NO327709B1 -
2'-substituted 1,1'-biphenyl-2-carbonamides, their use in the preparation of a drug as well as pharmaceutical preparations containing them
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2'-substituted 1,1'-biphenyl-2-carbonamides, their use in the preparation of a drug as well as pharmaceutical preparations containing them
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NO327709B1
NO327709B1NO20021398ANO20021398ANO327709B1NO 327709 B1NO327709 B1NO 327709B1NO 20021398 ANO20021398 ANO 20021398ANO 20021398 ANO20021398 ANO 20021398ANO 327709 B1NO327709 B1NO 327709B1
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1.
Forbindelser av formel I,
hvor R(l) betyr C(0)OR(9), SO2R(10), COR(l 1), C(0)NR(12)R(13) eller C(S)NR(12)R(13); R(9) betyr CxH2x-R(14);
x betyr 0,1,2, 3 eller 4,
hvor x ikke kan være 0, når R(14) betyr OR(15) eller S02Me;
R(14) betyr alkyl med 1,2, 3,4,5 eller 6 C-atomer, cykloalkyl med 3,4, 5,6,7,8,9,10 eller 11 C-atomer, CF3, C2F5, C3F7, CH2F, CHF2, OR(15), S02Me, fenyl, naftyl, bifenylyl, furyl, tienyl eller et N-holdig heteroaromat med 1,2, 3,4, 5,6, 7, 8 eller 9 C-atomer,
hvor fenyl, naftyl, bifenylyl, furyl, tienyl og det N-holdige heteroaromat er usubstituert eller substituert med 1, 2 eller 3 substituenter valgt blant gruppen bestående av F, Cl, Br, I, CF3, OCF3, N02, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1,2, 3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(15) betyr alkyl med 1,2,3,4 eller 5 C-atomer, cykloalkyl med 3,4, 5 eller 6 C-atomer, CF3 eller fenyl, som er usubstituert eller substituert med 1,2 eller 3 substituenter valgt blant gruppen bestående av F, Cl, Br, I, CF3, N02, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1, 2, 3 eller 4 C-atomer, alkoksy med 1,2, 3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(10),R(ll)ogR(12)
er uavhengig av hverandre definert som R(9);
R(13) betyr hydrogen, alkyl med 1, 2, 3, eller 4 C-atomer eller CF3; R(2) betyr hydrogen, alkyl med 1,2,3 eller 4 C-atomer eller CF3; R(3) betyr CyH2y-R(16);
y betyr 0,1,2,3 eller 4,
hvor y ikke kan være 0, når R(16) betyr OR(17) eller S02Me;
R(16) betyr alkyl med 1,2, 3,4, 5 eller 6 C-atomer, cykloalkyl med 3,4, 5,6,7, 8,9,10 eller 11 C-atomer, CF3, C2F5, C3F7, CH2F, CHF2, OR(17), S02Me, fenyl, naftyl, furyl, tienyl eller en N-holdig heteroaromat med 1, 2,3,4,5,6, 7,8 eller 9 C-atomer,
hvor fenyl, naftyl, furyl, tienyl og det N-holdige heteroaromatet er usubstituert eller substituert med 1,2 eller 3 substituenter valgt blant gruppen bestående av F, Cl, Br, I, CF3, OCF3, N02, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2, 3 eller 4 C-atomer, alkoksy med 1,2,3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(17) betyr hydrogen, alkyl med 1,2, 3,4 eller 5 C-atomer, cykloalkyl
med 3,4, 5 eller 6 C-atomer, CF3, fenyl eller 2-, 3- eller 4-pyridyl,
hvor fenyl eller 2-, 3- eller 4-pyridyl er usubstituert eller substituert med 1,2 eller 3 substituenter valgt fra gruppen
bestående av F, Cl, Br, I, CF3, OCF3, N02, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1, 2, 3 eller 4 C-atomer, alkoksy med 1,2,3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
eller R(3) betyr CHR(18)R(19);
R(18) betyr hydrogen eller CzH2z-R(16), hvor R(16) er definert som angitt over; z betyr 0,1,2 eller 3;
R(19) betyr COOH, CONH2, CONR(20)R(21), COOR(22), CH2OH;
R(20) betyr hydrogen, alkyl med 1,2, 3,4 eller 5 C-atomer, CvH2v-CF3
eller CwH2w-fenyl,
hvor fenylringen er usubstituert eller substituert med 1,2 eller 3 substituenter valgt fra gruppen bestående F, Cl, Br, I, CF3, OCF3, N02, CN, COOMe, CONH2, COMe, NH2,
OH, alkyl med 1,2, 3 eller 4 C-atomer, alkoksy med 1,2, 3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfo-
nyl og metylsulfonylamino;
v betyr 0,1,2 eller 3;
w betyr 0,1,2 eller 3;
R(21) betyr hydrogen eller alkyl med 1,2,3,4 eller 5 C-atomer; R(22) betyr alkyl med 1,2,3,4 eller 5 C-atomer; R(4) betyr hydrogen, alkyl med 1,2, 3,4,5 eller 6 C-atomer eller CF3;
eller R(3) ogR(4)
betyr sammen en kjede på 4 eller 5 metylengrupper, av hvilke en metylengruppe kan være erstattet med -O-, -SO-, -NH-, -N(metyl)- eller -N(benzyl)-;
R(5),R(6),R(7)ogR(8)
betyr uavhengig av hverandre hydrogen, F, Cl, Br, I, CF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1,2, 3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl eller metylsulfonylamino;
R(30)ogR(31)
betyr uavhengig av hverandre hydrogen eller alkyl med 1,2 eller 3 C-atomer;
eller
R(30)ogR(31)
betyr sammen en kjede på 2 metylengrupper;
så vel som deres farmasøytisk akseptable salter.1.
