NO305952B1 - 1,5-benzodiazepinderivater, anvendelse derav og farmasoeytiske preparater - Google Patents

1,5-benzodiazepinderivater, anvendelse derav og farmasoeytiske preparater

Info

Publication number: NO305952B1
Authority: NO; Norway
Prior art keywords: pharmaceutical preparations; benzodiazepine derivatives; benzodiazepine; derivatives; preparations
Prior art date: 1992-01-21

Application number

NO942720A

Other languages

English (en)

Other versions

NO942720D0 (no

NO942720L (no

Inventor

Harry Finch

David Gordon Trist

Giorgio Tarzia

Aldo Feriani

Original Assignee

Glaxo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-21

Filing date

1994-07-20

Publication date

1999-08-23

1994-07-20 Application filed by Glaxo Spa filed Critical Glaxo Spa

1994-07-20 Publication of NO942720D0 publication Critical patent/NO942720D0/no

1994-07-20 Publication of NO942720L publication Critical patent/NO942720L/no

1999-08-23 Publication of NO305952B1 publication Critical patent/NO305952B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO942720A 1992-01-21 1994-07-20 1,5-benzodiazepinderivater, anvendelse derav og farmasoeytiske preparater NO305952B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929201180A GB9201180D0 (en)	1992-01-21	1992-01-21	Chemical compounds
PCT/EP1993/000098 WO1993014074A1 (en)	1992-01-21	1993-01-19	1,5-benzodiazepine derivatives and their use in medicine

Publications (3)

Publication Number	Publication Date
NO942720D0 NO942720D0 (no)	1994-07-20
NO942720L NO942720L (no)	1994-07-20
NO305952B1 true NO305952B1 (no)	1999-08-23

Family

ID=10708914

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO942720A NO305952B1 (no)	1992-01-21	1994-07-20	1,5-benzodiazepinderivater, anvendelse derav og farmasoeytiske preparater

Country Status (29)

