NO303778B1 - Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomprodukt - Google Patents
Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomproduktInfo
- Publication number
- NO303778B1 NO303778B1 NO19951813A NO951813A NO303778B1 NO 303778 B1 NO303778 B1 NO 303778B1 NO 19951813 A NO19951813 A NO 19951813A NO 951813 A NO951813 A NO 951813A NO 303778 B1 NO303778 B1 NO 303778B1
- Authority
- NO
- Norway
- Prior art keywords
- derivative
- ring
- nitrogen
- optionally substituted
- sulfonamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24861493 | 1993-09-10 | ||
| PCT/JP1994/001487 WO1995007276A1 (fr) | 1993-09-10 | 1994-09-08 | Derives bicycliques heterocycliques d'ester sulfonique et de sulfonamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO951813L NO951813L (no) | 1995-05-09 |
| NO951813D0 NO951813D0 (no) | 1995-05-09 |
| NO303778B1 true NO303778B1 (no) | 1998-08-31 |
Family
ID=17180741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19951813A NO303778B1 (no) | 1993-09-10 | 1995-05-09 | Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomprodukt |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5767283A (no) |
| EP (1) | EP0673937B1 (no) |
| KR (2) | KR0174752B1 (no) |
| CN (2) | CN1221533C (no) |
| AT (1) | ATE255106T1 (no) |
| AU (2) | AU683492B2 (no) |
| CA (1) | CA2146961C (no) |
| DE (1) | DE69433353T2 (no) |
| DK (1) | DK0673937T3 (no) |
| ES (1) | ES2206469T3 (no) |
| HU (1) | HU224069B1 (no) |
| NO (1) | NO303778B1 (no) |
| NZ (1) | NZ273073A (no) |
| PT (1) | PT673937E (no) |
| RU (2) | RU2121997C1 (no) |
| WO (1) | WO1995007276A1 (no) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2122290T3 (es) * | 1993-06-25 | 1998-12-16 | Kumiai Chemical Industry Co | Derivado de indazolsulfonilurea, su utilizacion e intermediario para su produccion. |
| AU5348396A (en) * | 1995-05-01 | 1996-11-21 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors |
| WO1997030706A1 (fr) * | 1996-02-26 | 1997-08-28 | Eisai Co., Ltd. | Compositions contenant un agent antitumoral |
| JP4516942B2 (ja) * | 1999-02-26 | 2010-08-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有インドール化合物 |
| JP2000247949A (ja) | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
| US6521658B1 (en) | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
| KR100767002B1 (ko) * | 2000-02-03 | 2007-10-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 인테그린 발현 저해제 |
| DE60141889D1 (de) | 2000-02-03 | 2010-06-02 | Eisai R&D Man Co Ltd | Inhibitoren der integrinexpression |
| TWI283575B (en) * | 2000-10-31 | 2007-07-11 | Eisai Co Ltd | Medicinal compositions for concomitant use as anticancer agent |
| KR100858644B1 (ko) * | 2000-11-24 | 2008-09-17 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 항암제에 대한 종양 세포의 감수성을 검정하기 위한 시약 |
| CA2438427C (en) * | 2001-02-21 | 2011-04-12 | Eisai Co., Ltd. | Method for testing effect of angiogenesis inhibitor via integrin expression inhibition |
| US7186745B2 (en) | 2001-03-06 | 2007-03-06 | Astrazeneca Ab | Indolone derivatives having vascular damaging activity |
| WO2003022271A1 (fr) * | 2001-09-05 | 2003-03-20 | Eisai C0. Ltd. | Inhibiteur d'activation lymphocytaire et remede pour maladie auto-immune |