Compounds of formula I,
where R(l) means C(0)OR(9), SO2R(10), COR(l 1), C(0)NR(12)R(13) or C(S)NR(12)R(13 ); R(9) means CxH2x-R(14);
x means 0,1,2,3 or 4,
where x cannot be 0, when R(14) is OR(15) or SO 2 Me;
R(14) means alkyl with 1,2, 3,4,5 or 6 C atoms, cycloalkyl with 3,4, 5,6,7,8,9,10 or 11 C atoms, CF3, C2F5, C3F7 , CH2F, CHF2, OR(15), SO2Me, phenyl, naphthyl, biphenylyl, furyl, thienyl or an N-containing heteroaromatic with 1,2, 3,4, 5,6, 7, 8 or 9 C atoms,
where phenyl, naphthyl, biphenylyl, furyl, thienyl and the N-containing heteroaromatic are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH 2 , COMe, NH 2 , OH, alkyl of 1,2,3 or 4 carbon atoms, alkoxy of 1,2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(15) means alkyl with 1,2,3,4 or 5 C atoms, cycloalkyl with 3,4, 5 or 6 C atoms, CF 3 or phenyl, which is unsubstituted or substituted with 1,2 or 3 substituents chosen from the group consisting of F, Cl, Br, I, CF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl with 1, 2, 3 or 4 C atoms, alkoxy with 1,2, 3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl, and methylsulfonylamino;
R(10),R(ll)andR(12)
are independently defined as R(9);
R(13) means hydrogen, alkyl with 1, 2, 3, or 4 carbon atoms or CF3; R(2) means hydrogen, alkyl with 1,2,3 or 4 carbon atoms or CF3; R(3) means CyH2y-R(16);
y means 0,1,2,3 or 4,
where y cannot be 0, when R(16) is OR(17) or SO 2 Me;
R(16) means alkyl with 1,2, 3,4, 5 or 6 C atoms, cycloalkyl with 3,4, 5,6,7, 8,9,10 or 11 C atoms, CF3, C2F5, C3F7 , CH2F, CHF2, OR(17), SO2Me, phenyl, naphthyl, furyl, thienyl or an N-containing heteroaromatic with 1, 2,3,4,5,6, 7,8 or 9 C atoms,
where phenyl, naphthyl, furyl, thienyl and the N-containing heteroaromatic are unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl of 1,2, 3 or 4 C atoms, alkoxy of 1,2,3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(17) means hydrogen, alkyl with 1,2, 3,4 or 5 C atoms, cycloalkyl
with 3,4, 5 or 6 C atoms, CF3, phenyl or 2-, 3- or 4-pyridyl,
wherein phenyl or 2-, 3- or 4-pyridyl is unsubstituted or substituted with 1, 2 or 3 substituents selected from the group
consisting of F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl with 1, 2, 3 or 4 C atoms, alkoxy with 1,2,3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl, and methylsulfonylamino;
or R(3) means CHR(18)R(19);
R(18) means hydrogen or CzH2z-R(16), where R(16) is defined as above; z means 0, 1, 2 or 3;
R(19) means COOH, CONH2, CONR(20)R(21), COOR(22), CH2OH;
R(20) means hydrogen, alkyl with 1,2, 3,4 or 5 carbon atoms, CvH2v-CF3
or CwH2w-phenyl,
where the phenyl ring is unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2,
OH, alkyl with 1,2, 3 or 4 C atoms, alkoxy with 1,2, 3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfo-
nyl and methylsulfonylamino;
v means 0, 1, 2 or 3;
w means 0, 1, 2 or 3;
R(21) means hydrogen or alkyl with 1,2,3,4 or 5 carbon atoms; R(22) means alkyl with 1,2,3,4 or 5 carbon atoms; R(4) means hydrogen, alkyl with 1,2, 3,4,5 or 6 carbon atoms or CF3;
or R(3) andR(4)
together means a chain of 4 or 5 methylene groups, of which one methylene group may be replaced by -O-, -SO-, -NH-, -N(methyl)- or -N(benzyl)-;
R(5),R(6),R(7)andR(8)
independently means hydrogen, F, Cl, Br, I, CF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl with 1,2,3 or 4 C atoms, alkoxy with 1,2, 3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl or methylsulfonylamino;
R(30)andR(31)
means independently hydrogen or alkyl of 1,2 or 3 carbon atoms;
or
R(30)andR(31)
together means a chain of 2 methylene groups;
as well as their pharmaceutically acceptable salts.2.
