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NO20053176L - Fremgangsmate for fremstilling av tolperisonsalter. - Google Patents

Fremgangsmate for fremstilling av tolperisonsalter.

Info

Publication number
NO20053176L
NO20053176L NO20053176A NO20053176A NO20053176L NO 20053176 L NO20053176 L NO 20053176L NO 20053176 A NO20053176 A NO 20053176A NO 20053176 A NO20053176 A NO 20053176A NO 20053176 L NO20053176 L NO 20053176L
Authority
NO
Norway
Prior art keywords
tolperisone
salts
preparation
acid
addition salt
Prior art date
Application number
NO20053176A
Other languages
English (en)
Other versions
NO20053176D0 (no
Inventor
Laszlo Czollner
Stefan Welzig
Beate Kalz
Jan Rothenburger
Original Assignee
Sanochemia Pharmazeutika Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanochemia Pharmazeutika Ag filed Critical Sanochemia Pharmazeutika Ag
Publication of NO20053176D0 publication Critical patent/NO20053176D0/no
Publication of NO20053176L publication Critical patent/NO20053176L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Det beskrives en fremgangsmåte for fremstilling av et addisjonssalt av 2,4'-dimetyl-3-piperidino-propiofenon (tolperison) med en farmasøytisk godtakbar syre, med formelen der 4-metylpropiofenon omsettes med piperidinhydroklorid og 1,2-dioksolan i nærvær av en syre som katalysator og at det oppnådde tolperison filtreres av som syreaddisjons-salt etter avkjøling av reaksjonsblandingen.
NO20053176A 2002-12-05 2005-06-28 Fremgangsmate for fremstilling av tolperisonsalter. NO20053176L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0182302A AT413539B (de) 2002-12-05 2002-12-05 Verfahren zum herstellen von salzen des tolperison
PCT/AT2003/000092 WO2004050648A1 (de) 2002-12-05 2003-03-31 Verfahren zum herstellen von salzen des tolperison

Publications (2)

Publication Number Publication Date
NO20053176D0 NO20053176D0 (no) 2005-06-28
NO20053176L true NO20053176L (no) 2005-09-05

Family

ID=32398619

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053176A NO20053176L (no) 2002-12-05 2005-06-28 Fremgangsmate for fremstilling av tolperisonsalter.

Country Status (15)

Country Link
US (2) US7385060B2 (no)
EP (1) EP1567510B1 (no)
AT (2) AT413539B (no)
AU (1) AU2003227075A1 (no)
CA (1) CA2507691C (no)
DE (1) DE50306068D1 (no)
DK (1) DK1567510T3 (no)
ES (1) ES2275140T3 (no)
HK (1) HK1085199A1 (no)
HR (1) HRP20050501A2 (no)
MX (1) MXPA05005571A (no)
NO (1) NO20053176L (no)
PL (1) PL378082A1 (no)
PT (1) PT1567510E (no)
WO (1) WO2004050648A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT413539B (de) * 2002-12-05 2006-03-15 Sanochemia Pharmazeutika Ag Verfahren zum herstellen von salzen des tolperison
DE102005014080B4 (de) * 2005-03-21 2007-11-22 Birds Pharma Gmbh Berolina Innovative Research & Development Services Additionssalze des Tolperison, Verfahren zu deren Herstellung, Verwendung derselben und diese enthaltende Arzneimittel
AT505225A1 (de) * 2007-04-26 2008-11-15 Sanochemia Pharmazeutika Ag 0erfahren zur herstellung von hoch reinem 2,4'-dimethyl-3-piperidino-propiophenon (tolperison), dieses enthaltende pharmazeutische zusammensetzungen, sowie tolperison enthaltende wirkstoffformulierungen
US20100249423A1 (en) * 2009-03-09 2010-09-30 Sanochemia Pharmazeutika Ag Tolperisone controlled release tablet
CN107868065B (zh) * 2017-10-19 2021-05-18 湖北美林药业有限公司 一种盐酸托哌酮化合物及其制备方法
CN116253699A (zh) * 2021-12-09 2023-06-13 广州白云山汉方现代药业有限公司 一种盐酸托哌酮新晶型及其制备方法
CN115932082A (zh) * 2022-11-24 2023-04-07 嘉实（湖南）医药科技有限公司 一种盐酸托哌酮有关物质的测定方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5295674A (en) 1976-02-09 1977-08-11 Nippon Carbide Ind Co Ltd Preparation of 4#-substituted-2-methyl-2-piperidinopropiophenone and i ts salts
AT413539B (de) * 2002-12-05 2006-03-15 Sanochemia Pharmazeutika Ag Verfahren zum herstellen von salzen des tolperison

Also Published As

Publication number Publication date
ES2275140T3 (es) 2007-06-01
HRP20050501A2 (en) 2005-08-31
US20080188522A1 (en) 2008-08-07
NO20053176D0 (no) 2005-06-28
PT1567510E (pt) 2007-02-28
US20060041141A1 (en) 2006-02-23
US7385060B2 (en) 2008-06-10
PL378082A1 (pl) 2006-02-20
DE50306068D1 (de) 2007-02-01
MXPA05005571A (es) 2005-10-18
EP1567510B1 (de) 2006-12-20
CA2507691C (en) 2010-10-12
ATA18232002A (de) 2005-08-15
HK1085199A1 (en) 2006-08-18
AT413539B (de) 2006-03-15
CA2507691A1 (en) 2004-06-17
DK1567510T3 (da) 2007-04-02
ATE348821T1 (de) 2007-01-15
WO2004050648A1 (de) 2004-06-17
AU2003227075A1 (en) 2004-06-23
EP1567510A1 (de) 2005-08-31

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