NO20060202L - Pyrrolodihydroisokinoliner som PDE-10-inhibitorer - Google Patents

Pyrrolodihydroisokinoliner som PDE-10-inhibitorer

Info

Publication number: NO20060202L
Authority: NO; Norway
Prior art keywords: inhibitors; pyrrolodihydroisoquinolines; pde; pdeio; relates
Prior art date: 2003-06-30

Application number

NO20060202A

Other languages

English (en)

Norwegian (no)

Inventor

Camille-Georges Wermuth

Thomas Maier

Ulrich Graedler

Petra Gimmnich

Gianluca Quintini

Paola Ciapetti

Jean-Marie Contreras

Matthias Vennemann

Thomas Bar

Jueergen Braunger

Original Assignee

Altana Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-30

Filing date

2006-01-13

Publication date

2006-01-13

2006-01-13 Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag

2006-01-13 Publication of NO20060202L publication Critical patent/NO20060202L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20060202A 2003-06-30 2006-01-13 Pyrrolodihydroisokinoliner som PDE-10-inhibitorer NO20060202L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03014424		2003-06-30
PCT/EP2004/051307 WO2005003129A1 (en)	2003-06-30	2004-06-30	Pyrrolodihydroisoquinolines as pde10 inhibitors

Publications (1)

Publication Number	Publication Date
NO20060202L true NO20060202L (no)	2006-01-13

Family

ID=33560746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20060202A NO20060202L (no)	2003-06-30	2006-01-13	Pyrrolodihydroisokinoliner som PDE-10-inhibitorer

Country Status (22)