Forbindelser av formel I ifølge krav 1, i hvilke: R(l) betyr C(0)OR(9), SO^IO), COR(l 1) eller C(0)NR(12)R(13); R(9) betyr CxH2x-R(14);
x betyr 0,1,2, 3 eller 4,
hvor x ikke kan være 0, når R(14) betyr OR(15);
R(14) betyr alkyl med 1,2,3,4, 5 eller 6 C-atomer, cykloalkyl med 3,4, 5,6,7, 8 eller 9 C-atomer, CF3, C2F5, OCF3, fenyl, furyl, tienyl eller et N-holdig heteroaromat med 1,2, 3,4, 5, 6, 7, 8 eller 9 C-atomer,
hvor fenyl, furyl, tienyl og det N-holdige heteroaromat er usubstituert eller substituert med 1,2 eller 3 substituenter valgt blant gruppen bestående av F, Cl, Br, CF3, N02, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2, 3 eller 4 C-atomer, alkoksy med 1,2,3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(15) betyr alkyl med 1,2,3,4 eller 5 C-atomer, cykloalkyl med 3,4, 5 eller 6 C-atomer, CF3 eller fenyl,
som er usubstituert eller substituert med 1,2 eller 3 substituenter valgt blant gruppen bestående av F, Cl, Br, CF3, N02, CN, COOMe, CONH2, COMe, OH, alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1,2,3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(10),R(ll)ogR(12)
er uavhengig av hverandre definert som R(9);
R(13) betyr hydrogen, alkyl med 1,2,3, eller 4 C-atomer eller CF3; R(2) betyr hydrogen, alkyl med 1, 2, 3 eller 4 C-atomer eller CF3; R(3) betyr CyH2y-R(16);
y betyr 0,1,2,3 eller 4,
hvor y ikke kan være 0, når R(l6) betyr OR(l 7);
R(16) betyr alkyl med 1,2,3 eller 4 C-atomer, cykloalkyl med 3,4, 5,6, 7, 8 eller 9 C-atomer, CF3, C2F5, OR(17), fenyl, furyl, tienyl eller en N-holdig heteroaromat med 1,2,3,4, 5, 6, 7, 8 eller 9 C-atomer,
hvor fenyl, furyl, tienyl og det N-holdige heteroaromatet er usubstituert eller substituert med 1,2 eller 3 substituenter valgt blant gruppen bestående av F, Cl, Br, CF3, OCF3, N02, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1,2, 3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(17) betyr alkyl med 1,2,3,4 eller 5 C-atomer, cykloalkyl
med 3,4,5 eller 6 C-atomer, CF3, fenyl eller 2-, 3- eller 4-pyridyl,
hvor fenyl eller 2-, 3- eller 4-pyridyl er usubstituert eller substituert med 1,2 eller 3 substituenter valgt fra gruppen bestående av F, Cl, Br, CF3, OCF3, N02, CN, COOMe, CONH2, COMe, OH, alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1,2,3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
eller R(3) betyr CHR(18)R(19); R( 18) betyr hydrogen eller CZH2Z-R( 16), hvor R( 16) er definert som angitt i
krav 1;
z betyr 0,1,2 eller 3;
R(19) betyr CONH2, CONR(20)R(21), COOR(22), CH2OH;
R(20) betyr hydrogen, alkyl med 1,2,3,4 eller 5 C-atomer, CvH2v-CF3
eller CwH2w-fenyl,
hvor fenylringen er usubstituert eller substituert med 1,2 eller 3 substituenter utvalgt fra gruppen bestående F, Cl, Br, CF3, OCF3, N02, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1,2, 3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
v betyr 0,1,2 eller 3;
w betyr 0,1,2 eller 3;
R(21) betyr hydrogen eller alkyl med 1,2, 3,4 eller 5 C-atomer; R(22) betyr alkyl med 1,2,3,4 eller 5 C-atomer; R(4) betyr hydrogen, alkyl med 1,2, 3,4, 5 eller 6 C-atomer eller CF3; R(5),R(6),R(7)ogR(8)
betyr uavhengig av hverandre hydrogen, F, Cl, Br, CF3, NC^, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1,2, 3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl eller metylsulfonylamino;
R(30)ogR(31)
betyr uavhengig av hverandre hydrogen eller alkyl med 1,2 eller 3 C-atomer;
eller
R(30)ogR(31)
betyr sammen en kjede på 2 metylengrupper;
så vel som deres farmasøytisk akseptable salter.2.
Compounds of formula I according to claim 1, in which: R(1) means C(0)OR(9), SO2IO), COR(11) or C(0)NR(12)R(13); R(9) means CxH2x-R(14);
x means 0,1,2,3 or 4,
where x cannot be 0, when R(14) means OR(15);
R(14) means alkyl with 1,2,3,4, 5 or 6 C atoms, cycloalkyl with 3,4, 5,6,7, 8 or 9 C atoms, CF3, C2F5, OCF3, phenyl, furyl , thienyl or an N-containing heteroaromatic with 1,2, 3,4, 5, 6, 7, 8 or 9 C atoms,
where phenyl, furyl, thienyl and the N-containing heteroaromatic are unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, CF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl of 1,2, 3 or 4 carbon atoms, alkoxy of 1,2,3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(15) means alkyl with 1,2,3,4 or 5 C atoms, cycloalkyl with 3,4, 5 or 6 C atoms, CF3 or phenyl,
which is unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, CF3, NO2, CN, COOMe, CONH2, COMe, OH, alkyl with 1,2,3 or 4 C atoms, 1,2,3 or 4 C-atom alkoxy, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(10),R(ll)andR(12)
are independently defined as R(9);
R(13) means hydrogen, alkyl with 1,2,3, or 4 carbon atoms or CF3; R(2) means hydrogen, alkyl of 1, 2, 3 or 4 carbon atoms or CF3; R(3) means CyH2y-R(16);
y means 0,1,2,3 or 4,
where y cannot be 0, when R(l6) means OR(l7);
R(16) means alkyl with 1,2,3 or 4 C atoms, cycloalkyl with 3,4, 5,6, 7, 8 or 9 C atoms, CF3, C2F5, OR(17), phenyl, furyl, thienyl or an N-containing heteroaromatic with 1,2,3,4, 5, 6, 7, 8 or 9 C atoms,
wherein phenyl, furyl, thienyl and the N-containing heteroaromatic are unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl of 1,2,3 or 4 C atoms, alkoxy of 1,2, 3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(17) means alkyl with 1,2,3,4 or 5 C atoms, cycloalkyl
with 3,4,5 or 6 C atoms, CF3, phenyl or 2-, 3- or 4-pyridyl,
wherein phenyl or 2-, 3- or 4-pyridyl is unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, OH, alkyl of 1,2,3 or 4 C atoms, alkoxy of 1,2,3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
or R(3) means CHR(18)R(19); R( 18 ) means hydrogen or CZH2Z-R( 16 ), where R( 16 ) is defined as given in
claim 1;
z means 0, 1, 2 or 3;
R(19) means CONH2, CONR(20)R(21), COOR(22), CH2OH;
R(20) means hydrogen, alkyl with 1,2,3,4 or 5 carbon atoms, CvH2v-CF3
or CwH2w-phenyl,
where the phenyl ring is unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alkyl with 1,2,3 or 4 C-atoms, 1,2, 3 or 4 C-atom alkoxy, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
v means 0, 1, 2 or 3;
w means 0, 1, 2 or 3;
R(21) means hydrogen or alkyl with 1,2, 3,4 or 5 carbon atoms; R(22) means alkyl with 1,2,3,4 or 5 carbon atoms; R(4) means hydrogen, alkyl of 1,2, 3,4, 5 or 6 carbon atoms or CF3; R(5),R(6),R(7)andR(8)
independently means hydrogen, F, Cl, Br, CF3, NC^, CN, COOMe, CONH2, COMe, NH2, OH, alkyl with 1,2,3 or 4 C atoms, alkoxy with 1,2, 3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl or methylsulfonylamino;
R(30)andR(31)
means independently hydrogen or alkyl of 1,2 or 3 carbon atoms;
or
R(30)andR(31)
together means a chain of 2 methylene groups;
as well as their pharmaceutically acceptable salts.3.
