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NO20052887L - Pyridazinonderivater som GSK-3Beta inhibitorer. - Google Patents

Pyridazinonderivater som GSK-3Beta inhibitorer.

Info

Publication number
NO20052887L
NO20052887L NO20052887A NO20052887A NO20052887L NO 20052887 L NO20052887 L NO 20052887L NO 20052887 A NO20052887 A NO 20052887A NO 20052887 A NO20052887 A NO 20052887A NO 20052887 L NO20052887 L NO 20052887L
Authority
NO
Norway
Prior art keywords
gsk
pyridazinone derivatives
alkyl
aryl
3beta inhibitors
Prior art date
Application number
NO20052887A
Other languages
English (en)
Other versions
NO20052887D0 (no
Inventor
Hans Matter
Karl Schoenafinger
David William Will
Bernard Baudoin
Gilles Tiraboschi
Dominique Le Suisse
Thomas Rooney
Franck Halley
Guenter Mueller
Swen Hoelder
Thorsten Naumann
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20052887D0 publication Critical patent/NO20052887D0/no
Publication of NO20052887L publication Critical patent/NO20052887L/no

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/12—Antihypertensives
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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
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  • Organic Chemistry (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse angår nye pyridazinonderivater med generell formel (I) hvori A er lik Al eller A2; R er usubstituert eller minst monosubstituert Ci-Cio-alkyI, aryl, aryl(C]-Ci(ralkyl)-, heteroaryl, heteoraryl-(Ci-Cio-alkyl)-, heterosyklyl, heterosyklyl- (Ci-Cio-alkyl)-, Cs-Cio-sykloalkyl, polysykloalkyl, Ci-Cio-alkenyl eller Q-Cio-alkinyl og Ar er usubstituert eller minst monosubstituert aryl eller heteioaryl.
NO20052887A 2002-11-19 2005-06-14 Pyridazinonderivater som GSK-3Beta inhibitorer. NO20052887L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0214443A FR2847253B1 (fr) 2002-11-19 2002-11-19 Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant
PCT/EP2003/012950 WO2004046117A1 (en) 2002-11-19 2003-11-19 Pyridazinone derivatives as gsk-3beta inhibitors

Publications (2)

Publication Number Publication Date
NO20052887D0 NO20052887D0 (no) 2005-06-14
NO20052887L true NO20052887L (no) 2005-07-29

Family

ID=32187711

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Application Number Title Priority Date Filing Date
NO20052887A NO20052887L (no) 2002-11-19 2005-06-14 Pyridazinonderivater som GSK-3Beta inhibitorer.

Country Status (19)

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EP (2) EP1611121B1 (no)
JP (1) JP2006509748A (no)
KR (1) KR20050083918A (no)
CN (1) CN1741999A (no)
AR (2) AR042202A1 (no)
AT (2) ATE369356T1 (no)
AU (2) AU2003283414A1 (no)
BR (1) BR0316720A (no)
CA (2) CA2506022A1 (no)
CO (1) CO5700722A2 (no)
DE (2) DE60315516T2 (no)
FR (1) FR2847253B1 (no)
MA (1) MA27814A1 (no)
MX (1) MXPA05005270A (no)
NO (1) NO20052887L (no)
PL (1) PL376129A1 (no)
RU (1) RU2005119151A (no)
TW (2) TW200503727A (no)
WO (2) WO2004046130A1 (no)

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