NO801182L - Fremgangsmaate ved fremstilling av imidazolinderivater - Google Patents

Fremgangsmaate ved fremstilling av imidazolinderivater

Info

Publication number: NO801182L
Authority: NO; Norway
Prior art keywords: phenyl; compound; general formula; fluoro; solution
Prior art date: 1979-04-24

Application number

NO801182A

Other languages

English (en)

Norwegian (no)

Inventor

Helmut Link

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-04-24

Filing date

1980-04-23

Publication date

1980-10-27

1980-04-23 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1980-10-27 Publication of NO801182L publication Critical patent/NO801182L/no

Links

238000000034 method Methods 0.000 title claims abstract description 11
238000002360 preparation method Methods 0.000 title description 3
150000002462 imidazolines Chemical class 0.000 title 1
229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 26
-1 hydantoin compound Chemical class 0.000 claims abstract description 23
229940091173 hydantoin Drugs 0.000 claims abstract description 7
239000001257 hydrogen Substances 0.000 claims abstract description 6
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 4
150000002461 imidazolidines Chemical class 0.000 claims abstract description 4
239000001301 oxygen Chemical group 0.000 claims abstract description 4
229910052760 oxygen Chemical group 0.000 claims abstract description 4
125000001841 imino group Chemical group [H]N=* 0.000 claims abstract description 3
238000004519 manufacturing process Methods 0.000 claims abstract description 3
229910052736 halogen Inorganic materials 0.000 claims description 6
150000002367 halogens Chemical class 0.000 claims description 6
125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 2
150000002431 hydrogen Chemical class 0.000 claims description 2
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims description 2
230000003301 hydrolyzing effect Effects 0.000 abstract 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 56
239000000243 solution Substances 0.000 description 37
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 29
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 18
239000000047 product Substances 0.000 description 15
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
238000001035 drying Methods 0.000 description 14
229910000030 sodium bicarbonate Inorganic materials 0.000 description 12
235000017557 sodium bicarbonate Nutrition 0.000 description 12
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
238000003756 stirring Methods 0.000 description 10
239000003208 petroleum Substances 0.000 description 9
229910052938 sodium sulfate Inorganic materials 0.000 description 9
235000011152 sodium sulphate Nutrition 0.000 description 9
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 9
238000006243 chemical reaction Methods 0.000 description 8
JQULXIOYDDCNGR-UHFFFAOYSA-N 2-amino-2-methylpropanenitrile Chemical compound CC(C)(N)C#N JQULXIOYDDCNGR-UHFFFAOYSA-N 0.000 description 7
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
239000002253 acid Substances 0.000 description 5
150000002148 esters Chemical class 0.000 description 5
239000007858 starting material Substances 0.000 description 5
OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 4
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
238000009835 boiling Methods 0.000 description 4
239000004202 carbamide Substances 0.000 description 4
238000004587 chromatography analysis Methods 0.000 description 4
238000001816 cooling Methods 0.000 description 4
239000000203 mixture Substances 0.000 description 4
AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 description 4
YGAIHENVDYKRCA-UHFFFAOYSA-N 1-[4-fluoro-3-(trifluoromethyl)phenyl]-5-imino-4,4-dimethylimidazolidin-2-one Chemical compound N=C1C(C)(C)NC(=O)N1C1=CC=C(F)C(C(F)(F)F)=C1 YGAIHENVDYKRCA-UHFFFAOYSA-N 0.000 description 3
KXALCBULAZGRHX-UHFFFAOYSA-N 4-amino-1,5-dihydroimidazol-2-one Chemical compound NC1=NC(=O)NC1 KXALCBULAZGRHX-UHFFFAOYSA-N 0.000 description 3
PGFQDLOMDIBAPY-UHFFFAOYSA-N 4-fluoro-3-(trifluoromethyl)aniline Chemical compound NC1=CC=C(F)C(C(F)(F)F)=C1 PGFQDLOMDIBAPY-UHFFFAOYSA-N 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
239000002552 dosage form Substances 0.000 description 3
238000001704 evaporation Methods 0.000 description 3
230000008020 evaporation Effects 0.000 description 3
239000000284 extract Substances 0.000 description 3
WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 3
230000001843 schistosomicidal effect Effects 0.000 description 3
239000000126 substance Substances 0.000 description 3
KXJGSEHRBVEMQL-UHFFFAOYSA-N 3-(3-chloro-4-fluorophenyl)-5,5-dimethylimidazolidine-2,4-dione Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C(F)C(Cl)=C1 KXJGSEHRBVEMQL-UHFFFAOYSA-N 0.000 description 2
BTGSGTWRNQCEQY-UHFFFAOYSA-N 3-[4-fluoro-3-(trifluoromethyl)phenyl]-5,5-dimethylimidazolidine-2,4-dione Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C(F)C(C(F)(F)F)=C1 BTGSGTWRNQCEQY-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 description 2