Forbindelser av formel I ifølge krav 1 eller 2, i hvilke: R(l) betyr C(0)OR(9), SO^IO), COR(l 1) eller C(0)NR(12)R(13); R(9) erCxH2x-R(14);
x betyr 0,1,2, 3 eller 4,
hvor x ikke kan være 0, når R(14) betyr OR(15) eller S02Me;
R(14) betyr cykloalkyl med 3,4,5,6, 7, 8 eller 9 C-atomer, CF3,
OR(15), fenyl, furyl, tienyl eller et N-holdig heteroaromat med 3,4 eller 5 C-atomer,
hvor fenyl, furyl, tienyl og det N-holdige heteroaromat er usubstituert eller substituert med 1 eller 2 substituenter valgt blant gruppen bestående av F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl med 1,2 eller 3 C-atomer, alkoksy med 1 eller 2 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsmfon<y>larnino;
R(15) betyr alkyl med 1 eller 2 C-atomer, cykloalkyl med 3,4,5 eller 6 C-atomer, CF3 eller fenyl, som er usubstituert eller substituert med 1 eller 2 substituenter valgt blant gruppen bestående av F, Cl, Br, CF3, CN, COOMe, CONH2, COMe, OH, alkyl med 1,2 eller 3 C-atomer, alkoksy med 1 eller 2 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(10),R(ll)ogR(12)
er uavhengig av hverandre definert som R(9);
R(13) betyr hydrogen; R(2) betyr hydrogen eller alkyl med 1,2 eller 3 C-atomer; R(3) betyrCHR(18)R(19);
R(l8) betyr hydrogen eller CzH2z-R(l6);
z betyr 0,1,2 eller 3;
R(19) betyr CONH2, CONR(20)R(21), COOR(22) eller CH2OH;
R(20) betyr hydrogen, alkyl med 1,2,3,4 eller 5 C-atomer, CvH2v-CF3
eller CwH2w-fenyl,
hvor fenylringen er usubstituert eller substituert med 1,2 eller 3 substituenter utvalgt fra gruppen bestående F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl med 1,2 eller 3 C-atomer, alkoksy med 1 eller 2 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
v betyr 0,1,2 eller 3;
w betyr 0,1,2 eller 3;
R(21) betyr hydrogen eller alkyl med 1,2,3,4 eller 5 C-atomer;
R(22) betyr alkyl med 1,2, 3,4 eller 5 C-atomer;
R(16) betyr alkyl med 1,2 eller 3 C-atomer, cykloalkyl med 3,4, 5,6, 7, 8 eller 9 C-atomer, CF3, OR(17), fenyl, furyl, tienyl eller en N-holdig heteroaromat med 3,4 eller 5 C-atomer, hvor fenyl, furyl, tienyl og det N-holdige heteromatet er usubstituert eller substituert med 1 eller 2 valgt blant gruppen bestående av F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1, 2 eller 3 C-atomer, alkoksy med 1 eller 2 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(17) betyr alkyl med 1,2,3,4 eller 5 C-atomer, cykloalkyl
med 3,4, 5 eller 6 C-atomer, CF3, fenyl eller 2-, 3- eller 4-pyridyl,
hvor fenyl eller 2-, 3- eller 4-pyridyl er usubstituert eller substituert med 1,2 eller 3 substituenter valgt fra gruppen bestående av F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl med 1,2,3 eller 4 C-atomer, alkoksy med 1,2,3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino; R(4) betyr hydrogen eller alkyl med 1 eller 2 C-atomer; R(5),R(6),R(7)ogR(8)
betyr uavhengig av hverandre hydrogen, F, Cl, Br, CF3, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2 eller 3 C-atomer, alkoksy med 1 eller 2 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl eller metylsulfonylamino;
R(30)ogR(31)
betyr uavhengig av hverandre hydrogen eller metyl;
eller
R(30)ogR(31)
betyr sammen en kjede på 2 metylengrupper;
så vel som deres farmasøytisk akseptable salter.3.