Country	Link
US (2)	US5580895A (no)
JP (1)	JP3253723B2 (no)
KR (1)	KR100263625B1 (no)
CN (1)	CN1049217C (no)
AP (1)	AP369A (no)
AU (2)	AU3450193A (no)
BG (1)	BG61876B1 (no)
CA (1)	CA2087672C (no)
CZ (1)	CZ283950B6 (no)
FI (1)	FI111632B (no)
GB (1)	GB9201180D0 (no)
GE (1)	GEP20001968B (no)
HU (2)	HU221297B1 (no)
IL (1)	IL104447A (no)
IS (1)	IS3970A (no)
MX (1)	MX9300261A (no)
MY (1)	MY131307A (no)
NO (1)	NO305952B1 (no)
NZ (1)	NZ245715A (no)
OA (1)	OA09964A (no)
PH (1)	PH30894A (no)
PL (1)	PL175340B1 (no)
RO (1)	RO114128B1 (no)
RU (1)	RU2124009C1 (no)
SK (1)	SK280173B6 (no)
TW (1)	TW226013B (no)
UA (1)	UA29416C2 (no)
WO (1)	WO1993014074A1 (no)
ZA (1)	ZA93375B (no)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
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GB9225492D0 (en) *	1992-12-05	1993-01-27	Glaxo Group Ltd	Amine derivatives
GB9307833D0 (en) *	1993-04-15	1993-06-02	Glaxo Inc	Modulators of cholecystokinin and gastrin
WO1994024151A1 (en) *	1993-04-15	1994-10-27	Glaxo Inc.	1,5 benzodiazepine derivatives having cck and/or gastrin antagonistic activity
GB9308431D0 (en) *	1993-04-23	1993-06-09	Glaxo Spa	Chemical compounds
GB9308421D0 (en) *	1993-04-23	1993-06-09	Glaxo Spa	Chemical compounds
GB9314977D0 (en) *	1993-07-20	1993-09-01	Glaxo Spa	Chemical compounds
GB9315018D0 (en) *	1993-07-20	1993-09-01	Glaxo Spa	Chemical compounds
GB9314981D0 (en) *	1993-07-20	1993-09-01	Glaxo Spa	Chemical compounds
GB2280182A (en) *	1993-07-20	1995-01-25	Glaxo Spa	Benzodiazepine derivatives
US5739129A (en) *	1994-04-14	1998-04-14	Glaxo Wellcome Inc.	CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
CN1176646A (zh) *	1994-04-14	1998-03-18	葛兰素惠尔康公司	5－杂环－1,5－苯并二氮杂䓬衍生物
PE27497A1 (es) *	1994-04-15	1997-08-07	Glaxo Inc	Derivados de 1,5 benzodiazepina
GB9420748D0 (en) *	1994-10-14	1994-11-30	Glaxo Inc	1,5 benzodiazepine derivatives
US5780464A (en) *	1994-10-14	1998-07-14	Glaxo Wellcome Inc.	Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
KR100561963B1 (ko)	1995-12-11	2006-11-30	뉴 잉글랜드 메디컬 센터 호스피털스 인코퍼레이티드	펩타이드호르몬수용체리간드의검사방법및용도
US5750353A (en) *	1995-12-11	1998-05-12	New England Medical Center Hospitals, Inc.	Assay for non-peptide agonists to peptide hormone receptors
WO1998025911A1 (fr) *	1996-12-10	1998-06-18	Zeria Pharmaceutical Co., Ltd.	Derives de 1,5-benzodiazepine
US7399866B2 (en) *	2003-01-14	2008-07-15	Cytokinetics, Inc.	Compounds, compositions, and methods
GB0307918D0 (en) *	2003-04-05	2003-05-14	Astrazeneca Ab	Therapeutic use
KR20060125805A (ko) *	2003-11-18	2006-12-06	베링거 인겔하임 인터내셔날 게엠베하	고체 약제학적 제제 형태
SI1765327T1 (sl)	2004-06-17	2014-12-31	Cytokinetics, Inc.	Spojine, sestavki in postopki
US7538223B2 (en)	2005-08-04	2009-05-26	Cytokinetics, Inc.	Compounds, compositions and methods
US7825120B2 (en)	2005-12-15	2010-11-02	Cytokinetics, Inc.	Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
AR058347A1 (es)	2005-12-15	2008-01-30	Cytokinetics Inc	Entidades quimias composiciones y metodos
EP1959962A2 (en)	2005-12-16	2008-08-27	Cytokinetics, Inc.	Certain chemical entities, compositions, and methods
WO2007078839A2 (en)	2005-12-19	2007-07-12	Cytokinetics, Inc.	Compounds, compositions and methods
CU20090172A6 (es)	2009-10-09	2011-10-05	Facultad De Quimica Universidad De La Habana	Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
EP2738255B1 (en)	2011-07-29	2016-11-23	Tokushima University	Erap1-derived peptide and use thereof
CN103435562B (zh) *	2013-08-26	2016-02-24	华东理工大学	6-取代苯并二氮卓-2,4-二酮类化合物及其用途
CN108200760B (zh)	2015-07-22	2022-04-01	英安塔制药有限公司	作为rsv抑制剂的苯并二氮杂䓬衍生物
US20170226129A1 (en)	2016-01-15	2017-08-10	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as rsv inhibitors
CA3065368A1 (en)	2017-02-16	2018-08-23	Enanta Pharmaceuticals, Inc.	Processes for the preparation of benzodiazepine derivatives
US10752598B2 (en) *	2017-06-07	2020-08-25	Enanta Pharmaceuticals, Inc.	Aryldiazepine derivatives as RSV inhibitors
WO2019006295A1 (en)	2017-06-30	2019-01-03	Enanta Pharmaceuticals, Inc.	HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
WO2019006291A1 (en)	2017-06-30	2019-01-03	Enanta Pharmaceuticals, Inc.	HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
AU2018339068B2 (en)	2017-09-29	2022-12-15	Enanta Pharmaceuticals, Inc.	Combination pharmaceutical agents as RSV inhibitors
US10647711B2 (en)	2017-11-13	2020-05-12	Enanta Pharmaceuticals, Inc.	Azepin-2-one derivatives as RSV inhibitors
WO2019199908A1 (en)	2018-04-11	2019-10-17	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as rsv inhibitors
EP3889264A4 (en)	2018-11-30	2022-10-12	Tokushima University	Therapeutic agent for breast caner comprising big3-phb2 interaction-inhibiting peptide derived from phb2
CA3133300A1 (en)	2019-03-18	2020-09-24	Enanta Pharmaceuticals, Inc.	Benzodiazepine derivatives as rsv inhibitors
US11179400B2 (en)	2019-04-09	2021-11-23	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as RSV inhibitors
US11505558B1 (en)	2019-10-04	2022-11-22	Enanta Pharmaceuticals, Inc.	Antiviral heterocyclic compounds
UY39032A (es)	2020-01-24	2021-07-30	Enanta Pharm Inc	Compuestos heterocíclicos como agentes antivirales
WO2022010882A1 (en)	2020-07-07	2022-01-13	Enanta Pharmaceuticals, Inc,	Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors
US11945824B2 (en)	2020-10-19	2024-04-02	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as anti-viral agents
US12162857B2 (en)	2022-04-27	2024-12-10	Enanta Pharmaceuticals, Inc.	Antiviral compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2641280B1 (fr) *	1988-12-29	1994-01-21	Roussel Uclaf	Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments

