NO320356B1 - Fremgangsmate for fremstilling av et matrikstype-medisinsk forlenget-frigjoring granulaert preparater - Google Patents
Fremgangsmate for fremstilling av et matrikstype-medisinsk forlenget-frigjoring granulaert preparater Download PDFInfo
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- NO320356B1 NO320356B1 NO19972814A NO972814A NO320356B1 NO 320356 B1 NO320356 B1 NO 320356B1 NO 19972814 A NO19972814 A NO 19972814A NO 972814 A NO972814 A NO 972814A NO 320356 B1 NO320356 B1 NO 320356B1
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- Prior art keywords
- polymer
- plasticizer
- granules
- temperature
- extended
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- ABTXGJFUQRCPNH-UHFFFAOYSA-N procainamide hydrochloride Chemical compound [H+].[Cl-].CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 ABTXGJFUQRCPNH-UHFFFAOYSA-N 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
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- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
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- MTKNGOHFNXIVOS-UHFFFAOYSA-N ticlopidine hydrochloride Chemical compound [H+].[Cl-].ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 MTKNGOHFNXIVOS-UHFFFAOYSA-N 0.000 description 1
- 229960002961 ticlopidine hydrochloride Drugs 0.000 description 1
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- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31441494 | 1994-12-19 | ||
| PCT/JP1995/002594 WO1996019200A1 (fr) | 1994-12-19 | 1995-12-18 | Preparation granulaire a liberation prolongee et procede de production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO972814D0 NO972814D0 (no) | 1997-06-18 |
| NO972814L NO972814L (no) | 1997-08-18 |
| NO320356B1 true NO320356B1 (no) | 2005-11-28 |
Family
ID=18053063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19972814A NO320356B1 (no) | 1994-12-19 | 1997-06-18 | Fremgangsmate for fremstilling av et matrikstype-medisinsk forlenget-frigjoring granulaert preparater |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5858411A (pt) |
| EP (1) | EP0797987B1 (pt) |
| JP (1) | JP3893439B2 (pt) |
| KR (1) | KR100424931B1 (pt) |
| CN (1) | CN1093758C (pt) |
| AT (1) | ATE251896T1 (pt) |
| DE (1) | DE69531957T2 (pt) |
| DK (1) | DK0797987T3 (pt) |
| ES (1) | ES2210321T3 (pt) |
| FI (1) | FI119720B (pt) |
| NO (1) | NO320356B1 (pt) |
| PT (1) | PT797987E (pt) |
| TW (1) | TW406022B (pt) |
| WO (1) | WO1996019200A1 (pt) |
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| US6524832B1 (en) * | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
| DK0901786T3 (da) | 1997-08-11 | 2007-10-08 | Pfizer Prod Inc | Faste farmaceutiske dispersioner med foröget biotilgængelighed |
| US6632455B2 (en) * | 1997-12-22 | 2003-10-14 | Schering Corporation | Molecular dispersion composition with enhanced bioavailability |
| DE19820801A1 (de) * | 1998-05-09 | 1999-11-25 | Gruenenthal Gmbh | Orale Arzneiformen mit reproduzierbarer Wirkstofffreisetzung von Gatifloxacin oder pharmazeutisch verwendbaren Salzen oder Hydraten |
| CN1165296C (zh) * | 1998-09-30 | 2004-09-08 | Basf公司 | 水溶性或水可分散性含聚醚聚合物作为在药物给药形式中的包衣剂、粘合剂和/或成膜赋形剂的应用 |
| EP1970052A2 (en) * | 1999-02-09 | 2008-09-17 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
| US6316462B1 (en) * | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| GB0003782D0 (en) * | 2000-02-17 | 2000-04-05 | Dumex Ltd As | Process |
| JP4310605B2 (ja) * | 2001-05-25 | 2009-08-12 | 大塚製薬株式会社 | 医薬用組成物 |
| US20050025825A1 (en) * | 2003-07-31 | 2005-02-03 | Xanodyne Pharmacal, Inc. | Tranexamic acid formulations with reduced adverse effects |