Compounds of formula I according to claim 1 or 2, in which: R(l) means C(0)OR(9), SO^IO), COR(l 1) or C(0)NR(12)R(13) ; R(9) is CxH2x-R(14);
x means 0,1,2,3 or 4,
where x cannot be 0, when R(14) is OR(15) or SO 2 Me;
R(14) means cycloalkyl with 3,4,5,6, 7, 8 or 9 C atoms, CF3,
OR(15), phenyl, furyl, thienyl or an N-containing heteroaromatic with 3,4 or 5 C atoms,
where phenyl, furyl, thienyl and the N-containing heteroaromatic are unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl with 1, 2 or 3 C atoms, 1 or 2 C alkoxy, dimethylamino, sulfamoyl, methylsulfonyl and methylsmfon<y>larnino;
R(15) means alkyl with 1 or 2 C atoms, cycloalkyl with 3,4,5 or 6 C atoms, CF3 or phenyl, which is unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, Br, CF3, CN, COOMe, CONH2, COMe, OH, alkyl of 1,2 or 3 carbon atoms, alkoxy of 1 or 2 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(10),R(ll)andR(12)
are independently defined as R(9);
R(13) means hydrogen; R(2) means hydrogen or alkyl of 1,2 or 3 carbon atoms; R(3) means CHR(18)R(19);
R(18) means hydrogen or CzH2z-R(16);
z means 0, 1, 2 or 3;
R(19) is CONH2, CONR(20)R(21), COOR(22) or CH2OH;
R(20) means hydrogen, alkyl with 1,2,3,4 or 5 carbon atoms, CvH2v-CF3
or CwH2w-phenyl,
where the phenyl ring is unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl with 1,2 or 3 C atoms, alkoxy with 1 or 2 C atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
v means 0, 1, 2 or 3;
w means 0, 1, 2 or 3;
R(21) means hydrogen or alkyl with 1,2,3,4 or 5 carbon atoms;
R(22) means alkyl with 1,2, 3,4 or 5 carbon atoms;
R(16) means alkyl with 1,2 or 3 C atoms, cycloalkyl with 3,4, 5,6, 7, 8 or 9 C atoms, CF3, OR(17), phenyl, furyl, thienyl or an N -containing heteroaromatic with 3,4 or 5 C atoms, where phenyl, furyl, thienyl and the N-containing heteromate are unsubstituted or substituted with 1 or 2 selected from the group consisting of F, Cl, Br, CF3, OCF3, CN, COOMe, CONH 2 , COMe, NH 2 , OH, alkyl of 1, 2 or 3 C atoms, alkoxy of 1 or 2 C atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(17) means alkyl with 1,2,3,4 or 5 C atoms, cycloalkyl
with 3,4, 5 or 6 C atoms, CF3, phenyl or 2-, 3- or 4-pyridyl,
wherein phenyl or 2-, 3- or 4-pyridyl is unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl with 1,2,3 or 4 C atoms, 1,2,3 or 4 C alkoxy, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino; R(4) means hydrogen or alkyl with 1 or 2 carbon atoms; R(5),R(6),R(7)andR(8)
independently means hydrogen, F, Cl, Br, CF3, CN, COOMe, CONH2, COMe, NH2, OH, alkyl with 1,2 or 3 C atoms, alkoxy with 1 or 2 C atoms, dimethylamino, sulfamoyl, methylsulfonyl or methylsulfonylamino;
R(30)andR(31)
means independently hydrogen or methyl;
or
R(30)andR(31)
together means a chain of 2 methylene groups;
as well as their pharmaceutically acceptable salts.4.
Forbindelser av formel I ifølge krav 1 eller 2, i hvilke: R(l) betyr C(0)OR(9), SO2R(10), COR(l 1) eller C(0)NR(12)R(13); R(9) erCxH2x-R(14);
x betyr 0,1,2,3 eller 4,
hvor x ikke kan være 0, når R(14) betyr OR(l 5);
R(14) betyr alkyl med 1,2,3 eller 4 C-atomer, cykloalkyl med 3,4, 5,6, 7, 8 eller 9 C-atomer, CF3, OR(15), fenyl, furyl, tienyl eller et N-holdig heteroaromat med 3,4 eller 5 C-atomer,
hvor fenyl, furyl, tienyl og det N-holdige heteroaromat er usubstituert eller substituert med 1 eller 2 substituenter valgt blant gruppen bestående av F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl med 1,2 eller 3 C-atomer, alkoksy med 1 eller 2 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(15) betyr alkyl med 1 eller 2 C-atomer, cykloalkyl med 3,4, 5 eller 6 C-atomer, CF3 eller fenyl,
som er usubstituert eller substituert med 1 eller 2 substituenter valgt blant gruppen bestående av F, Cl, Br, CF3, CN, COOMe, CONH2, COMe, OH, alkyl med 1,2 eller 3 C-atomer, alkoksy med 1 eller 2 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(10),R(ll)ogR(12)
er uavhengig av hverandre definert som R(9);
R(13) betyr hydrogen; R(2) betyr hydrogen eller alkyl med 1,2 eller 3 C-atomer; R(3) betyr CyH2y-R(16);
y betyr 0,1,2,3 eller 4,
hvor y ikke kan være 0, når R(16) betyr OR(17);
R(16) betyr alkyl med 1,2 eller 3 C-atomer, cykloalkyl med 3,4, 5,6, 7, 8 eller 9 C-atomer, CF3, OR(17), fenyl, furyl, tienyl eller en N-holdig heteroaromat med 3,4 eller 5 C-atomer,
hvor fenyl, furyl, tienyl og det N-holdige heteroaromatet er usubstituert eller substituert med 1 eller 2 substituenter valgt blant gruppen bestående av F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2 eller 3 C-atomer, alkoksy med 1 eller 2 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino;
R(17) betyr alkyl med 1,2, 3,4 eller 5 C-atomer, cykloalkyl
med 3,4, 5 eller 6 C-atomer, CF3, fenyl eller 2-, 3- eller 4-pyridyl,
hvor fenyl eller 2-, 3- eller 4-pyridyl er usubstituert eller substituert med 1,2 eller 3 substituenter valgt fra gruppen bestående av F, Cl, Br, CF3, OCF3, N02, CN, COOMe, CONH2, COMe, OH, alkyl med 1,2, 3 eller 4 C-atomer, alkoksy med 1,2, 3 eller 4 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl og metylsulfonylamino; R(4) betyr hydrogen eller alkyl med 1 eller 2 C-atomer; R(5),R(6),R(7)ogR(8)
betyr uavhengig av hverandre hydrogen, F, Cl, Br, CF3, CN, COOMe, CONH2, COMe, NH2, OH, alkyl med 1,2 eller 3 C-atomer, alkoksy med 1 eller 2 C-atomer, dimetylamino, sulfamoyl, metylsulfonyl eller metylsulfonylamino;
R(30)ogR(31)
betyr uavhengig av hverandre hydrogen eller metyl;
eller
R(30)ogR(31)
betyr sammen en kjede på 2 metylengrupper;
så vel som deres farmasøytisk akseptable salter.4.