| CN100549011C (zh) * | 2002-09-19 | 2009-10-14 | 先灵公司 | 用作细胞周期蛋白依赖性激酶抑制剂的新颖咪唑并吡啶 |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| EP1797877A4 (en) | 2004-09-13 | 2010-12-15 | Eisai Co Ltd | JOINT USE OF A SULFONAMIDE-BASED COMPOUND AND AN ANGIOGENESIS INHIBITOR |
| EP1813602A4 (en) * | 2004-11-17 | 2009-08-05 | Eisai R&D Man Co Ltd | HETEROCYCLIC SULFONAMIDE COMPOUND CRYSTAL WITH TWO RINGS |
| JPWO2006090930A1 (ja) * | 2005-02-28 | 2008-07-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の新規併用 |
| EP2308839B1 (en) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| KR101509440B1 (ko) * | 2005-05-12 | 2015-04-07 | 애브비 바하마스 리미티드 | 아폽토시스 촉진제 |
| JPWO2007123274A1 (ja) | 2006-04-20 | 2009-09-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の新規感受性マーカー |
| JP5260507B2 (ja) | 2006-10-19 | 2013-08-14 | 武田薬品工業株式会社 | インドール化合物 |
| WO2008131000A2 (en) * | 2007-04-16 | 2008-10-30 | Abbott Laboratories | 7-substituted indole mcl-1 inhibitors |
| CN101784543B (zh) | 2007-08-17 | 2013-10-16 | 株式会社Lg生命科学 | 作为细胞坏死抑制剂的吲哚和吲唑化合物 |
| EP2230238B1 (en) | 2008-01-04 | 2013-12-11 | LG Life Sciences Ltd. | Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect |
| EP2229929B1 (en) | 2009-03-18 | 2017-06-14 | DENTSPLY DETREY GmbH | Temporary root canal sealer dispersion |
| TWI410408B (zh) * | 2010-03-16 | 2013-10-01 | Purzer Pharmaceutical Co Ltd | 苯磺醯胺衍生物及其醫藥組合物 |
| CN102199148A (zh) * | 2010-03-25 | 2011-09-28 | 瑞安大药厂股份有限公司 | 苯磺酰胺衍生物及其医药组合物 |
| US8692001B2 (en) | 2010-10-27 | 2014-04-08 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of PKM2 |
| CN102875549B (zh) * | 2012-09-14 | 2015-11-04 | 浙江大学 | 7-芳（甲）胺基-5-胺基-6-氮杂吲哚衍生物及制备与用途 |
| ES2835851T3 (es) | 2013-08-22 | 2021-06-23 | Lg Chemical Ltd | Compuesto de indol amida como inhibidor de necrosis |
| US10927097B2 (en) | 2013-08-22 | 2021-02-23 | Lg Chem, Ltd. | Indole compound as inhibitor of necrosis |
| WO2020210139A1 (en) * | 2019-04-10 | 2020-10-15 | Peloton Therapeutics, Inc. | Pyrazolesulfonamides as antitumor agents |
| WO2020256430A1 (ko) | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| KR102397752B1 (ko) | 2019-06-19 | 2022-05-16 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| WO2020256437A1 (ko) | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| WO2020256429A1 (ko) | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
| EP4404929A2 (en) * | 2021-09-21 | 2024-07-31 | The Trustees of Princeton University | Inhibitors of the mtdh-snd1 protein complex for cancer therapy |
| MA54773B1 (fr) * | 2021-10-29 | 2023-10-31 | Univ Euro Mediterraneenne De Fes Uemf | Nouvelles familles de composés à base de sulfonamides pour le traitement du cancer du sein triple négatif |
| WO2024039689A1 (en) * | 2022-08-15 | 2024-02-22 | Recursion Pharmaceuticals, Inc. | Heterocycle rbm39 modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS539256A (en) * | 1976-07-14 | 1978-01-27 | Hitachi Kiden Kogyo Kk | Two hook type club |
| DE3686688T2 (de) * | 1985-06-24 | 1993-03-18 | Merck & Co Inc | Verwendung von sulfanilamido quinoxalinen zur behandlung von neoplastischen krankheiten. |
| JP2790926B2 (ja) * | 1990-08-20 | 1998-08-27 | エーザイ株式会社 | スルホンアミド誘導体 |