| US20090214644A1 (en) * | 2003-07-31 | 2009-08-27 | Xanodyne Pharmaceuticals, Inc. | Tranexamic acid formulations with reduced adverse effects |
| US7947739B2 (en) | 2004-03-04 | 2011-05-24 | Ferring B.V. | Tranexamic acid formulations |
| US20050244495A1 (en) | 2004-03-04 | 2005-11-03 | Xanodyne Pharmaceuticals, Inc. | Tranexamic acid formulations |
| US20050245614A1 (en) * | 2004-03-04 | 2005-11-03 | Xanodyne Pharmaceuticals, Inc. | Tranexamic acid formulations |
| US8022106B2 (en) * | 2004-03-04 | 2011-09-20 | Ferring B.V. | Tranexamic acid formulations |
| US20090215898A1 (en) * | 2004-03-04 | 2009-08-27 | Xanodyne Pharmaceuticals, Inc. | Tranexamic acid formulations |
| WO2006023001A1 (en) * | 2004-07-30 | 2006-03-02 | Xanodyne Pharmaceuticals, Inc. | Tranexamic acid formulations |
| US20060275365A1 (en) * | 2005-06-07 | 2006-12-07 | Thomas Backensfeld | Immediate-release and high-drug-load pharmaceutical formulations of micronised (4-chlorophenyl) [4-(4-pyridylmethyl)phthalazin-1-yl] and salts thereof |
| US20070059359A1 (en) * | 2005-06-07 | 2007-03-15 | Thomas Backensfeld | Immediate-release and high-drug-load pharmaceutical formulations of non-micronised (4-chlorophenyl)[4-(4-pyridylmethyl)phthalazin-1-yl] and salts thereof |
| US20070082048A1 (en) * | 2005-06-08 | 2007-04-12 | Ronald Warner | Sleep aid formulations |
| CA2612292C (en) | 2005-06-20 | 2013-09-03 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use |
| US20070036859A1 (en) * | 2005-08-11 | 2007-02-15 | Perry Ronald L | Sustained release antihistamine and decongestant composition |
| US9034373B2 (en) * | 2006-03-16 | 2015-05-19 | Euro-Celtique S.A. | Pharmaceutical spheroids |
| KR101697773B1 (ko) * | 2008-03-10 | 2017-01-18 | 유로드러그 레버러토리즈 비. 브이. | 독소필린을 포함하는 변형 방출 조성물 |
| US20100280117A1 (en) * | 2009-04-30 | 2010-11-04 | Xanodyne Pharmaceuticals, Inc. | Menorrhagia Instrument and Method for the Treatment of Menstrual Bleeding Disorders |
| US20110184060A1 (en) * | 2010-01-22 | 2011-07-28 | Xenoport, Inc. | Oral dosage forms having a high loading of a tranexamic acid prodrug |
| WO2011102505A1 (ja) * | 2010-02-22 | 2011-08-25 | 第一三共株式会社 | 経口用徐放性固形製剤 |
| GB201010083D0 (en) * | 2010-06-16 | 2010-07-21 | Univ Bradford | Compositions and methods |
| KR102286952B1 (ko) * | 2013-12-31 | 2021-08-09 | 롯데정밀화학 주식회사 | 입도분포가 조절된 히드록시프로필 메틸셀룰로오스 아세테이트 숙시네이트(hpmcas) 입자의 제조방법 및 hpmcas 분말 |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| ES2908479T3 (es) | 2015-08-26 | 2022-04-29 | Achillion Pharmaceuticals Inc | Compuestos para el tratamiento de trastornos inmunitarios e inflamatorios |
| CN109414441A (zh) | 2016-06-27 | 2019-03-01 | 艾其林医药公司 | 治疗医学障碍的喹唑啉和吲哚化合物 |
| CA3053818A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders |
| WO2020041301A1 (en) | 2018-08-20 | 2020-02-27 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| WO2020081723A1 (en) | 2018-10-16 | 2020-04-23 | Georgia State University Research Foundation, Inc. | Carbon monoxide prodrugs for the treatment of medical disorders |
| WO2021168320A1 (en) | 2020-02-20 | 2021-08-26 | Achillion Pharmaceuticals, Inc. | Heteroaryl compounds for treatment of complement factor d mediated disorders |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4330338A (en) * | 1978-10-02 | 1982-05-18 | Purdue Research Foundation | Pharmaceutical coating composition, and preparation and dosages so coated |
| US4329451A (en) * | 1980-11-03 | 1982-05-11 | The Dow Chemical Company | Preparing an aqueous dispersion of colloidal size particles of a water-insoluble polysaccharide derivative |
| JPS57171428A (en) * | 1981-04-13 | 1982-10-22 | Sankyo Co Ltd | Preparation of coated solid preparation |