Compounds of formula I according to claim 1 or 2, in which: R(l) means C(0)OR(9), SO2R(10), COR(l 1) or C(0)NR(12)R(13) ; R(9) is CxH2x-R(14);
x means 0,1,2,3 or 4,
where x cannot be 0, when R(14) means OR(15);
R(14) means alkyl with 1,2,3 or 4 C atoms, cycloalkyl with 3,4, 5,6, 7, 8 or 9 C atoms, CF3, OR(15), phenyl, furyl, thienyl or an N-containing heteroaromatic with 3,4 or 5 C atoms,
where phenyl, furyl, thienyl and the N-containing heteroaromatic are unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl with 1, 2 or 3 C atoms, 1 or 2 C alkoxy, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(15) means alkyl with 1 or 2 C atoms, cycloalkyl with 3,4, 5 or 6 C atoms, CF3 or phenyl,
which is unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, Br, CF3, CN, COOMe, CONH2, COMe, OH, alkyl with 1,2 or 3 C atoms, alkoxy with 1 or 2 C -atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(10),R(ll)andR(12)
are independently defined as R(9);
R(13) means hydrogen; R(2) means hydrogen or alkyl of 1,2 or 3 carbon atoms; R(3) means CyH2y-R(16);
y means 0,1,2,3 or 4,
where y cannot be 0, when R(16) means OR(17);
R(16) means alkyl with 1,2 or 3 C atoms, cycloalkyl with 3,4, 5,6, 7, 8 or 9 C atoms, CF3, OR(17), phenyl, furyl, thienyl or an N -containing heteroaromatic with 3,4 or 5 C atoms,
where phenyl, furyl, thienyl and the N-containing heteroaromatic are unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, Br, CF3, OCF3, CN, COOMe, CONH2, COMe, NH2, OH, alkyl with 1,2 or 3 carbon atoms, 1 or 2 carbon atom alkoxy, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino;
R(17) means alkyl with 1,2, 3,4 or 5 C atoms, cycloalkyl
with 3,4, 5 or 6 C atoms, CF3, phenyl or 2-, 3- or 4-pyridyl,
wherein phenyl or 2-, 3- or 4-pyridyl is unsubstituted or substituted with 1,2 or 3 substituents selected from the group consisting of F, Cl, Br, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, OH, alkyl of 1,2, 3 or 4 C atoms, alkoxy of 1,2, 3 or 4 C atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino; R(4) means hydrogen or alkyl with 1 or 2 carbon atoms; R(5),R(6),R(7)andR(8)
independently means hydrogen, F, Cl, Br, CF3, CN, COOMe, CONH2, COMe, NH2, OH, alkyl with 1,2 or 3 C atoms, alkoxy with 1 or 2 C atoms, dimethylamino, sulfamoyl, methylsulfonyl or methylsulfonylamino;
R(30)andR(31)
means independently hydrogen or methyl;
or
R(30)andR(31)
together means a chain of 2 methylene groups;
as well as their pharmaceutically acceptable salts.5.
Forbindelser av formel I ifølge et eller flere av kravene 1,2 eller 4, hvor: R(l) betyr C(0)OR(9), SO^IO), COR(l 1) eller C(0)NR(12)R(13); R(9) erCxHzx-RCH);
x betyr 0,1,2 eller 3,
R(14) betyr alkyl med 1,2,3 eller 4 C-atomer, cykloalkyl med 3,4, 5,6, 7, 8 eller 9 C-atomer, CF3, fenyl eller pyridyl,
hvor fenyl og pyridyl er usubstituert eller substituert med 1 eller 2 substituenter valgt blant gruppen bestående av F, Cl, CF3, OCF3, alkyl med 1,2 eller 3 C-atomer og alkoksy med 1 eller 2 C-atomer;
R(10),R(ll)ogR(12)
er uavhengig av hverandre definert som R(9);
R(13) betyr hydrogen; R(2) betyr hydrogen; R(3) betyr CyH2y-R(16);
y betyr 0,1 eller 2,
R(16) betyr alkyl med 1,2 eller 3 C-atomer, cykloalkyl med 5 eller 6 C-
atomer, CF3, fenyl eller pyridyl,
hvor fenyl og pyridyl er usubstituert eller substituert med 1 eller 2 substituenter uvalgt fra gruppen bestående av F, Cl, CF3, OCF3, OH, alkyl med 1,2 eller 3 C-atomer og alkoksy med 1 eller 2 C-atomer; R(4) betyr hydrogen;
R(5),R(6),R(7)ogR(8)
betyr uavhengig av hverandre hydrogen, F, CF3, CN, COOMe, NH2, OH, alkyl med 1,2 eller 3 C-atomer eller alkoksy med 1 eller 2 C-atomer;
R(30)ogR(31)
betyr uavhengig av hverandre hydrogen eller metyl;
eller
R(30)ogR(31)
betyr sammen en kjede på 2 metylengrupper;
så vel som deres farmasøytisk akseptable salter.5.
