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NO20062569L - Nye krystallinske anhydrider med antikolinergisk effekt - Google Patents

Nye krystallinske anhydrider med antikolinergisk effekt

Info

Publication number
NO20062569L
NO20062569L NO20062569A NO20062569A NO20062569L NO 20062569 L NO20062569 L NO 20062569L NO 20062569 A NO20062569 A NO 20062569A NO 20062569 A NO20062569 A NO 20062569A NO 20062569 L NO20062569 L NO 20062569L
Authority
NO
Norway
Prior art keywords
new crystalline
anticholinergic effect
anhydrides
crystalline anhydrides
treatment
Prior art date
Application number
NO20062569A
Other languages
English (en)
Inventor
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530662&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20062569(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO20062569L publication Critical patent/NO20062569L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oppfinnelsen angår et nytt, krystallinsk anhydrat av tiotropiumbromid, en metode for fremstilling av nevnte anhydrat, og anvendelsen av dette for fremstilling av et legemiddel for behandling av luftveislidelser, spesielt for behandling av kronisk obstruktiv lungesykdom (KOLS) og astma.
NO20062569A 2003-11-03 2006-06-02 Nye krystallinske anhydrider med antikolinergisk effekt NO20062569L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025077 2003-11-03
PCT/EP2004/012269 WO2005042527A1 (de) 2003-11-03 2004-10-29 Neues kristallines anhydrat mit anticholinerger wirksamkeit

Publications (1)

Publication Number Publication Date
NO20062569L true NO20062569L (no) 2006-07-12

Family

ID=34530662

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062569A NO20062569L (no) 2003-11-03 2006-06-02 Nye krystallinske anhydrider med antikolinergisk effekt

Country Status (34)

Country Link
EP (1) EP1682542B1 (no)
JP (1) JP4553902B2 (no)
KR (2) KR101313904B1 (no)
CN (1) CN100509809C (no)
AR (1) AR046319A1 (no)
AT (1) ATE453641T1 (no)
AU (1) AU2004285684B2 (no)
BR (1) BRPI0415636A (no)
CA (1) CA2544352C (no)
CO (1) CO5690641A2 (no)
CY (1) CY1110339T1 (no)
DE (1) DE502004010602D1 (no)
DK (1) DK1682542T3 (no)
EA (1) EA008587B1 (no)
EC (1) ECSP066543A (no)
ES (1) ES2338563T3 (no)
HK (1) HK1099752A1 (no)
HR (1) HRP20100029T1 (no)
IL (1) IL175126A (no)
ME (1) ME00349B (no)
MX (1) MX272045B (no)
MY (1) MY146628A (no)
NO (1) NO20062569L (no)
NZ (1) NZ547581A (no)
PE (1) PE20050996A1 (no)
PL (1) PL1682542T3 (no)
PT (1) PT1682542E (no)
RS (2) RS51599B (no)
SI (1) SI1682542T1 (no)
TW (1) TWI336330B (no)
UA (1) UA82909C2 (no)
UY (1) UY28596A1 (no)
WO (1) WO2005042527A1 (no)
ZA (1) ZA200602344B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0611091A2 (pt) * 2005-05-02 2010-08-03 Boehringer Ingelheim Int formas cristalinas de brometo de tiotrópico
ATE552256T1 (de) 2005-12-19 2012-04-15 Sicor Inc Neuartige form von tiotropium-bromid und herstellungsverfahren dafür
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
DK1971332T3 (da) * 2006-01-04 2011-04-18 Boehringer Ingelheim Int Anvendelse af tiotropium-salte til behandling af moderat vedvarende astma
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
CN101032484B (zh) * 2007-04-02 2010-05-26 南京卡文迪许生物工程技术有限公司 一种噻托溴铵胶囊型吸入粉雾剂
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
CN102238939B (zh) * 2008-11-04 2015-05-20 希普拉有限公司 药物气溶胶组合物
CA2742356A1 (en) * 2008-11-04 2010-05-14 Cipla Limited Tiotropium bromide having a low degree of crystallinity
CA2768553C (en) * 2009-08-07 2016-08-02 Generics [Uk] Limited Anhydrate of tiotropium bromide
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
BR112015009654A2 (pt) 2012-11-05 2017-07-04 Zentiva Ks métodos para a estabilização de solvatos micronizados ou moídos de brometo de tiotrópio e preparar o solvato de brometo de tiotrópio, solvato de brometo de tiotrópio, e, uso de solvatos estabilizados
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
EP3414243A1 (en) 2016-02-11 2018-12-19 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI Crystalline form of tiotropium bromide anhydrate
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
WO2002030928A1 (de) * 2000-10-12 2002-04-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
CN100586948C (zh) * 2001-06-22 2010-02-03 贝林格尔英格海姆法玛两合公司 结晶性抗胆碱能药,其制备方法及其在药物制备中的用途

Also Published As

Publication number Publication date
EP1682542A1 (de) 2006-07-26
AU2004285684A1 (en) 2005-05-12
HK1099752A1 (en) 2007-08-24
KR101313904B1 (ko) 2013-09-30
ECSP066543A (es) 2006-10-17
BRPI0415636A (pt) 2006-12-12
CN1875019A (zh) 2006-12-06
KR20060121131A (ko) 2006-11-28
ES2338563T3 (es) 2010-05-10
MY146628A (en) 2012-09-14
JP4553902B2 (ja) 2010-09-29
PL1682542T3 (pl) 2010-06-30
JP2007509894A (ja) 2007-04-19
EP1682542B1 (de) 2009-12-30
PE20050996A1 (es) 2005-12-20
CA2544352C (en) 2013-07-16
SI1682542T1 (sl) 2010-04-30
RS51599B (en) 2011-08-31
WO2005042527A1 (de) 2005-05-12
TW200526652A (en) 2005-08-16
UA82909C2 (en) 2008-05-26
MEP51708A (en) 2011-02-10
AR046319A1 (es) 2005-11-30
ATE453641T1 (de) 2010-01-15
UY28596A1 (es) 2005-06-30
MXPA06004940A (es) 2006-07-20
RS20060291A (en) 2008-06-05
KR101285571B1 (ko) 2013-07-15
PT1682542E (pt) 2010-01-27
KR20120036381A (ko) 2012-04-17
TWI336330B (en) 2011-01-21
IL175126A (en) 2010-11-30
AU2004285684B2 (en) 2011-07-14
CA2544352A1 (en) 2005-05-12
CO5690641A2 (es) 2006-10-31
DE502004010602D1 (de) 2010-02-11
HRP20100029T1 (hr) 2010-02-28
EA008587B1 (ru) 2007-06-29
ZA200602344B (en) 2007-07-25
EA200600853A1 (ru) 2006-10-27
IL175126A0 (en) 2006-09-05
DK1682542T3 (da) 2010-05-10
CY1110339T1 (el) 2015-01-14
NZ547581A (en) 2009-03-31
CN100509809C (zh) 2009-07-08
MX272045B (en) 2009-11-23
ME00349B (me) 2011-05-10

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