| JPS6143108A (ja) * | 1984-08-03 | 1986-03-01 | Nippon Shinyaku Co Ltd | 医薬品製剤及びその製造法 |
| LU86099A1 (fr) * | 1985-09-30 | 1987-04-02 | Pharlyse | Formes galeniques a liberation prolongee du verapamil,leur fabrication et medicaments les contenant |
| US5051261A (en) * | 1987-11-24 | 1991-09-24 | Fmc Corporation | Method for preparing a solid sustained release form of a functionally active composition |
| CA1334379C (en) * | 1987-11-24 | 1995-02-14 | James William Mcginity | Method for preparing a solid sustained release form of a functionally active composition |
| US4835188A (en) * | 1987-12-08 | 1989-05-30 | American Home Products Corporation | Spray dried ibuprofen |
| US4916161A (en) * | 1988-10-25 | 1990-04-10 | Bristol-Myers Squibb | Taste-masking pharmaceutical agents |
| US5326572A (en) * | 1989-03-23 | 1994-07-05 | Fmc Corporation | Freeze-dried polymer dispersions and the use thereof in preparing sustained-release pharmaceutical compositions |
| EP0421582A1 (en) * | 1989-10-03 | 1991-04-10 | Warner-Lambert Company | Chewable spray dried spheroidal microcapsules and polymer coated microcapsules and method for preparing same |
| JPH03232814A (ja) * | 1990-02-08 | 1991-10-16 | Shin Etsu Chem Co Ltd | 徐放性錠剤の製造方法 |
| JP2915590B2 (ja) * | 1991-02-15 | 1999-07-05 | 第一製薬株式会社 | マスクされた粒状物 |
| WO1992018106A1 (en) * | 1991-04-16 | 1992-10-29 | Nippon Shinyaku Co., Ltd. | Method of manufacturing solid dispersion |
| DE4244466C2 (de) * | 1992-12-24 | 1995-02-23 | Pharmatech Gmbh | Verfahren zur Herstellung von Pseudolatices und Mikro- oder Nanopartikeln und deren Verwendung zur Herstellung von pharmazeutischen Präparaten |
-
1995
- 1995-12-18 PT PT95940461T patent/PT797987E/pt unknown
- 1995-12-18 DK DK95940461T patent/DK0797987T3/da active
- 1995-12-18 WO PCT/JP1995/002594 patent/WO1996019200A1/ja active IP Right Grant
- 1995-12-18 JP JP51966196A patent/JP3893439B2/ja not_active Expired - Fee Related
- 1995-12-18 ES ES95940461T patent/ES2210321T3/es not_active Expired - Lifetime
- 1995-12-18 DE DE69531957T patent/DE69531957T2/de not_active Expired - Lifetime
- 1995-12-18 KR KR1019970703851A patent/KR100424931B1/ko not_active IP Right Cessation
- 1995-12-18 TW TW084113515A patent/TW406022B/zh not_active IP Right Cessation
- 1995-12-18 US US08/849,457 patent/US5858411A/en not_active Expired - Lifetime
- 1995-12-18 CN CN95196885A patent/CN1093758C/zh not_active Expired - Fee Related
- 1995-12-18 EP EP95940461A patent/EP0797987B1/en not_active Expired - Lifetime
- 1995-12-18 AT AT95940461T patent/ATE251896T1/de not_active IP Right Cessation
-
1997
- 1997-06-18 NO NO19972814A patent/NO320356B1/no not_active IP Right Cessation
- 1997-06-18 FI FI972622A patent/FI119720B/fi active IP Right Grant
-
1998
- 1998-06-11 US US09/095,661 patent/US6030644A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE251896T1 (de) | 2003-11-15 |
| EP0797987A1 (en) | 1997-10-01 |
| US6030644A (en) | 2000-02-29 |
| FI119720B (fi) | 2009-02-27 |
| JP3893439B2 (ja) | 2007-03-14 |
| TW406022B (en) | 2000-09-21 |
| EP0797987A4 (en) | 1998-09-09 |
| ES2210321T3 (es) | 2004-07-01 |
| US5858411A (en) | 1999-01-12 |
| CN1093758C (zh) | 2002-11-06 |
| FI972622A0 (fi) | 1997-06-18 |
| PT797987E (pt) | 2004-02-27 |
| FI972622A (fi) | 1997-06-18 |
| CN1170357A (zh) | 1998-01-14 |
| NO972814D0 (no) | 1997-06-18 |
| KR100424931B1 (ko) | 2004-07-05 |
| DE69531957T2 (de) | 2004-08-12 |
| EP0797987B1 (en) | 2003-10-15 |
| NO972814L (no) | 1997-08-18 |
| WO1996019200A1 (fr) | 1996-06-27 |
| DE69531957D1 (de) | 2003-11-20 |
| DK0797987T3 (da) | 2004-02-16 |
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| MM1K | Lapsed by not paying the annual fees |