NO20032236L - Laktamforbindelse - Google Patents

Laktamforbindelse

Info

Publication number: NO20032236L
Authority: NO; Norway
Prior art keywords: lactam compound; lactam; compound
Prior art date: 2000-11-17

Application number

NO20032236A

Other languages

English (en)

Other versions

NO20032236D0 (no

NO324324B1 (no

Inventor

James Edmund Audia

Varghese John

Lee H Latimer

Stacey Leigh Mcdaniel

Jeffrey Scott Nissen

Eugene D Thorsett

Jay S Tung

Original Assignee

Elan Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-17

Filing date

2003-05-16

Publication date

2003-07-10

2003-05-16 Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc

2003-05-16 Publication of NO20032236D0 publication Critical patent/NO20032236D0/no

2003-07-10 Publication of NO20032236L publication Critical patent/NO20032236L/no

2007-09-24 Publication of NO324324B1 publication Critical patent/NO324324B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Hydrogenated Pyridines (AREA)
Medicinal Preparation (AREA)

NO20032236A 2000-11-17 2003-05-16 Laktamforbindelse samt farmasoytisk sammensetning inneholdende denne NO324324B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24955200P	2000-11-17	2000-11-17
PCT/US2001/027799 WO2002047671A2 (en)	2000-11-17	2001-11-05	Lactam compound to inhibit beta-amyloid peptide release or synthesis

Publications (3)

Publication Number	Publication Date
NO20032236D0 NO20032236D0 (no)	2003-05-16
NO20032236L true NO20032236L (no)	2003-07-10
NO324324B1 NO324324B1 (no)	2007-09-24

Family

ID=22943982

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20032236A NO324324B1 (no)	2000-11-17	2003-05-16	Laktamforbindelse samt farmasoytisk sammensetning inneholdende denne

Country Status (34)