Compounds of formula I according to one or more of claims 1, 2 or 4, where: R(l) means C(0)OR(9), SO^IO), COR(l 1) or C(0)NR(12 )R(13); R(9) is CxHzx-RCH);
x means 0,1,2 or 3,
R(14) means alkyl with 1,2,3 or 4 C atoms, cycloalkyl with 3,4, 5,6, 7, 8 or 9 C atoms, CF3, phenyl or pyridyl,
wherein phenyl and pyridyl are unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, CF 3 , OCF 3 , alkyl with 1,2 or 3 C atoms and alkoxy with 1 or 2 C atoms;
R(10),R(ll)andR(12)
are independently defined as R(9);
R(13) means hydrogen; R(2) means hydrogen; R(3) means CyH2y-R(16);
y means 0,1 or 2,
R(16) means alkyl with 1,2 or 3 C atoms, cycloalkyl with 5 or 6 C-
atoms, CF3, phenyl or pyridyl,
where phenyl and pyridyl are unsubstituted or substituted with 1 or 2 substituents unselected from the group consisting of F, Cl, CF3, OCF3, OH, alkyl with 1,2 or 3 C atoms and alkoxy with 1 or 2 C atoms; R(4) means hydrogen;
R(5),R(6),R(7)andR(8)
means independently hydrogen, F, CF 3 , CN, COOMe, NH 2 , OH, alkyl of 1,2 or 3 C atoms or alkoxy of 1 or 2 C atoms;
R(30)andR(31)
means independently hydrogen or methyl;
or
R(30)andR(31)
together means a chain of 2 methylene groups;
as well as their pharmaceutically acceptable salts.6.
Forbindelser av formel I ifølge et eller flere av kravene 1,2 eller 4, hvor: R(l) betyr C(0)OR(9) eller COR(l 1); R(9) erC,H2x-R(14);
x betyr 0,1,2 eller 3,
R(14) betyr alkyl med 5 eller 6 C-atomer eller fenyl,
hvor fenyl er usubstituert eller substituert med 1 eller 2 substituenter valgt fra gruppen bestående av F, Cl, CF3, OCF3, alkyl med 1,2 eller 3 C-atomer og alkoksy med 1 eller 2 C-atomer;
R(ll) er definert som R(9); R(2) betyr hydrogen; R(3) betyrCyH2y-R(16);
y betyr 0,1 eller 2,
R(16) betyr alkyl med 1,2 eller 3 C-atomer, cykloalkyl med 5 eller 6 C-
atomer, CF3, fenyl eller pyridyl,
hvor fenyl og pyridyl er usubstituert eller substituert med 1 eller 2 substituenter uvalgt fra gruppen bestående av F, Cl, CF3, OCF3, alkyl med 1,2 eller 3 C-atomer og alkoksy med 1 eller 2 C-atomer; R(4) betyr hydrogen;
R(5),R(6),R(7)ogR(8)
betyr uavhengig av hverandre hydrogen, F, CF3, alkyl med 1,2 eller 3 C-atomer eller alkoksy med 1 eller 2 C-atomer;
R(30)ogR(31)
betyr hydrogen;
så vel som deres farmasøytisk: akseptable salter.6.
Compounds of formula I according to one or more of claims 1, 2 or 4, where: R(l) means C(0)OR(9) or COR(l 1); R(9) is C,H 2 x -R(14);
x means 0,1,2 or 3,
R(14) means alkyl with 5 or 6 carbon atoms or phenyl,
wherein phenyl is unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, CF 3 , OCF 3 , alkyl with 1, 2 or 3 C atoms and alkoxy with 1 or 2 C atoms;
R(II) is defined as R(9); R(2) means hydrogen; R(3) means CyH2y-R(16);
y means 0,1 or 2,
R(16) means alkyl with 1,2 or 3 C atoms, cycloalkyl with 5 or 6 C-
atoms, CF3, phenyl or pyridyl,
where phenyl and pyridyl are unsubstituted or substituted with 1 or 2 substituents unselected from the group consisting of F, Cl, CF3, OCF3, alkyl with 1,2 or 3 C atoms and alkoxy with 1 or 2 C atoms; R(4) means hydrogen;
R(5),R(6),R(7)andR(8)
independently means hydrogen, F, CF 3 , alkyl of 1,2 or 3 C atoms or alkoxy of 1 or 2 C atoms;
R(30)andR(31)
means hydrogen;
as well as their pharmaceutically:acceptable salts.7.
Forbindelse av formel I ifølge et eller flere av kravene 1,2,4, S eller 6 som er
så vel som dens farmasøytisk akseptable salter.7.
Compound of formula I according to one or more of claims 1, 2, 4, S or 6 which is
as well as its pharmaceutically acceptable salts.8.