1992
- 1992-01-21 GE GEAP19922651A patent/GEP20001968B/en unknown
- 1992-01-21 GB GB929201180A patent/GB9201180D0/en active Pending
1993
- 1993-01-15 US US08/256,359 patent/US5580895A/en not_active Expired - Fee Related
- 1993-01-19 WO PCT/EP1993/000098 patent/WO1993014074A1/en active IP Right Grant
- 1993-01-19 HU HU9402150A patent/HU221297B1/hu not_active IP Right Cessation
- 1993-01-19 RU RU94037768A patent/RU2124009C1/ru active
- 1993-01-19 RO RO94-01216A patent/RO114128B1/ro unknown
- 1993-01-19 PL PL93304684A patent/PL175340B1/pl unknown
- 1993-01-19 UA UA94005364A patent/UA29416C2/uk unknown
- 1993-01-19 SK SK864-94A patent/SK280173B6/sk unknown
- 1993-01-19 KR KR1019940702491A patent/KR100263625B1/ko not_active IP Right Cessation
- 1993-01-19 AU AU34501/93A patent/AU3450193A/en not_active Abandoned
- 1993-01-19 CZ CZ941736A patent/CZ283950B6/cs not_active IP Right Cessation
- 1993-01-20 AU AU31935/93A patent/AU661749B2/en not_active Ceased
- 1993-01-20 AP APAP/P/1993/000478A patent/AP369A/en active
- 1993-01-20 MY MYPI93000093A patent/MY131307A/en unknown
- 1993-01-20 JP JP02483193A patent/JP3253723B2/ja not_active Expired - Fee Related
- 1993-01-20 CA CA002087672A patent/CA2087672C/en not_active Expired - Fee Related
- 1993-01-20 NZ NZ245715A patent/NZ245715A/en unknown
- 1993-01-20 ZA ZA93375A patent/ZA93375B/xx unknown
- 1993-01-20 IS IS3970A patent/IS3970A/is unknown
- 1993-01-20 MX MX9300261A patent/MX9300261A/es not_active IP Right Cessation
- 1993-01-20 PH PH45583A patent/PH30894A/en unknown
- 1993-01-20 IL IL104447A patent/IL104447A/en not_active IP Right Cessation
- 1993-01-21 CN CN93101143A patent/CN1049217C/zh not_active Expired - Fee Related
- 1993-02-02 TW TW082100666A patent/TW226013B/zh active
1994
- 1994-06-27 BG BG98881A patent/BG61876B1/bg unknown
- 1994-07-18 OA OA60539A patent/OA09964A/en unknown
- 1994-07-19 FI FI943421A patent/FI111632B/fi active
- 1994-07-20 NO NO942720A patent/NO305952B1/no unknown
1995
- 1995-06-16 HU HU95P/P00242P patent/HU211295A9/hu unknown
1996
- 1996-07-01 US US08/674,259 patent/US5637697A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1049217C (zh)	2000-02-09
HU9402150D0 (en)	1994-09-28
BG61876B1 (bg)	1998-08-31
UA29416C2 (uk)	2000-11-15
US5637697A (en)	1997-06-10
RO114128B1 (ro)	1999-01-29
CA2087672A1 (en)	1993-07-22
GEP20001968B (en)	2000-03-05
AU3193593A (en)	1993-07-22
AU661749B2 (en)	1995-08-03
MX9300261A (es)	1994-03-31
OA09964A (en)	1995-12-11
HU221297B1 (en)	2002-09-28
MY131307A (en)	2007-08-30
NZ245715A (en)	1995-07-26
NO942720D0 (no)	1994-07-20
IL104447A (en)	1998-02-22
IS3970A (is)	1993-07-22
ZA93375B (en)	1994-07-18
RU94037768A (ru)	1996-08-10
BG98881A (bg)	1995-03-31
SK86494A3 (en)	1995-03-08
KR100263625B1 (ko)	2000-11-01
FI943421A0 (fi)	1994-07-19
CZ173694A3 (en)	1995-09-13
AP9300478A0 (en)	1993-01-31
US5580895A (en)	1996-12-03
CN1074678A (zh)	1993-07-28
PH30894A (en)	1997-12-23
AP369A (en)	1994-11-06
GB9201180D0 (en)	1992-03-11
WO1993014074A1 (en)	1993-07-22
HU211295A9 (en)	1995-11-28
AU3450193A (en)	1993-08-03
NO942720L (no)	1994-07-20
SK280173B6 (sk)	1999-09-10
HUT67375A (en)	1995-03-28
PL175340B1 (pl)	1998-12-31
FI111632B (fi)	2003-08-29
FI943421A (fi)	1994-07-19
IL104447A0 (en)	1993-05-13
TW226013B (no)	1994-07-01
CA2087672C (en)	2003-08-05
RU2124009C1 (ru)	1998-12-27
JPH07118244A (ja)	1995-05-09
JP3253723B2 (ja)	2002-02-04
CZ283950B6 (cs)	1998-07-15