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
239000013543 active substance Substances 0.000 description 2
230000002280 anti-androgenic effect Effects 0.000 description 2
239000001110 calcium chloride Substances 0.000 description 2
229910001628 calcium chloride Inorganic materials 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
229910021641 deionized water Inorganic materials 0.000 description 2
239000003814 drug Substances 0.000 description 2
NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 2
239000012065 filter cake Substances 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
239000005457 ice water Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
230000009965 odorless effect Effects 0.000 description 2
UYMCNKBLWIZQGB-UHFFFAOYSA-N phenyl n-(3-chloro-4-fluorophenyl)carbamate Chemical compound C1=C(Cl)C(F)=CC=C1NC(=O)OC1=CC=CC=C1 UYMCNKBLWIZQGB-UHFFFAOYSA-N 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
NXLNNXIXOYSCMB-UHFFFAOYSA-N (4-nitrophenyl) carbonochloridate Chemical compound [O-][N+](=O)C1=CC=C(OC(Cl)=O)C=C1 NXLNNXIXOYSCMB-UHFFFAOYSA-N 0.000 description 1
VTWDOMAUSAHNFK-UHFFFAOYSA-N 1-(2-cyanopropyl)-3-[4-fluoro-3-(trifluoromethyl)phenyl]urea Chemical compound C(#N)C(CNC(=O)NC1=CC(=C(C=C1)F)C(F)(F)F)C VTWDOMAUSAHNFK-UHFFFAOYSA-N 0.000 description 1
GGUGWVOGQXTERV-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-5-imino-4,4-dimethylimidazolidin-2-one Chemical compound N=C1C(C)(C)NC(=O)N1C1=CC=C(Cl)C(Cl)=C1 GGUGWVOGQXTERV-UHFFFAOYSA-N 0.000 description 1
NWCVKLWDIQFILS-UHFFFAOYSA-N 1-(3-chloro-4-fluorophenyl)-5-imino-4,4-dimethylimidazolidin-2-one Chemical compound N=C1C(C)(C)NC(=O)N1C1=CC=C(F)C(Cl)=C1 NWCVKLWDIQFILS-UHFFFAOYSA-N 0.000 description 1
ZUFUZSVHWNKTSD-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)-5,5-dimethylimidazolidine-2,4-dione Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C(Cl)C(Cl)=C1 ZUFUZSVHWNKTSD-UHFFFAOYSA-N 0.000 description 1
KHMUGGRQTYOIFY-UHFFFAOYSA-N 3-(4-bromophenyl)-5,5-dimethylimidazolidine-2,4-dione Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C(Br)C=C1 KHMUGGRQTYOIFY-UHFFFAOYSA-N 0.000 description 1
RLAOTBYZHSLMDN-UHFFFAOYSA-N 3-(4-chlorophenyl)-5,5-dimethylimidazolidine-2,4-dione Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C(Cl)C=C1 RLAOTBYZHSLMDN-UHFFFAOYSA-N 0.000 description 1
YSEMCVGMNUUNRK-UHFFFAOYSA-N 3-chloro-4-fluoroaniline Chemical compound NC1=CC=C(F)C(Cl)=C1 YSEMCVGMNUUNRK-UHFFFAOYSA-N 0.000 description 1
TUNLSLFBJPZFNN-UHFFFAOYSA-N 5,5-dimethyl-3-[4-(trifluoromethyl)phenyl]imidazolidine-2,4-dione Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C(C(F)(F)F)C=C1 TUNLSLFBJPZFNN-UHFFFAOYSA-N 0.000 description 1
241000238876 Acari Species 0.000 description 1
208000002874 Acne Vulgaris Diseases 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
206010020112 Hirsutism Diseases 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
241000700159 Rattus Species 0.000 description 1
241000242680 Schistosoma mansoni Species 0.000 description 1
206010039792 Seborrhoea Diseases 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
QLDISJBNQHJOHZ-UHFFFAOYSA-N [4-fluoro-3-(trifluoromethyl)phenyl]urea Chemical compound NC(=O)NC1=CC=C(F)C(C(F)(F)F)=C1 QLDISJBNQHJOHZ-UHFFFAOYSA-N 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
206010000496 acne Diseases 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
239000003098 androgen Substances 0.000 description 1
239000000051 antiandrogen Substances 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000007664 blowing Methods 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
229940125890 compound Ia Drugs 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
150000001923 cyclic compounds Chemical class 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000008298 dragée Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
150000001469 hydantoins Chemical class 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000000155 melt Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
MVXLHYKEKXUFFZ-UHFFFAOYSA-N phenyl n-(3,4-dichlorophenyl)carbamate Chemical compound C1=C(Cl)C(Cl)=CC=C1NC(=O)OC1=CC=CC=C1 MVXLHYKEKXUFFZ-UHFFFAOYSA-N 0.000 description 1
239000010773 plant oil Substances 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
201000004409 schistosomiasis Diseases 0.000 description 1
208000008742 seborrheic dermatitis Diseases 0.000 description 1
210000001625 seminal vesicle Anatomy 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
201000010653 vesiculitis Diseases 0.000 description 1
238000005406 washing Methods 0.000 description 1
230000004580 weight loss Effects 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Tropical Medicine & Parasitology (AREA)
General Chemical & Material Sciences (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Epoxy Resins (AREA)
Emergency Protection Circuit Devices (AREA)
Control Of Transmission Device (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)

