-12-23	PROCEDURE FOR THE PREPARATION OF AMINOCYCLOPENTYLETERS.
NO170022C (en)	1992-09-02	PROCEDURE FOR THE PREPARATION OF SIALOCYLGYLEROLIPIDES.
NO901422D0 (en)	1990-03-28	PROCEDURE FOR THE PREPARATION OF ALFA-GLUCOSIDASE INHIBITORS.
NO881055L (en)	1988-09-12	PROCEDURE FOR THE PREPARATION OF OXO-ISOINDOLINYL DERIVATIVES.
NO880106L (en)	1988-08-19	PROCEDURE FOR THE PREPARATION OF THE LALKNITROGEN.
NO883610D0 (en)	1988-08-12	PROCEDURE FOR THE PREPARATION OF SUBSTITUTED TIENOIMIDAZOLE DERIVATIVES.
NO880834L (en)	1988-08-29	PROCEDURE FOR THE PREPARATION OF HETEROCYCLYL-2-PROPYN-1-AMINES.
NO883398D0 (en)	1988-08-01	PROCEDURE FOR THE PREPARATION OF BENZOCSAZINE DERIVATIVES.
NO872355D0 (en)	1987-06-04	PROCEDURE FOR THE PREPARATION OF MONOCALIUM PHOSPHATE.
NO892761D0 (en)	1989-07-04	PROCEDURE FOR MANUFACTURING INHIBITORS FOR 3-KETO-HMG-COA REDUCTASE.
NO913089L (en)	1988-08-26	PROCEDURE FOR THE PREPARATION OF TETRAZOLIC COMPOUNDS.
NO890375L (en)	1989-03-29	PROCEDURE FOR THE PREPARATION OF HEXANITROSTILBEN.