Forbindelser av formel I ifølge et eller flere av kravene 1 til 7 og deres farmasøytisk akseptable salter for anvendelse som legemiddel.8.
Compounds of formula I according to one or more of claims 1 to 7 and their pharmaceutically acceptable salts for use as medicine.9.
Farmasøytisk preparat inneholdende en effektiv mengde av minst en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt derav som virkestoff, sammen med farmasøytisk akseptable bære- og tilsetningsstoffer og eventuelt også et eller flere andre farmakologiske virkestoffer.9.
Pharmaceutical preparation containing an effective amount of at least one compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof as active ingredient, together with pharmaceutically acceptable carriers and additives and optionally also one or more other pharmacological active ingredients .10.
Anvendelse av en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt derav for fremstilling av et medikament med K<+->kanalblokkerende virkning for terapi eller profylakse av K<+->kanalmedierte sykdommer.10.
Use of a compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof for the preparation of a drug with K<+-> channel-blocking action for therapy or prophylaxis of K<+-> channel-mediated diseases.11.
Anvendelse av en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt herav for fremstilling av et medikament for terapi eller profylakse av hjerterytmeforstyrrelser, som kan oppheves ved forskyvning av aksjonspotensialet.11.
Use of a compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof for the preparation of a drug for the therapy or prophylaxis of heart rhythm disturbances, which can be reversed by shifting the action potential.12.
Anvendelse av en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt derav for fremstilling av et medikament for terapi eller profylakse av Reentry-arrytmier.12.
Use of a compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the therapy or prophylaxis of reentry arrhythmias.13.
Anvendelse av en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt derav for fremstilling av et medikament for terapi eller profylakse av supraventrikulære arrytmier.13.
Use of a compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the therapy or prophylaxis of supraventricular arrhythmias.14.
Anvendelse av en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt derav for fremstilling av et medikament for terapi eller profylakse av atriell fibrillasjon eller atriell flapring.14.
Use of a compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the therapy or prophylaxis of atrial fibrillation or atrial flutter.15.
Anvendelse av en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt derav for fremstilling av et medikament for terminering av arteriell fibrillasjon eller arteriell flapring (kardioversjon).15.
Use of a compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the termination of arterial fibrillation or arterial flapping (cardioversion).16.
Farmasøytisk preparat inneholdende en effektiv mengde av minst en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt derav så vel som en IKr-kanalblokker som virkestoff sammen med farmasøytisk akseptable bære- og tilsetningsstoffer.16.
Pharmaceutical preparation containing an effective amount of at least one compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof as well as an IKr channel blocker as active ingredient together with pharmaceutically acceptable carriers and additives.17.
Farmasøytisk preparat inneholdende en effektiv mengde av minst en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt derav så vel som en IKs-kanalblokker som virkestoff sammen med farmasøytisk akseptable bære- og tilsetningsstoffer.17.
Pharmaceutical preparation containing an effective amount of at least one compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof as well as an IKs channel blocker as active ingredient together with pharmaceutically acceptable carriers and additives.18.
Farmasøytisk preparat inneholdende en effektiv mengde av minst en forbindelse av formel I ifølge et eller flere av kravene 1 til 7 og/eller et farmasøytisk akseptabelt salt derav så vel som en betablokker som virkestoff sammen med farmasøytisk anvendelige bære- og tilsetningsstoffer.18.
Pharmaceutical preparation containing an effective amount of at least one compound of formula I according to one or more of claims 1 to 7 and/or a pharmaceutically acceptable salt thereof as well as a beta blocker as active ingredient together with pharmaceutically usable carriers and additives.
NO20021398A1999-10-022002-03-20
2'-substituted 1,1'-biphenyl-2-carbonamides, their use in the preparation of a drug as well as pharmaceutical preparations containing them
NO327709B1
(en)
New 2'-aminomethyl-biphenyl-2-carboxamide derivatives, are potassium channel blockers especially useful for treating re-entry or supraventricular arrhythmia or atrial fibrillation or flutter
2'-substituted 1,1'-biphenyl-2-carbonamides, method for the production thereof, use thereof as a medicament and pharmaceutical preparations containing said compounds
Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments and pharmaceutical preparations containing them
New 2-(heteroarylsulfonyl-amino)-benzamide derivatives, which are potassium ion channel blocking antiarrhythmic agents, useful for e.g. treating atrial fibrillation or flutter
Composition, useful to treat e.g. atrial fibrillation, atrial flutter and atrial arrhythmia, comprises at least one beta-blocker and at least one compound of a phenylcarboxylic acid amide derivative
Use of specific 2-substituted benzamides for treating and preventing cardiac insufficiency, especially where caused by diastolic dysfunction, act by inhibition of the Kv1.5 potassium channel
ORTHO-, META-SUBSTITUTED BIS-Aryl COMPOUNDS, METHOD FOR PRODUCING THEM, THEIR APPLICATION AS MEDICINES, AND ALSO CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS
ORTHO-SUBSTITUTED NITROGEN-CONTAINING BISARYL COMPOUNDS FOR APPLICATION AS POTASSIUM CHANNEL INHIBITORS, AND ALSO CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS
Anthranilic acid amides with a heteroarylsulfonyl side chain, method for the production thereof, use thereof as a medicament or a diagnostic agent and pharmaceutical preparations containing said compounds
1,3-DIGIDRO-2N-IMIDAZO / 4,5-V / QUINOLIN-2-SHE DERIVATIVES AS AN INHIBITORS, PHOSPHODESTERRASES, METHOD OF THEIR RECEIVING, INTERMEDIATE FOR THEM, PHARMACEUTICAL COMPOSITION CHAPTER.