NO801182A 1979-04-24 1980-04-23 Fremgangsmaate ved fremstilling av imidazolinderivater NO801182L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH383779		1979-04-24

Publications (1)

Publication Number	Publication Date
NO801182L true NO801182L (no)	1980-10-27

Family

ID=4264536

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO801182A NO801182L (no)	1979-04-24	1980-04-23	Fremgangsmaate ved fremstilling av imidazolinderivater

Country Status (13)

Country	Link
EP (1)	EP0017976B1 (fi)
JP (1)	JPS55143974A (fi)
KR (1)	KR850000719B1 (fi)
AT (1)	ATE3860T1 (fi)
CA (1)	CA1135706A (fi)
DE (1)	DE3063837D1 (fi)
DK (1)	DK174480A (fi)
ES (1)	ES8104243A1 (fi)
FI (1)	FI801184A (fi)
GR (1)	GR67605B (fi)
HU (1)	HU184271B (fi)
NO (1)	NO801182L (fi)
PT (1)	PT71135B (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5411981A (en) *	1991-01-09	1995-05-02	Roussel Uclaf	Phenylimidazolidines having antiandrogenic activity
USRE35956E (en) *	1991-01-09	1998-11-10	Roussel Uclaf	Phenylimidazolidines having antiandrogenic activity
FR2724169B1 (fr) *	1994-09-06	1997-01-03	Roussel Uclaf	Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
TW521073B (en) *	1994-01-05	2003-02-21	Hoechst Marion Roussel Inc	New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2715402B1 (fr) *	1994-01-05	1996-10-04	Roussel Uclaf	Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
EP2299266A1 (en)	2003-12-19	2011-03-23	The Regents of the University of California	Methods and materials for assessing prostate cancer therapies
AU2005232526B2 (en)	2004-02-24	2011-06-23	The Regents Of The University Of California	Methods and materials for assessing prostate cancer therapies and compounds
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ES2588606T3 (es)	2006-03-27	2016-11-03	The Regents Of The University Of California	Modulador del receptor de andrógenos para el tratamiento del cáncer de próstata y enfermedades asociadas con el receptor de andrógenos
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1980
- 1980-04-14 FI FI801184A patent/FI801184A/fi not_active Application Discontinuation
- 1980-04-16 AT AT80102042T patent/ATE3860T1/de not_active IP Right Cessation
- 1980-04-16 EP EP80102042A patent/EP0017976B1/de not_active Expired
- 1980-04-16 DE DE8080102042T patent/DE3063837D1/de not_active Expired
- 1980-04-18 CA CA000350162A patent/CA1135706A/en not_active Expired
- 1980-04-21 JP JP5180480A patent/JPS55143974A/ja active Pending
- 1980-04-22 GR GR61749A patent/GR67605B/el unknown
- 1980-04-23 NO NO801182A patent/NO801182L/no unknown
- 1980-04-23 HU HU80995A patent/HU184271B/hu unknown
- 1980-04-23 DK DK174480A patent/DK174480A/da not_active Application Discontinuation
- 1980-04-23 PT PT71135A patent/PT71135B/pt unknown
- 1980-04-23 ES ES490799A patent/ES8104243A1/es not_active Expired
- 1980-04-24 KR KR1019800001691A patent/KR850000719B1/ko active IP Right Grant