Country	Link
US (2)	US20060148840A1 (zh)
EP (2)	EP1641794A1 (zh)
JP (2)	JP2009513494A (zh)
KR (1)	KR20060030483A (zh)
CN (2)	CN1809565A (zh)
AR (2)	AR044956A1 (zh)
AT (1)	ATE478868T1 (zh)
AU (2)	AU2004253690B2 (zh)
BR (1)	BRPI0411897A (zh)
CA (2)	CA2530316A1 (zh)
DE (1)	DE602004028827D1 (zh)
EA (1)	EA012110B1 (zh)
IL (1)	IL171997A0 (zh)
IS (1)	IS8238A (zh)
MX (2)	MXPA05013553A (zh)
NO (1)	NO20060202L (zh)
NZ (1)	NZ544591A (zh)
RS (2)	RS20050946A (zh)
TW (2)	TW200510413A (zh)
UA (1)	UA86591C2 (zh)
WO (2)	WO2005003129A1 (zh)
ZA (2)	ZA200509265B (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2530316A1 (en) *	2003-06-30	2005-01-13	Altana Pharma Ag	Pyrrolodihydroisoquinolines as pde10 inhibitors
ATE430148T1 (de) *	2005-01-12	2009-05-15	Nycomed Gmbh	Neue pyrrolodihydroisochinoline als pde10- inhibitoren
CA2595075A1 (en) *	2005-01-12	2006-07-20	Matthias Vennemann	Pyrrolodihydroisoquinolines as antiproliferative agents
US20100179131A1 (en)	2006-09-07	2010-07-15	Nycomed Gmbh	Combination treatment for diabetes mellitus
CN101742906A (zh)	2007-06-04	2010-06-16	本古里安大学内盖夫研究发展局	三芳基化合物和包含它们的组合物
US7858620B2 (en)	2007-09-19	2010-12-28	H. Lundbeck A/S	Cyanoisoquinoline
TW200918519A (en) *	2007-09-19	2009-05-01	Lundbeck & Co As H	Cyanoisoquinoline
TW200944523A (en)	2008-02-08	2009-11-01	Organon Nv	(Dihydro)pyrrolo[2,1-a]isoquinolines
WO2009108383A2 (en)	2008-02-29	2009-09-03	Concert Pharmaceuticals, Inc.	Substituted xanthine derivatives
US8133897B2 (en)	2008-06-20	2012-03-13	H. Lundbeck A/S	Phenylimidazole derivatives as PDE10A enzyme inhibitors
UA102693C2 (ru)	2008-06-20	2013-08-12	Х. Луннбек А/С	Производные фенилимидазола как ингибиторы фермента pde10a
TWI501965B (zh) *	2008-06-20	2015-10-01	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
US20110053961A1 (en)	2009-02-27	2011-03-03	Concert Pharmaceuticals, Inc.	Substituted xanthine derivatives
TWI461426B (zh) *	2009-05-27	2014-11-21	Merck Sharp & Dohme	（二氫）咪唑並異〔５，１－ａ〕喹啉類
TWI481607B (zh)	2009-12-17	2015-04-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI487705B (zh)	2009-12-17	2015-06-11	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
TWI485151B (zh)	2009-12-17	2015-05-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TW201200516A (en)	2009-12-17	2012-01-01	Lundbeck & Co As H	Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
TW201215607A (en)	2010-07-02	2012-04-16	Lundbeck & Co As H	Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor
TW201206935A (en)	2010-07-16	2012-02-16	Lundbeck & Co As H	Triazolo-and pyrazoloquinazoline derivatives as PDE10A enzyme inhibitor
DE102010042833B4 (de)	2010-10-22	2018-11-08	Helmholtz-Zentrum Dresden - Rossendorf E.V.	Neue Halogenalkoxychinazoline, deren Herstellung und Verwendung
JO3089B1 (ar)	2010-11-19	2017-03-15	H Lundbeck As	مشتقات ايميدازول كمثبطات لانزيمات pde10a
JP2014510055A (ja)	2011-02-18	2014-04-24	アラーガンインコーポレイテッド	ホスホジエステラーゼ１０（ｐｄｅ１０ａ）阻害剤としての置換６，７−ジアルコキシ−３−イソキノリノール誘導体
WO2013013052A1 (en)	2011-07-19	2013-01-24	Concert Pharmaceuticals, Inc.	Substituted xanthine derivatives
WO2013045607A1 (en)	2011-09-30	2013-04-04	H. Lundbeck A/S	Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors
WO2013050527A1 (en)	2011-10-05	2013-04-11	H. Lundbeck A/S	Quinazoline derivatives as pde10a enzyme inhibitors
AR089361A1 (es)	2011-12-21	2014-08-20	Lundbeck & Co As H	Derivados de quinolina como inhibidores de la enzima pde10a
WO2013127817A1 (en)	2012-02-27	2013-09-06	H. Lundbeck A/S	Imidazole derivatives as pde10a enzyme inhibitors
WO2014071044A1 (en)	2012-11-01	2014-05-08	Allergan, Inc.	Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
CN103059029B (zh) *	2012-12-28	2014-12-10	塔里木大学	一种六氢吡咯[2,3]并吲哚类化合物及其制备方法和在杀菌活性中的应用
SI3027613T1 (sl) *	2013-07-25	2018-10-30	Uniwersytet Jagiellonski	Derivati pirolokvinolina kot 5-HT6 antagonisti, postopek priprave in uporabe le-teh
JP6657101B2 (ja)	2013-11-05	2020-03-04	ベングリオンユニバーシティオブザネガフリサーチアンドディベロップメントオーソリティ	糖尿病及びそれから生じる疾患合併症の治療のための化合物
US9200016B2 (en)	2013-12-05	2015-12-01	Allergan, Inc.	Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
CA2981791A1 (en)	2014-04-18	2015-10-22	Concert Pharmaceuticals, Inc.	Methods of treating hyperglycemia