| LU87814A1 (fr) * | 1990-09-27 | 1992-05-25 | Oreal | Composition cosmetique comportant une dispersion de vesicules lipidiques ainsi que des pigments melaniques,et son utilisation |
-
1994
- 1994-09-08 ES ES94926372T patent/ES2206469T3/es not_active Expired - Lifetime
- 1994-09-08 AT AT94926372T patent/ATE255106T1/de active
- 1994-09-08 CA CA002146961A patent/CA2146961C/en not_active Expired - Fee Related
- 1994-09-08 DK DK94926372T patent/DK0673937T3/da active
- 1994-09-08 EP EP94926372A patent/EP0673937B1/en not_active Expired - Lifetime
- 1994-09-08 WO PCT/JP1994/001487 patent/WO1995007276A1/ja active IP Right Grant
- 1994-09-08 HU HU9501363A patent/HU224069B1/hu not_active IP Right Cessation
- 1994-09-08 NZ NZ273073A patent/NZ273073A/en not_active IP Right Cessation
- 1994-09-08 CN CNB011194561A patent/CN1221533C/zh not_active Expired - Fee Related
- 1994-09-08 PT PT94926372T patent/PT673937E/pt unknown
- 1994-09-08 KR KR1019950701862A patent/KR0174752B1/ko not_active IP Right Cessation
- 1994-09-08 RU RU96119782A patent/RU2121997C1/ru not_active IP Right Cessation
- 1994-09-08 CN CN94190672A patent/CN1079097C/zh not_active Expired - Fee Related
- 1994-09-08 DE DE69433353T patent/DE69433353T2/de not_active Expired - Lifetime
- 1994-09-08 AU AU76237/94A patent/AU683492B2/en not_active Ceased
- 1994-09-08 RU RU95112848A patent/RU2128648C1/ru not_active IP Right Cessation
-
1995
- 1995-05-09 NO NO19951813A patent/NO303778B1/no not_active IP Right Cessation
-
1997
- 1997-01-17 US US08/785,610 patent/US5767283A/en not_active Expired - Lifetime
- 1997-04-09 AU AU17785/97A patent/AU711438B2/en not_active Ceased
-
1998
- 1998-09-07 KR KR1019980707044A patent/KR100188846B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT673937E (pt) | 2004-04-30 |
| RU2121997C1 (ru) | 1998-11-20 |
| DE69433353D1 (de) | 2004-01-08 |
| DK0673937T3 (da) | 2004-03-22 |
| CN1221533C (zh) | 2005-10-05 |
| NO951813L (no) | 1995-05-09 |
| NZ273073A (en) | 1996-09-25 |
| CA2146961A1 (en) | 1995-03-16 |
| ES2206469T3 (es) | 2004-05-16 |
| EP0673937A4 (en) | 1996-01-17 |
| KR0174752B1 (ko) | 1999-02-01 |
| KR950704304A (ko) | 1995-11-17 |
| HU9501363D0 (en) | 1995-06-28 |
| RU95112848A (ru) | 1997-03-20 |
| EP0673937A1 (en) | 1995-09-27 |
| KR100188846B1 (en) | 1999-06-01 |
| AU711438B2 (en) | 1999-10-14 |
| HUT71551A (en) | 1995-12-28 |
| CN1491941A (zh) | 2004-04-28 |
| NO951813D0 (no) | 1995-05-09 |
| CN1114506A (zh) | 1996-01-03 |
| DE69433353T2 (de) | 2004-09-09 |
| RU2128648C1 (ru) | 1999-04-10 |
| ATE255106T1 (de) | 2003-12-15 |
| AU683492B2 (en) | 1997-11-13 |
| CN1079097C (zh) | 2002-02-13 |
| CA2146961C (en) | 2006-11-07 |
| AU7623794A (en) | 1995-03-27 |
| EP0673937B1 (en) | 2003-11-26 |
| HU224069B1 (hu) | 2005-05-30 |
| WO1995007276A1 (fr) | 1995-03-16 |
| AU1778597A (en) | 1997-08-14 |
| US5767283A (en) | 1998-06-16 |
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| NO920619L (no) | Oxazinobenzazolforbindelser | |
| EP1433479B8 (en) | Appetite-stimulating agents and remedies for anorexia | |
| DE69000806D1 (de) | Indol-derivate. | |
| DK480389A (da) | Antitumor-aktivt derivat af sf2587, fremgangsmaade til det fremstilling og anticancermiddel indeholdende stoffet |
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