Country	Link
US (1)	US20050261495A1 (no)
EP (1)	EP1341531B1 (no)
JP (1)	JP4116437B2 (no)
KR (1)	KR100819679B1 (no)
CN (1)	CN1486184A (no)
AR (1)	AR035927A1 (no)
AU (2)	AU4319202A (no)
BR (1)	BR0115427A (no)
CA (1)	CA2427227C (no)
CY (1)	CY1106366T1 (no)
CZ (1)	CZ20031351A3 (no)
DE (1)	DE60126132T2 (no)
DK (1)	DK1341531T3 (no)
DZ (1)	DZ3453A1 (no)
EA (1)	EA005954B1 (no)
EC (1)	ECSP034600A (no)
ES (1)	ES2278804T3 (no)
HK (1)	HK1059731A1 (no)
HR (1)	HRP20030383B1 (no)
HU (1)	HU228117B1 (no)
IL (2)	IL155960A0 (no)
MX (1)	MXPA03004292A (no)
MY (1)	MY134559A (no)
NO (1)	NO324324B1 (no)
NZ (1)	NZ525854A (no)
PE (1)	PE20020802A1 (no)
PL (1)	PL212199B1 (no)
PT (1)	PT1341531E (no)
SI (1)	SI1341531T1 (no)
SK (1)	SK288065B6 (no)
TW (1)	TWI305204B (no)
UA (1)	UA74849C2 (no)
WO (1)	WO2002047671A2 (no)
ZA (1)	ZA200303789B (no)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7468365B2 (en)	2000-11-17	2008-12-23	Eli Lilly And Company	Lactam compound
UA74849C2 (en) *	2000-11-17	2006-02-15	Lilly Co Eli	Lactam
ES2413705T3 (es)	2005-04-08	2013-07-17	Daiichi Sankyo Company, Limited	Derivado de piridilmetilsulfona
US8362075B2 (en)	2005-05-17	2013-01-29	Merck Sharp & Dohme Corp.	Cyclohexyl sulphones for treatment of cancer
US8258302B2 (en) *	2006-01-31	2012-09-04	Api Corporation	Method for producing benzazepinone
WO2008099210A2 (en)	2007-02-12	2008-08-21	Merck & Co., Inc.	Piperazine derivatives for treatment of ad and related conditions
EP2193117A1 (en) *	2007-07-16	2010-06-09	Wyeth a Corporation of the State of Delaware	Inhibitors of beta amyloid production
MX2010001754A (es)	2007-08-14	2010-05-14	Lilly Co Eli	Derivados de azepina como inhibidores de gamma secretasa.
TW200920362A (en)	2007-09-11	2009-05-16	Daiichi Sankyo Co Ltd	Alkylsulfone derivatives
US8354446B2 (en)	2007-12-21	2013-01-15	Ligand Pharmaceuticals Incorporated	Selective androgen receptor modulators (SARMs) and uses thereof
EP2291181B9 (en)	2008-04-18	2013-09-11	University College Dublin National University Of Ireland, Dublin	Captodiamine for the treatment of depression symptoms
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
JP5099731B1 (ja)	2009-10-14	2012-12-19	メルク・シャープ・アンド・ドーム・コーポレーション	ｐ５３活性を増大する置換ピペリジン及びその使用
US8999957B2 (en)	2010-06-24	2015-04-07	Merck Sharp & Dohme Corp.	Heterocyclic compounds as ERK inhibitors
US8518907B2 (en)	2010-08-02	2013-08-27	Merck Sharp & Dohme Corp.	RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
US9029341B2 (en)	2010-08-17	2015-05-12	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
EP2615916B1 (en)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel erk inhibitors
WO2012040444A2 (en) *	2010-09-24	2012-03-29	Bristol-Myers Squibb Company	Treatment of patients with incipient alzheimer's disease
US9260471B2 (en)	2010-10-29	2016-02-16	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
US9351965B2 (en)	2010-12-21	2016-05-31	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
EP2770987B1 (en)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
CN102690231B (zh) *	2012-04-11	2014-07-09	南京友杰医药科技有限公司	治疗阿尔茨海默病潜在药物司马西特的合成方法
EP2844261B1 (en)	2012-05-02	2018-10-17	Sirna Therapeutics, Inc.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
CN104869987B (zh)	2012-09-07	2020-10-16	麻省眼耳医院	用于再生毛细胞和/或支持细胞的方法及组合物
EP2892506B1 (en)	2012-09-07	2021-11-03	Massachusetts Eye & Ear Infirmary	Treating hearing loss with the gamma-secretase inhibitor ly411575
CA2882950A1 (en)	2012-09-28	2014-04-03	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
MX363243B (es)	2012-11-28	2019-03-14	Merck Sharp & Dohme	Composiciones para tratar cáncer y usos de dichas composiciones.
TW201429969A (zh)	2012-12-20	2014-08-01	Merck Sharp & Dohme	作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
EP2951180B1 (en)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
EP2987496B1 (en)	2013-04-19	2018-08-08	National University Corporation Okayama University	Treatment agent for cognitive disorders, induced by amyloid -protein, therapeutic agent for alzheimer's disease, and treatment method and pathological analysis method related to these
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
EP3094323A4 (en)	2014-01-17	2017-10-11	Ligand Pharmaceuticals Incorporated	Methods and compositions for modulating hormone levels
EP3212773B1 (en)	2014-10-29	2021-09-15	Massachusetts Eye and Ear Infirmary	Efficient delivery of therapeutic molecules to cells of the inner ear
JP6840774B2 (ja)	2016-05-16	2021-03-10	ザジェネラルホスピタルコーポレイション	肺上皮エンジニアリングにおけるヒト気道幹細胞
EP3525785A4 (en)	2016-10-12	2020-03-25	Merck Sharp & Dohme Corp.	KDM5 INHIBITORS
WO2019094312A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
WO2019148067A1 (en)	2018-01-26	2019-08-01	Massachusetts Eye And Ear Infirmary	Treatment of hearing loss
WO2020033282A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
US11981701B2 (en)	2018-08-07	2024-05-14	Merck Sharp & Dohme Llc	PRMT5 inhibitors
CN112805006B (zh)	2018-08-07	2024-09-24	默沙东有限责任公司	Prmt5抑制剂
JP7589247B2 (ja)	2019-12-17	2024-11-25	メルク・シャープ・アンド・ドーム・エルエルシー	Ｐｒｍｔ５阻害剤
AU2023336062A1 (en)	2022-09-02	2025-03-13	Merck Sharp & Dohme Llc	Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof
AR130844A1 (es)	2022-10-25	2025-01-22	Merck Sharp & Dohme Llc	Enlazadores-cargas útiles de adc derivados de exatecán, composiciones farmacéuticas, y usos de los mismos
WO2024129628A1 (en)	2022-12-14	2024-06-20	Merck Sharp & Dohme Llc	Auristatin linker-payloads, pharmaceutical compositions, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI0951466T1 (sl) *	1996-12-23	2009-10-31	Elan Pharm Inc	Cikloalkili, laktami, laktoni in sorodne spojine, farmacevtske zmesi, ki jih vsebujejo, in metode inhibicije sproĹˇÄŤanja beta-amiloidnega peptida in/ali njegove sinteze z uporabo takih spojin
EP1089977A1 (en) *	1998-06-22	2001-04-11	Elan Pharmaceuticals, Inc.	Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
EP1230220A1 (en) *	1999-11-09	2002-08-14	Eli Lilly And Company	Beta-aminoacid compounds useful for inhibiting beta-amyloid peptide release and/or its synthesis
CA2425558C (en) *	2000-11-17	2012-01-03	Eli Lilly And Company	Lactam compound
UA77165C2 (en) *	2000-11-17	2006-11-15	Lilly Co Eli	(n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
UA74849C2 (en) *	2000-11-17	2006-02-15	Lilly Co Eli	Lactam