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE690792A (zh) *	1966-12-07	1967-05-16
DE3401018A1 (de) *	1984-01-13	1985-07-18	Boehringer Ingelheim KG, 6507 Ingelheim	Verfahren zur herstellung von 5,6-dihydro-pyrrolo(2,1-a)isochinolinen
FR2761358B1 (fr) *	1997-03-27	1999-05-07	Adir	Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2004517843A (ja) *	2000-12-13	2004-06-17	バイエルアクチェンゲゼルシャフト	ピロロ［２．１−ａ］ジヒドロイソキノリンおよびホスホジエステラーゼ１０ａ阻害薬としてのその使用
US20030032579A1 (en) *	2001-04-20	2003-02-13	Pfizer Inc.	Therapeutic use of selective PDE10 inhibitors
US20030018047A1 (en) *	2001-04-20	2003-01-23	Pfizer Inc.	Therapeutic use of selective PDE10 inhibitors
IL149106A0 (en) *	2001-04-20	2002-11-10	Pfizer Prod Inc	Therapeutic use of selective pde10 inhibitors
DE10130151A1 (de) *	2001-06-22	2003-01-02	Bayer Ag	Neue Verwendung für PDE 10A-Inhibitoren
WO2003014116A1 (en) *	2001-08-06	2003-02-20	Bayer Corporation	Pyrrolo[2.1-a]isoquinoline derivatives
WO2003014115A1 (en) *	2001-08-06	2003-02-20	Bayer Aktiengesellschaft	3-substituted pyrrolo (2.1-a) isoquinoline derivatives
WO2003051877A1 (en) *	2001-12-18	2003-06-26	Bayer Corporation	2-substituted pyrrolo[2.1-a]isoquinolines against cancer
CA2530316A1 (en) *	2003-06-30	2005-01-13	Altana Pharma Ag	Pyrrolodihydroisoquinolines as pde10 inhibitors
CA2595075A1 (en) *	2005-01-12	2006-07-20	Matthias Vennemann	Pyrrolodihydroisoquinolines as antiproliferative agents
ATE430148T1 (de) *	2005-01-12	2009-05-15	Nycomed Gmbh	Neue pyrrolodihydroisochinoline als pde10- inhibitoren

2004
- 2004-06-30 CA CA002530316A patent/CA2530316A1/en not_active Abandoned
- 2004-06-30 WO PCT/EP2004/051307 patent/WO2005003129A1/en active Application Filing
- 2004-06-30 AR ARP040102290A patent/AR044956A1/es not_active Application Discontinuation
- 2004-06-30 MX MXPA05013553A patent/MXPA05013553A/es active IP Right Grant
- 2004-06-30 AR ARP040102291A patent/AR045696A1/es not_active Application Discontinuation
- 2004-06-30 CA CA002530317A patent/CA2530317A1/en not_active Abandoned
- 2004-06-30 RS YUP-2005/0946A patent/RS20050946A/sr unknown
- 2004-06-30 CN CNA2004800175231A patent/CN1809565A/zh active Pending
- 2004-06-30 US US10/562,137 patent/US20060148840A1/en not_active Abandoned
- 2004-06-30 AU AU2004253690A patent/AU2004253690B2/en not_active Ceased
- 2004-06-30 CN CNA2004800175104A patent/CN1809564A/zh active Pending
- 2004-06-30 NZ NZ544591A patent/NZ544591A/xx unknown
- 2004-06-30 TW TW093119579A patent/TW200510413A/zh unknown
- 2004-06-30 EA EA200501928A patent/EA012110B1/ru not_active IP Right Cessation
- 2004-06-30 US US10/562,149 patent/US20060148838A1/en not_active Abandoned
- 2004-06-30 RS YUP-2005/0945A patent/RS20050945A/sr unknown
- 2004-06-30 MX MXPA05013822A patent/MXPA05013822A/es unknown
- 2004-06-30 EP EP04766106A patent/EP1641794A1/en not_active Withdrawn
- 2004-06-30 BR BRPI0411897-9A patent/BRPI0411897A/pt not_active IP Right Cessation
- 2004-06-30 AU AU2004253694A patent/AU2004253694A1/en not_active Abandoned
- 2004-06-30 DE DE602004028827T patent/DE602004028827D1/de not_active Expired - Lifetime
- 2004-06-30 JP JP2006516197A patent/JP2009513494A/ja active Pending
- 2004-06-30 WO PCT/EP2004/051315 patent/WO2005003130A1/en active Application Filing
- 2004-06-30 UA UAA200600505A patent/UA86591C2/ru unknown
- 2004-06-30 JP JP2006516198A patent/JP2009513495A/ja active Pending
- 2004-06-30 TW TW093119589A patent/TW200510407A/zh unknown
- 2004-06-30 EP EP04741932A patent/EP1641792B1/en not_active Expired - Lifetime
- 2004-06-30 AT AT04741932T patent/ATE478868T1/de not_active IP Right Cessation
- 2004-06-30 KR KR1020057024872A patent/KR20060030483A/ko not_active Ceased
2005
- 2005-11-16 ZA ZA200509265A patent/ZA200509265B/en unknown
- 2005-11-16 ZA ZA200509267A patent/ZA200509267B/en unknown
- 2005-11-16 IL IL171997A patent/IL171997A0/en unknown
2006
- 2006-01-13 NO NO20060202A patent/NO20060202L/no not_active Application Discontinuation
- 2006-01-18 IS IS8238A patent/IS8238A/is unknown