Publication	Publication Date	Title
NO305952B1 (no)	1999-08-23	1,5-benzodiazepinderivater, anvendelse derav og farmasoeytiske preparater
NO943511D0 (no)	1994-09-21	Farmasöytiske preparater og anvendelse derav
NO308298B1 (no)	2000-08-28	Substituerte kinazolinderivater, anvendelse derav og farmasøytiske preparater inneholdende dem
IS3720A7 (is)	1991-12-21	Afleiður dialkoxy-pyridinyl-benzimidazole, aðferðvið lögun þeirra og lyfjafræðileg notkun
DE69221059D1 (de)	1997-09-04	Indolderivate und antiulcerose Zubereitungen
NO921012L (no)	1992-09-21	Farmasoeytiske preparater og deres anvendelse
BR1100824A (pt)	1999-08-31	Composto e composição farmacêutica
EP0498268A3 (en)	1993-12-08	5-oxo-l-proline derivatives and pharmaceutical use thereof
NO307092B1 (no)	2000-02-07	Sordaridin-derivater, anvendelse derav og farmasoeytisk blanding
DK130389D0 (da)	1989-03-17	Catecholderivater og farmaceutiske praeparater omfatende samme
NO304890B1 (no)	1999-03-01	Farmas°ytiske forbindelser og farmas°ytiske preparater
DK650089A (da)	1990-06-22	Furanalkylketoner og farmaceutiske praeparater deraf
DK578589A (da)	1990-05-20	Farmaceutisk praeparat indeholdende labdanterpenoidderivater og pyrimido(6,1-a)isoquinolin-4-onderivater, dets fremstilling og anvendelse
ZA913171B (en)	1992-02-26	1,5-benzothiazepinone derivatives,their preparations and pharmaceutical use
NO951350D0 (no)	1995-04-06	Farmasöytiske preparater inneholdende 3-substituerte 2-oksindol-1-karboksamider
HUP9602220A3 (en)	1998-04-28	Substituted 4h-piranes and pharmaceutical preparations containing them
GB9302553D0 (en)	1993-03-24	Pharmaceutical preparations and their manufacture and use
NO179907C (no)	1997-01-08	Benzokinoksaliner og farmasöytiske preparater inneholdende de samme
GR890300186T1 (en)	1990-10-31	N-cycloalkylaminoethylbenzamide derivatives, their synthesis and pharmaceutical preparations
NO985572D0 (no)	1998-11-27	Substituerte amidinobenzenderivater og medisinske preparater derav
DE69304453D1 (de)	1996-10-10	Pyridin-Derivate und diese enthaltende pharmazeutische Zubereitungen
NO920039L (no)	1993-07-05	Farmasoeytiske preparater
NO941426D0 (no)	1994-04-20	Antisporiatiske farmasöytiske preparater og fremgangsmåte for fremstilling av slike
GB2266887B (en)	1996-04-17	Substituted pyridines,their preparation and pharmaceutical use
NO920564D0 (no)	1992-02-13	Farmasoeytiske adenosinholdige preparater