2001
- 2001-05-11 UA UA2003054408A patent/UA74849C2/uk unknown
- 2001-11-05 EA EA200300580A patent/EA005954B1/ru not_active IP Right Cessation
- 2001-11-05 ES ES01989070T patent/ES2278804T3/es not_active Expired - Lifetime
- 2001-11-05 PT PT01989070T patent/PT1341531E/pt unknown
- 2001-11-05 HU HU0301842A patent/HU228117B1/hu not_active IP Right Cessation
- 2001-11-05 IL IL15596001A patent/IL155960A0/xx unknown
- 2001-11-05 JP JP2002549245A patent/JP4116437B2/ja not_active Expired - Fee Related
- 2001-11-05 SK SK559-2003A patent/SK288065B6/sk not_active IP Right Cessation
- 2001-11-05 CA CA2427227A patent/CA2427227C/en not_active Expired - Fee Related
- 2001-11-05 MX MXPA03004292A patent/MXPA03004292A/es active IP Right Grant
- 2001-11-05 PL PL362688A patent/PL212199B1/pl unknown
- 2001-11-05 KR KR1020037006721A patent/KR100819679B1/ko not_active IP Right Cessation
- 2001-11-05 EP EP01989070A patent/EP1341531B1/en not_active Expired - Lifetime
- 2001-11-05 CN CNA018221009A patent/CN1486184A/zh active Pending
- 2001-11-05 NZ NZ525854A patent/NZ525854A/en not_active IP Right Cessation
- 2001-11-05 DK DK01989070T patent/DK1341531T3/da active
- 2001-11-05 WO PCT/US2001/027799 patent/WO2002047671A2/en active IP Right Grant
- 2001-11-05 AU AU4319202A patent/AU4319202A/xx active Pending
- 2001-11-05 DZ DZ013453A patent/DZ3453A1/fr active
- 2001-11-05 US US10/416,771 patent/US20050261495A1/en not_active Abandoned
- 2001-11-05 SI SI200130701T patent/SI1341531T1/sl unknown
- 2001-11-05 DE DE60126132T patent/DE60126132T2/de not_active Expired - Lifetime
- 2001-11-05 AU AU2002243192A patent/AU2002243192B2/en not_active Ceased
- 2001-11-05 BR BR0115427-3A patent/BR0115427A/pt not_active IP Right Cessation
- 2001-11-05 CZ CZ20031351A patent/CZ20031351A3/cs unknown
- 2001-11-12 TW TW090128005A patent/TWI305204B/zh not_active IP Right Cessation
- 2001-11-14 AR ARP010105312A patent/AR035927A1/es not_active Application Discontinuation
- 2001-11-15 MY MYPI20015236A patent/MY134559A/en unknown
- 2001-11-16 PE PE2001001142A patent/PE20020802A1/es not_active Application Discontinuation
2003
- 2003-05-13 EC EC2003004600A patent/ECSP034600A/es unknown
- 2003-05-14 HR HR20030383A patent/HRP20030383B1/xx not_active IP Right Cessation
- 2003-05-15 IL IL155960A patent/IL155960A/en not_active IP Right Cessation
- 2003-05-15 ZA ZA200303789A patent/ZA200303789B/en unknown
- 2003-05-16 NO NO20032236A patent/NO324324B1/no not_active IP Right Cessation
2004
- 2004-02-20 HK HK04101245A patent/HK1059731A1/xx not_active IP Right Cessation
2007
- 2007-03-09 CY CY20071100331T patent/CY1106366T1/el unknown

