NO842990L - Fremgangsmaate for fremstilling av tiogenin-cellobiosid - Google Patents

Fremgangsmaate for fremstilling av tiogenin-cellobiosid

Info

Publication number: NO842990L
Authority: NO; Norway
Prior art keywords: tigogenin; cellobioside; cholesterol; anomer; mixture
Prior art date: 1984-04-20

Application number

NO842990A

Other languages

English (en)

Norwegian (no)

Inventor

M Rene Malinow

Original Assignee

Oregon Medical Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-20

Filing date

1984-07-23

Publication date

1985-10-21

1984-07-23 Application filed by Oregon Medical Res Found filed Critical Oregon Medical Res Found

1985-10-21 Publication of NO842990L publication Critical patent/NO842990L/no

Links

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238000002360 preparation method Methods 0.000 title description 24
239000000203 mixture Substances 0.000 claims abstract description 46
150000001875 compounds Chemical class 0.000 claims abstract description 42
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WOTQVEKSRLZRSX-HYSGBLIFSA-N [(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1 WOTQVEKSRLZRSX-HYSGBLIFSA-N 0.000 claims description 12
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235000020679 tap water Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
230000008719 thickening Effects 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
230000007306 turnover Effects 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1
230000008673 vomiting Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Anesthesiology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Vascular Medicine (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Cephalosporin Compounds (AREA)
Inorganic Compounds Of Heavy Metals (AREA)

NO842990A 1984-04-20 1984-07-23 Fremgangsmaate for fremstilling av tiogenin-cellobiosid NO842990L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/602,298 US4602005A (en)	1982-05-17	1984-04-20	Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis

Publications (1)

Publication Number	Publication Date
NO842990L true NO842990L (no)	1985-10-21

Family

ID=24410793

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO842990A NO842990L (no)	1984-04-20	1984-07-23	Fremgangsmaate for fremstilling av tiogenin-cellobiosid

Country Status (16)

Country	Link
US (1)	US4602005A (da)
EP (1)	EP0159431B1 (da)
JP (1)	JPS60224697A (da)
KR (1)	KR940002114B1 (da)
AT (1)	ATE42959T1 (da)
AU (1)	AU580005B2 (da)
CA (1)	CA1246544A (da)
DE (1)	DE3478114D1 (da)
DK (2)	DK165839C (da)
ES (1)	ES8601233A1 (da)
FI (2)	FI82253C (da)
HU (1)	HUT37802A (da)
IE (1)	IE58015B1 (da)
NO (1)	NO842990L (da)
NZ (1)	NZ208961A (da)
ZA (1)	ZA845690B (da)