Also Published As

Publication number	Publication date
EP0017976A3 (en)	1981-04-01
ES490799A0 (es)	1981-04-16
ES8104243A1 (es)	1981-04-16
DE3063837D1 (en)	1983-07-28
JPS55143974A (en)	1980-11-10
EP0017976B1 (de)	1983-06-22
PT71135A (en)	1980-05-01
KR830002722A (ko)	1983-05-30
FI801184A (fi)	1980-10-25
PT71135B (en)	1981-08-07
CA1135706A (en)	1982-11-16
ATE3860T1 (de)	1983-07-15
GR67605B (fi)	1981-08-31
HU184271B (en)	1984-07-30
KR850000719B1 (ko)	1985-05-23
EP0017976A2 (de)	1980-10-29
DK174480A (da)	1980-10-25

Publication	Publication Date	Title
NO801182L (no)	1980-10-27	Fremgangsmaate ved fremstilling av imidazolinderivater
US4234736A (en)	1980-11-18	Antiandrogenic and schistosomicidal imidazolidine derivatives
NO151461B (no)	1985-01-02	Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazolidinderivater
NO125974B (fi)	1972-12-04
JPS604815B2 (ja)	1985-02-06	プロリン誘導体
DE69805473T2 (de)	2003-01-16	Arylsulfonylaminohydroxamsäurederivate
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NO157979B (no)	1988-03-14	Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive benzotiazindioksyd-salter.
US4670469A (en)	1987-06-02	Hydroxamic acid and pharmaceutical preparations containing the same
US4249021A (en)	1981-02-03	Indanacetic acid compounds
US4544655A (en)	1985-10-01	Antiinflammatory, analgesic, and antirheumatic 4-hydroxy-2-methyl-n-(2-pyridyl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide, corresponding compositions, and 3-carboxylic acid lower alkyl ester intermediates
US4435420A (en)	1984-03-06	Anti-inflammatory agents and antiasthmatic agents
CA1090798A (en)	1980-12-02	8 and/or 9 substituted 2-benzazepine compounds
JPS62230782A (ja)	1987-10-09	イミダゾリン誘導体、その製法および除草剤
US3509211A (en)	1970-04-28	Sulfamides
DK141749B (da)	1980-06-09	Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser.
NO761723L (fi)	1976-11-23
US3982018A (en)	1976-09-21	4-Ethers of 3-amino-5-sulfamoylbenzoic acids
US4208430A (en)	1980-06-17	Pharmaceutical compositions and method of inhibiting phenylethanolamine N-methyltransferase
JPS6388170A (ja)	1988-04-19	３−アリ−ル−２，１−ベンゾイソオキサゾールの酢酸誘導体及びそのエステルならびにアミド
US4112102A (en)	1978-09-05	Halopyridyl derivatives of m-aminotetramisole as anthelmintics
DE2438779A1 (de)	1975-02-27	Neue halogenpyrazolderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel
NZ199228A (en)	1984-05-31	Imidazolecarboxamide derivatives and pharmaceutical compositions
RU2024507C1 (ru)	1994-12-15	5-хлор-2-пиридиламид-4-нитро-n-(карбоксиметил)антраниловой кислоты, проявляющий противовоспалительную активность