Also Published As

Publication number	Publication date
EP1341531B1 (en)	2007-01-17
DE60126132T2 (de)	2007-10-18
SI1341531T1 (sl)	2007-06-30
KR100819679B1 (ko)	2008-04-04
CN1486184A (zh)	2004-03-31
SK288065B6 (sk)	2013-04-03
CA2427227A1 (en)	2002-06-20
PT1341531E (pt)	2007-04-30
HUP0301842A3 (en)	2010-03-29
AR035927A1 (es)	2004-07-28
NO20032236D0 (no)	2003-05-16
AU4319202A (en)	2002-06-24
NO324324B1 (no)	2007-09-24
EA005954B1 (ru)	2005-08-25
MY134559A (en)	2007-12-31
ES2278804T3 (es)	2007-08-16
HUP0301842A2 (hu)	2003-09-29
DK1341531T3 (da)	2007-05-14
IL155960A0 (en)	2003-12-23
HRP20030383B1 (en)	2007-12-31
BR0115427A (pt)	2003-10-07
EP1341531A2 (en)	2003-09-10
WO2002047671A3 (en)	2003-03-06
SK5592003A3 (en)	2003-12-02
AU2002243192B2 (en)	2006-07-20
WO2002047671A2 (en)	2002-06-20
HU228117B1 (en)	2012-11-28
US20050261495A1 (en)	2005-11-24
PL212199B1 (pl)	2012-08-31
IL155960A (en)	2009-06-15
MXPA03004292A (es)	2004-02-12
UA74849C2 (en)	2006-02-15
CZ20031351A3 (cs)	2003-11-12
NZ525854A (en)	2004-06-25
JP2004517090A (ja)	2004-06-10
CA2427227C (en)	2010-08-17
HK1059731A1 (en)	2004-07-16
EA200300580A1 (ru)	2003-10-30
KR20030051846A (ko)	2003-06-25
ECSP034600A (es)	2003-06-25
ZA200303789B (en)	2004-08-16
DZ3453A1 (fr)	2002-06-20
DE60126132D1 (de)	2007-03-08
CY1106366T1 (el)	2011-10-12
TWI305204B (en)	2009-01-11
PL362688A1 (en)	2004-11-02
JP4116437B2 (ja)	2008-07-09
HRP20030383A2 (en)	2005-10-31
PE20020802A1 (es)	2002-09-10

Publication	Publication Date	Title
NO20032236D0 (no)	2003-05-16	Laktamforbindelse
NO20026196L (no)	2003-02-24	Kinazolinditosylatsalt-forbindelser
DK1619192T3 (da)	2010-03-29	Arylkondeserede azapolycykliske forbindelser
DK1226127T3 (da)	2009-10-19	Substituerede phenylsulfamoylcarboxamider
DK1255740T3 (da)	2006-02-06	Substituerede arylpyraziner
AR028393A1 (es)	2003-05-07	Iminoazidas substituidas
NO20032215L (no)	2003-07-16	Laktamforbindelse
PT1268453E (pt)	2006-10-31	Metabolitos de agonista/antagonista de estrogenio
ATE365721T1 (de)	2007-07-15	Substituierte benzoylcyclohexenone
AR028302A1 (es)	2003-05-07	Feniluracilos substituidos
ID29755A (id)	2001-10-11	Senyawa-senyawa organosilikon
IT250181Y1 (it)	2003-07-24	Custodia perfezionata per rivoltella
ATE372338T1 (de)	2007-09-15	Deshalogenverbindungen
NO20030303D0 (no)	2003-01-20	Kalsilytiske forbindelser
NO20023508D0 (no)	2002-07-23	Kalsilyttiske forbindelser
NO20031837L (no)	2003-06-20	Kalsilytiske forbindelser
TR200100070A3 (tr)	2001-08-21	Bilesim
MX231963B (es)	2005-11-09	Poliamidas
SE0003477D0 (sv)	2000-09-28	Compounds
SE0004680D0 (sv)	2000-12-18	New compound
SE0003979D0 (sv)	2000-10-31	Novel Compounds
SE0002331D0 (sv)	2000-06-20	Novel compounds
SE0000620D0 (sv)	2000-02-25	Novel compounds
SE0003203D0 (sv)	2000-09-08	Novel compounds
SE0003436D0 (sv)	2000-09-26	Novel compounds

Legal Events

Date	Code	Title	Description
2015-06-22	MM1K	Lapsed by not paying the annual fees