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HUT67035A (en) *	1991-11-25	1995-01-30	Pfizer	New process for the production of steroidal glycosides derivatives
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US5530107A (en) *	1992-10-15	1996-06-25	Pfizer Inc.	Method for making steroidal peracyl glycosides
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ES2074006B1 (es) *	1993-07-05	1996-03-16	Pfizer	Glicosidos esteroidales para tratar hipercolesterolemia.
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US6150336A (en) *	1995-05-29	2000-11-21	Pfizer Inc.	Steroidal glycosides
US5698527A (en) *	1995-08-08	1997-12-16	Merck & Co., Inc.	Steroidal glycosides as antihyperlipidemic agents
US5756470A (en) *	1996-10-29	1998-05-26	Schering Corporation	Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
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GB9923076D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
GB9923078D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
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GB0000228D0 (en) *	2000-01-06	2000-03-01	Phytopharm Plc	Fluoro substituted sapogenins and their use
US6982251B2 (en) *	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
ES2296894T3 (es) *	2001-01-26	2008-05-01	Schering Corporation	Combinaciones de ezetimiba con aspirina para tratar estados vasculares.
US7071181B2 (en) *	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
EP1353695A2 (en) *	2001-01-26	2003-10-22	Schering Corporation	Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
WO2002058733A2 (en) *	2001-01-26	2002-08-01	Schering Corporation	Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
CN100522159C (zh) *	2001-01-26	2009-08-05	先灵公司	取代的氮杂环丁烷酮化合物在制备治疗谷甾醇血症的药物中的应用
RS20100015A (en) *	2001-01-26	2010-12-31	Schering Corporation	Combination of receptor activator activated by fenofibrate peroxisome-proliferator (ppar) with sterol absorption inhibitor ezetimibe for vascular indications
DK1385548T3 (da) *	2001-01-26	2007-09-10	Schering Corp	Kombinationer af sterolabsorptionsinhibitor(er) med (et eller flere) kardiovaskulære midler til behandling af vaskulære tilstande
GB0107822D0 (en) *	2001-03-28	2001-05-23	Phytopharm Plc	Sapogenin derivatives their synthesis and use methods based upon their use
CA2447884A1 (en) *	2001-05-25	2002-12-05	Schering Corporation	Use of azetidinone substituted derivatives in the treatment of alzheimer's disease
MXPA04002572A (es) *	2001-09-21	2004-05-31	Schering Corp	Metodos para el tratamiento o prevencion de inflamacion vascular usando inhibidores de absorcion de esterol.
US7053080B2 (en) *	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
WO2003026643A2 (en) *	2001-09-21	2003-04-03	Schering Corporation	Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7056906B2 (en) *	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119808A1 (en) *	2001-09-21	2003-06-26	Schering Corporation	Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
KR101130212B1 (ko) *	2002-03-27	2012-04-13	파이토팜 피엘씨	사포게닌 및 그 유도체의 치료 방법 및 사용법
US20050130948A1 (en) *	2002-03-27	2005-06-16	Daryl Rees	Therapeutic methods and uses of sapogenins and their derivatives
EP1560579A1 (en) *	2002-11-06	2005-08-10	Schering Corporation	Cholesterol absorption inhibitors for the treatment of autoimmune disorders
DE602004018617D1 (de)	2003-03-07	2009-02-05	Schering Corp	Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
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US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EP1606287B1 (en) *	2003-03-07	2013-10-02	Merck Sharp & Dohme Corp.	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
JP2007510659A (ja) *	2003-11-05	2007-04-26	シェーリング　コーポレイション	脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置
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DE2759171A1 (de) *	1977-12-31	1979-07-12	Roecar Holdings Nv	Arzneimittel mit wirkung als prostaglandinsynthetaseninhibitor
DE2926463A1 (de) *	1978-07-05	1980-01-24	Roecar Holdings Nv	Spiroketaline und ihre verwendung
US4260603A (en) *	1979-01-02	1981-04-07	Pegel Karl H	Sterol glycoside with activity as prostaglandin synthetase inhibitor
US4242502A (en) *	1979-04-20	1980-12-30	United States Of America	Enhancement of cholesterol combining properties of saponins
US4602003A (en) *	1982-05-17	1986-07-22	Medical Research Foundation Of Oregon	Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
US4602005A (en) *	1982-05-17	1986-07-22	Medical Research Foundation Of Oregon	Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis

1984
- 1984-04-20 US US06/602,298 patent/US4602005A/en not_active Expired - Lifetime
- 1984-07-20 NZ NZ208961A patent/NZ208961A/en unknown
- 1984-07-23 DK DK361084A patent/DK165839C/da not_active IP Right Cessation
- 1984-07-23 IE IE190484A patent/IE58015B1/en not_active IP Right Cessation
- 1984-07-23 ZA ZA845690A patent/ZA845690B/xx unknown
- 1984-07-23 KR KR1019840004369A patent/KR940002114B1/ko not_active IP Right Cessation
- 1984-07-23 AT AT84304993T patent/ATE42959T1/de not_active IP Right Cessation
- 1984-07-23 JP JP59153899A patent/JPS60224697A/ja active Granted
- 1984-07-23 ES ES534553A patent/ES8601233A1/es not_active Expired
- 1984-07-23 AU AU30977/84A patent/AU580005B2/en not_active Ceased
- 1984-07-23 HU HU842837A patent/HUT37802A/hu unknown
- 1984-07-23 NO NO842990A patent/NO842990L/no unknown
- 1984-07-23 EP EP84304993A patent/EP0159431B1/en not_active Expired
- 1984-07-23 FI FI842935A patent/FI82253C/fi not_active IP Right Cessation
- 1984-07-23 DE DE8484304993T patent/DE3478114D1/de not_active Expired
- 1984-07-23 CA CA000459491A patent/CA1246544A/en not_active Expired
1990
- 1990-02-02 FI FI900531A patent/FI87792C/fi not_active IP Right Cessation
1992
- 1992-02-06 DK DK014892A patent/DK166213C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI87792B (fi)	1992-11-13
DK165839C (da)	1993-06-21
DK166213C (da)	1993-08-16
AU3097784A (en)	1985-10-24
IE58015B1 (en)	1993-06-16
EP0159431A3 (en)	1986-01-08
HUT37802A (en)	1986-02-28
FI842935A (fi)	1985-10-21
IE841904L (en)	1985-10-20
AU580005B2 (en)	1988-12-22
FI87792C (fi)	1993-02-25
ATE42959T1 (de)	1989-05-15
US4602005A (en)	1986-07-22
FI82253C (fi)	1991-02-11
FI842935A0 (fi)	1984-07-23
CA1246544A (en)	1988-12-13
FI82253B (fi)	1990-10-31
ES534553A0 (es)	1985-11-16
DK14892A (da)	1992-02-06
EP0159431A2 (en)	1985-10-30
DK361084D0 (da)	1984-07-23
DK166213B (da)	1993-03-22
DK361084A (da)	1985-10-21
EP0159431B1 (en)	1989-05-10
JPS60224697A (ja)	1985-11-09
NZ208961A (en)	1988-01-08
ES8601233A1 (es)	1985-11-16
DK14892D0 (da)	1992-02-06
KR850007432A (ko)	1985-12-04
DK165839B (da)	1993-01-25
ZA845690B (en)	1986-03-26
FI900531A0 (fi)	1990-02-02
DE3478114D1 (en)	1989-06-15
KR940002114B1 (ko)	1994-03-17
JPH0456840B2 (da)	1992-09-09