Also Published As

Publication number	Publication date
US20060148840A1 (en)	2006-07-06
EP1641794A1 (en)	2006-04-05
JP2009513495A (ja)	2009-04-02
MXPA05013553A (es)	2006-03-09
TW200510413A (en)	2005-03-16
EP1641792B1 (en)	2010-08-25
JP2009513494A (ja)	2009-04-02
RS20050945A (en)	2008-06-05
AR045696A1 (es)	2005-11-09
CA2530317A1 (en)	2005-01-13
AU2004253694A1 (en)	2005-01-13
ZA200509265B (en)	2006-10-25
RS20050946A (en)	2008-06-05
MXPA05013822A (es)	2006-02-28
CA2530316A1 (en)	2005-01-13
IL171997A0 (en)	2011-08-01
US20060148838A1 (en)	2006-07-06
AU2004253690A1 (en)	2005-01-13
NZ544591A (en)	2009-07-31
ATE478868T1 (de)	2010-09-15
EP1641792A1 (en)	2006-04-05
WO2005003129A1 (en)	2005-01-13
DE602004028827D1 (de)	2010-10-07
UA86591C2 (ru)	2009-05-12
IS8238A (is)	2006-01-18
ZA200509267B (en)	2006-08-30
WO2005003130A1 (en)	2005-01-13
CN1809565A (zh)	2006-07-26
KR20060030483A (ko)	2006-04-10
EA200501928A1 (ru)	2006-12-29
AU2004253690B2 (en)	2010-03-25
CN1809564A (zh)	2006-07-26
BRPI0411897A (pt)	2006-08-29
EA012110B1 (ru)	2009-08-28
TW200510407A (en)	2005-03-16
AR044956A1 (es)	2005-10-12

Publication	Publication Date	Title
NO20060202L (no)	2006-01-13	Pyrrolodihydroisokinoliner som PDE-10-inhibitorer
DK1682530T3 (da)	2007-07-16	Pyrrolsubstituerede indoler som inhibitorer af PAI-1
ATE362932T1 (de)	2007-06-15	Azaindolverbindungen als kinaseinhibitoren
CY1110064T1 (el)	2015-01-14	Παραγωγα φαινυλ-πιπεραζινης ως αναστολεις επαναπροσληψης σεροτονινης
NO20081636L (no)	2008-05-29	FAP - inhibitorer
DK1483265T3 (da)	2007-03-19	Purinderivater som kinaseinhibitorer
EA200800321A1 (ru)	2008-06-30	Ингибиторы гистондеацетилазы
ATE548374T1 (de)	2012-03-15	2'-fluor-2'-desoxytetrahydrouridine als cytidindeaminaseinhibitoren
NO20092710L (no)	2009-09-21	Cyclopaminanaloger
DK1881967T3 (da)	2010-08-16	Substituerede benzo (D) isoaxol-3-yl-amin-forbindelser som analgetika
CY1109911T1 (el)	2014-09-10	Πυρρολοβενζοδιαζεπινες
BRPI1015043A2 (pt)	2019-07-09	derivados de diazahomoadamantano e métodos de uso dos mesmos
NO20061317L (no)	2006-03-23	Imidazopyridinderivater som induserbare NO-syntaseinhibatorer
EA200701396A1 (ru)	2007-12-28	Триазолофталазины в качестве ингибиторов pde-2
ATE510822T1 (de)	2011-06-15	Kaliumkanalinhibitoren
EA201270630A1 (ru)	2012-12-28	Гетероциклические сетр ингибиторы
EA200801608A1 (ru)	2008-10-30	Производные бензимидазолонкарбоновой кислоты
EA200801366A1 (ru)	2008-10-30	Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
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