Publication	Publication Date	Title
NO842990L (no)	1985-10-21	Fremgangsmaate for fremstilling av tiogenin-cellobiosid
CA1280369C (en)	1991-02-19	Pharmaceutical with anti-tumor effect
AU629563B2 (en)	1992-10-08	Substituted 4-azatricyclo (22.3.1.0 4,9) octacos-18-ene derivatives
KOBAYASHI et al.	1991	Marine natural products. XXVII. Distribution of lanostane-type triterpene oligoglycosides in ten kinds of Okinawan sea cucumbers
CN102675403A (zh)	2012-09-19	抗乙肝药物lqc-x的合成及其应用
US5045532A (en)	1991-09-03	Inner esters of gangliosides with analgesic-antiinflammatory activity
GB1599863A (en)	1981-10-07	Pharmaceutical compositions for use in the inhibition of the biosynthesis of mevalonic acid
US4117121A (en)	1978-09-26	Method of increasing bile flow and decreasing lipid levels
US5643869A (en)	1997-07-01	Pipecolic acid-containing peptolides, their preparation and pharmaceutical compositions containing them
SK43593A3 (en)	1995-07-11	Tricyclic and tetracyclic macrolides contains heteroatoms, method of their preparation and pharmaceutical agent
US6136800A (en)	2000-10-24	17-Difluoromethylene-estratrienes
US6833443B1 (en)	2004-12-21	Gymnemic acid derivatives, process for the preparation thereof and use thereof as medicine
DE69310721T2 (de)	1997-09-04	Zuckerderivate von makroliden
DE69314947T2 (de)	1998-03-05	2-aminozuckermakrolid-derivate
US3914212A (en)	1975-10-21	New anhydrofuranose derivatives and processes for their manufacture
US3767800A (en)	1973-10-23	Substituted ribofuranosides as hypolipidemics
CN115737653B (zh)	2024-11-19	一种三萜类化合物在制备降血糖药物或功能食品中的应用
WO1998007739A1 (en)	1998-02-26	Novel ouabain analogs
US4914234A (en)	1990-04-03	10,10-Dihydro-10-((substituted-carbonyl)imino)-10-phenyl-10H-phenoxaphosphine, hydrochloride
US5625044A (en)	1997-04-29	Methods for the preparation of pure homologous series of mono to tetra fatty acyl esters of sugars and pharmaceutical formulations useful in the treatment of cancer
US4378369A (en)	1983-03-29	Esters of 2,5-anhydro-D-mannitol
JPH01143877A (ja)	1989-06-06	スタウロスポリン誘導体
JP3380667B2 (ja)	2003-02-24	新規生理活性物質ｐｆ１０９２ａ物質、ｐｆ１０９２ｂ物質及びｐｆ１０９２ｃ物質，それらの製造法並びにそれらを有効成分とする避妊剤及び制癌剤
KR0154504B1 (ko)	1998-11-16	콜레스테릴 에스테르 전이 단백질 저해제 및 이의 제조방법
KR830000630B1 (ko)	1983-03-23	스피로케탈-스테로이드 글리코 사이드의 제조방법